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General Information
Symbol
Dmel\Doa7
Species
D. melanogaster
Name
FlyBase ID
FBal0002725
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Doa105
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The wings of Doa7/Doa9 mutant flies exhibit a held-out phenotype.

Doa7/DoaE786 mutants exhibit defects in the mesothoracic tarsi.

Doa7/Doa3 mutants where the Doa7 allele is from the mother are viable. When the Doa3 allele comes from the mother there are no survivors.

In Doa7/Doa5 mutants where the Doa7 allele is from the mother only the males survive and they have held-out and fragile wings, ectopic crossveins, missing scutellar bristles. When the Doa5 allele comes from the mother there are no survivors.

In Doa7/Doa9 mutants where the Doa7 allele is from the mother it is predominantly males that are observed. These have rough eyes, held-out and fragile wings, duplication of the postalar bristles, missing scutellar or ocellar bristles, slight sexual transformations of females and disorganisation of the vaginal bristles. When the Doa9 allele comes from the mother there are no survivors.

In Doa7/DoaE777 mutants where the Doa7 allele is from the mother only the males survive and the flies have held-out wings and duplication of the postalar bristles. When the DoaE777 allele comes from the mother there are no survivors.

In Doa7/Doa04743 mutants where the Doa7 allele is from the mother only males are observed. These have extremely rough eyes, ectopic wing veins, missing head, scutellar and thoracic bristles. When the Doa04743 allele comes from the mother there are no survivors.

Transheterozygotes with Doa01705b have rough eyes and duplicated scutellar bristles.

XX ; Doa7/DoaDem and XX ; Doaunspecified/Doa7 adults have subtle intersexual characteristics.

Heterozygotes with DoaHD have ommatidia of varying size and disorganization of the interommatidial bristles. Random interruption of the normal lattice of pigment cells and random vacuolization of the retina and pigment cells are restored to at least normal levels (suppression of wa).

Rare DoaHD/Doa7 escapers of lethality are found at a frequency of approximately 0.5%.

Heterozygotes with DoaHD survive rarely and when they do, wa is darkened to nearly wild-type color; wsp55 reacts in the opposite manner, becoming nearly white; eyes of escapers have disarranged facets; both sexes involving Doa7 are weakly fertile.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhanced by
Statement
Reference

Doa7/DoaHD has phenotype, non-enhanceable by Ras85De2F

Doa7/DoaHD has phenotype, non-enhanceable by gl2

Doa7/DoaHD has phenotype, non-enhanceable by gl60j

Doa7/DoaHD has phenotype, non-enhanceable by rl1

Doa7/DoaHD has phenotype, non-enhanceable by rlSem

Doa7/DoaHD has phenotype, non-enhanceable by sina1

NOT suppressed by
Statement
Reference

Doa7/DoaHD has phenotype, non-suppressible by Ras85De2F

Doa7/DoaHD has phenotype, non-suppressible by gl2

Doa7/DoaHD has phenotype, non-suppressible by gl60j

Doa7/DoaHD has phenotype, non-suppressible by rl1

Doa7/DoaHD has phenotype, non-suppressible by rlSem

Doa7/DoaHD has phenotype, non-suppressible by sina1

Enhancer of
Statement
Reference

Doa7 is an enhancer of phenotype of wsp55

NOT Enhancer of
Statement
Reference

Doa7 is a non-enhancer of phenotype of wa57i11

Doa7 is a non-enhancer of phenotype of wa58l

Doa7 is a non-enhancer of phenotype of wa2

Doa7 is a non-enhancer of phenotype of wr

Doa7 is a non-enhancer of phenotype of wIR5

Doa7 is a non-enhancer of phenotype of wa3

Doa7 is a non-enhancer of phenotype of wsp81d

Doa7 is a non-enhancer of phenotype of wa59k1

Doa7 is a non-enhancer of phenotype of wsp2

Doa7 is a non-enhancer of phenotype of wE

Doa7 is a non-enhancer of phenotype of wec3

Doa7 is a non-enhancer of phenotype of wapl/wapl

Doa7 is a non-enhancer of phenotype of wIR2

Doa7 is a non-enhancer of phenotype of wsat

Doa7 is a non-enhancer of phenotype of wbl

Doa7 is a non-enhancer of phenotype of wBwx

Doa7 is a non-enhancer of phenotype of wa4

Doa7 is a non-enhancer of phenotype of wIR3

Doa7 is a non-enhancer of phenotype of wcol

Doa7 is a non-enhancer of phenotype of we2

Doa7 is a non-enhancer of phenotype of wco

Doa7 is a non-enhancer of phenotype of wi

Doa7 is a non-enhancer of phenotype of wIR4

Doa7 is a non-enhancer of phenotype of wIR6

Doa7 is a non-enhancer of phenotype of wmo

Doa7 is a non-enhancer of phenotype of wIR1

Doa7 is a non-enhancer of phenotype of wh

Doa7 is a non-enhancer of phenotype of wbf2

Doa7 is a non-enhancer of phenotype of wzm

Doa7 is a non-enhancer of phenotype of wbf

Doa7 is a non-enhancer of phenotype of we

Suppressor of
Statement
Reference

Doa7 is a suppressor of phenotype of waR84h

Doa7 is a suppressor of phenotype of wa

Doa7 is a suppressor of phenotype of waM

NOT Suppressor of
Statement
Reference

Doa7 is a non-suppressor of phenotype of wa57i11

Doa7 is a non-suppressor of phenotype of wa58l

Doa7 is a non-suppressor of phenotype of we

Doa7 is a non-suppressor of phenotype of wa2

Doa7 is a non-suppressor of phenotype of wr

Doa7 is a non-suppressor of phenotype of wIR5

Doa7 is a non-suppressor of phenotype of wa3

Doa7 is a non-suppressor of phenotype of wsp81d

Doa7 is a non-suppressor of phenotype of wa59k1

Doa7 is a non-suppressor of phenotype of wsp2

Doa7 is a non-suppressor of phenotype of wE

Doa7 is a non-suppressor of phenotype of wec3

Doa7 is a non-suppressor of phenotype of wapl/wapl

Doa7 is a non-suppressor of phenotype of wIR2

Doa7 is a non-suppressor of phenotype of wsat

Doa7 is a non-suppressor of phenotype of wIR3

Doa7 is a non-suppressor of phenotype of wbl

Doa7 is a non-suppressor of phenotype of wBwx

Doa7 is a non-suppressor of phenotype of wa4

Doa7 is a non-suppressor of phenotype of wcol

Doa7 is a non-suppressor of phenotype of we2

Doa7 is a non-suppressor of phenotype of wco

Doa7 is a non-suppressor of phenotype of wi

Doa7 is a non-suppressor of phenotype of wIR4

Doa7 is a non-suppressor of phenotype of wIR6

Doa7 is a non-suppressor of phenotype of wmo

Doa7 is a non-suppressor of phenotype of wIR1

Doa7 is a non-suppressor of phenotype of wh

Doa7 is a non-suppressor of phenotype of wbf2

Doa7 is a non-suppressor of phenotype of wzm

Doa7 is a non-suppressor of phenotype of wbf

Other
Additional Comments
Genetic Interactions
Statement
Reference

SRm160B103 produces a female to male somatic sex transformation phenotype in DoaHD/Doa7 mutant flies. The male genital arch and "claspers" are seen in XX individuals.

Doa7 in combination with E(gl)3Cunspecified results in flies with normal eyes, wings and bristles. No suppression of wa is seen in these flies.

Heterozygous traunspecified/+ adults have normal sexual differentiation. XX ; traunspecified/+ adults that are also carrying Doaunspecified/Doa7 are clearly intersexual with respect to the number or morphology of sex combs. Heterozygous tra2B/+ adults have normal sexual differentiation. XX ; tra2B/+ adults that are also carrying Doaunspecified/Doa7 are clearly intersexual with respect to the number or morphology of sex combs.

Rare DoaHD/Doa7 escapers show extreme suppression of the wa phenotype, such that eyes, Malpighian tubules, ocelli and testes are essentially wild-type in colour. They have disordered eye facets and scutellar bristles are often missing or abnormal. Male escapers carrying wsp55 have bleach-white eyes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (8)