FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Rab5UAS.cEa
Open Close
General Information
Symbol
Dmel\Rab5UAS.cEa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Entchev
FlyBase ID
FBal0120655
Feature type
allele
Associated gene
Dmel\Rab5
Associated Insertion(s)
Carried in Construct
P{UAS-Rab5.E}
Also Known As
UAS-rab5
Key Links
Transgenic product class
cDNA
(Entchev et al., 2000)
wild_type
(Entchev et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Entchev et al., 2000)
wild_type
(Entchev et al., 2000)
Mutagen
in vitro construct
(Wucherpfennig et al., 2003, Entchev et al., 2000)
Progenitor genotype
Carried in construct
P{UAS-Rab5.E}
Cytology
Description

UAS regulatory sequences drive expression of the Rab5 GM02432 EST.

(Entchev et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Rab5
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      egg chamber & basement membrane | apical, with Scer\GAL4slbo.2.6

      (Medioni and Noselli, 2005)
      Detailed Description
      Statement
      Reference

      Expression of Rab5Scer\UAS.cEa under the control of Scer\GAL4ap-md544 in a wild-type background has no effect on leg joint development.

      (Capilla et al., 2012)

      Expression of Rab5Scer\UAS.cEa under the control of Scer\GAL4bbg-C96 appears to have no effect on adult wing formation.

      (Seto and Bellen, 2006)

      Expression of Rab5Scer\UAS.cEa in border cells, driven by Scer\GAL4slbo.2.6, induces a 5% increase in the number of egg chambers with an apical cap. Micro caps are seen less frequently than in wild-type egg chambers.

      (Medioni and Noselli, 2005)

      Rab5Scer\UAS.cEa, under the regulation of Scer\GAL4elav-C155 does not significantly alter the synaptic area, nor the active zone density of presynaptic terminals, implying that the total number of active zones is normal. The mean quantal content, however, is significantly increased by 1.74 times in Rab5Scer\UAS.cEa mutants compared to wild-type. Because the number of docked vesicles and the spontaneous release rate is normal, the higher quantal content indicates that elevated levels of Rab5 function leads to an increased probability of Ca2+-triggered synaptic vesicle release. Rab5Scer\UAS.cEa; Scer\GAL4elav-C155 larvae have expanded endosomal structures at pre-synaptic termini, producing large tubular structures and multivesicular bodies and only 1-3 endosomal structures per synaptic bouton.

      (Wucherpfennig et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Rab5UAS.cEa, Scer\GAL4GMR.PF is an enhancer of eye phenotype of Scer\GAL4GMR.PF, egrUAS.cIa

      (Igaki et al., 2009)
      Suppressor of
      Statement
      Reference

      Rab5UAS.cEa/Scer\GAL4ap-md544 is a suppressor of leg joint | ectopic phenotype of dsh1

      (Capilla et al., 2012)

      Rab5UAS.cEa/Scer\GAL4ap-md544 is a suppressor of leg phenotype of dsh1

      (Capilla et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Rab5Scer\UAS.cEa under the control of Scer\GAL4ap-md544 partially suppresses the dsh1 ectopic leg joint phenotype, with partial suppression being seen in 80% of the legs examined.

      (Capilla et al., 2012)

      Expression of egrScer\UAS.cIa and Rab5Scer\UAS.cEa in the eye under the control of Scer\GAL4GMR.PF results in a severe small-eye phenotype.

      (Igaki et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Drab5WT
      (Medioni and Noselli, 2005)
      Rab5Scer\UAS.cEa
      Rab5UAS.cEa
      UAS-DRab5
      (Wucherpfennig et al., 2003)
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Entchev
      (Entchev et al., 2000)
      Secondary FlyBase IDs
        References (11)