FlyBase Allele Report: Dmel\RasGAP1[rI533]

General Information

Symbol

Dmel\RasGAP1^rI533

Species

D. melanogaster

Name

FlyBase ID

FBal0260895

Feature type

allele

Associated gene

Dmel\RasGAP1

Associated Insertion(s)

P{PZ}RasGAP1^rI533

Carried in Construct

Also Known As

rI533^PB

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Gaul et al., 1992)

Mutagen

P-element activity

(Gaul et al., 1992)

Progenitor genotype

Associated Insertion(s)

P{PZ}RasGAP1^rI533

Cytology

Description

P{PZ} insertion within Gap1 coding region.

(Gaul et al., 1992)

P-element insertion into the open reading frame 66bp downstream of the first initiation codon and 85bp upstream of the first splice donor site.

(Gaul et al., 1992)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Guo et al., 1997)

visible | recessive

(Gaul et al., 1992, Lai and Rubin, 1992)

Phenotype Manifest In

eye

(Guo et al., 1997)

eye photoreceptor cell

(Lai and Rubin, 1992)

mesothoracic tibial bract

(Gaul et al., 1992)

metathoracic tibial bract

(Gaul et al., 1992)

ommatidium

(Gaul et al., 1992)

photoreceptor cell R7

(Gaul et al., 1992)

prothoracic tibial bract

(Gaul et al., 1992)

sex comb | ectopic

(Gaul et al., 1992)

wing vein

(Gaul et al., 1992)

Detailed Description

Statement

Reference

Disrupted eye development. PACAP38 (neuropeptide pituitary adenylyl cyclase-activating polypeptide) induced normal enhancement of K⁺ currents.

(Guo et al., 1997)

No effect on the faf eye phenotype.

(Huang and Fischer-Vize, 1996)

Rough eye phenotype.

Rough eye phenotype. Ommatidia are improperly oriented and occasionally are fused. Ommatidia contain supernumerary cells that are characteristic of R7 cells. Supernumerary cells are derived from a cone cell precursor, or a mystery cell, that adopts a neural fate in the disc. Wings show additional longitudinal veinlet branches of the posterior crossvein and delta-like structures. One or two extra sex combs form in ectopic positions and in both sexes duplications of epidermal structures associated with bristles of the distal leg.

(Gaul et al., 1992)

Rough eye phenotype, 86% ommatidia contain supernumerary R7-like cells, at the expense of cone cell precursors.

(Lai and Rubin, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

RasGAP1^rI533 is a suppressor of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

RasGAP1^rI533 is a suppressor of visible phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Phenotype Manifest In

Enhancer of

Statement

Reference

RasGAP1^rI533 is an enhancer of phenotype of svp^1.sev

(Begemann et al., 1995)

RasGAP1^rI533 is an enhancer of phenotype of svp^2.sev

(Begemann et al., 1995)

RasGAP1^rI533 is an enhancer of eye phenotype of aop^A141

(Lai and Rubin, 1992)

RasGAP1^rI533 is an enhancer of ommatidium phenotype of aop^A141

(Lai and Rubin, 1992)

RasGAP1^rI533 is an enhancer of eye photoreceptor cell phenotype of aop^A141

(Lai and Rubin, 1992)

Suppressor of

Statement

Reference

RasGAP1^rI533 is a suppressor of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

RasGAP1^rI533 is a suppressor of eye phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Enhancer of the dosage-dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors.

(Begemann et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Precise excision of the P{PZ} element reverts the mutant eye phenotype to wild type.

(Gaul et al., 1992)

Excision of the P-element results in reversion of the mutant phenotype.

(Gaul et al., 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Gap1^PB

Gap1^rI533

RasGAP1^rI533

gap1^rI533

(Chang et al., 1995)

rI533^PB

(Zhong, 1995, Gaul et al., 1992)

rI533PB

(Guo et al., 1997)

Name Synonyms

Secondary FlyBase IDs

FBal0042597
FBal0033723

References (9)

Report Sections

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