FlyBase Allele Report: Dmel\svp[1.sev]

General Information

Symbol

Dmel\svp^1.sev

Species

D. melanogaster

Name

FlyBase ID

FBal0032835

Feature type

allele

Associated gene

Dmel\svp

Associated Insertion(s)

Carried in Construct

P{sev-svp1}

Key Links

Transgenic product class

cDNA

(Hiromi et al., 1993)

wild_type

(Hiromi et al., 1993)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Hiromi et al., 1993)

wild_type

(Hiromi et al., 1993)

Mutagen

in vitro construct

(Begemann et al., 1995, Kramer et al., 1995, Hiromi et al., 1993)

Progenitor genotype

Carried in construct

P{sev-svp1}

Cytology

Description

svp type 1 cDNA expressed from a sev enhancer/promoter cassette.

(Hiromi et al., 1993)

Allele components

Component

Use(s)

Regulatory region(s)

sev

Encoded product / tool

svp

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

cone cell

(Begemann et al., 1995, Kramer et al., 1995)

photoreceptor cell R7

(Begemann et al., 1995, Kramer et al., 1995, Hiromi et al., 1993)

Detailed Description

Statement

Reference

One copy causes mild external eye roughening, two copies enhances the roughening. Dosage-dependent (two or more copies of P{sev-svp1}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors. Also an increasing number of ommatidia have malformed and collapsed lenses.

(Begemann et al., 1995)

Rough eye phenotype. Transformation of cone cells towards R7 neurons. Increased copies of P{sev-svp1} cause ommatidia to contain seven or more outer photoreceptors and one or more R7 cells, this represents a transformation of R7 to an outer photoreceptor.

(Kramer et al., 1995)

Eye roughening, due to cone cells being transformed into extra photoreceptor R7-like cells. Extra cells are recruited to become cone cells: there is no depletion of cone cell numbers. sina, but neither sev nor boss, is required for this cone cell transformation.

(Hiromi et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

svp^1.sev has phenotype, enhanceable by RasGAP1^rI533

(Begemann et al., 1995)

svp^1.sev has phenotype, enhanceable by Ras85D^V12.sev

(Begemann et al., 1995)

svp^1.sev has phenotype, enhanceable by Sos^JC2

(Begemann et al., 1995)

svp^1.sev has phenotype, enhanceable by aop^A141

(Begemann et al., 1995)

svp^1.sev has phenotype, enhanceable by aop^yan-1

(Begemann et al., 1995)

svp^1.sev has phenotype, enhanceable by Raf::tor^12D.hs.sev

(Begemann et al., 1995)

svp^1.sev has phenotype, enhanceable by rl^Sem

(Begemann et al., 1995)

svp^1.sev has phenotype, enhanceable by sev^S11.Tag:MYC

(Begemann et al., 1995)

Suppressed by

Statement

Reference

svp^1.sev has phenotype, suppressible by Egfr^f11

(Begemann et al., 1995)

svp^1.sev has phenotype, suppressible by Egfr^t1

(Begemann et al., 1995)

svp^1.sev has phenotype, suppressible by rl^10a

(Begemann et al., 1995)

svp^1.sev has phenotype, suppressible by Ras85D^e2F

(Begemann et al., 1995)

svp^1.sev has phenotype, suppressible by Sos^e4G

(Begemann et al., 1995, Kramer et al., 1995)

svp^1.sev has phenotype, suppressible by drk^e0A

(Begemann et al., 1995)

svp^1.sev has phenotype, suppressible by Raf¹

(Begemann et al., 1995)

svp^1.sev has phenotype, suppressible by Raf⁷

(Begemann et al., 1995)

svp^1.sev has phenotype, suppressible by phyl^odin17L1

(Begemann et al., 1995)

svp^1.sev has phenotype, suppressible by phyl^odin3G6

(Begemann et al., 1995)

svp^1.sev has phenotype, suppressible by rl¹⁰

(Begemann et al., 1995)

svp^1.sev has phenotype, suppressible by Dsor1^LF133

(Kramer et al., 1995)

svp^1.sev has phenotype, suppressible by Egfr^A3

(Kramer et al., 1995)

svp^1.sev has phenotype, suppressible by Egfr^B24

(Kramer et al., 1995)

svp^1.sev has phenotype, suppressible by Ras85D^C33

(Kramer et al., 1995)

svp^1.sev has phenotype, suppressible by Sos^F1

(Kramer et al., 1995)

svp^1.sev has phenotype, suppressible by Raf^LQ129

(Kramer et al., 1995)

Other

Statement

Reference

sina¹/sina³, svp^1.sev has photoreceptor cell R7 phenotype

(Hiromi et al., 1993)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Effect is weaker than for svp^2.sev. Phenotype depends on C terminal portion of the protein, see svp^sev.ΔMlu, svp^sev.ΔSal and svp^sev.ΔSal.

(Hiromi et al., 1993)

Cone cell transformation can be dominantly suppressed by mutations in components of the Ras85D signal transduction cascade. Mutations in negative regulators of Ras85D activity act as dominant enhancers.

(Begemann et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

svp^1.sev

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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