FlyBase Allele Report: Dmel\Nrg[HMS01638]

General Information

Symbol

Dmel\Nrg^HMS01638

Species

D. melanogaster

Name

FlyBase ID

FBal0266545

Feature type

allele

Associated gene

Dmel\Nrg

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01638}

Also Known As

nrg RNAi #2, UAS-nrgRNAi, UAS-Nrg RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS01638}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01638

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates carcinoma

modeled by Egfr^UAS.cBa, psq^KK111691

(Fereres et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased occurrence of cell division | adult stage, with Scer\GAL4^bun-GSG5961

(Resnik-Docampo et al., 2021)

decreased occurrence of cell division | adult stage, with Scer\GAL4^GSG5966

(Resnik-Docampo et al., 2021)

decreased occurrence of cell division | adult stage, with Scer\GAL4^Su(H).GBE

(Resnik-Docampo et al., 2021)

Phenotype Manifest In

adult posterior midgut epithelium, with Scer\GAL4^bun-GSG5961

(Resnik-Docampo et al., 2021)

adult posterior midgut epithelium, with Scer\GAL4^GSG5966

(Resnik-Docampo et al., 2021)

adult posterior midgut epithelium, with Scer\GAL4^Su(H).GBE

(Resnik-Docampo et al., 2021)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Nrg^HMS01638, Scer\GAL4^bun-GSG5961 is a non-enhancer of increased occurrence of cell division | adult stage phenotype of Scer\GAL4^bun-GSG5961, btl::Egfr^λ.UAS

(Resnik-Docampo et al., 2021)

Suppressor of

Statement

Reference

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor of abnormal neuroanatomy | P-stage phenotype of Arf4^JF02581, Scer\GAL4^ppk.PU

(Rui et al., 2023)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor of abnormal neuroanatomy | P-stage phenotype of Droj2^TH02998.N, Scer\GAL4^ppk.PU

(Rui et al., 2023)

Nrg^HMS01638, Scer\GAL4^ap-md544 is a suppressor of neoplasia | larval stage phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691

(Fereres et al., 2019)

Nrg^HMS01638, Scer\GAL4^ap-md544 is a suppressor of increased cell number | larval stage phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691

(Fereres et al., 2019)

Nrg^HMS01638, Scer\GAL4^ap-md544 is a suppressor of increased mortality during development phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691

(Fereres et al., 2019)

Nrg^HMS01638, Scer\GAL4^ap-md544 is a suppressor of partially lethal phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691

(Fereres et al., 2019)

Nrg^HMS01638/Scer\GAL4^ppk.PU is a suppressor of abnormal neuroanatomy | somatic clone | pupal stage phenotype of Yif1^10-46

(Wang et al., 2018)

Nrg^HMS01638/Scer\GAL4^ppk.PU is a suppressor of abnormal neuroanatomy | somatic clone | pupal stage phenotype of Yip1d1^1-21

(Wang et al., 2018)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of abnormal neuroanatomy | pupal stage phenotype of Scer\GAL4^ppk.PU, Sec71^HMS00357

(Wang et al., 2017)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of abnormal neuroanatomy | pupal stage phenotype of Arf1^GD12522, Scer\GAL4^ppk.PU

(Wang et al., 2017)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of abnormal neuroanatomy | P-stage phenotype of Scer\GAL4^ppk.PU, brm^{K804R.UAS.Tag:HA}

(Zhang et al., 2014)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of abnormal neuroanatomy | P-stage phenotype of EcR^{B1-ΔC655.W650A.UAS}, Scer\GAL4^ppk.PU

(Zhang et al., 2014)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of abnormal neuroanatomy | P-stage phenotype of Rab5^S43N.UAS, Scer\GAL4^ppk.PU

(Zhang et al., 2014)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of abnormal neuroanatomy | P-stage phenotype of Scer\GAL4^ppk.PU, nej^GD1494

(Zhang et al., 2014)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of abnormal neuroanatomy | P-stage phenotype of Scer\GAL4^ppk.PU, Vps4^{DN.UAS.Tag:HA}

(Zhang et al., 2014)

NOT Suppressor of

Statement

Reference

Nrg^HMS01638, Scer\GAL4^bun-GSG5961 is a non-suppressor of increased occurrence of cell division | adult stage phenotype of Scer\GAL4^bun-GSG5961, btl::Egfr^λ.UAS

(Resnik-Docampo et al., 2021)

Nrg^HMS01638, Scer\GAL4^ap-md544 is a non-suppressor of neoplasia | larval stage phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544, dia^HM05027, psq^KK111691

(Fereres et al., 2019)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Egfr^UAS.cBa, Nrg^HMS01638, Scer\GAL4^ap-md544, psq^KK111691 has wing disc phenotype, non-suppressible by dia^HM05027, Scer\GAL4^ap-md544

(Fereres et al., 2019)

NOT Enhancer of

Statement

Reference

Nrg^HMS01638, Scer\GAL4^bun-GSG5961 is a non-enhancer of adult posterior midgut epithelium phenotype of Scer\GAL4^bun-GSG5961, btl::Egfr^λ.UAS

(Resnik-Docampo et al., 2021)

Suppressor of

Statement

Reference

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor of larval dorsal multidendritic neuron ddaC | P-stage phenotype of Arf4^JF02581, Scer\GAL4^ppk.PU

(Rui et al., 2023)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor of dendrite | P-stage phenotype of Arf4^JF02581, Scer\GAL4^ppk.PU

(Rui et al., 2023)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor of larval dorsal multidendritic neuron ddaC | P-stage phenotype of Droj2^TH02998.N, Scer\GAL4^ppk.PU

(Rui et al., 2023)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor of dendrite | P-stage phenotype of Droj2^TH02998.N, Scer\GAL4^ppk.PU

(Rui et al., 2023)

Nrg^HMS01638, Scer\GAL4^ap-md544 is a suppressor of wing disc phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691

(Fereres et al., 2019)

Nrg^HMS01638/Scer\GAL4^ppk.PU is a suppressor of larval dorsal multidendritic neuron ddaC | somatic clone | pupal stage phenotype of Yif1^10-46

(Wang et al., 2018)

Nrg^HMS01638/Scer\GAL4^ppk.PU is a suppressor of dendritic tree | somatic clone | pupal stage phenotype of Yif1^10-46

(Wang et al., 2018)

Nrg^HMS01638/Scer\GAL4^ppk.PU is a suppressor of larval dorsal multidendritic neuron ddaC | somatic clone | pupal stage phenotype of Yip1d1^1-21

(Wang et al., 2018)

Nrg^HMS01638/Scer\GAL4^ppk.PU is a suppressor of dendritic tree | somatic clone | pupal stage phenotype of Yip1d1^1-21

(Wang et al., 2018)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of larval dorsal multidendritic neuron ddaC | pupal stage phenotype of Arf1^GD12522, Scer\GAL4^ppk.PU

(Wang et al., 2017)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of dendritic tree | pupal stage phenotype of Arf1^GD12522, Scer\GAL4^ppk.PU

(Wang et al., 2017)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of larval dorsal multidendritic neuron ddaC | pupal stage phenotype of Scer\GAL4^ppk.PU, Sec71^HMS00357

(Wang et al., 2017)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of dendritic tree | pupal stage phenotype of Scer\GAL4^ppk.PU, Sec71^HMS00357

(Wang et al., 2017)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of larval dorsal multidendritic neuron ddaC | P-stage phenotype of Scer\GAL4^ppk.PU, brm^{K804R.UAS.Tag:HA}

(Zhang et al., 2014)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of dendritic tree | P-stage phenotype of Scer\GAL4^ppk.PU, brm^{K804R.UAS.Tag:HA}

(Zhang et al., 2014)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of larval dorsal multidendritic neuron ddaC | P-stage phenotype of EcR^{B1-ΔC655.W650A.UAS}, Scer\GAL4^ppk.PU

(Zhang et al., 2014)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of dendritic tree | P-stage phenotype of EcR^{B1-ΔC655.W650A.UAS}, Scer\GAL4^ppk.PU

(Zhang et al., 2014)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of larval dorsal multidendritic neuron ddaC | P-stage phenotype of Rab5^S43N.UAS, Scer\GAL4^ppk.PU

(Zhang et al., 2014)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of dendritic tree | P-stage phenotype of Rab5^S43N.UAS, Scer\GAL4^ppk.PU

(Zhang et al., 2014)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of larval dorsal multidendritic neuron ddaC | P-stage phenotype of Scer\GAL4^ppk.PU, nej^GD1494

(Zhang et al., 2014)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of dendritic tree | P-stage phenotype of Scer\GAL4^ppk.PU, nej^GD1494

(Zhang et al., 2014)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of larval dorsal multidendritic neuron ddaC | P-stage phenotype of Scer\GAL4^ppk.PU, Vps4^{DN.UAS.Tag:HA}

(Zhang et al., 2014)

Nrg^HMS01638, Scer\GAL4^ppk.PU is a suppressor | partially of dendritic tree | somatic clone | P-stage phenotype of Scer\GAL4^ppk.PU, Vps4^{DN.UAS.Tag:HA}

(Zhang et al., 2014)

NOT Suppressor of

Statement

Reference

Nrg^HMS01638, Scer\GAL4^bun-GSG5961 is a non-suppressor of adult posterior midgut epithelium phenotype of Scer\GAL4^bun-GSG5961, btl::Egfr^λ.UAS

(Resnik-Docampo et al., 2021)

Nrg^HMS01638, Scer\GAL4^ap-md544 is a non-suppressor of wing disc phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544, dia^HM05027, psq^KK111691

(Fereres et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

All larvae co-expressing psq^KK111691 and Egfr^UAS.cBa under the control of Scer\GAL4^ap-md544 during larval stages (using Gal80[ts] for the temporal regulation of expression) wing discs tumors, associated with higher numbers of myoblasts. These phenotypes are partially suppressed by the co-expression of Nrg^HMS01638, but not further suppressed by dia^HM05027, Nrg^HMS01638 combined co-expression..

(Fereres et al., 2019)

The co-expression of Nrg^HMS01638 partially suppresses the pruning defects of dorsal multidendritic ddaC neurons at 16h after puparium formation resulting from the expression of either Arf79F^GD12522 or Sec71^HMS00357 under the combined control of Scer\GAL4^ppk.PU and Dicer-2 transgene.

(Wang et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

37496

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01638}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Nrg^HMS01638

(Resnik-Docampo et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

Open Close