FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Yip1d11-21
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General Information
Symbol
Dmel\Yip1d11-21
Species
D. melanogaster
Name
FlyBase ID
FBal0342891
Feature type
allele
Associated gene
Dmel\Yip1d1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Wang et al., 2018)
Mutagen
CRISPR/Cas9
(Wang et al., 2018)
Progenitor genotype
Cytology
Description

7bp deletion in the first exon of Yip1d1.

(Wang et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2L:13,000,496..13,000,506 [-]
Comment:

11 bases (CTCCGCGCCCT) are deleted and replaced with 4 bases (ACTC) in the first coding exon of Yip1d1. This results in a frameshift and early translation termination.

Inserted_sequence:

ACTC

(Wang et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Yip1d11-21 mutant ddaC neuron clones show significantly simplified dendrite arbors with fewer dendritic termini in wandering third instar larvae and show strong pruning defects in pupae (16h APF); mutant ddaD/E neuron clones also show strong pruning defects in pupae (19h APF); mutant ddaF neuron clones are removed by 19h APF, similar to wild-type controls.

      Yip1d11-21 mutant ddaC neuron clones in wandering third instar larvae show disrupted cis- and trans-Golgi (as shown by the diffuse patterns of fluorescent GM130 and Arf1), but no defect in ER exit sites (as shown by the normal punctate pattern of fluorescent Sec31).

      (Wang et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Yip1d11-21
      (Wang et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)