FlyBase Gene Report: Dmel\Tehao

General Information

Symbol

Dmel\Tehao

Species

D. melanogaster

Name

Tehao

Annotation Symbol

CG7121

Feature Type

protein_coding_gene

FlyBase ID

FBgn0026760

Gene Model Status

Current

Stock Availability

13 publicly available

Gene Summary

Tehao (Tehao) encodes a homologue of the receptor encoded by Tl. It is involved in the Toll signaling pathway and innate immune response. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

Toll-5, Tl-5, Toll 5, dToll5

Key Links

Genomic Location

Cytogenetic map

34C1-34C1

Sequence location

2L:13,435,622..13,439,930 [+]

Recombination map

2-48

RefSeq locus

NT_033779 REGION:13435622..13439930

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables coreceptor activity

inferred from direct assay

(Luo et al., 2001)

enables protein kinase binding

inferred from physical interaction with FLYBASE:pll; FB:FBgn0010441

(Luo et al., 2001)

enables Toll binding

inferred from physical interaction with FLYBASE:Tl; FB:FBgn0262473

(Luo et al., 2001)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables signaling receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN002808045

(GO Reference Genome Project, 2011-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in antifungal innate immune response

inferred from mutant phenotype

(Tauszig et al., 2000)

involved_in innate immune response

inferred from mutant phenotype

(Luo et al., 2001)

involved_in positive regulation of antimicrobial peptide biosynthetic process

inferred from mutant phenotype

(Luo et al., 2001)

involved_in signal transduction

inferred from mutant phenotype

(Chowdhury et al., 2019)

involved_in Toll signaling pathway

inferred from genetic interaction with FLYBASE:pll; FB:FBgn0010441

(Tauszig et al., 2000)

inferred from direct assay

(Luo et al., 2001)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in innate immune response

inferred from biological aspect of ancestor with PANTHER:PTN001555455

(GO Reference Genome Project, 2011-)

involved_in signal transduction

inferred from electronic annotation with InterPro:IPR000157

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN002808045

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002808045

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

TOLL RECEPTORS

Pathway (FlyBase)

TOLL-NF-kappaB SIGNALING PATHWAY CORE COMPONENTS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Tehao (Tehao) encodes a homologue of the receptor encoded by Tl. It is involved in the Toll signaling pathway and innate immune response. [Date last reviewed: 2019-09-12]

Gene Group (FlyBase)

TOLL RECEPTORS -: The Toll/Toll-like receptor (TLR) family members are type-I single-pass transmembrane receptors with an intracellular Toll IL-1R homology (TIR) domain and extracellular Leucine-rich repeats. The archetypal family member, Tl, was first characterized for its role in embryonic dorsal/ventral patterning. In larval and adult stages, Tl is involved with innate immune response. Tl is activated by binding an endogenous spatzle ligand and activation of NF-κB is the target of canonical Toll/Toll-like receptor signaling. Non-canonical signaling pathways are less well characterized. (Adapted from FBrf0130108, FBrf0212564 and FBrf0239503).

Pathway (FlyBase)

TOLL-NF-kappaB SIGNALING PATHWAY CORE COMPONENTS -: In Drosophila, the canonical Toll signaling pathway is initiated by the binding of a spatzle ligand to Toll (Tl) or a Toll-like receptor leading to the nuclear localization of the NF-κB (dl or Dif) transcription factor. (Adapted from FBrf0091014 and FBrf0223077).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Tehao for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VJX9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.56

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Tehao-RA

FBtr0080502

NM_058090

2749

795

Tehao-RB

FBtr0346423

NM_001298972

3181

795

Additional Transcript Data and Comments

Reported size (kB)

3.2 (northern blot)

(Tauszig et al., 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Tehao-PA

FBpp0080080

90.2

795

6.15

FBpp0312090

90.2

795

6.15

Q9VJX9

NP_001285901

AHN54415

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

795 aa isoforms: Tehao-PA, Tehao-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

795 (aa)

(Tauszig et al., 2000)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tehao using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Tehao_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.43

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 10

ventral midline of embryo

(Kambris et al., 2002)

embryonic stage 10 -- 13

somatic muscle primordium

(Kambris et al., 2002)

embryonic stage 13

embryonic/larval dorsal vessel

(Kambris et al., 2002)

embryonic/larval midgut

(Kambris et al., 2002)

embryonic stage 16

embryonic/larval salivary gland

(Kambris et al., 2002)

embryonic/larval proventriculus | restricted

(Kambris et al., 2002)

keyhole structure | posterior to

(Kambris et al., 2002)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage & adult stage

(Tauszig et al., 2000)

Additional Descriptive Data

Tehao expression is observed at embryonic stage 10 in the ventral midline and in clusters of muscle progenitor cells. At stage 13, it is observed in some ventral muscles and in the dorsal vessel. At stage 16, expression is found in the salivery glands and in the proventriculus posterior to the keyhole. Faint midgut expression is also observed.

(Kambris et al., 2002)

Tehao transcripts are expressed in larvae and adults but not in early embryos or pupae.

(Tauszig et al., 2000)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

organism

(Luo et al., 2001)

adult stage | female

ovary

(Luo et al., 2001)

Additional Descriptive Data

Higher molecular weight bands are also observed on Western blots due to glycosylation of Tehao protein.

(Luo et al., 2001)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Tehao in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Tehao

View exonic expression by tissue for Dmel\Tehao

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34761/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026760

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026760

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026760

Flygut - An atlas of the Drosophila adult midgut

FBgn0026760

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Tehao

Transgenic constructs containing regulatory region of Tehao

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Tehao^GD14382

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Other Phenotypes

Allele

abnormal behavior | recessive

Tehao^BG01765

abnormal cell number | oogenesis, with Scer\GAL4^bab1-Gal4

Tehao^GD2534

some die during pupal stage, with Scer\GAL4^pnr-MD237

Tehao^GD14382

visible, with Scer\GAL4^pnr-MD237

Tehao^GD14382

Phenotype manifest in

Allele

female germline stem cell, with Scer\GAL4^bab1-Gal4

Tehao^GD2534

germarium, with Scer\GAL4^bab1-Gal4

Tehao^GD2534

tormogen cell, with Scer\GAL4^pnr-MD237

Tehao^GD14382

trichogen cell, with Scer\GAL4^pnr-MD237

Tehao^GD14382

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (74)

Hsap\TLR1

6 of 14

Yes

Hsap\TLR2

6 of 14

Yes

Hsap\TLR6

6 of 14

Yes

Hsap\TLR10

6 of 14

Yes

Hsap\TLR4

5 of 14

Yes

Hsap\CD180

3 of 14

Yes

Hsap\TLR3

3 of 14

Hsap\TLR5

3 of 14

Yes

Hsap\TLR7

3 of 14

Yes

Hsap\TLR8

3 of 14

Yes

Hsap\TLR9

3 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\F11R

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\TPBG

1 of 14

Hsap\TRIL

1 of 14

Hsap\TTN

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (53)

Rnor\Tlr2

6 of 14

Yes

Rnor\Tlr6

6 of 14

Yes

Rnor\Tlr1

5 of 14

Rnor\Tlr4

5 of 14

Yes

Rnor\Tlr3

4 of 14

Yes

Rnor\Tlr5

4 of 14

Yes

Rnor\Tlr11

4 of 14

Yes

Rnor\Tlr13

4 of 14

Yes

Rnor\Cd180

3 of 14

Yes

Rnor\Tlr7

3 of 14

Yes

Rnor\Tlr8

3 of 14

Yes

Rnor\Tlr9

3 of 14

Yes

Rnor\Tlr12

3 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Il1r2

1 of 14

Yes

Rnor\Il1rapl1

1 of 14

Yes

Rnor\Il1rapl2

1 of 14

Yes

Rnor\Il1rap

1 of 14

Yes

Rnor\Il1rl1

1 of 14

Yes

Rnor\Il1rl2

1 of 14

Yes

Rnor\Il18r1

1 of 14

Yes

Rnor\Il18rap

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Tlr10

1 of 14

Yes

Rnor\Tril

1 of 14

Mus musculus (laboratory mouse) (52)

Mmus\Tlr1

6 of 14

Yes

Mmus\Tlr2

6 of 14

Yes

Mmus\Tlr4

5 of 14

Yes

Mmus\Tlr6

5 of 14

Mmus\Tlr13

5 of 14

Yes

Mmus\Tlr3

4 of 14

Yes

Mmus\Tlr12

4 of 14

Yes

Mmus\Cd180

3 of 14

Yes

Mmus\Tlr7

3 of 14

Yes

Mmus\Tlr8

3 of 14

Yes

Mmus\Tlr9

3 of 14

Yes

Mmus\Tlr11

3 of 14

Yes

Mmus\Cpn2

2 of 14

Mmus\Tlr5

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Il1r2

1 of 14

Yes

Mmus\Il1rapl1

1 of 14

Yes

Mmus\Il1rapl2

1 of 14

Yes

Mmus\Il1rap

1 of 14

Yes

Mmus\Il1rl1

1 of 14

Yes

Mmus\Il1rl2

1 of 14

Yes

Mmus\Il18r1

1 of 14

Yes

Mmus\Il18rap

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Tril

1 of 14

Xenopus tropicalis (Western clawed frog) (60)

Xtro\tlr1

6 of 13

Yes

Xtro\tlr2

6 of 13

Yes

Xtro\tlr6

6 of 13

Yes

Xtro\XB5889249

6 of 13

Yes

5 of 13

5 of 13

4 of 13

3 of 13

Yes

Xtro\tlr8

3 of 13

Yes

Xtro\tlr9

3 of 13

Yes

3 of 13

3 of 13

2 of 13

2 of 13

Yes

Xtro\MGC147172

2 of 13

Xtro\tlr3

2 of 13

Xtro\tlr7

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Xtro\adamtsl1

1 of 13

Xtro\cd22

1 of 13

Xtro\cd180

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\il1rapl2

1 of 13

Yes

Xtro\il1rap

1 of 13

Yes

Xtro\il18rap

1 of 13

Yes

Xtro\LOC100485927

1 of 13

Yes

Xtro\LOC100496647

1 of 13

Yes

Xtro\LOC116410887

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (56)

Drer\tlr2

7 of 14

Yes

Drer\tlr4al

7 of 14

Yes

Drer\tlr4bb

7 of 14

Yes

Drer\tlr21

7 of 14

Yes

Drer\tlr4ba

6 of 14

Yes

Drer\tlr18

6 of 14

Yes

Drer\tlr1

5 of 14

Yes

Drer\tlr20.2

5 of 14

Drer\tlr22

5 of 14

Drer\cd180

4 of 14

Yes

Drer\tlr3

4 of 14

Yes

Drer\tlr5a

4 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

Yes

Drer\tlr9

3 of 14

Yes

Drer\tlr19.1

3 of 14

Yes

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\il1rapl1b

1 of 14

Yes

Drer\il1rapl2

1 of 14

Yes

Drer\il1rl1

1 of 14

Yes

Drer\lingo4b

1 of 14

Drer\LOC563710

1 of 14

Drer\LOC799279

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkey-182i3.11

1 of 14

Drer\sigirr

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\tlr7

1 of 14

Drer\tlr20f

1 of 14

Yes

Drer\zmp:0000000936

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (19)

Cele\tol-1

5 of 14

Yes

Cele\lron-14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (55)

Agam\AgaP_AGAP013027

5 of 12

Yes

Agam\TOLL1A

5 of 12

Yes

Agam\TOLL1B

5 of 12

Yes

Agam\TOLL5A

5 of 12

Yes

Agam\TOLL5B

5 of 12

Yes

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

3 of 12

3 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (133)

Atha\AT1G09665

2 of 13

Yes

Atha\AT1G57670

2 of 13

Yes

Atha\AT1G57830

2 of 13

Yes

Atha\AT1G57850

2 of 13

Yes

Atha\AT1G60320

2 of 13

Yes

Atha\AT1G65850

2 of 13

Yes

Atha\AT1G72870

2 of 13

Yes

Atha\AT2G03030

2 of 13

Yes

Atha\AT2G03300

2 of 13

Yes

Atha\AT2G20142

2 of 13

Yes

Atha\AT3G04220

2 of 13

Yes

Atha\AT4G09420

2 of 13

Yes

Atha\AT4G09430

2 of 13

Yes

Atha\AT4G11340

2 of 13

Yes

Atha\AT4G19920

2 of 13

Yes

Atha\AT4G23510

2 of 13

Yes

Atha\AT4G23515

2 of 13

Yes

Atha\AT5G38344

2 of 13

Yes

Atha\AT5G45220

2 of 13

Yes

Atha\RLM3

2 of 13

Yes

Atha\AT1G17600

1 of 13

Yes

Atha\AT1G27170

1 of 13

Yes

Atha\AT1G27180

1 of 13

Yes

Atha\AT1G31540

1 of 13

Yes

Atha\AT1G47370

1 of 13

Yes

Atha\AT1G51270

1 of 13

Atha\AT1G52900

1 of 13

Yes

Atha\AT1G56520

1 of 13

Yes

Atha\AT1G56540

1 of 13

Yes

Atha\AT1G57630

1 of 13

Yes

Atha\AT1G61105

1 of 13

Yes

Atha\AT1G63730

1 of 13

Yes

Atha\AT1G63740

1 of 13

Yes

Atha\AT1G63750

1 of 13

Yes

Atha\AT1G63860

1 of 13

Yes

Atha\AT1G63870

1 of 13

Yes

Atha\AT1G63880

1 of 13

Yes

Atha\AT1G66090

1 of 13

Yes

Atha\AT1G69550

1 of 13

Yes

Atha\AT1G72840

1 of 13

Yes

Atha\AT1G72850

1 of 13

Yes

Atha\AT1G72860

1 of 13

Yes

Atha\AT1G72890

1 of 13

Yes

Atha\AT1G72900

1 of 13

Atha\AT1G72910

1 of 13

Atha\AT1G72920

1 of 13

Yes

Atha\AT1G72940

1 of 13

Yes

Atha\AT1G72950

1 of 13

Yes

Atha\AT2G16870

1 of 13

Yes

Atha\AT2G17050

1 of 13

Yes

Atha\AT2G17060

1 of 13

Yes

Atha\AT2G32140

1 of 13

Yes

Atha\AT2G41820

1 of 13

Yes

Atha\AT3G04210

1 of 13

Yes

Atha\AT3G44400

1 of 13

Yes

Atha\AT3G44630

1 of 13

Yes

Atha\AT3G44670

1 of 13

Yes

Atha\AT3G51560

1 of 13

Yes

Atha\AT3G51570

1 of 13

Yes

Atha\AT4G04110

1 of 13

Yes

Atha\AT4G08450

1 of 13

Atha\AT4G11170

1 of 13

Yes

Atha\AT4G12010

1 of 13

Yes

Atha\AT4G14370

1 of 13

Yes

Atha\AT4G16900

1 of 13

Yes

Atha\AT4G16920

1 of 13

Yes

Atha\AT4G16940

1 of 13

Yes

Atha\AT4G16960

1 of 13

Yes

Atha\AT4G19500

1 of 13

Yes

Atha\AT4G19510

1 of 13

Yes

Atha\AT4G19520

1 of 13

Yes

Atha\AT4G19530

1 of 13

Yes

Atha\AT4G19910

1 of 13

Yes

Atha\AT4G19925

1 of 13

Yes

Atha\AT4G36140

1 of 13

Atha\AT4G36150

1 of 13

Yes

Atha\AT5G05400

1 of 13

Yes

Atha\AT5G11250

1 of 13

Yes

Atha\AT5G17680

1 of 13

Atha\AT5G17970

1 of 13

Yes

Atha\AT5G18350

1 of 13

Yes

Atha\AT5G18360

1 of 13

Yes

Atha\AT5G18370

1 of 13

Yes

Atha\AT5G22690

1 of 13

Yes

Atha\AT5G36930

1 of 13

Yes

Atha\AT5G38340

1 of 13

Yes

Atha\AT5G38850

1 of 13

Yes

Atha\AT5G40100

1 of 13

Yes

Atha\AT5G40910

1 of 13

Yes

Atha\AT5G41540

1 of 13

Yes

Atha\AT5G41550

1 of 13

Yes

Atha\AT5G41740

1 of 13

Yes

Atha\AT5G41750

1 of 13

Yes

Atha\AT5G44900

1 of 13

Yes

Atha\AT5G44910

1 of 13

Yes

Atha\AT5G44920

1 of 13

Yes

Atha\AT5G45000

1 of 13

Yes

Atha\AT5G45060

1 of 13

Yes

Atha\AT5G45200

1 of 13

Yes

Atha\AT5G45210

1 of 13

Yes

Atha\AT5G45230

1 of 13

Yes

Atha\AT5G45240

1 of 13

Yes

Atha\AT5G46260

1 of 13

Yes

Atha\AT5G46270

1 of 13

Yes

Atha\AT5G46450

1 of 13

Yes

Atha\AT5G46490

1 of 13

Yes

Atha\AT5G46510

1 of 13

Yes

Atha\AT5G46520

1 of 13

Yes

Atha\AT5G48770

1 of 13

Yes

Atha\AT5G48780

1 of 13

Yes

Atha\AT5G49140

1 of 13

Yes

Atha\AT5G51630

1 of 13

Yes

Atha\AT5G58120

1 of 13

Yes

Atha\BAM3

1 of 13

Yes

Atha\CSA1

1 of 13

Yes

Atha\GSO1

1 of 13

Atha\LAZ5

1 of 13

Yes

Atha\LRR XI-23

1 of 13

Yes

Atha\PP2-A5

1 of 13

Yes

Atha\PP2-A6

1 of 13

Yes

Atha\PP2-A8

1 of 13

Yes

Atha\RLM1

1 of 13

Yes

Atha\RLP34

1 of 13

Yes

Atha\RLP47

1 of 13

Atha\RPP1

1 of 13

Yes

Atha\RPP4

1 of 13

Yes

Atha\RPP5

1 of 13

Yes

Atha\RPS4

1 of 13

Yes

Atha\RPS6

1 of 13

Yes

Atha\SNC1

1 of 13

Atha\TAO1

1 of 13

Yes

Atha\TIR

1 of 13

Yes

Atha\WRR4

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Tehao. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (46)

9 of 13

Toll-4

8 of 13

Toll-9

7 of 13

18w

6 of 13

6 of 13

6 of 13

6 of 13

5 of 13

atk

1 of 13

bdl

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

chp

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

haf

1 of 13

hfw

1 of 13

kek4

1 of 13

Lar

1 of 13

lbk

1 of 13

Lrt

1 of 13

Myd88

1 of 13

Nrg

1 of 13

otk

1 of 13

rdo

1 of 13

sli

1 of 13

swi2

1 of 13

trn

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 4 )

Human Ortholog

Disease

Evidence

References

TLR2; toll like receptor 2

model of colorectal cancer

IEA

(FlyBase, 2019-)

TLR7; toll like receptor 7

model of X-Linked immunodeficiency 74

IEA

(FlyBase, 2019-)

TLR8; toll like receptor 8

model of immunodeficiency 98

IEA

(FlyBase, 2019-)

FGFR3; fibroblast growth factor receptor 3

model of colorectal cancer

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

TLR1; toll like receptor 1

6 of 14

601194

LEPROSY, SUSCEPTIBILITY TO, 5; LPRS5

TLR2; toll like receptor 2

6 of 14

603028

colorectal cancer

TLR6; toll like receptor 6

6 of 14

605403

TLR10; toll like receptor 10

6 of 14

606270

TLR4; toll like receptor 4

5 of 14

603030

CD180; CD180 molecule

3 of 14

602226

TLR3; toll like receptor 3

3 of 14

603029

TLR5; toll like receptor 5

3 of 14

603031

TLR7; toll like receptor 7

3 of 14

300365

X-Linked immunodeficiency 74

TLR8; toll like receptor 8

3 of 14

300366

IMMUNODEFICIENCY 98 WITH AUTOINFLAMMATION, X-LINKED; IMD98

immunodeficiency 98

TLR9; toll like receptor 9

3 of 14

605474

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Tehao - Tl

pull down, autoradiography

(Luo et al., 2001)

Tehao - pll

pull down, autoradiography, protein kinase assay

(Luo et al., 2001)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

piwi

suppressible

Tehao

(Lin et al., 2020)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0026760

MIST (protein-protein) - An integrated Molecular Interaction Database

34761

Pathways

Signaling Pathways (FlyBase)

TOLL-NF-kappaB SIGNALING PATHWAY CORE COMPONENTS

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-48

Cytogenetic map

34C1-34C1

Sequence location

2L:13,435,622..13,439,930 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

34C1-34C1

Limits computationally determined from genome sequence between P{lacW}l(2)k00302^k00302 and P{PZ}kuz⁰³⁷⁸²&P{lacW}kuz^k14817

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

34B10-34C2

(Tauszig, 2000.3.23)

34C-34C

(Luo, 1999.4.1)

Experimentally Determined Recombination Data

Location

2-48

(FlyBase, 2016)

2-43.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

29533

y¹ v¹; P{TRiP.HM05212}attP2

64862

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05735}attP40/CyO

NIG-Fly

7121R-3

P{NIG.7121R}3

7121R-4

P{NIG.7121R}4

M2L-1310

y¹ w¹¹¹⁸; Tehao^SK1 P{neoFRT}40A/CyO-Tb

M2L-1311

y¹ w¹¹¹⁸; Tehao^SK3 P{neoFRT}40A/CyO-Tb

2LG-1047

y² VhaAC39-1^cho-1 v¹; P{U6-Tehao.NIG.sgRNA}attP40/CyO

VDRC

v109705

P{KK103753}VIE-260B

v839

w¹¹¹⁸; P{GD38}v839

v17903

w¹¹¹⁸; P{GD2534}v17903

v342743

P{hsFLP}1, y1 w1118; P{HD_CFD01597}attP40/CyO-GFP

v342555

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02206}attP40/CyO-GFP

More stocks available...

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (1)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

RT09936

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0026760

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0026760

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Luo et al., 2001)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Tehao CG7121

(Guan, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

CG7121

(National Institute of Genetics Fly Stocks, 2022-, Keleman et al., 2009.8.5, Perkins et al., 2009, Holloway et al., 2008)

CT22017

(Hynes and Zhao, 2000)

Tehao

(Huang et al., 2024, Zhang et al., 2023, National Institute of Genetics Fly Stocks, 2022-, Bilder et al., 2021, Gene Disruption Project members, 2018-, Ozkan et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Kim and Orr-Weaver, 2011, Dworkin et al., 2009, Holloway et al., 2008, Lazzaro et al., 2006, Tsuda et al., 2006, Luo et al., 2001)

Tho

(Lazzaro et al., 2004)

Tl-5

(Khush and Lemaitre, 2000, Lemaitre, 2000.12.20)

Toll 5

(Leclerc and Reichhart, 2004)

Toll5

(Lima et al., 2021)

dTLR5

(Silverman and Maniatis, 2001)

dToll5

(Brennan and Anderson, 2004, Singh et al., 2003)

tehao

(Lemaitre, 2000.12.20)

toll

(Janssens and Beyaert, 2002)

Name Synonyms

Tehao

(Keebaugh and Schlenke, 2014, Edwards et al., 2009, Lazzaro et al., 2004, Luo et al., 2001)

Toll 5

(Yadav et al., 2017)

Toll-5

(Anthoney et al., 2018, Nie et al., 2018, Christophides et al., 2002, Tauszig-Delamasure et al., 2002)

toll receptor

(Haesemeyer M et al., 2007)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 80 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34761

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VJX9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VJX9

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34761/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026760

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026760

FlyMine - An integrated database for Drosophila genomics

FBgn0026760

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7121

MARRVEL_MODEL - MARRVEL (model organism gene)

34761

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0026760

DroID - A comprehensive database of gene and protein interactions.

FBgn0026760

DRSC - Results frm RNAi screens

FBgn0026760

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Tehao_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026760

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0026760

Flygut - An atlas of the Drosophila adult midgut

FBgn0026760

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0026760

MIST (protein-protein) - An integrated Molecular Interaction Database

34761

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (84)

The following external sites may use different assemblies or annotations than FlyBase.

-0.43

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