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General Information
Symbol
Dmel\Nrg167.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0147729
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-nrg167
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

The MtnA promoter is replaced with UASt sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Scer\GAL4MS1075-driven expression of Nrg167.Scer\UAS results in some weak alterations in ocellar sensory system axon guidance.

Overexpression of Nrg167.Scer\UAS in wing sensory neurons and two wing epithelial layers, mediated by Scer\GAL4MS1075, causes a reduction in wing size and the appearance of ectopic sensory neurons. Additionally, there are severe axonal pathfinding defects including the distal extension of L1 axons, the absence of the proximal projection where the L1 and L3 nerve join in wild type, the clumping together of L1 axons and the penetration of the wing epithelium by the L1 nerve, an aberrant process which can extend beyond the wing tissue. Expression of Nrg167.Scer\UAS under Scer\GAL4MS1075 in a Nrgl3 background results in the same phenotype.

When Nrg180.I.Scer\UAS is driven by Scer\GAL4GMR.PF no effects are seen on the number of photoreceptor cells or cone cells present in the eye.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The defective wing phenotype of Nrg167.Scer\UAS; Scer\GAL4MS1075 mutants is partially suppressed in a Egfrt1 or Egfrt1/+ background. Egfrt1 also suppresses the wing phenotype when Nrg167.Scer\UAS is expressed in a Nrgl3 background.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of Nrg167.Scer\UAS under the control of Scer\GAL4c316 results in substantial rescue of the Nrgibx central brain phenotype.

Expression of Nrg167.Scer\UAS under the control of either Scer\GAL4Mef2.247, Scer\GAL430Y or Scer\GAL4Tab2-201Y does not appear to rescue the Nrgibx central brain phenotype.

Expression of Nrg167.Scer\UAS under the control of either Scer\GAL4Mef2.247 or Scer\GAL4c316 results in a significant increase in the sexual receptivity of Nrgibx females, while expression under the control of Scer\GAL4Tab2-201Y has no significant effect.

Expression of Nrg167.Scer\UAS under the control of Scer\GAL430Y results in a small but significant decrease in the sexual receptivity of Nrgibx females.

Scer\GAL4MS1075-driven expression of Nrg167.Scer\UAS in Nrgl3 mutant animals shows a synergistic increase in the expressivity of OP axon alterations (i.e. axonal alterations are much more severe in those individuals that display the phenotype).

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Nrg167.Scer\UAS
Nrg167.UAS
Name Synonyms
Secondary FlyBase IDs
    References (8)