FlyBase Allele Report: Scer\GAL4[shakB.lethal.4.1]

ScerGAL4^{shakB.lethal.4.1} drives expression in the tergotrochanteral muscle motor neuron, a postsynaptic target of the giant fiber neuron, but not in the giant fiber neuron.

(Lee and Godenschwege, 2015)

ScerGAL4^{shakB.lethal.4.1} drives expression in the tergotrochanteral muscle motor neuron (TTMn), and peripherally synapsing interneuron (PSI). and dorsal longitudinal motor neuron, but not in the giant fiber neuron.

(Godenschwege et al., 2002)

ScerGAL4^{shakB.lethal.4.1} drives expression in relatively few neurons in the CNS, most prominently in the tergotrochanteral muscle motor neuron (TTMn), but not in the giant fiber neuron. Pupal expression is also observed in several neurons in the optic lobes, central brain, subesophageal ganglion, and the thoracico-abdominal ganglion.

(Jacobs et al., 2000)

Marker for

Reflects expression of

shakB

(Newman et al., 2017, Gao et al., 2013, Freeman et al., 2011, Godenschwege et al., 2002, Jacobs et al., 2000)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage | drug conditional, with Rnor\P2rx2^UAS.cLa

(Lima and Miesenbock, 2005)

abnormal locomotor behavior | third instar larval stage, with Ca-α1D^GD1737

(Hsu et al., 2020)

abnormal locomotor behavior | third instar larval stage, with Stacl^KK111487

(Hsu et al., 2020)

abnormal neuroanatomy, with Nrg^GPI.UAS

(Godenschwege et al., 2006)

abnormal neuroanatomy, with robo1^UAS.cKa

(Godenschwege et al., 2002)

abnormal neuroanatomy, with robo1^UAS.Tag:MYC

(Godenschwege et al., 2002)

abnormal neuroanatomy, with robo1^{ΔCC2CC3.UAS.Tag:MYC}

(Godenschwege et al., 2002)

abnormal neuroanatomy, with Scer\GAL4^shot-OK307, robo1^UAS.cKa

(Godenschwege et al., 2002)

abnormal neurophysiology, with GlyRS^{P234KY.UAS.Tag:HA}

(Ermanoska et al., 2014)

abnormal neurophysiology, with NFAT^EP1508

(Freeman et al., 2011)

abnormal neurophysiology, with NFAT^EP19579

(Freeman et al., 2011)

abnormal neurophysiology, with Nrg^180.UAS, Nrg⁸⁴⁹

(Godenschwege et al., 2006)

abnormal neurophysiology, with Nrg⁸⁴⁹, Nrg^GPI.UAS

(Godenschwege et al., 2006)

abnormal neurophysiology, with robo1^UAS.Tag:MYC

(Godenschwege et al., 2002)

abnormal neurophysiology, with robo1^{ΔCC2CC3.UAS.Tag:MYC}

(Godenschwege et al., 2002)

abnormal neurophysiology, with robo2^UAS.Tag:MYC

(Godenschwege et al., 2002)

abnormal neurophysiology | partially, with robo3^UAS.cSa

(Godenschwege et al., 2002)

Phenotype Manifest In

giant fiber neuron, with Cdc42^V12.UAS

(Jacobs et al., 2000)

giant fiber neuron, with robo1^{ΔCC2CC3.UAS.Tag:MYC}

(Godenschwege et al., 2002)

larval RP2 motor neuron, with NFAT^EP1508

(Freeman et al., 2011)

RP neuron, with NFAT^EP19579

(Freeman et al., 2011)

synapse, with Nrg^GPI.UAS

(Godenschwege et al., 2006)

synapse | adult stage, with robo1^UAS.cKa

(Godenschwege et al., 2002)

synapse | adult stage, with Scer\GAL4^shot-OK307, robo1^UAS.cKa

(Godenschwege et al., 2002)

tergal depressor of trochanter muscle motor neuron & dendrite, with Cdc42^V12.UAS

(Jacobs et al., 2000)

tergal depressor of trochanter muscle motor neuron & dendrite, with robo1^UAS.cKa

(Godenschwege et al., 2002)

tergal depressor of trochanter muscle motor neuron & dendrite, with robo1^UAS.Tag:MYC

(Godenschwege et al., 2002)

tergal depressor of trochanter muscle motor neuron & dendrite, with robo1^{ΔCC2CC3.UAS.Tag:MYC}

(Godenschwege et al., 2002)

tergal depressor of trochanter muscle motor neuron & dendrite, with robo2^UAS.Tag:MYC

(Godenschwege et al., 2002)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^{shakB.lethal.4.1}, robo1^UAS.cKa has abnormal neuroanatomy phenotype, suppressible | partially by Scer\GAL4^{shakB.lethal.4.1}/comm^UAS.cKa

(Godenschwege et al., 2002)

Scer\GAL4^{shakB.lethal.4.1}, robo1^UAS.cKa has abnormal neurophysiology phenotype, suppressible by Scer\GAL4^{shakB.lethal.4.1}/comm^UAS.cKa

(Godenschwege et al., 2002)

Scer\GAL4^{shakB.lethal.4.1}, robo2^UAS.cSa has abnormal neuroanatomy phenotype, suppressible by Scer\GAL4^{shakB.lethal.4.1}/comm^ΔC.UAS

(Godenschwege et al., 2002)

Scer\GAL4^{shakB.lethal.4.1}, robo2^UAS.cSa has abnormal neurophysiology phenotype, suppressible by Scer\GAL4^{shakB.lethal.4.1}/comm^ΔC.UAS

(Godenschwege et al., 2002)

NOT suppressed by

Statement

Reference

Rnor\P2rx2^UAS.cLa, Scer\GAL4^{shakB.lethal.4.1} has abnormal locomotor behavior | adult stage | drug conditional phenotype, non-suppressible by norpA^EE5/norpA^EE5

(Lima and Miesenbock, 2005)

Scer\GAL4^{shakB.lethal.4.1}, robo1^UAS.cKa has abnormal neuroanatomy phenotype, non-suppressible by Scer\GAL4^{shakB.lethal.4.1}/comm^ΔC.UAS

(Godenschwege et al., 2002)

Suppressor of

Statement

Reference

Scer\GAL4^{shakB.lethal.4.1}/comm^UAS.cKa is a suppressor | partially of abnormal neuroanatomy phenotype of Scer\GAL4^{shakB.lethal.4.1}, robo1^UAS.cKa

(Godenschwege et al., 2002)

Scer\GAL4^{shakB.lethal.4.1}/comm^UAS.cKa is a suppressor of abnormal neurophysiology phenotype of Scer\GAL4^{shakB.lethal.4.1}, robo1^UAS.cKa

(Godenschwege et al., 2002)

Scer\GAL4^{shakB.lethal.4.1}/comm^ΔC.UAS is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^{shakB.lethal.4.1}, robo2^UAS.cSa

(Godenschwege et al., 2002)

Scer\GAL4^{shakB.lethal.4.1}/comm^ΔC.UAS is a suppressor of abnormal neurophysiology phenotype of Scer\GAL4^{shakB.lethal.4.1}, robo2^UAS.cSa

(Godenschwege et al., 2002)

NOT Suppressor of

Statement

Reference

Scer\GAL4^{shakB.lethal.4.1}/comm^ΔC.UAS is a non-suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^{shakB.lethal.4.1}, robo1^UAS.cKa

(Godenschwege et al., 2002)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^{shakB.lethal.4.1}, robo2^UAS.cSa has giant fiber neuron phenotype, suppressible by Scer\GAL4^{shakB.lethal.4.1}/comm^ΔC.UAS

(Godenschwege et al., 2002)

NOT suppressed by

Statement

Reference

Scer\GAL4^{shakB.lethal.4.1}, robo1^UAS.cKa has giant fibers & dendrite phenotype, non-suppressible by Scer\GAL4^{shakB.lethal.4.1}/comm^ΔC.UAS

(Godenschwege et al., 2002)

Suppressor of

Statement

Reference

Scer\GAL4^{shakB.lethal.4.1}/comm^ΔC.UAS is a suppressor of giant fiber neuron phenotype of Scer\GAL4^{shakB.lethal.4.1}, robo2^UAS.cSa

(Godenschwege et al., 2002)

NOT Suppressor of

Statement

Reference

Scer\GAL4^{shakB.lethal.4.1}/comm^ΔC.UAS is a non-suppressor of giant fibers & dendrite phenotype of Scer\GAL4^{shakB.lethal.4.1}, robo1^UAS.cKa

(Godenschwege et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^{shakB.lethal.4.1}/Nrg^180.UAS rescues Nrg⁸⁴⁹

(Godenschwege et al., 2006)

Fails to rescue

Scer\GAL4^{shakB.lethal.4.1}/Tusp^UAS.cYa fails to rescue Df(3R)Tusp-D

(Yoon et al., 2017)

Scer\GAL4^{shakB.lethal.4.1}/ben^UAS.cUa fails to rescue ben¹

(Uthaman et al., 2008)

Scer\GAL4^{shakB.lethal.4.1}/Nrg^GPI.UAS fails to rescue Nrg⁸⁴⁹

(Godenschwege et al., 2006)

Scer\GAL4^{shakB.lethal.4.1}/Itpr^UAS.cVa fails to rescue Itpr^wc703/Itpr^ug3

(Banerjee et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

51633

y¹ w^*; P{shakB(lethal)-GAL4.4.1}2GL152

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Scer\GAL4^{shakB.lethal.4.1}

Name Synonyms

Secondary FlyBase IDs

References (22)

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