FlyBase Gene Report: Dmel\Nrg

General Information

Symbol

Dmel\Nrg

Species

D. melanogaster

Name

Neuroglian

Annotation Symbol

CG1634

Feature Type

protein_coding_gene

FlyBase ID

FBgn0264975

Gene Model Status

Current

Stock Availability

35 publicly available

Gene Summary

Neuroglian (Nrg) encodes an immunoglobulin domain-containing cell adhesion molecule that mediates cell-cell adhesion by forming homo- or heterophilic interactions. The long isoform of the product of Nrg is neuron specific and plays roles in neurite outgrowth, axon guidance and synapse formation. The short isoform of the product of Nrg contributes to the formation of septate junctions in epithelial cells. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Red Book
Interactive Fly

Also Known As

ceb, central brain deranged, Nrg180, CT4318, fs(1)M72

Key Links

Genomic Location

Cytogenetic map

7F2-7F4

Sequence location

X:8,517,373..8,555,170 [+]

Recombination map

1-23

RefSeq locus

NC_004354 REGION:8517373..8555170

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (34 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables calcium ion binding

inferred from direct assay

(Teng et al., 1994)

enables cell adhesion molecule binding

inferred from physical interaction with FLYBASE:ed; FB:FBgn0000547

(Islam et al., 2003)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (21 terms)

Terms Based on Experimental Evidence (21 terms)

CV Term

Evidence

References

involved_in axon ensheathment

inferred from mutant phenotype

(Banerjee et al., 2006)

involved_in axon extension

inferred from mutant phenotype

(Yamamoto et al., 2006)

involved_in axonogenesis

inferred from mutant phenotype

(Islam et al., 2004)

involved_in cell adhesion involved in heart morphogenesis

inferred from mutant phenotype

(Yi et al., 2008)

involved_in cell-cell adhesion

inferred from direct assay

(Islam et al., 2003)

involved_in central complex development

inferred from mutant phenotype

(Carhan et al., 2005)

involved_in dendrite morphogenesis

inferred from mutant phenotype

(Yamamoto et al., 2006)

involved_in establishment of glial blood-brain barrier

inferred from mutant phenotype

(Stork et al., 2008, Schwabe et al., 2005)

involved_in female courtship behavior

inferred from mutant phenotype

(Kerr et al., 1997)

involved_in imaginal disc morphogenesis

inferred from mutant phenotype

(Hortsch et al., 1990)

involved_in male courtship behavior

inferred from mutant phenotype

(Carhan et al., 2005)

involved_in melanotic encapsulation of foreign target

inferred from mutant phenotype

(Williams, 2009)

involved_in motor neuron axon guidance

inferred from mutant phenotype

(Zarin et al., 2014)

involved_in mushroom body development

inferred from mutant phenotype

(Carhan et al., 2005, de Belle and Heisenberg, 1996)

involved_in nerve maturation

inferred from mutant phenotype

(Banerjee et al., 2006)

involved_in neuron cell-cell adhesion

inferred from mutant phenotype

(Hortsch et al., 1990)

involved_in photoreceptor cell axon guidance

inferred from mutant phenotype

(Kristiansen et al., 2005)

involved_in regulation of female receptivity

inferred from mutant phenotype

(Carhan et al., 2005)

involved_in regulation of tube size, open tracheal system

inferred from mutant phenotype

(Paul et al., 2003)

involved_in septate junction assembly

inferred from mutant phenotype

(Banerjee et al., 2006, Faivre-Sarrailh et al., 2004)

involved_in synapse organization

inferred from mutant phenotype

(Enneking et al., 2013, Godenschwege et al., 2006)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (11 terms)

Terms Based on Experimental Evidence (10 terms)

CV Term

Evidence

References

located_in axon

inferred from direct assay

(Gross et al., 2013)

colocalizes_with cytoneme

inferred from direct assay

(Roy et al., 2014)

located_in dendrite

inferred from direct assay

(Gross et al., 2013)

located_in filopodium

inferred from direct assay

(Williams, 2009)

located_in lateral plasma membrane

inferred from direct assay

(Mukherjee et al., 2023)

located_in membrane

inferred from mutant phenotype

(Tempesta et al., 2017)

located_in neuronal cell body

inferred from direct assay

(Gross et al., 2013)

located_in plasma membrane

inferred from high throughput direct assay

(Lye et al., 2014)

inferred from direct assay

(Hortsch et al., 1990)

inferred from direct assay

(Williams, 2009, Islam et al., 2003)

located_in pleated septate junction

inferred from direct assay

(Faivre-Sarrailh et al., 2004)

located_in septate junction

inferred from direct assay

(Hall et al., 2014, Schulte et al., 2006, Genova and Fehon, 2003)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in neuron projection

inferred from biological aspect of ancestor with PANTHER:PTN000456776

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Protein Function (UniProtKB)

Essential for septate junctions. Septate junctions, which are the equivalent of vertebrate tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for formation of the hemolymph-brain barrier (the insect blood-brain barrier). Vital for embryonic development. Involved in the targeting for degradation or recycling of certain septate junction components, including kune and bou/boudin, by regulating their endocytosis (PubMed:28977027).

(UniProt, P20241)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

ceb: central brain deranged (J.C. Hall)

Extra lobe, in adult brain, of approximately 400 coiled Kenyon-cell fibers next to calyx of mushroom bodies; olfactory learning in adults slightly reduced; memory is normal.

Nrg: Neuroglian

Encodes a protein that is likely to play a role in neural and glial cell adhesion in the developing Drosophila embryo. Widely expressed in the embryo, particularly on the surfaces of a large subset of neurons and glia that interact with and adhere to one another along the dorsal surface of the developing CNS and within the peripheral nerve roots; the protein can be detected along neuronal axons, but not cell bodies. Three polypeptides of 155, 167, and 180 kd are detected on Western blots; deglycosylation experiments reduce these to a single 155 kd band; removal of N-linked high-mannose oligosaccharides causes a shift to about 162 kd. It is also expressed in a number of non-neuronal tissues such as trachea, hindgut, salivary gland and muscle. Recessive alleles are embryonic lethals and show little or no evidence of Neuroglian expression; the overall structure of the CNS and PNS, and in particular the peripheral nerve roots and CNS axon pathways develop in a relatively normal way in lethal embryos.

Summary (Interactive Fly)

IG superfamily - NgCAM related - a cell aggregaton and signaling molecule that transmits the positional value of cell adhesion to the cytoplasmic assembly of ankyrin and spectrin

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Nrg for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P20241)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

1CFB

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Nrg-RA

FBtr0071207

NM_078535

5247

1239

Nrg-RB

FBtr0071208

NM_167160

4492

1302

Nrg-RC

FBtr0071209

NM_206657

5090

1239

Nrg-RD

FBtr0301762

NM_001169233

5059

1239

Nrg-RE

FBtr0301763

NM_001169234

7386

1302

Nrg-RF

FBtr0301764

NM_001169235

5064

1239

Nrg-RG

FBtr0305914

NM_001258652

5403

1309

Nrg-RH

FBtr0333522

NM_001272407

5272

1239

Nrg-RI

FBtr0333523

NM_001272408

5548

1302

Additional Transcript Data and Comments

Reported size (kB)

7.6, 5.7, 5.5 (northern blot)

(Hortsch et al., 1990)

5.1 (northern blot)

(Bieber et al., 1989)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Nrg-PA

FBpp0071154

138.4

1239

5.15

FBpp0071155

143.6

1302

5.15

FBpp0089326

138.4

1239

5.15

FBpp0290976

138.4

1239

5.15

FBpp0290977

143.6

1302

5.15

FBpp0290978

138.4

1239

5.15

FBpp0297081

145.5

1309

5.24

FBpp0305702

138.4

1239

5.15

FBpp0305703

143.6

1302

5.15

P20241

NP_001259337

AGB95181

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1239 aa isoforms: Nrg-PA, Nrg-PC, Nrg-PD, Nrg-PF, Nrg-PH

1302 aa isoforms: Nrg-PB, Nrg-PE, Nrg-PI

Additional Polypeptide Data and Comments

Reported size (kDa)

1302, 1239 (aa)

(Zhao and Hortsch, 1998)

180 (kD observed)

(Hortsch et al., 1990)

1216 (aa); 145-155 (kD predicted)

(Bieber et al., 1989)

Comments

Neuron-specific 180kD form.

(Zhao and Hortsch, 1998)

The core 145-155 kD Nrg protein is glycosylated

to produce a 167-180 kD protein. Nrg may play a role in neural and glial

adhesion in the developing embryo.

(Dubreuil et al., 1997)

External Data

Subunit Structure (UniProtKB)

Forms a complex with Nrx-IV/Nrx and Cont (PubMed:15459097). Forms a complex composed of septate junction proteins Nrx-IV/Nrx, Tsf2/MTf, Cont and Nrg during late embryogenesis (PubMed:20935638).

(UniProt, P20241)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

1CFB

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nrg using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.83

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Hortsch et al., 1990)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 17

organism

Comment: extended 3' UTR isoform

(Hilgers et al., 2011)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)

embryonic anal pad

(Fisher et al., 2012)

embryonic brain

(Fisher et al., 2012)

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic head sensory system

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

embryonic/larval posterior spiracle

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

larval midline neuron

(Kearney et al., 2004)

embryonic stage 15

larval DA1 motor neuron

(Zarin et al., 2014)

larval RP2 motor neuron

(Zarin et al., 2014)

embryonic stage 15 -- 17

Comment: reference states >=11-12 hr AEL

(Bieber et al., 1989)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Hortsch et al., 1990)

embryonic stage 13 -- 17

Comment: reference states >=9 hr AEL

(Hortsch et al., 1990)

Additional Descriptive Data

Isoforms of nmo with extended 3' UTRs appear later in embryogenesis. Sequential, phased, 3' UTR lengthening is seen (3' UTR lengthening ocurring in multiple steps during later stages of embryogenesis).

(Hilgers et al., 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis & adult stage | female

follicle cell

• plasma membrane

(Dubreuil et al., 1997)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Hortsch et al., 1990)

embryonic stage 11 -- 17

central nervous system | restricted

Comment: reference states >6 hr AEL

(Hortsch et al., 1990)

presumptive embryonic/larval peripheral nervous system | restricted

Comment: reference states >=7 hr AEL

(Hortsch et al., 1990)

embryonic stage 12 -- 17

Comment: reference states >=8 hr AEL

(Hortsch et al., 1990)

embryonic stage 15

larval channel glial cell

(Strigini et al., 2006)

embryonic stage 15 -- 16

exit glial cell

(Strigini et al., 2006)

PNS glial cell

(Strigini et al., 2006)

embryonic stage 15 -- 17

central nervous system | restricted

Comment: reference states >=11-12 hr AEL

(Bieber et al., 1989)

embryonic/larval hindgut

Comment: reference states >=11-12 hr AEL

(Bieber et al., 1989)

embryonic/larval salivary gland

Comment: reference states >=11-12 hr AEL

(Bieber et al., 1989)

embryonic/larval tracheal section

Comment: reference states >=11-12 hr AEL

(Bieber et al., 1989)

larval muscle system

Comment: reference states >=11-12 hr AEL

(Bieber et al., 1989)

embryonic stage 17

larval ventral nerve cord

(Bouley et al., 2000)

embryonic brain

(Bouley et al., 2000)

presumptive embryonic/larval peripheral nervous system

(Bouley et al., 2000)

larval segmental nerve

• axon

(Bouley et al., 2000)

larval intersegmental nerve

• axon

(Bouley et al., 2000)

first instar larval stage

gamma Kenyon cell

• axon & neuronal cell body & dendrite | faint

(Gross et al., 2013)

calyx of larval mushroom body | faint

(Gross et al., 2013)

third instar larval stage

epidermis of imaginal disc

(Hortsch et al., 1990)

neuron of imaginal disc

(Hortsch et al., 1990)

larval brain | ubiquitous

Comment: applies to longer protein isoform

(Goossens et al., 2011)

embryonic/larval mushroom body

Comment: applies to longer protein isoform

(Goossens et al., 2011)

prepupal stage P1 -- P4

pioneer neuron of ocellus

(Kristiansen et al., 2005)

ocellar nerve

(Kristiansen et al., 2005)

mechanosensory neuron of ocellus

(Kristiansen et al., 2005)

pupal stage & adult stage

adult mushroom body

Comment: applies to longer protein isoform

(Goossens et al., 2011)

adult stage

adult brain | ubiquitous

Comment: applies to longer protein isoform

(Goossens et al., 2011)

adult mushroom body gamma-lobe

Comment: applies to longer protein isoform

(Goossens et al., 2011)

adult mushroom body alpha-lobe

Comment: applies to longer protein isoform

(Goossens et al., 2011)

adult mushroom body beta-lobe

Comment: applies to longer protein isoform

(Goossens et al., 2011)

adult mushroom body alpha'-lobe

Comment: applies to longer protein isoform

(Goossens et al., 2011)

adult mushroom body beta'-lobe

Comment: applies to longer protein isoform

(Goossens et al., 2011)

oogenesis stage S9

border follicle cell

(Wang et al., 2006)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Nrg-XP is excluded from the calyx of the larval mushroom body, but not from the lobes.

(Gross et al., 2013)

The long Nrg protein isoform (designated NRG-180) is expressed throughout the third instar larval and adult brain. It is prominent in axons but is also present in cell bodies. In larval, pupal, and adult mushroom bodies, staining is observed in all lobes. High expression levels are observed in the adult gamma and alpha beta lobes. Expression is lower in axons of the alpha'beta' neurons.

(Goossens et al., 2011)

Nrg protein is detected in the glial cell membranes in the peripheral nerves, ensheathing the axons and in the axons themselves. In the chordotonal organs, it is detected in the scolopale and cap cells, and in the scolopidial neuron.

(Banerjee et al., 2006)

Nrg protein expression is enriched in border follicle cells relative to other cells in the egg chamber in early stage 9.

(Wang et al., 2006)

In the early prepupal stages before head eversion, tThe neural-specific Nrg180 isoform is expressed by both ocellar pioneer and bristle mechanosensory neurons, but not by the external bristle cells.

(Kristiansen et al., 2005)

Nrg is expressed at the lateral cell contacts of follicle cells in the ovary.

(Dubreuil et al., 1997)

The shorter form of the Nrg protein is expressed in the epidermal cells of the imaginal discs. Since the antibody which detects the short form of Nrg also detects the long form, it is not clear how much of the signal detected is attributable to the short form. Developmental western blots show that the shorter Nrg polypeptide is first unambiguously detected in 8 hour embryos, and is most strongly expressed in 8-12 hour embryos.

(Hortsch et al., 1990)

The long form of Nrg protein is expressed on the surface of central and peripheral nervous system neurons, and on some PNS support cells. The long form is detected starting at 6 hours of embryogenesis, in one neuron per CNS hemisegment. At 7 hours, CNS expression extends to a 4-5 cell wide longitudinal stripe which prefigures the location of the longitudinal axon tracts. PNS expression is detected by 7 hours. Expression observed in larval imaginal discs is also restricted to neurons. Developmental western blots indicate that the peak of expression for the longer Nrg polypeptide is reached shortly after the peak for the shorter form.

(Hortsch et al., 1990)

A monoclonal antibody which recognizes both forms of the Nrg protein detects Nrg protein in neurons of the central nervous system and peripheral nervous system of the embryo, as well as in epidermal cells and neurons of third instar larval imaginal discs.

(Hortsch et al., 1990)

Nrg protein is expressed on neurons and glia in the developing nervous system, and in some non-neuronal tissues including the trachea, hindgut, salivary gland and muscle.

(Bieber et al., 1989)

Marker for

PNS glial cell

(Strigini et al., 2006)

exit glial cell

(Strigini et al., 2006)

larval channel glial cell

(Strigini et al., 2006)

Subcellular Localization

CV Term

Evidence

References

located_in axon

inferred from direct assay

(Gross et al., 2013)

colocalizes_with cytoneme

inferred from direct assay

(Roy et al., 2014)

located_in dendrite

inferred from direct assay

(Gross et al., 2013)

located_in filopodium

inferred from direct assay

(Williams, 2009)

located_in lateral plasma membrane

inferred from direct assay

(Mukherjee et al., 2023)

located_in membrane

inferred from mutant phenotype

(Tempesta et al., 2017)

located_in neuronal cell body

inferred from direct assay

(Gross et al., 2013)

located_in plasma membrane

inferred from high throughput direct assay

(Lye et al., 2014)

inferred from direct assay

(Hortsch et al., 1990)

inferred from direct assay

(Williams, 2009, Islam et al., 2003)

located_in pleated septate junction

inferred from direct assay

(Faivre-Sarrailh et al., 2004)

located_in septate junction

inferred from direct assay

(Hall et al., 2014, Schulte et al., 2006, Genova and Fehon, 2003)

Expression Deduced from Reporters

Reporter: P{PTT-GA}Nrg^G00305

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis & adult stage | female

follicle cell

• cytoplasm

(Cooley et al., 2003.5)

follicle cell

• plasma membrane

(Cooley et al., 2003.5)

border follicle cell

• plasma membrane

(Cooley et al., 2003.5)

nurse cell

• plasma membrane | faint

(Cooley et al., 2003.5)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Nrg in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Nrg

View exonic expression by tissue for Dmel\Nrg

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264975

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31792/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264975

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0002968

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264975

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1634

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 28 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 47 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Nrg

Transgenic constructs containing regulatory region of Nrg

Aberrations (Deficiencies and Duplications) ( 13 )

Inferred from experimentation ( 13 )

Gene not duplicated in

Dp(1;Y)578

(Lilly and Botas, 1999)

Dp(1;Y)619

(Lilly and Botas, 1999)

Dp(1;Y)850

(Lilly and Botas, 1999)

Dp(1;Y)867

(Lilly and Botas, 1999)

Dp(1;Y)921

(Lilly and Botas, 1999)

Gene disrupted in

Df(1)24/14A

(Eeken et al., 1985)

Df(1)KA14

(Kerr et al., 1997, Bieber et al., 1989, King et al., 1986)

Df(1)RA2

(Kerr et al., 1997, Bieber et al., 1989, King et al., 1986)

In(1)RA35

(Kerr et al., 1997, Bieber et al., 1989)

Gene duplicated in

Dp(1;2)sn⁺72d

(King et al., 1986)

Gene not disrupted in

Df(1)Sp8A

(Schalet, 1986)

In(1)oc

(Kerr et al., 1997)

T(1;2)GE208

(Kerr et al., 1997)

Inferred from location ( 12 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

abnormal neuroanatomy, with Scer\GAL4^{shakB.lethal.4.1}

Nrg^GPI.UAS

abnormal neurophysiology, with Nrg^180.UAS, Scer\GAL4^{shakB.lethal.4.1}

Nrg⁸⁴⁹

abnormal neurophysiology, with Nrg⁸⁴⁹, Scer\GAL4^{shakB.lethal.4.1}

abnormal neurophysiology, with Nrg^GPI.UAS, Scer\GAL4^{shakB.lethal.4.1}

Nrg⁸⁴⁹

lethal

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Nrg^GD82

lethal, with Scer\GAL4^Act5C.PU

lethal (with Nrg^G0413)

Nrg^l10

lethal (with Nrg^G0488b)

Nrg^l10

lethal (with Nrg^l10)

lethal | adult stage

Nrg^G0099

lethal | embryonic stage

Nrg^l7

lethal | heat sensitive (with Nrg^G0099)

Nrg^l10

lethal | heat sensitive (with Nrg^l4)

Nrg^l10

lethal | heat sensitive (with Nrg^l7)

Nrg^l10

lethal | heat sensitive (with Nrg^l10)

lethal | larval stage

Nrg^l7

lethal | maternal effect | recessive

Nrg^ibx

lethal | pharate adult stage

Nrg^G0099

lethal | pupal stage

Nrg^G0099

lethal | recessive

lethal | recessive | heat sensitive

Nrg^l10

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

Nrg^GD82

lethal - all die during embryonic stage

lethal - all die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Nrg^GD82

lethal - all die during embryonic stage | recessive

lethal - all die during embryonic stage | recessive | heat sensitive

Nrg^l10

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Nrg^GD14467

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Nrg^GD14467

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^tin.CΔ4

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal cell number | adult stage | somatic clone

abnormal cell number | adult stage | somatic clone, with Scer\GAL4^Tub.PU

Nrg^GD14467

abnormal cell shape | third instar larval stage, with Scer\GAL4^pnr-MD237

Nrg^GD14467

abnormal courtship behavior | female (with Df(1)KA14)

Nrg^ibx

abnormal courtship behavior | female (with Df(1)RA2)

Nrg^ibx

abnormal courtship behavior | female (with Nrg⁸⁴⁹)

abnormal courtship behavior | female (with Nrg⁸⁹²)

abnormal courtship behavior | female (with Nrg^G0099)

abnormal courtship behavior | female (with Nrg^G0413)

abnormal courtship behavior | female (with Nrg^G0488b)

abnormal courtship behavior | female (with Nrg^ibx)

abnormal courtship behavior | female (with Nrg^l4)

abnormal courtship behavior | female | heat sensitive (with Nrg⁸⁴⁹)

Nrg^l10

abnormal courtship behavior | female | heat sensitive (with Nrg⁸⁹²)

Nrg^l10

abnormal courtship behavior | female | heat sensitive (with Nrg^l10)

abnormal courtship behavior | female | recessive

abnormal courtship behavior | male

abnormal immune response | conditional | larval stage

Nrg^G00305

abnormal immune response | conditional | larval stage, with Scer\GAL4^He.PZ

Nrg^GD14467

abnormal locomotor behavior | larval stage | recessive

Nrg⁸⁴⁹

abnormal mating | female | recessive

Nrg^ibx

abnormal memory

Nrg⁸⁴⁹

abnormal neuroanatomy

abnormal neuroanatomy, with Nrg^167ΔFIGQY

Nrg^l4

abnormal neuroanatomy, with Nrg^180YA

Nrg^l4

abnormal neuroanatomy, with Nrg^180YD

Nrg^l4

abnormal neuroanatomy, with Nrg^l4

abnormal neuroanatomy, with Nrg^l7, Scer\GAL4^pk-IG1-1

Nrg^UAS.Tag:HA

abnormal neuroanatomy, with Nrg^UAS.Tag:HA, Scer\GAL4^pk-IG1-1

Nrg^l7

abnormal neuroanatomy, with Scer\GAL4^c17

Nrg^GPI.UAS

abnormal neuroanatomy, with Scer\GAL4^MS1075

Nrg^167.UAS

abnormal neuroanatomy, with Scer\GAL4^pk-IG1-1, Scer\GAL4^repo

Nrg^RNAi.UAS

abnormal neuroanatomy, with Scer\GAL4^repo

Nrg^RNAi.UAS

abnormal neuroanatomy, with Scer\GAL4^shot-OK307

abnormal neuroanatomy | adult stage

abnormal neuroanatomy | adult stage, with Nrg^180YA

Nrg^l4

abnormal neuroanatomy | adult stage, with Nrg^180YD

Nrg^l4

abnormal neuroanatomy | adult stage, with Nrg^180YF

Nrg^l4

abnormal neuroanatomy | adult stage, with Nrg^180ΔC

Nrg^l4

abnormal neuroanatomy | adult stage, with Nrg^180ΔFIGQY

Nrg^l4

abnormal neuroanatomy | adult stage, with Nrg^l4

abnormal neuroanatomy | adult stage, with Scer\GAL4^Ilp2.PR

abnormal neuroanatomy | adult stage, with Scer\GAL4^repo.PL

abnormal neuroanatomy | adult stage (with Nrg⁸⁴⁹)

abnormal neuroanatomy | adult stage (with Nrg⁸⁹²)

Nrg⁸⁴⁹

abnormal neuroanatomy | adult stage (with Nrg^G00305)

Nrg⁸⁴⁹

abnormal neuroanatomy | adult stage (with Nrg^l4)

Nrg⁸⁴⁹

abnormal neuroanatomy | adult stage (with Nrg^l10)

Nrg⁸⁴⁹

abnormal neuroanatomy | embryonic stage

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^how-24B

Nrg^180.I.UAS

abnormal neuroanatomy | heat sensitive

Nrg^l3

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

abnormal neuroanatomy | P-stage

Nrg⁸⁴⁹

abnormal neuroanatomy | P-stage, with Scer\GAL4^ppk.PU

abnormal neuroanatomy | P-stage | somatic clone

Nrg^l4

abnormal neuroanatomy | somatic clone | third instar larval stage

Nrg^l4

abnormal neuroanatomy | third instar larval stage, with Nrg^180YF

Nrg^l4

abnormal neuroanatomy | third instar larval stage, with Nrg^180ΔC

Nrg^l4

abnormal neuroanatomy | third instar larval stage, with Nrg^180ΔFIGQY

Nrg^l4

abnormal neuroanatomy | third instar larval stage, with Nrg^l4

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^elav-C155

Nrg^GD82

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^elav-C155, Scer\GAL4^sca.PU

Nrg^KK100482

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^VGlut1-OK371, Scer\GAL4^elav-C155

Nrg^GD82

abnormal neurophysiology

Nrg⁸⁴⁹

abnormal neurophysiology, with Nrg^180.UAS, Scer\GAL4^c17

Nrg⁸⁴⁹

abnormal neurophysiology, with Nrg^180.UAS, Scer\GAL4^shot-OK307

Nrg⁸⁴⁹

abnormal neurophysiology, with Nrg⁸⁴⁹, Scer\GAL4^c17

abnormal neurophysiology, with Nrg⁸⁴⁹, Scer\GAL4^shot-OK307

abnormal neurophysiology, with Nrg^GPI.UAS, Scer\GAL4^c17

Nrg⁸⁴⁹

abnormal neurophysiology, with Nrg^GPI.UAS, Scer\GAL4^shot-OK307

Nrg⁸⁴⁹

abnormal neurophysiology | adult stage, with Nrg^180YA

Nrg^l4

abnormal neurophysiology | adult stage, with Nrg^180YD

Nrg^l4

abnormal neurophysiology | adult stage, with Nrg^180YF

Nrg^l4

abnormal neurophysiology | adult stage, with Nrg^180ΔC

Nrg^l4

abnormal neurophysiology | adult stage, with Nrg^180ΔFIGQY

Nrg^l4

abnormal neurophysiology | adult stage, with Nrg^l4

abnormal neurophysiology | heat sensitive

Nrg^l3

abnormal neurophysiology | P-stage | somatic clone

Nrg^l4

abnormal oxidative stress response | adult stage

Nrg⁸⁴⁹

abnormal oxidative stress response | adult stage, with Scer\GAL4^Ilp2.PR

Nrg^GD82

abnormal size, with Scer\GAL4^Bx-MS1096

Nrg^180.UAS

abnormal starvation stress response | adult stage

Nrg⁸⁴⁹

abnormal starvation stress response | adult stage, with Scer\GAL4^Ilp2.PR

Nrg^GD82

abnormal starvation stress response | adult stage, with Scer\GAL4^repo.PL

Nrg^GD82

abnormal thermotaxis

Nrg⁸⁴⁹

decreased occurrence of cell division | adult stage, with Scer\GAL4^bun-GSG5961

Nrg^HMS01638

decreased occurrence of cell division | adult stage, with Scer\GAL4^GSG5966

Nrg^HMS01638

decreased occurrence of cell division | adult stage, with Scer\GAL4^Su(H).GBE

Nrg^HMS01638

increased cell number | adult stage, with Scer\GAL4^bun-GSG5961

Nrg^167.UAS

increased cell number | adult stage, with Scer\GAL4^Su(H).GBE

Nrg^167.UAS

increased cell size | third instar larval stage, with Scer\GAL4^pnr-MD237

Nrg^GD14467

increased occurrence of cell division | adult stage, with Scer\GAL4^bun-GSG5961

Nrg^167.UAS

increased occurrence of cell division | adult stage, with Scer\GAL4^Su(H).GBE

Nrg^167.UAS

some die during embryonic stage

some die during embryonic stage | recessive

some die during embryonic stage | recessive | heat sensitive

Nrg^l10

some die during pupal stage, with Scer\GAL4^pnr-MD237

visible, with Scer\GAL4^pnr-MD237

Nrg^GD14467

Phenotype manifest in

Allele

abdominal 1 lateral campaniform sensillum lc1 | larval stage | heat sensitive

Nrg^l10

abdominal 1 lateral monoscolopidial chordotonal organ lch1 | heat sensitive

Nrg^l10

abdominal 1 lateral pentascolopidial chordotonal organ lch5 | heat sensitive

Nrg^l10

abdominal 1 lateral trichoid sensillum lh1 | heat sensitive

Nrg^l10

abdominal 1 lateral trichoid sensillum lh2 | heat sensitive

Nrg^l10

abdominal 2 lateral campaniform sensillum lc1 | larval stage | heat sensitive

Nrg^l10

abdominal 2 lateral monoscolopidial chordotonal organ lch1 | heat sensitive

Nrg^l10

abdominal 2 lateral pentascolopidial chordotonal organ lch5 | heat sensitive

Nrg^l10

abdominal 2 lateral trichoid sensillum lh1 | heat sensitive

Nrg^l10

abdominal 2 lateral trichoid sensillum lh2 | heat sensitive

Nrg^l10

abdominal 3 lateral campaniform sensillum lc1 | larval stage | heat sensitive

Nrg^l10

abdominal 3 lateral monoscolopidial chordotonal organ lch1 | heat sensitive

Nrg^l10

abdominal 3 lateral pentascolopidial chordotonal organ lch5 | heat sensitive

Nrg^l10

abdominal 3 lateral trichoid sensillum lh1 | heat sensitive

Nrg^l10

abdominal 3 lateral trichoid sensillum lh2 | heat sensitive

Nrg^l10

abdominal 4 lateral campaniform sensillum lc1 | larval stage | heat sensitive

Nrg^l10

abdominal 4 lateral monoscolopidial chordotonal organ lch1 | heat sensitive

Nrg^l10

abdominal 4 lateral pentascolopidial chordotonal organ lch5 | heat sensitive

Nrg^l10

abdominal 4 lateral trichoid sensillum lh1 | heat sensitive

Nrg^l10

abdominal 4 lateral trichoid sensillum lh2 | heat sensitive

Nrg^l10

abdominal 5 lateral campaniform sensillum lc1 | larval stage | heat sensitive

Nrg^l10

abdominal 5 lateral monoscolopidial chordotonal organ lch1 | heat sensitive

Nrg^l10

abdominal 5 lateral pentascolopidial chordotonal organ lch5 | heat sensitive

Nrg^l10

abdominal 5 lateral trichoid sensillum lh1 | heat sensitive

Nrg^l10

abdominal 5 lateral trichoid sensillum lh2 | heat sensitive

Nrg^l10

abdominal 6 lateral campaniform sensillum lc1 | larval stage | heat sensitive

Nrg^l10

abdominal 6 lateral monoscolopidial chordotonal organ lch1 | heat sensitive

Nrg^l10

abdominal 6 lateral pentascolopidial chordotonal organ lch5 | heat sensitive

Nrg^l10

abdominal 6 lateral trichoid sensillum lh1 | heat sensitive

Nrg^l10

abdominal 6 lateral trichoid sensillum lh2 | heat sensitive

Nrg^l10

abdominal 7 lateral campaniform sensillum lc1 | larval stage | heat sensitive

Nrg^l10

abdominal 7 lateral monoscolopidial chordotonal organ lch1 | heat sensitive

Nrg^l10

abdominal 7 lateral pentascolopidial chordotonal organ lch5 | heat sensitive

Nrg^l10

abdominal 7 lateral trichoid sensillum lh1 | heat sensitive

Nrg^l10

abdominal 7 lateral trichoid sensillum lh2 | heat sensitive

Nrg^l10

abdominal lateral pentascolopidial chordotonal organ lch5

Nrg^l4

adult antennal lobe

Nrg^ibx

adult central complex

adult insulin secreting cell of pars intercerebralis

adult insulin secreting cell of pars intercerebralis, with Scer\GAL4^Ilp2.PR

adult insulin secreting cell of pars intercerebralis, with Scer\GAL4^repo.PL

adult insulin secreting cell of pars intercerebralis (with Nrg⁸⁴⁹)

adult insulin secreting cell of pars intercerebralis (with Nrg⁸⁹²)

Nrg⁸⁴⁹

adult insulin secreting cell of pars intercerebralis (with Nrg^G00305)

Nrg⁸⁴⁹

adult insulin secreting cell of pars intercerebralis (with Nrg^l4)

Nrg⁸⁴⁹

adult insulin secreting cell of pars intercerebralis (with Nrg^l10)

Nrg⁸⁴⁹

adult mushroom body

adult neuromuscular junction, with Nrg^180ΔFIGQY

Nrg^l4

adult neuromuscular junction, with Nrg^l4

Nrg^180ΔFIGQY

adult posterior midgut epithelium, with Scer\GAL4^bun-GSG5961

adult posterior midgut epithelium, with Scer\GAL4^GSG5966

Nrg^HMS01638

adult posterior midgut epithelium, with Scer\GAL4^Su(H).GBE

adult posterior midgut epithelium | somatic clone

adult posterior midgut epithelium | somatic clone, with Scer\GAL4^Tub.PU

Nrg^GD14467

air sac primordium | third instar larval stage, with Scer\GAL4^btl.PS

Nrg^RNAi.UAS.cUa

axon & mechanosensory neuron & adult head | conditional ts

Nrg^l10

axon & nerve

Nrg^l4

axon & ocellus sensory structure | conditional ts

Nrg^l10

axon | embryonic stage

axon | embryonic stage, with Scer\GAL4^how-24B

Nrg^180.I.UAS

calyx of adult mushroom body

Nrg⁸⁴⁹

cell cortex & cortical cytoskeleton

Nrg^l4

dendrite & vesicle, with Scer\GAL4^shot-OK307

Nrg^GPI.UAS

dendrite | larval stage, with Scer\GAL4^elav-C155

dendritic arborizing neuron | larval stage, with Scer\GAL4^elav-C155

dendritic tree, with Nrg^l7, Scer\GAL4^pk-IG1-1

Nrg^UAS.Tag:HA

dendritic tree, with Nrg^UAS.Tag:HA, Scer\GAL4^pk-IG1-1

Nrg^l7

dendritic tree | P-stage, with Scer\GAL4^ppk.PU

dendritic tree | P-stage | somatic clone

Nrg^l4

dorsal multidendritic neuron ddaD & axon

dorsal multidendritic neuron ddaD & axon | conditional ts

Nrg^l3

dorsal multidendritic neuron ddaD & dendritic tree

dorsal multidendritic neuron ddaD & dendritic tree, with Scer\GAL4^repo

Nrg^RNAi.UAS

dorsal multidendritic neuron ddaD & dendritic tree | conditional ts

Nrg^l3

dorsal multidendritic neuron ddaE & axon

dorsal multidendritic neuron ddaE & axon, with Scer\GAL4^pk-IG1-1, Scer\GAL4^repo

Nrg^RNAi.UAS

dorsal multidendritic neuron ddaE & axon, with Scer\GAL4^repo

Nrg^RNAi.UAS

dorsal multidendritic neuron ddaE & axon | conditional ts

Nrg^l3

dorsal multidendritic neuron ddaE & axon | somatic clone

Nrg^l4

dorsal multidendritic neuron ddaE & dendritic tree

Nrg^l7

dorsal multidendritic neuron ddaE & dendritic tree | conditional ts

Nrg^l3

ellipsoid body

embryonic/larval epidermis | third instar larval stage, with Scer\GAL4^pnr-MD237

Nrg^GD14467

embryonic/larval neuromuscular junction | embryonic stage

embryonic/larval neuromuscular junction | embryonic stage, with Scer\GAL4^how-24B

Nrg^180.I.UAS

embryonic/larval neuromuscular junction | somatic clone | third instar larval stage

Nrg^l4

embryonic/larval neuromuscular junction | third instar larval stage, with Nrg^167ΔFIGQY

Nrg^l4

embryonic/larval neuromuscular junction | third instar larval stage, with Nrg^180YA

Nrg^l4

embryonic/larval neuromuscular junction | third instar larval stage, with Nrg^180YD

Nrg^l4

embryonic/larval neuromuscular junction | third instar larval stage, with Nrg^180YF

Nrg^l4

embryonic/larval neuromuscular junction | third instar larval stage, with Nrg^180ΔC

Nrg^l4

embryonic/larval neuromuscular junction | third instar larval stage, with Nrg^180ΔFIGQY

Nrg^l4

embryonic/larval neuromuscular junction | third instar larval stage, with Nrg^l4

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^elav-C155

Nrg^GD82

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^elav-C155, Scer\GAL4^sca.PU

Nrg^KK100482

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^VGlut1-OK371, Scer\GAL4^elav-C155

Nrg^GD82

embryonic/larval plasmatocyte | conditional | larval stage

Nrg^G00305

embryonic epidermis & pleated septate junction

Nrg^l4

embryonic ganglionic branch & embryonic tracheole

Nrg^l7

embryonic salivary gland & epithelial cell

Nrg^l4

embryonic somatic muscle cell

Nrg^unspecified

eye, with Scer\GAL4^GMR.PF, Scer\GAL4^ey.PH

fan-shaped body

giant fiber neuron

Nrg⁸⁴⁹

giant fiber neuron, with Scer\GAL4^shot-OK307

Nrg^GPI.UAS

giant fiber neuron | adult stage

Nrg⁸⁴⁹

giant fiber neuron | adult stage, with Nrg^180YA

Nrg^l4

giant fiber neuron | adult stage, with Nrg^180YD

Nrg^l4

giant fiber neuron | adult stage, with Nrg^180YF

Nrg^l4

giant fiber neuron | adult stage, with Nrg^180ΔC

Nrg^l4

giant fiber neuron | adult stage, with Nrg^180ΔFIGQY

Nrg^l4

giant fiber neuron | adult stage, with Nrg^l4

giant fiber neuron | heat sensitive

Nrg^l3

giant fibers & synapse, with Scer\GAL4^shot-OK307

Nrg^Y1234F.UAS

insulin secreting cell of pars intercerebralis | P-stage

Nrg⁸⁴⁹

Kenyon cell

lamellocyte | conditional | larval stage

Nrg^G00305

larval abdominal segmental nerve

larval abdominal segmental nerve | heat sensitive

Nrg^l10

larval DA1 motor neuron

larval DA1 motor neuron, with Scer\GAL4^eve.RN2

Nrg^180.I.UAS

larval DA1 motor neuron | heat sensitive

Nrg^l10

larval dorsal multidendritic neuron ddaC | P-stage, with Scer\GAL4^ppk.PU

larval dorsal multidendritic neuron ddaC | P-stage | somatic clone

Nrg^l4

larval dorsal multidendritic neuron ddaD | heat sensitive

Nrg^l3

larval dorsal multidendritic neuron ddaE

Nrg^l3

larval dorsal multidendritic neuron ddaE, with Nrg^l7, Scer\GAL4^pk-IG1-1

Nrg^UAS.Tag:HA

larval dorsal multidendritic neuron ddaE, with Nrg^UAS.Tag:HA, Scer\GAL4^pk-IG1-1

Nrg^l7

larval intersegmental nerve

larval intersegmental nerve branch ISNb of A1-7 | embryonic stage

larval intersegmental nerve branch ISNb of A1-7 | embryonic stage, with Scer\GAL4^how-24B

Nrg^180.I.UAS

larval RP2 motor neuron, with Scer\GAL4^eve.RN2

Nrg^180.I.UAS

larval ventral nerve cord

Nrg^l4

lateral cord surface glia & nucleus

Nrg^l4

lobe system of adult mushroom body

mechanosensory neuron

Nrg^l3

medial lobe of adult mushroom body

Nrg⁸⁴⁹

mitochondrion & synapse

Nrg⁸⁴⁹

motor neuron

Nrg⁸⁴⁹

motor neuron, with Scer\GAL4^shot-OK307

Nrg^GPI.UAS

motor neuron | heat sensitive

Nrg^l10

mushroom body vertical lobe

Nrg⁸⁴⁹

neurite | adult stage, with Scer\GAL4^Ilp2.PR

Nrg^180.I.UAS

neurite | adult stage, with Scer\GAL4^repo.PL

Nrg^167.UAS

neurite | adult stage | ectopic

neurite | adult stage | ectopic, with Scer\GAL4^Ilp2.PR

Nrg^GD82

neurite | adult stage | ectopic, with Scer\GAL4^repo.PL

Nrg^GD82

neurite | adult stage | ectopic (with Nrg⁸⁴⁹)

neurite | adult stage | ectopic (with Nrg⁸⁹²)

Nrg⁸⁴⁹

neurite | adult stage | ectopic (with Nrg^G00305)

Nrg⁸⁴⁹

neurite | adult stage | ectopic (with Nrg^l4)

Nrg⁸⁴⁹

neurite | adult stage | ectopic (with Nrg^l10)

Nrg⁸⁴⁹

neurite | P-stage | ectopic

Nrg⁸⁴⁹

NMJ bouton | third instar larval stage, with Nrg^180YA

Nrg^l4

NMJ bouton | third instar larval stage, with Nrg^180YD

Nrg^l4

NMJ bouton | third instar larval stage, with Nrg^180YF

Nrg^l4

NMJ bouton | third instar larval stage, with Nrg^180ΔC

Nrg^l4

NMJ bouton | third instar larval stage, with Nrg^180ΔFIGQY

Nrg^l4

NMJ bouton | third instar larval stage, with Nrg^l4

ocellar nerve

Nrg^l3

ocellar nerve, with Scer\GAL4^MS1075

Nrg^167.UAS

peripheral nervous system

PNS glial cell

Nrg^l4

presumptive embryonic salivary gland

Nrg^unspecified

presynapse | heat sensitive

Nrg^l3

scolopidium & abdominal lateral pentascolopidial chordotonal organ lch5

Nrg^l4

seminal receptacle | maternal effect

Nrg^ibx

septate junction

Nrg^l4

septate junction & peripheral glial cell

Nrg^l4

synapse

Nrg⁸⁴⁹

synapse, with Scer\GAL4^c17

Nrg^GPI.UAS

synapse, with Scer\GAL4^{shakB.lethal.4.1}

Nrg^GPI.UAS

synapse, with Scer\GAL4^shot-OK307

Nrg^GPI.UAS

synapse | heat sensitive

Nrg^l3

thorax, with Scer\GAL4^pnr-MD237

tracheal branch primordium

Nrg^unspecified

tracheal dorsal trunk primordium

Nrg^l7

trichogen cell | increased number, with Scer\GAL4^pnr-MD237

Nrg^GD14467

wing, with Nrg^167.UAS, Scer\GAL4^MS1075

Nrg^l3

wing, with Nrg^GPI.UAS, Scer\GAL4^MS1075

Nrg^l3

wing, with Nrg^l3, Scer\GAL4^MS1075

wing, with Scer\GAL4^Bx-MS1096

wing, with Scer\GAL4^MS1075

wing & sensory neuron | ectopic, with Scer\GAL4^MS1075

wing margin & axon tract, with Scer\GAL4^Bx-MS1096

Nrg^GPI.UAS

wing vein L1 & wing nerve, with Scer\GAL4^MS1075

wing vein L3 & wing nerve, with Scer\GAL4^MS1075

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (175)

Hsap\NRCAM

12 of 14

Yes

Hsap\CHL1

11 of 14

Yes

Hsap\L1CAM

11 of 14

Yes

Hsap\NFASC

11 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CEACAM4

1 of 14

Yes

Hsap\CEACAM5

1 of 14

Hsap\CEACAM6

1 of 14

Hsap\CEACAM7

1 of 14

Yes

Hsap\CEACAM8

1 of 14

Hsap\CEACAM16

1 of 14

Hsap\CEACAM18

1 of 14

Yes

Hsap\CEACAM19

1 of 14

Yes

Hsap\CEACAM20

1 of 14

Yes

Hsap\CEACAM21

1 of 14

Yes

Hsap\CLMP

1 of 14

Yes

Hsap\CXADR

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\FCER1A

1 of 14

Yes

Hsap\FCGR1A

1 of 14

Yes

Hsap\FCGR1B

1 of 14

Yes

Hsap\FCGR2A

1 of 14

Yes

Hsap\FCGR2B

1 of 14

Yes

Hsap\FCGR2C

1 of 14

Yes

Hsap\FCGR3A

1 of 14

Yes

Hsap\FCGR3B

1 of 14

Yes

Hsap\FCRL3

1 of 14

Yes

Hsap\FCRL4

1 of 14

Yes

Hsap\FCRL5

1 of 14

Yes

Hsap\FCRL6

1 of 14

Yes

Hsap\FCRLA

1 of 14

Yes

Hsap\FCRLB

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\FSTL5

1 of 14

Yes

Hsap\GPA33

1 of 14

Yes

Hsap\HEPACAM2

1 of 14

Yes

Hsap\HEPACAM

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\IGFBPL1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\IL1R1

1 of 14

Hsap\IL1R2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\JAM2

1 of 14

Yes

Hsap\JAM3

1 of 14

Yes

Hsap\JAML

1 of 14

Yes

Hsap\KALRN

1 of 14

Hsap\KAZALD1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\PSG4

1 of 14

Yes

Hsap\PSG5

1 of 14

Hsap\PSG6

1 of 14

Yes

Hsap\PSG7

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\SEMA5A

1 of 14

Hsap\SIGIRR

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\VSIG2

1 of 14

Yes

Hsap\VSIG8

1 of 14

Yes

Hsap\VSIG10L2

1 of 14

Hsap\VSIG10L

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (57)

Rnor\Nrcam

12 of 14

Yes

Rnor\Nfasc

11 of 14

Yes

Rnor\Chl1

10 of 14

Yes

Rnor\L1cam

10 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Igfbpl1

1 of 14

Yes

Rnor\Igsf9b

1 of 14

Rnor\Il1r1

1 of 14

Yes

Rnor\Il1r2

1 of 14

Yes

Rnor\Il1rapl1

1 of 14

Yes

Rnor\Il1rapl2

1 of 14

Yes

Rnor\Il1rap

1 of 14

Yes

Rnor\Il1rl1

1 of 14

Yes

Rnor\Il1rl2

1 of 14

Yes

Rnor\Il18r1

1 of 14

Yes

Rnor\Il18rap

1 of 14

Yes

Rnor\Jaml

1 of 14

Rnor\Kazald1

1 of 14

Yes

Rnor\Kirrel2

1 of 14

Rnor\Lag3

1 of 14

Yes

Rnor\Lrig1

1 of 14

Rnor\Lrrc24

1 of 14

Rnor\Mxra8

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Sdk2

1 of 14

Rnor\Sigirr

1 of 14

Yes

Rnor\Speg

1 of 14

Mus musculus (laboratory mouse) (61)

Mmus\Nrcam

12 of 14

Yes

Mmus\Chl1

11 of 14

Yes

Mmus\L1cam

11 of 14

Yes

Mmus\Nfasc

10 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Igfbpl1

1 of 14

Yes

Mmus\Igsf10

1 of 14

Mmus\Il1r1

1 of 14

Yes

Mmus\Il1r2

1 of 14

Yes

Mmus\Il1rapl1

1 of 14

Yes

Mmus\Il1rapl2

1 of 14

Yes

Mmus\Il1rap

1 of 14

Yes

Mmus\Il1rl1

1 of 14

Yes

Mmus\Il1rl2

1 of 14

Yes

Mmus\Il18r1

1 of 14

Yes

Mmus\Il18rap

1 of 14

Yes

Mmus\Jaml

1 of 14

Mmus\Kazald1

1 of 14

Yes

Mmus\Kirrel2

1 of 14

Mmus\Lag3

1 of 14

Yes

Mmus\Lrig1

1 of 14

Mmus\Mxra8

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Sigirr

1 of 14

Yes

Mmus\Speg

1 of 14

Mmus\Ttn

1 of 14

Xenopus tropicalis (Western clawed frog) (65)

Xtro\nrcam

11 of 13

Yes

Xtro\nfasc

7 of 13

Yes

Xtro\l1cam

6 of 13

Yes

Xtro\chl1

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\col20a1

1 of 13

Xtro\cxadr

1 of 13

Yes

Xtro\dcc

1 of 13

Xtro\dscam

1 of 13

Xtro\esam

1 of 13

Yes

Xtro\fgfr1op2

1 of 13

Xtro\fgfr3

1 of 13

Xtro\hepacam2

1 of 13

Yes

Xtro\hepacam

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\il1rapl2

1 of 13

Yes

Xtro\il1rap

1 of 13

Yes

Xtro\jam2

1 of 13

Yes

Xtro\jam3

1 of 13

Yes

Xtro\kazald1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\mdga2

1 of 13

Xtro\mpzl1

1 of 13

Yes

Xtro\mpzl2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\nectin4

1 of 13

Yes

Xtro\npffr1.1

1 of 13

Xtro\pcasp3

1 of 13

Yes

Xtro\pecam1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\tyro3

1 of 13

Yes

Xtro\u2af2

1 of 13

Xtro\upk2

1 of 13

Xtro\vsig8

1 of 13

Yes

Xtro\vsig10

1 of 13

Yes

Xtro\XB5960289

1 of 13

Xtro\XB5991222

1 of 13

Danio rerio (Zebrafish) (91)

Drer\chl1a

11 of 14

Yes

Drer\l1camb

11 of 14

Yes

Drer\nfasca

11 of 14

Yes

Drer\nrcama

11 of 14

Yes

Drer\chl1b

10 of 14

Yes

Drer\cntn3a.1

3 of 14

Drer\nfascb

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\igsf9bb

1 of 14

Drer\il1rapl1a

1 of 14

Yes

Drer\il1rapl1b

1 of 14

Yes

Drer\il1rapl2

1 of 14

Yes

Drer\il1rl1

1 of 14

Yes

Drer\jam2a

1 of 14

Drer\jam2b

1 of 14

Drer\kazald2

1 of 14

Yes

Drer\kazald3

1 of 14

Yes

Drer\kirrel1a

1 of 14

Drer\kirrel1b

1 of 14

Drer\LOC556776

1 of 14

Yes

Drer\LOC563995

1 of 14

Yes

Drer\LOC799279

1 of 14

Yes

Drer\LOC100329818

1 of 14

Yes

Drer\LOC100332721

1 of 14

Drer\LOC100333752

1 of 14

Yes

Drer\LOC101883325

1 of 14

Drer\LOC108191960

1 of 14

Yes

Drer\LOC110437796

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\mxra8b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\si:ch211-159i8.4

1 of 14

Drer\si:ch211-165f21.7

1 of 14

Yes

Drer\si:ch211-222f23.6

1 of 14

Drer\si:ch211-225p5.8

1 of 14

Yes

Drer\si:dkey-19a16.12

1 of 14

Yes

Drer\si:dkey-24p1.1

1 of 14

Drer\si:dkey-24p1.7

1 of 14

Drer\sigirr

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\zgc:172133

1 of 14

Yes

Drer\zmp:0000000936

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (31)

Cele\lad-2

11 of 14

Yes

Cele\sax-7

8 of 14

Yes

Cele\oig-5

4 of 14

Yes

Cele\him-4

2 of 14

Cele\F13H10.9

1 of 14

Yes

Cele\igcm-4

1 of 14

Cele\ketn-1

1 of 14

Cele\mig-21

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\zig-7

1 of 14

Yes

Cele\zig-8

1 of 14

Anopheles gambiae (African malaria mosquito) (84)

Agam\AgaP_AGAP000720

11 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Nrg. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (85)

4 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Lac

2 of 13

robo1

2 of 13

robo2

2 of 13

Ama

1 of 13

bdl

1 of 13

boi

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

fra

1 of 13

hbs

1 of 13

ihog

1 of 13

ImpL2

1 of 13

kirre

1 of 13

klg

1 of 13

Lar

1 of 13

loofah

1 of 13

MstProx

1 of 13

nrm

1 of 13

Obsc

1 of 13

otk

1 of 13

plum

1 of 13

Pvr

1 of 13

Pxn

1 of 13

robo3

1 of 13

rst

1 of 13

sdk

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

sls

1 of 13

sns

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

L1 syndrome

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 4 )

Allele

Disease

Evidence

References

Nrg^l7

model of epilepsy

CEA

(Chen et al., 2023)

Nrg^UAS.180.cEa

model of MASA syndrome

CEA

(Kakad et al., 2018)

Nrg^{ICD.UAS.180.Tag:HA}

model of MASA syndrome

CEA

(Kakad et al., 2018)

Nrg^{UAS.180.Tag:HA}

model of MASA syndrome

CEA

(Kakad et al., 2018)

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

L1CAM; L1 cell adhesion molecule

model of MASA syndrome

IEA

(FlyBase, 2019-)

model of hydrocephalus

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

Nrg^180.I.UAS

ameliorates epilepsy

modeled by pk^IG1-1

(Chen et al., 2023)

modeled by pk³²⁵

(Chen et al., 2023)

Nrg^G0099

ameliorates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Nrg^HMS01638

ameliorates carcinoma

modeled by Egfr^UAS.cBa, psq^KK111691

(Fereres et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

NRCAM; neuronal cell adhesion molecule

12 of 14

601581

NEURODEVELOPMENTAL DISORDER WITH NEUROMUSCULAR AND SKELETAL ABNORMALITIES; NEDNMS

CHL1; cell adhesion molecule L1 like

11 of 14

607416

L1CAM; L1 cell adhesion molecule

11 of 14

L1 CELL ADHESION MOLECULE; L1CAM

NFASC; neurofascin

11 of 14

609145

NEURODEVELOPMENTAL DISORDER WITH CENTRAL AND PERIPHERAL MOTOR DYSFUNCTION; NEDCPMD

CNTN1; contactin 1

3 of 14

600016

CONGENITAL MYOPATHY 12; CMYO12

Compton-North congenital myopathy

CNTN2; contactin 2

3 of 14

190197

EPILEPSY, EARLY-ONSET, 5, WITH OR WITHOUT DEVELOPMENTAL DELAY; EPEO5

familial adult myoclonic epilepsy 5

3 of 14

3 of 14

3 of 14

3 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

Nrg

Hsap\L1CAM

(Kudumala et al., 2013, Nagaraj et al., 2009, Godenschwege et al., 2006, Kristiansen et al., 2005)

Nrg

Hsap\NCAM1

(Kristiansen et al., 2005)

Nrg

Mmus\L1cam

(Kristiansen et al., 2005)

Nrg

Rnor\Nrcam

(Kristiansen et al., 2005)

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Nrg

fluorescence microscopy, inferred by author, anti bait coimmunoprecipitation, western blot, bead aggregation assay

(Yang et al., 2019, Goossens et al., 2011, Strigini et al., 2006, Butler et al., 1997)

Nrg - Ank2

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot

(Chen et al., 2023, Enneking et al., 2013)

Nrg - Cont

anti bait coimmunoprecipitation, western blot

(Banerjee et al., 2006, Faivre-Sarrailh et al., 2004)

Nrg - Ilp8

pull down, Identification by mass spectrometry

(Garelli et al., 2015)

Nrg - Nrx-IV

anti bait coimmunoprecipitation, western blot

(Banerjee et al., 2006, Genova and Fehon, 2003)

Nrg - Tsf2

anti bait coimmunoprecipitation, western blot

(Tiklová et al., 2010)

Nrg - cora

anti bait coimmunoprecipitation, western blot

(Genova and Fehon, 2003)

Nrg - ed

bead aggregation assay, fluorescence microscopy, inferred by author, anti bait coimmunoprecipitation, western blot

(Islam et al., 2003)

Nrg - pyd

filter binding

(Goossens et al., 2011)

Nrg - yrt

anti tag coimmunoprecipitation, western blot

(Laprise et al., 2009)

RNA-protein

Physical Interaction

Assay

References

Nrg - elav

anti bait coimmunoprecipitation, primer specific pcr

(Hilgers et al., 2012)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

unc-5|Nrg

enhanceable

beat-Ia

(Zarin et al., 2014)

Nrg

suppressible

Egfr

(Resnik-Docampo et al., 2021, Islam et al., 2004, Garcia-Alonso et al., 2000)

Nrg

enhanceable

Egfr

(Garcia-Alonso et al., 2000)

Nrg

enhanceable

eve

(Zarin et al., 2014)

beat-Ia|unc-5|Nrg

enhanceable

Fas2

(Zarin et al., 2014)

Nrg

enhanceable

Fas2

(Kristiansen et al., 2005)

enhanceable

(Lu et al., 2014)

suppressible

(Garcia-Alonso et al., 2000)

Nrg

enhanceable

htl

(Garcia-Alonso et al., 2000)

Nrg

suppressible

Rab5

(Zhang et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

AP-2α

suppressible

Nrg

(Zong et al., 2018)

Arf1

suppressible

Nrg

(Wang et al., 2017)

suppressible

(Rui et al., 2023)

enhanceable

(Zarin et al., 2014)

beat-Ia

enhanceable

Nrg

(Zarin et al., 2014)

brm

suppressible

Nrg

(Zhang et al., 2014)

suppressible

(Rui et al., 2023)

suppressible

(Zhang et al., 2014)

enhanceable

Nrg

(Islam et al., 2003)

suppressible

Nrg

(Islam et al., 2003)

Egfr|psq

suppressible

Nrg

(Fereres et al., 2019)

eve

enhanceable

Nrg

(Zarin et al., 2014)

suppressible

(Lu et al., 2014)

enhanceable

(Yang et al., 2011)

nej

suppressible

Nrg

(Zhang et al., 2014)

Nrt

enhanceable

Nrg

(Speicher et al., 1998)

Pi3K92E|btl::Egfr

suppressible

Nrg

(Portela et al., 2019)

prd1

suppressible

Nrg

(Zong et al., 2018)

Rab5

enhanceable

Nrg

(Zhang et al., 2014)

Rab5

suppressible

Nrg

(Zhang et al., 2014)

enhanceable

(Fic et al., 2021)

suppressible

(Wang et al., 2017)

unc-5

enhanceable

Nrg

(Zarin et al., 2014)

unc-5

enhanceable

beat-Ia|Nrg

(Zarin et al., 2014)

unc-5

enhanceable

Fas2|beat-Ia|Nrg

(Zarin et al., 2014)

unc-104

suppressible

Nrg

(Zong et al., 2018)

Vps4

enhanceable

Nrg

(Zhang et al., 2014)

Vps4

suppressible

Nrg

(Zhang et al., 2014)

Yif1

suppressible

Nrg

(Wang et al., 2018)

Yip1d1

suppressible

Nrg

(Wang et al., 2018)

External Data

Subunit Structure (UniProtKB)

Forms a complex with Nrx-IV/Nrx and Cont (PubMed:15459097). Forms a complex composed of septate junction proteins Nrx-IV/Nrx, Tsf2/MTf, Cont and Nrg during late embryogenesis (PubMed:20935638).

(UniProt, P20241 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0264975

MIST (genetic) - An integrated Molecular Interaction Database

31792

MIST (protein-protein) - An integrated Molecular Interaction Database

31792

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-23

Cytogenetic map

7F2-7F4

Sequence location

X:8,517,373..8,555,170 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

7F2-7F4

Limits computationally determined from genome sequence between P{EP}CG1632^EP1583 and P{EP}Moe^EP1652

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

7F1-7F4

(determined by in situ hybridisation)

(Peter et al., 2002, Schäfer et al., 1999.6.15)

7F-7F

(determined by in situ hybridisation)

(Schäfer et al., 1999.12.2)

7F1-8A5

(Lindsley and Zimm, 1992)

7F1-7F1

(determined by in situ hybridisation)

(Hortsch et al., 1990, Bieber et al., 1989)

Experimentally Determined Recombination Data

Location

1-23

(FlyBase, 2016, Varnam et al., 1996)

1-23.7

(Comeron et al., 2012)

1-23.6

(King et al., 1986)

Left of (cM)

Right of (cM)

(King et al., 1986)

Notes

Stocks and Reagents

Stocks (35)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

35827

Nrg⁸⁴⁹

5708

Nrg^l4/FM7c

24168

w^*; P{UAS-Nrg.GPI}2

5595

Nrg^l7/FM7c, sn⁺

48094

w¹¹¹⁸; P{GMR29H05-GAL4}attP2

Korea

16283

P{GMR30A03-lexA}attP40

16258

PBac{GMR30A03-lexA}VK00027

108320

108384

v107991

v27201

w¹¹¹⁸; P{GD14467}v27201

v27202

w¹¹¹⁸; P{GD14467}v27202

More stocks available...

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (89)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

RT01988

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0264975

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Finegan et al., 2024, Resnik-Docampo et al., 2021, Enneking et al., 2013)

monoclonal

(Hortsch et al., 1990, Bieber et al., 1989)

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

BP_104_anti-Neuroglian

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

New stable cell line derived from S2-unspecified : Stable cell lines were created containing Nrg constructs. They are designated S2:pRmHa3-nrg [167] (short isoform), S2:pRmHa3-nrg [180] (long isoform), and S2:pRmHa3-nrg [GPI] (containing the first 1121 amino acids of Nrg fused to the 53 C-terminal amino acids of Fas1 containing the GPI attachment signal.
(Hortsch et al., 1995)

Other Comments

Nrg has an endogenous pre- and postsynaptic function in giant synapse formation. The intracellular domain of Nrg is indispensable for giant-synapse formation.

(Godenschwege et al., 2006)

One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.

(Inlow and Restifo, 2004)

Nrg appears to act as a heterophilic ligand and receptor of ed which in turn antagonises Egfr signaling.

(Islam et al., 2003)

The probability of mating is reduced in ibx mutant females and the frequency of rejection behaviour towards courting males is increased.

(Kerr et al., 1997)

Inhibition of cell adhesion by ethanol in Nrg expressing cells cannot be explained by a simple direct effect of ethanol on the adhesion activity of Nrg.

(Vallejo et al., 1997)

Interaction between Ank and Nrg molecules occurs by a mechanism that couples the positional information of cell adhesion to the polar assembly of Ank.

(Dubreuil et al., 1996)

elav regulates neural expression of Nrg by promoting the formation of the neural-specific alternative splice variant of Nrg.

(Koushika et al., 1996)

Nrg mutant females show and abnormal response to the injection of SP. Nrg mutants affect mushroom bodies.

(Fleischmann et al., 1995)

Nrg is required for central complex formation.

(Fleischmann et al., 1995)

Mutations causing structural defects in the adult central complex also alter larval behavioural phenotypes.

(Varnam and Sokolowski, 1995)

Three polypeptides of 155, 167 and 180kD are detected on Western blots; deglycosylation experiments reduce these to a single 155kD band; removal of N-linked high-mannose oligosaccharides causes a shift to about 162kD.

(Lindsley and Zimm, 1992)

Encodes a protein that is likely to play a role in neural and glial cell adhesion in the developing Drosophila embryo.

(Lindsley and Zimm, 1992)

Recessive alleles are embryonic lethals and show little or no evidence of Neuroglian expression; the overall structure of the CNS and PNS and in particular the peripheral nerve roots and CNS axon pathways develop in a relatively normal way in lethal embryos.

(Lindsley and Zimm, 1992)

Two different forms of Nrg exist arising by tissue-specific, developmentally regulated alternative splicing. The two forms of Nrg have identical extracellular domains but differ in size of their cytoplasmic domains.

(Hortsch et al., 1990)

Relationship to Other Genes

Source for database merge of

Source for merge of: Nrg l(1)G0099 l(1)G0413

(Peter et al., 2002)

Source for merge of: Nrg ceb

(Kang et al., 2002)

Source for merge of: ibx fs(1)M72

(Kerr et al., 1997)

Source for merge of: Nrg ibx

(Carhan et al., 2005)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Nrg CG1634

(Lai, 1999.11)

Nomenclature comments

Etymology

The gene is named "icebox" after the primary phenotype of mutants (the sexual receptivity of mutant females is lowered).

(Kerr et al., 1997)

Synonyms and Secondary IDs (23)

Reported As

Symbol Synonym

CG1634

(Çiçek et al., 2016, Harris et al., 2016, Hosono et al., 2015, Christis and Munro, 2012, Jaspers et al., 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Khanna et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Sepp et al., 2008, Quinones-Coello, 2007, Yamamoto, 2006, Whitfield, 2000.5.2, Whitfield, 2000.11.29)

CT4318

(Vogel et al., 2003, Hynes and Zhao, 2000)

NFASC

(Wishart et al., 2012)

NRG

(Puñal et al., 2021, Banyai and Patthy, 2004, Genova and Fehon, 2003, Pulido et al., 1992)

Ngl

(Sprecher et al., 2011, Cantera et al., 2002)

Nrg

(Long et al., 2025, Zhao et al., 2025, Lee et al., 2024, Luedke et al., 2024, Rui, 2024, Banach-Latapy et al., 2023, Glashauser et al., 2023, Mukherjee et al., 2023, Olivares et al., 2023, Perlegos et al., 2023, Titlow et al., 2023, Dalton et al., 2022, Kakanj et al., 2022, Kawakami et al., 2022, Meltzer and Schuldiner, 2022, Bilder et al., 2021, Furusawa and Emoto, 2021, Götz et al., 2021, Pang et al., 2021, Resnik-Docampo et al., 2021, Shrestha et al., 2021, Yin et al., 2021, Finegan and Bergstralh, 2020, Graves et al., 2020, Hung et al., 2020, Khoroshko et al., 2020, Kurmangaliyev et al., 2020, Rui et al., 2020, Weiner et al., 2020, Yanagawa et al., 2020, Jiang et al., 2019, Kanda et al., 2019, Luo et al., 2019, Penserga et al., 2019, Yang et al., 2019, Carvalho et al., 2018, Gene Disruption Project members, 2018-, Wang et al., 2018, Zong et al., 2018, Fochler et al., 2017, Franz et al., 2017, Hartenstein et al., 2017, Tempesta et al., 2017, Vallejos Baier et al., 2017, Wilson and Bergstralh, 2017, Altenhein et al., 2016, Greiss et al., 2016, Luo et al., 2016, Malartre, 2016, Wang et al., 2016, Bergstralh et al., 2015, Bornstein et al., 2015, Byri et al., 2015, Garelli et al., 2015, Hildebrandt et al., 2015, Kanamori et al., 2015, Satoh et al., 2015, Wang et al., 2015, Ashwal-Fluss et al., 2014, Bätz et al., 2014, Bulat et al., 2014, DeSalvo et al., 2014, Hall et al., 2014, Hughes et al., 2014, Zarin et al., 2014, Zhang et al., 2014, Zhimulev et al., 2014, Burra et al., 2013, Diaper et al., 2013, Enneking et al., 2013, Gross et al., 2013, Osterfield et al., 2013, Ozkan et al., 2013, Ozkan et al., 2013, Sanchez-Garcia et al., 2013, Gistelinck et al., 2012, Ambegaokar and Jackson, 2011, Fauvarque and Williams, 2011, Goossens et al., 2011, Hatan et al., 2011, Hijazi et al., 2011, Mast et al., 2011, Pastor-Pareja and Xu, 2011, Seisenbacher et al., 2011, Sprecher et al., 2011, Pereanu et al., 2010, Popodi et al., 2010-, Tiklova et al., 2010, Tiklová et al., 2010, Godenschwege and Murphey, 2009, Laprise et al., 2009, Mao and Freeman, 2009, Massaro et al., 2009, Wang et al., 2009, Williams, 2009, Babcock et al., 2008, Chen and Hing, 2008, Derome et al., 2008, Kapelnikov et al., 2008, Kapelnikov et al., 2008, Laval et al., 2008, Sepp et al., 2008, Straub et al., 2008, Yi et al., 2008, Buszczak et al., 2007, Dietzl et al., 2007, Hortsch, 2007.9.19, Luque and Milan, 2007, Quinones-Coello, 2007, Szafranski and Goode, 2007, Whitington et al., 2007, Wu et al., 2007, Andrenacci et al., 2006, Furuse and Tsukita, 2006, Godenschwege, 2006, Godenschwege et al., 2006, Schneider et al., 2006, Schulte et al., 2006, Strigini et al., 2006, Kristiansen et al., 2005, Schwabe et al., 2005, Forni et al., 2004, Wei et al., 2004)

Nrg167

(Enneking et al., 2013)

Nrg180

(Bulat et al., 2014, Enneking et al., 2013)

RA35

(Schalet, 1986)

ceb

(Hong et al., 2008, Neckameyer and Matsuo, 2008, Liu et al., 2006, Gerber et al., 2003, Helfrich-Forster et al., 2002, Hitier et al., 2000, Scholz et al., 2000, Walcourt and Nash, 2000, Renn et al., 1999, Kerr et al., 1997, de Belle and Heisenberg, 1996, Varnam et al., 1996, Fleischmann et al., 1995, Fleischmann et al., 1995, Varnam and Sokolowski, 1995, Ferrus and Canal, 1994, Strauss and Heisenberg, 1993)

fs(1)M72

(Mohler and Carroll, 1984)

ibx

l(1)7Fa

l(1)G0099

(Schäfer et al., 1999.6.15)

l(1)G0413

(Schäfer et al., 1999.12.2)

l(1)G0488

nrg

(Wu et al., 2024, Clements et al., 2021, Fic et al., 2021, Lee et al., 2021, Rouka et al., 2021, Liu et al., 2020, Rui et al., 2020, Krämer et al., 2019, Du et al., 2018, Zong et al., 2018, Wang et al., 2017, Aigouy and Le Bivic, 2016, Deligiannaki et al., 2015, Siegenthaler et al., 2015, Zaharieva et al., 2015, Gibson et al., 2014, Lu et al., 2014, Roy et al., 2014, Kudumala et al., 2013, Foronda et al., 2012, Hilgers et al., 2012, Gibson et al., 2011, Hilgers et al., 2011, Seisenbacher et al., 2011, Yang et al., 2011, Boerner and Godenschwege, 2010, Laplante et al., 2010, Silies and Klämbt, 2010, Godenschwege and Murphey, 2009, Hijazi et al., 2009, Nagaraj et al., 2009, Stork et al., 2009, Martin et al., 2008, Moyer and Jacobs, 2008, Oland et al., 2008, Stork et al., 2008, Firth and Baker, 2007, Banerjee et al., 2006, Yamamoto et al., 2006, Borgeson and Samson, 2005, Carhan et al., 2005, Faivre-Sarrailh et al., 2004, Touchon et al., 2004, Wu and Beitel, 2004, Freeman et al., 2003, Gerber et al., 2003, Islam et al., 2003, Kang et al., 2002, Toba et al., 2002, Jenkins et al., 2001, Kang et al., 2001, Lisbin et al., 2001, White et al., 2001, Bouley et al., 2000, Koushika et al., 2000, Hortsch, 1998.2.22, Hortsch, 1998.2.22, Speicher et al., 1998, Hall and Bieber, 1997, Dubreuil et al., 1995, Singer and Piovant, 1995, Goodman and Doe, 1993)

Name Synonyms

Neuroglian

(Shafer, 2025, Sproston et al., 2025, Baldenius et al., 2023, Rapti, 2023, Rice et al., 2021, Graves et al., 2020, Hill et al., 2020, Lin et al., 2020, Wang et al., 2018, Wilson and Bergstralh, 2017, Harris et al., 2016, Malartre, 2016, Shepherd et al., 2016, Wang et al., 2016, Bergstralh et al., 2015, Bornstein et al., 2015, Hartenstein et al., 2015, Peterson and Krasnow, 2015, Kunduri et al., 2014, Lu et al., 2014, Zarin et al., 2014, Diaper et al., 2013, Gross et al., 2013, Lovick et al., 2013, Wong et al., 2013, Yu et al., 2013, Gistelinck et al., 2012, Jaspers et al., 2012, Moraru et al., 2012, Peltan et al., 2012, Cammarato et al., 2011, Choo et al., 2011, Goossens et al., 2011, Leiserson and Keshishian, 2011, Pastor-Pareja and Xu, 2011, Rodrigues et al., 2011, Seisenbacher et al., 2011, Sprecher et al., 2011, Khanna et al., 2010, Kim et al., 2010, Laplante et al., 2010, Silies and Klämbt, 2010, Wang and Ward, 2010, Godenschwege and Murphey, 2009, Massaro et al., 2009, Parrish et al., 2009, Spindler et al., 2009, Wang et al., 2009, Williams, 2009, Babcock et al., 2008, Chen and Hing, 2008, Denef et al., 2008, Kapelnikov et al., 2008, Laval et al., 2008, Oland et al., 2008, Petrovic and Hummel, 2008, Yi et al., 2008, Zhou et al., 2008, Bakal et al., 2007, Cornbrooks et al., 2007, Luque and Milan, 2007, Szafranski and Goode, 2007, Tiklová et al., 2007, Bayraktar et al., 2006, Schulte et al., 2006, Wang et al., 2006, Yamamoto et al., 2006, Daneman and Barres, 2005, Kristiansen et al., 2005, Banyai and Patthy, 2004, Forni et al., 2004, Wei et al., 2004, Firth and Baker, 2003, Hortsch et al., 2002, Gim et al., 2001)

central brain deranged

(Hong et al., 2008, Neckameyer and Matsuo, 2008)

female sterile(1)M72

icebox

(Yamamoto and Nakano, 1999)

lethal (1) G0488

Secondary FlyBase IDs

FBgn0002968
FBgn0004669
FBgn0027311
FBgn0040142
FBgn0040165
FBgn0000874
FBgn0041750

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 83 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31792

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P20241

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P20241

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

M9NEZ5

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P20241

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264975

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31792/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264975

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264975

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1634

MARRVEL_MODEL - MARRVEL (model organism gene)

31792

PDB - An information portal to biological macromolecular structures

1CFB

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0264975

DroID - A comprehensive database of gene and protein interactions.

FBgn0264975

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

BP_104_anti-Neuroglian

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0002968

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0264975

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1634

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC001889

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

31792

MIST (protein-protein) - An integrated Molecular Interaction Database

31792

References (471)

The following external sites may use different assemblies or annotations than FlyBase.

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