FlyBase Allele Report: Dmel\sina[1]

General Information

Symbol

Dmel\sina¹

Species

D. melanogaster

Name

FlyBase ID

FBal0015665

Feature type

allele

Associated gene

Dmel\sina

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Lindsley and Zimm, 1992, Carthew and Rubin, 1990)

Mutagen

ethyl methanesulfonate

(Carthew and Rubin, 1990)

Progenitor genotype

Cytology

Description

Amino acid replacement: L243R. Nucleotide substitution: T1630G.

(Carthew and Rubin, 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:16,857,145..16,857,145 [+]

Nucleotide change:

T16857145G

Reported nucleotide change:

T1630G

Amino acid change:

L243R | sina-PA; L243R | sina-PB; L243R | sina-PC

Reported amino acid change:

L243R

(Carthew and Rubin, 1990)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased rate of movement

(Lindsley and Zimm, 1992)

female sterile

(Lindsley and Zimm, 1992)

male sterile

(Lindsley and Zimm, 1992)

Phenotype Manifest In

macrochaeta

(Lindsley and Zimm, 1992)

ommatidium

(Lindsley and Zimm, 1992)

photoreceptor cell R1 | somatic clone | increased number

(Mavromatakis and Tomlinson, 2012)

photoreceptor cell R7

(Lindsley and Zimm, 1992, Carthew and Rubin, 1990)

wing

(Lindsley and Zimm, 1992)

Detailed Description

Statement

Reference

sina¹ mosaic eye clones exhibit fewer R1 cells and an increase in R1 photoreceptor cells.

(Mavromatakis and Tomlinson, 2012)

Photoreceptor cell R7 of eye transformed into a cone cell, resulting in the absence of R7 in adult ommatidia. In amorphic alleles, 40% of ommatidia also missing an additional photoreceptor cell and 10% of ommatidia also missing two photoreceptor cells. Eyes weakly rough; ocelli appear normal. Adult bristles sometimes missing and sometimes duplicated, arising from a common socket; occasionally three bristles arise from a common socket. Wings sometimes held outstretched. Adults eclose normally but fail to survive after 24 h; display lethargic behavior and are not fertile, though mature sperm and ova are produced.

(Lindsley and Zimm, 1992)

Weak allele. 10% of the sina¹ ommatidia have an R7 cell present.

(Carthew and Rubin, 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

sina¹/sina[+] is a suppressor of decreased occurrence of cell division phenotype of CycE^JP

(Brumby et al., 2004)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

sina¹ is a non-enhancer of phenotype of Doa⁷/Doa^HD

(Yun et al., 2000)

sina¹ is a non-enhancer of phenotype of Doa^HD/Doa^Dem

(Yun et al., 2000)

Suppressor of

Statement

Reference

sina¹ is a suppressor of eye disc & S phase phenotype of CycE^JP

(Brumby et al., 2004)

sina¹/sina[+] is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2004)

NOT Suppressor of

Statement

Reference

sina¹ is a non-suppressor of phenotype of Doa⁷/Doa^HD

(Yun et al., 2000)

sina¹ is a non-suppressor of phenotype of Doa^HD/Doa^Dem

(Yun et al., 2000)

Other

Statement

Reference

sina¹/sina³, svp^2.sev has photoreceptor cell R7 phenotype

(Hiromi et al., 1993)

sina¹/sina³, svp^1.sev has photoreceptor cell R7 phenotype

(Hiromi et al., 1993)

Additional Comments

Genetic Interactions

Statement

Reference

Suppresses the S phase defects seen in the CycE^JP eye disc.

(Brumby et al., 2004)

sina¹/sina³; svp^1.sev and sina¹/sina³; svp^2.sev flies differentiate neither normal nor ectopic R7 cells.

(Hiromi et al., 1993)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Residual Ecol\CAT activity of 6.9% is seen in sina¹ mutant flies transformed with Ecol\CAT^Rh4.PF, consistent with the finding that 10% of the sina¹ ommatidia have an R7 cell present.

(Carthew and Rubin, 1990)

No interaction with P{sev-svp1} or P{sev-svp2} exists.

(Begemann et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sina⁰

(Mavromatakis and Tomlinson, 2012)

sina¹

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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