FlyBase Gene Report: Dmel\Cont

General Information

Symbol

Dmel\Cont

Species

D. melanogaster

Name

Contactin

Annotation Symbol

CG1084

Feature Type

protein_coding_gene

FlyBase ID

FBgn0037240

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Contactin (Cont) encodes a GPI-anchored cell adhesion molecule. It interacts with the product of Nrx-IV in cis to organize septate junctions in epithelial cells and also between ensheathing glial cells and neurons. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

DCONT

Key Links

Genomic Location

Cytogenetic map

82A5-82A5

Sequence location

3R:4,381,306..4,387,018 [+]

Recombination map

3-47.1

RefSeq locus

NT_033777 REGION:4381306..4387018

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables cell-cell adhesion mediator activity

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(GO Reference Genome Project, 2011-)

Biological Process (9 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in axon ensheathment

inferred from mutant phenotype

(Banerjee et al., 2006)

involved_in cell adhesion involved in heart morphogenesis

inferred from mutant phenotype

(Yi et al., 2008)

involved_in establishment of glial blood-brain barrier

inferred from mutant phenotype

(Stork et al., 2008)

involved_in nerve maturation

inferred from mutant phenotype

(Banerjee et al., 2006)

involved_in septate junction assembly

inferred from mutant phenotype

(Banerjee et al., 2006)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in axon guidance

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(GO Reference Genome Project, 2011-)

involved_in dendrite self-avoidance

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(GO Reference Genome Project, 2011-)

involved_in establishment or maintenance of epithelial cell apical/basal polarity

inferred by curator from GO:0005918

(Faivre-Sarrailh et al., 2004)

involved_in homophilic cell-cell adhesion

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

located_in septate junction

inferred from direct assay

(Faivre-Sarrailh et al., 2004)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in axon

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(GO Reference Genome Project, 2011-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(GO Reference Genome Project, 2011-)

located_in plasma membrane

inferred from experiment

(Faivre-Sarrailh et al., 2004)

Gene Group (FlyBase)

C-TYPE LECTIN-LIKE

Protein Family (UniProt)

Belongs to the immunoglobulin superfamily. Contactin family. (Q9VN14)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

C-TYPE LECTIN-LIKE -: C-type lectins are Ca²⁺-dependent carbohydrate-binding proteins. They possess a C-type lectin fold, that is also present in proteins that do not bind carbohydrates. (Adapted from PMID:20301263.)

Protein Function (UniProtKB)

Required for organization of septate junctions and paracellular barrier functions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion.

(UniProt, Q9VN14)

Summary (Interactive Fly)

GPI-anchored cell adhesion molecule - required for organization of septate junctions and for function of the paracellular barrier - forms a tripartite complex with Neuroglian and Neurexin

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cont for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VN14)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cont-RA

FBtr0078917

NM_141204

4742

1390

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Cont-PA

FBpp0078557

158.2

1390

6.77

Q9VN14

NP_649461

AAF52137

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Forms a complex with Nrg and Nrx (PubMed:15459097). Forms a complex composed of septa junction proteins Nrx-IV/Nrx, Tsf2/MTf, Cont and Nrg during late embryogenesis (PubMed:20935638).

(UniProt, Q9VN14)

Post Translational Modification

N-glycosylated.

(UniProt, Q9VN14)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VN14

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cont using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cont_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.43

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

larval foregut atrium | precursor

Comment: reported as atrium primordium

(Fisher et al., 2012)

clypeo-labral primordium

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

salivary gland body primordium

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

oogenesis

border follicle cell

(Wang et al., 2006)

Additional Descriptive Data

Cont expression is enriched in border follicle cells relative to other cells in the egg chamber.

(Wang et al., 2006)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

larval channel glial cell

(Banerjee et al., 2017)

embryonic stage 16

glial cell | subset of larval peripheral nervous system

• plasma membrane

(Banerjee et al., 2006)

chordotonal organ | restricted

(Banerjee et al., 2006)

scolopale cell

(Banerjee et al., 2006)

scolopidial dendritic cap cell

(Banerjee et al., 2006)

oogenesis

border follicle cell

(Wang et al., 2006)

centripetal follicle cell

(Wang et al., 2006)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Cont protein is detected in the glial cell membranes in the peripheral nerves, ensheathing the axons. In the chordotonal organs, it is detected in the scolopale and cap cells.

(Banerjee et al., 2006)

Cont protein expression is enriched in centripetal cells relative to other cells in the egg chamber throughout migration.

(Wang et al., 2006)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

located_in septate junction

inferred from direct assay

(Faivre-Sarrailh et al., 2004)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cont in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cont

View exonic expression by tissue for Dmel\Cont

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037240

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40553/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037240

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037240

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037240

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1084

Flygut - An atlas of the Drosophila adult midgut

FBgn0037240

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Cont

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cont

Transgenic constructs containing regulatory region of Cont

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3R)XM3

(Faivre-Sarrailh et al., 2004)

Gene partially disrupted in

Df(3L)ex956

(Faivre-Sarrailh et al., 2004)

Inferred from location ( 9 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Cont^ex956

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cont^GD12610

viable, with Scer\GAL4^Mef2.PR

Cont^GD12610

viable, with Scer\GAL4^pnr-MD237

Cont^GD12610

viable, with Scer\GAL4^tin.CΔ4

Cont^GD12610

Other Phenotypes

Allele

abnormal behavior | adult stage, with Scer\GAL4^repo

Cont^HM05134

decreased rate of adult locomotory behavior, with Scer\GAL4^GMR71C07

Cont^HM05134

decreased size | adult stage, with Scer\GAL4^eya.enh1+E+2

visible, with Scer\GAL4^pnr-MD237

Cont^GD12610

Phenotype manifest in

Allele

abdominal lateral pentascolopidial chordotonal organ lch5

Cont^ex956

axolemma & nerve

Cont^ex956

embryonic epidermis & pleated septate junction

Cont^ex956

eye, with Scer\GAL4^eya.enh1+E+2

salivary gland

Cont^ex956

scolopidium & abdominal lateral pentascolopidial chordotonal organ lch5

Cont^ex956

septate junction & peripheral glial cell

Cont^ex956

trichogen cell, with Scer\GAL4^pnr-MD237

Cont^GD12610

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (94)

Hsap\CNTN2

12 of 14

Yes

Hsap\CNTN3

12 of 14

Yes

Hsap\CNTN4

12 of 14

Yes

Hsap\CNTN6

12 of 14

Yes

Hsap\CNTN1

11 of 14

Yes

Hsap\CNTN5

11 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CLEC2B

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\DCC

1 of 14

Hsap\FCER2

1 of 14

Hsap\FSTL4

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\IGFBPL1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\KIRREL2

1 of 14

Hsap\KIRREL3

1 of 14

Hsap\KLRB1

1 of 14

Yes

Hsap\KLRC1

1 of 14

Yes

Hsap\KLRC2

1 of 14

Yes

Hsap\KLRC3

1 of 14

Yes

Hsap\KLRC4-KLRK1

1 of 14

Yes

Hsap\KLRD1

1 of 14

Yes

Hsap\KLRF1

1 of 14

Yes

Hsap\KLRF2

1 of 14

Yes

Hsap\KLRG1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (21)

Rnor\Cntn3

12 of 14

Yes

Rnor\Cntn4

12 of 14

Yes

Rnor\Cntn1

11 of 14

Yes

Rnor\Cntn2

11 of 14

Yes

Rnor\Cntn5

11 of 14

Yes

Rnor\Cntn6

11 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Igsf10

1 of 14

Rnor\Myot

1 of 14

Yes

Rnor\Pigr

1 of 14

Yes

Rnor\Sdk2

1 of 14

Rnor\Wfikkn1

1 of 14

Rnor\Wfikkn2

1 of 14

Mus musculus (laboratory mouse) (28)

Mmus\Cntn3

12 of 14

Yes

Mmus\Cntn5

12 of 14

Yes

Mmus\Cntn6

12 of 14

Yes

Mmus\Cntn1

11 of 14

Yes

Mmus\Cntn4

11 of 14

Yes

Mmus\Cntn2

10 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Igsf10

1 of 14

Mmus\Myot

1 of 14

Yes

Mmus\Mypn

1 of 14

Mmus\Papln

1 of 14

Mmus\Pigr

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Wfikkn2

1 of 14

Xenopus tropicalis (Western clawed frog) (34)

Xtro\cntn1

6 of 13

Yes

Xtro\cntn2

6 of 13

Yes

Xtro\cntn4

6 of 13

Yes

Xtro\cntn5

6 of 13

Yes

Xtro\dscam

2 of 13

Xtro\hmcn1

2 of 13

Yes

Xtro\hmcn2

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\igsf9b

1 of 13

Xtro\igsf10

1 of 13

Xtro\kazald1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (39)

Drer\cntn3a.1

12 of 14

Yes

Drer\cntn2

11 of 14

Yes

Drer\cntn3a.2

11 of 14

Yes

Drer\cntn3b

11 of 14

Yes

Drer\cntn1a

10 of 14

Yes

Drer\cntn1b

10 of 14

Yes

Drer\cntn4

10 of 14

Yes

Drer\cntn5

10 of 14

Yes

Drer\chl1a

3 of 14

Drer\LOC101883325

3 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC101882195

1 of 14

Yes

Drer\LOC110437796

1 of 14

Yes

Drer\myot

1 of 14

Yes

Drer\nrcama

1 of 14

Drer\ntrk2b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\wfikkn2a

1 of 14

Drer\wfikkn2b

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (17)

Cele\rig-6

8 of 14

Yes

Cele\clec-180

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (30)

Agam\IGL1

12 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Cont. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (38)

Nrg

4 of 13

tutl

3 of 13

bdl

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

boi

1 of 13

Bsg

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

hbs

1 of 13

ihog

1 of 13

kek4

1 of 13

kirre

1 of 13

Lac

1 of 13

Lar

1 of 13

nrm

1 of 13

plum

1 of 13

Ppn

1 of 13

robo1

1 of 13

sdk

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

sns

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

CNTN2; contactin 2

model of familial adult myoclonic epilepsy 5

IEA

(FlyBase, 2019-)

CNTN1; contactin 1

model of Compton-North congenital myopathy

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

Cont^HM05134

ameliorates multiple congenital anomalies-hypotonia-seizures syndrome 2

modeled by PIG-A^HMJ23951

(Thorpe et al., 2025)

Cont^HMS00186

ameliorates multiple congenital anomalies-hypotonia-seizures syndrome 2

modeled by PIG-A^HMJ23951

(Thorpe et al., 2025)

Cont^GD12610

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.cUa

(Kim et al., 2021)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.cBa}

(Kim et al., 2021)

ameliorates Huntington's disease

modeled by Hsap\HTT^Q200.FL.UAS

(Greco et al., 2022)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CNTN2; contactin 2

12 of 14

190197

EPILEPSY, EARLY-ONSET, 5, WITH OR WITHOUT DEVELOPMENTAL DELAY; EPEO5

familial adult myoclonic epilepsy 5

12 of 14

12 of 14

12 of 14

11 of 14

CONGENITAL MYOPATHY 12; CMYO12

Compton-North congenital myopathy

CNTN5; contactin 5

11 of 14

607219

CHL1; cell adhesion molecule L1 like

3 of 14

607416

L1CAM; L1 cell adhesion molecule

3 of 14

L1 CELL ADHESION MOLECULE; L1CAM

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-RNA

Physical Interaction

Assay

References

Cont - mir-184

luminiscence technology

(Iovino et al., 2009, Kertesz et al., 2007)

RNA-protein

Physical Interaction

Assay

References

Cont - AGO1

anti bait coimmunoprecipitation, quantitative reverse transcription pcr

(Hong et al., 2009)

protein-protein

Physical Interaction

Assay

References

Cont - Nrg

anti bait coimmunoprecipitation, western blot

(Banerjee et al., 2006, Faivre-Sarrailh et al., 2004)

Cont - Nrx-IV

anti bait coimmunoprecipitation, western blot, anti tag western blot

(Banerjee et al., 2011, Tiklová et al., 2010, Banerjee et al., 2006, Faivre-Sarrailh et al., 2004)

Cont - Tsf2

anti bait coimmunoprecipitation, western blot

(Tiklová et al., 2010)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

PIG-A

suppressible

Cont

(Thorpe et al., 2025)

External Data

Subunit Structure (UniProtKB)

Forms a complex with Nrg and Nrx (PubMed:15459097). Forms a complex composed of septa junction proteins Nrx-IV/Nrx, Tsf2/MTf, Cont and Nrg during late embryogenesis (PubMed:20935638).

(UniProt, Q9VN14 )

Linkouts

BioGRID - A database of protein and genetic interactions.

65773

DroID - A comprehensive database of gene and protein interactions.

FBgn0037240

MIST (protein-protein) - An integrated Molecular Interaction Database

40553

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47.1

Cytogenetic map

82A5-82A5

Sequence location

3R:4,381,306..4,387,018 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

82A5-82A5

Limits computationally determined from genome sequence between P{PZ}l(3)02733⁰²⁷³³ and P{EP}EP974

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-47.1

(FlyBase, 2016)

3-44.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

63275

w¹¹¹⁸; P{EP}Cont^G5080/TM2

28923

y¹ v¹; P{TRiP.HM05134}attP2

34867

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00186}attP2/TM3, Sb¹

VDRC

v28294

w¹¹¹⁸; P{GD12610}v28294

v40613

w¹¹¹⁸; P{GD12610}v40613

v341764

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00889}attP40/CyO-GFP

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (54)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

RT02589

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0037240

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0037240

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Cont CG1084

(Faivre-Sarrailh, 2002.3.6)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG1084

(Kim et al., 2021, Harris et al., 2016, Hosono et al., 2015, Christis and Munro, 2012, Jaspers et al., 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Khanna et al., 2010, Rhiner et al., 2010, Hong et al., 2009, Perkins et al., 2009, Vogel et al., 2003, Faivre-Sarrailh, 2002.3.7)

CONT

(Rosenbaum et al., 2012)

CT1481

(Hynes and Zhao, 2000)

Cont

(De et al., 2022, Greco et al., 2022, Alhadyian et al., 2021, Schroeder et al., 2019, Tempesta et al., 2017, Aradska et al., 2015, Hall et al., 2014, Ozkan et al., 2013, Banerjee et al., 2011, Buffin and Gho, 2010, Tiklova et al., 2010, Tiklová et al., 2010, Iovino et al., 2009, Tan et al., 2009, Laval et al., 2008, Kertesz et al., 2007, Furuse and Tsukita, 2006, Schneider et al., 2006)

D-Axonin

(Vogel et al., 2003)

DCONT

(Bhat, 2003, Faivre-Sarrailh et al., 2001)

cont

(Parisi et al., 2023, Rouka et al., 2021, Goel et al., 2019, Laval et al., 2008, Yi et al., 2008, Banerjee et al., 2006, Faivre-Sarrailh et al., 2004)

Name Synonyms

Contactin

(Alhadyian et al., 2021, Rice et al., 2021, Finegan and Bergstralh, 2020, Lim et al., 2019, Harris et al., 2016, Kunduri et al., 2014, Jaspers et al., 2012, Cammarato et al., 2011, Buffin and Gho, 2010, Khanna et al., 2010, Khanna et al., 2010, Tiklová et al., 2010, Laval et al., 2008, Stork et al., 2008, Tiklová et al., 2007, Wang et al., 2006, Daneman and Barres, 2005, Faivre-Sarrailh et al., 2001)

D-Contactin

(Leiserson and Keshishian, 2011)

Dcontactin

(Rodrigues et al., 2011)

contactin

(Podolsky et al., 2018, Kunduri et al., 2014, Rosenbaum et al., 2012, Rhiner et al., 2010, Yi et al., 2008, Bhat, 2003)

Secondary FlyBase IDs

FBan0001084

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 49 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40553

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VN14

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VN14

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VN14

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037240

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40553/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037240

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037240

FlyMine - An integrated database for Drosophila genomics

FBgn0037240

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1084

MARRVEL_MODEL - MARRVEL (model organism gene)

40553

Linkouts

BioGRID - A database of protein and genetic interactions.

65773

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0037240

DroID - A comprehensive database of gene and protein interactions.

FBgn0037240

DRSC - Results frm RNAi screens

FBgn0037240

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cont_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037240

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0037240

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1084

Flygut - An atlas of the Drosophila adult midgut

FBgn0037240

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0037240

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

40553

References (93)

The following external sites may use different assemblies or annotations than FlyBase.

-0.43

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