FlyBase Gene Report: Dmel\Toll-9

General Information

Symbol

Dmel\Toll-9

Species

D. melanogaster

Name

Toll-9

Annotation Symbol

CG5528

Feature Type

protein_coding_gene

FlyBase ID

FBgn0036978

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

Toll-9 (Toll-9) encodes a transmembrane signalling receptor belonging to the Toll family of protein. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Tl-9, dToll9

Key Links

Genomic Location

Cytogenetic map

77B6-77B6

Sequence location

3L:20,361,843..20,366,724 [-]

Recombination map

3-47

RefSeq locus

NT_037436 REGION:20361843..20366724

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables signaling receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN002808045

(GO Reference Genome Project, 2011-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in signal transduction

inferred from mutant phenotype

(Chowdhury et al., 2019)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in inflammatory response

inferred from biological aspect of ancestor with PANTHER:PTN000687652

(GO Reference Genome Project, 2011-)

involved_in signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN002808045

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR000157

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002808045

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

TOLL RECEPTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Toll-9 (Toll-9) encodes a transmembrane signalling receptor belonging to the Toll family of protein. [Date last reviewed: 2019-03-14]

Gene Group (FlyBase)

TOLL RECEPTORS -: The Toll/Toll-like receptor (TLR) family members are type-I single-pass transmembrane receptors with an intracellular Toll IL-1R homology (TIR) domain and extracellular Leucine-rich repeats. The archetypal family member, Tl, was first characterized for its role in embryonic dorsal/ventral patterning. In larval and adult stages, Tl is involved with innate immune response. Tl is activated by binding an endogenous spatzle ligand and activation of NF-κB is the target of canonical Toll/Toll-like receptor signaling. Non-canonical signaling pathways are less well characterized. (Adapted from FBrf0130108, FBrf0212564 and FBrf0239503).

Summary (Interactive Fly)

Surface receptor - necessary and sufficient for a special form of compensatory proliferation after apoptotic cell loss (undead apoptosis-induced proliferation [AiP] - Toll-9 interacts with Toll-1 to activate the intracellular Toll-1 pathway for nuclear translocation of Dorsal, which induces expression of the pro-apoptotic genes reaper and hid

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Toll-9 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VPH1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.39

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Toll-9-RA

FBtr0078240

NM_140957

3490

900

Toll-9-RB

FBtr0308647

NM_001259916

2683

826

Toll-9-RC

FBtr0308648

NM_001259917

2905

900

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Toll-9-PA

FBpp0077898

104.0

900

6.06

FBpp0300870

95.3

826

5.96

FBpp0300871

104.0

900

6.06

Q9VPH1

NP_001246846

AFH04517

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

900 aa isoforms: Toll-9-PA, Toll-9-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Toll-9 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.42

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 5

yolk nucleus

(Kambris et al., 2002)

embryonic stage 7 -- 11

embryonic hemocyte anlage

(Kambris et al., 2002)

Additional Descriptive Data

Toll-9 is detected at embryonic stage 5 in the yolk nucleus. At stage 7, strong expression is observed in the head region corresponding to the site of origin of hemocytes.

(Kambris et al., 2002)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Toll-9 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Toll-9

View exonic expression by tissue for Dmel\Toll-9

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40245/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036978

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036978

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036978

Flygut - An atlas of the Drosophila adult midgut

FBgn0036978

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Toll-9

Transgenic constructs containing regulatory region of Toll-9

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)Exel6136

(Ryder, 2004.4.26)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^32B

Toll-9^UAS.cYa

lethal, with Scer\GAL4^71B

Toll-9^UAS.cYa

lethal, with Scer\GAL4^da.G32

Toll-9^UAS.cYa

lethal, with Scer\GAL4^e22c

Toll-9^UAS.cYa

lethal, with Scer\GAL4^ptc-559.1

Toll-9^UAS.cYa

partially lethal, with Scer\GAL4^Mef2.PR

Toll-9^GD30

partially lethal - majority die

Toll-9^KO

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

Toll-9^GD14431

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Toll-9^GD14431

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal developmental rate

Toll-9^KO

abnormal oxidative stress response | adult stage

Toll-9^KO

short lived

Toll-9^KO

short lived | chemical conditional

Toll-9^KO

some die during embryonic stage

Toll-9^KO

visible | adult stage, with Scer\GAL4^GMR.PF

Toll-9^UAS.cYa

Phenotype manifest in

Allele

embryonic/larval hemocyte

Toll-9^KO

eye, with Scer\GAL4^GMR.PF

Toll-9^UAS.cYa

eye, with Scer\GAL4^lz-gal4

Toll-9^UAS.cYa

leg, with Scer\GAL4^dpp.PS

Toll-9^UAS.cYa

retina, with Scer\GAL4^GMR.PF

Toll-9^UAS.cYa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (43)

Hsap\TLR1

8 of 14

Yes

Hsap\TLR2

8 of 14

Yes

Hsap\TLR6

8 of 14

Yes

Hsap\TLR10

8 of 14

Yes

Hsap\TLR4

3 of 14

Hsap\TLR5

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\TRIL

1 of 14

Hsap\TTN

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (38)

Rnor\Tlr6

8 of 14

Yes

Rnor\Tlr1

7 of 14

Yes

Rnor\Tlr2

7 of 14

Yes

Rnor\Tlr13

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Il1r2

1 of 14

Yes

Rnor\Il1rapl1

1 of 14

Yes

Rnor\Il1rapl2

1 of 14

Yes

Rnor\Il1rap

1 of 14

Yes

Rnor\Il1rl1

1 of 14

Yes

Rnor\Il1rl2

1 of 14

Yes

Rnor\Il18r1

1 of 14

Yes

Rnor\Il18rap

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Ticam2

1 of 14

Rnor\Tirap

1 of 14

Yes

Rnor\Tlr10

1 of 14

Yes

Rnor\Tril

1 of 14

Mus musculus (laboratory mouse) (37)

Mmus\Tlr1

8 of 14

Yes

Mmus\Tlr2

7 of 14

Yes

Mmus\Tlr6

7 of 14

Yes

Mmus\Tlr13

5 of 14

Yes

Mmus\Tlr3

3 of 14

Mmus\Tlr4

3 of 14

Mmus\Tlr11

3 of 14

Yes

Mmus\Tlr12

3 of 14

Mmus\Cd180

2 of 14

Mmus\Tlr5

2 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Il1r2

1 of 14

Yes

Mmus\Il1rapl1

1 of 14

Yes

Mmus\Il1rapl2

1 of 14

Yes

Mmus\Il1rap

1 of 14

Yes

Mmus\Il1rl1

1 of 14

Yes

Mmus\Il1rl2

1 of 14

Yes

Mmus\Il18r1

1 of 14

Yes

Mmus\Il18rap

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Tirap

1 of 14

Yes

Mmus\Tril

1 of 14

Xenopus tropicalis (Western clawed frog) (49)

Xtro\XB5889249

8 of 13

Yes

Xtro\tlr1

7 of 13

Yes

Xtro\tlr2

7 of 13

Yes

Xtro\tlr6

7 of 13

Yes

Xtro\tlr14.3

6 of 13

Yes

Xtro\LOC100485358

5 of 13

Yes

Xtro\ube2k

5 of 13

Xtro\tlr14.2

4 of 13

Yes

3 of 13

2 of 13

2 of 13

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Xtro\cd180

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\il1rapl2

1 of 13

Yes

Xtro\il1rap

1 of 13

Yes

Xtro\il18rap

1 of 13

Yes

Xtro\lgr5

1 of 13

Xtro\LOC100485927

1 of 13

Yes

Xtro\LOC100496647

1 of 13

Yes

Xtro\LOC116410887

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (41)

Drer\tlr21

7 of 14

Yes

Drer\tlr22

7 of 14

Yes

Drer\tlr20.2

6 of 14

Yes

Drer\LOC103911657

5 of 14

Yes

Drer\tlr1

5 of 14

Yes

Drer\tlr2

5 of 14

Drer\LOC572462

4 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

Yes

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Drer\il1rapl1b

1 of 14

Yes

Drer\il1rapl2

1 of 14

Yes

Drer\il1rl1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkey-182i3.11

1 of 14

Drer\sigirr

1 of 14

Yes

Drer\tirap

1 of 14

Yes

Drer\tlr7

1 of 14

Drer\tlr20f

1 of 14

Yes

Drer\zmp:0000000936

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (16)

Cele\tol-1

4 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (37)

Agam\TOLL9

11 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (128)

Atha\AT1G09665

2 of 13

Yes

Atha\AT1G57670

2 of 13

Yes

Atha\AT1G57830

2 of 13

Yes

Atha\AT1G57850

2 of 13

Yes

Atha\AT1G60320

2 of 13

Yes

Atha\AT1G65850

2 of 13

Yes

Atha\AT1G72870

2 of 13

Yes

Atha\AT1G72900

2 of 13

Yes

Atha\AT2G03030

2 of 13

Yes

Atha\AT2G03300

2 of 13

Yes

Atha\AT2G20142

2 of 13

Yes

Atha\AT3G04220

2 of 13

Yes

Atha\AT4G08450

2 of 13

Yes

Atha\AT4G09420

2 of 13

Yes

Atha\AT4G09430

2 of 13

Yes

Atha\AT4G11340

2 of 13

Yes

Atha\AT4G19920

2 of 13

Yes

Atha\AT4G23510

2 of 13

Yes

Atha\AT4G23515

2 of 13

Yes

Atha\AT5G38344

2 of 13

Yes

Atha\AT5G45220

2 of 13

Yes

Atha\RLM3

2 of 13

Yes

Atha\AT1G17600

1 of 13

Yes

Atha\AT1G27170

1 of 13

Yes

Atha\AT1G27180

1 of 13

Yes

Atha\AT1G31540

1 of 13

Yes

Atha\AT1G47370

1 of 13

Yes

Atha\AT1G51270

1 of 13

Atha\AT1G52900

1 of 13

Yes

Atha\AT1G56520

1 of 13

Yes

Atha\AT1G56540

1 of 13

Yes

Atha\AT1G57630

1 of 13

Yes

Atha\AT1G61105

1 of 13

Yes

Atha\AT1G63730

1 of 13

Yes

Atha\AT1G63740

1 of 13

Yes

Atha\AT1G63750

1 of 13

Yes

Atha\AT1G63860

1 of 13

Yes

Atha\AT1G63870

1 of 13

Yes

Atha\AT1G63880

1 of 13

Yes

Atha\AT1G66090

1 of 13

Yes

Atha\AT1G69550

1 of 13

Yes

Atha\AT1G72840

1 of 13

Yes

Atha\AT1G72850

1 of 13

Yes

Atha\AT1G72860

1 of 13

Yes

Atha\AT1G72890

1 of 13

Yes

Atha\AT1G72910

1 of 13

Atha\AT1G72920

1 of 13

Yes

Atha\AT1G72940

1 of 13

Yes

Atha\AT1G72950

1 of 13

Yes

Atha\AT2G16870

1 of 13

Yes

Atha\AT2G17050

1 of 13

Yes

Atha\AT2G17060

1 of 13

Yes

Atha\AT2G32140

1 of 13

Yes

Atha\AT3G04210

1 of 13

Yes

Atha\AT3G44400

1 of 13

Yes

Atha\AT3G44630

1 of 13

Yes

Atha\AT3G44670

1 of 13

Yes

Atha\AT3G51560

1 of 13

Yes

Atha\AT3G51570

1 of 13

Yes

Atha\AT4G04110

1 of 13

Yes

Atha\AT4G11170

1 of 13

Yes

Atha\AT4G12010

1 of 13

Yes

Atha\AT4G14370

1 of 13

Yes

Atha\AT4G16900

1 of 13

Yes

Atha\AT4G16920

1 of 13

Yes

Atha\AT4G16940

1 of 13

Yes

Atha\AT4G16960

1 of 13

Yes

Atha\AT4G19500

1 of 13

Yes

Atha\AT4G19510

1 of 13

Yes

Atha\AT4G19520

1 of 13

Yes

Atha\AT4G19530

1 of 13

Yes

Atha\AT4G19910

1 of 13

Yes

Atha\AT4G19925

1 of 13

Yes

Atha\AT4G36140

1 of 13

Atha\AT4G36150

1 of 13

Yes

Atha\AT5G05400

1 of 13

Yes

Atha\AT5G11250

1 of 13

Yes

Atha\AT5G17680

1 of 13

Atha\AT5G17970

1 of 13

Yes

Atha\AT5G18350

1 of 13

Yes

Atha\AT5G18360

1 of 13

Yes

Atha\AT5G18370

1 of 13

Yes

Atha\AT5G22690

1 of 13

Yes

Atha\AT5G36930

1 of 13

Yes

Atha\AT5G38340

1 of 13

Yes

Atha\AT5G38850

1 of 13

Yes

Atha\AT5G40100

1 of 13

Yes

Atha\AT5G40910

1 of 13

Yes

Atha\AT5G41540

1 of 13

Yes

Atha\AT5G41550

1 of 13

Yes

Atha\AT5G41740

1 of 13

Yes

Atha\AT5G41750

1 of 13

Yes

Atha\AT5G44900

1 of 13

Yes

Atha\AT5G44910

1 of 13

Yes

Atha\AT5G44920

1 of 13

Yes

Atha\AT5G45000

1 of 13

Yes

Atha\AT5G45060

1 of 13

Yes

Atha\AT5G45200

1 of 13

Yes

Atha\AT5G45210

1 of 13

Yes

Atha\AT5G45230

1 of 13

Yes

Atha\AT5G45240

1 of 13

Yes

Atha\AT5G46260

1 of 13

Yes

Atha\AT5G46270

1 of 13

Yes

Atha\AT5G46450

1 of 13

Yes

Atha\AT5G46490

1 of 13

Yes

Atha\AT5G46510

1 of 13

Yes

Atha\AT5G46520

1 of 13

Yes

Atha\AT5G48770

1 of 13

Yes

Atha\AT5G48780

1 of 13

Yes

Atha\AT5G49140

1 of 13

Yes

Atha\AT5G51630

1 of 13

Yes

Atha\AT5G58120

1 of 13

Yes

Atha\CSA1

1 of 13

Yes

Atha\LAZ5

1 of 13

Yes

Atha\PP2-A5

1 of 13

Yes

Atha\PP2-A6

1 of 13

Yes

Atha\PP2-A8

1 of 13

Yes

Atha\RLM1

1 of 13

Yes

Atha\RLP47

1 of 13

Atha\RPP1

1 of 13

Yes

Atha\RPP4

1 of 13

Yes

Atha\RPP5

1 of 13

Yes

Atha\RPS4

1 of 13

Yes

Atha\RPS6

1 of 13

Yes

Atha\SNC1

1 of 13

Atha\TAO1

1 of 13

Yes

Atha\TIR

1 of 13

Yes

Atha\WRR4

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Toll-9. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (40)

9 of 13

Toll-4

8 of 13

Tehao

7 of 13

18w

6 of 13

6 of 13

6 of 13

6 of 13

4 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

chp

2 of 13

trn

2 of 13

2mit

1 of 13

atk

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

lbk

1 of 13

Lrt

1 of 13

ltl

1 of 13

Myd88

1 of 13

rdo

1 of 13

sli

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

TLR2; toll like receptor 2

model of colorectal cancer

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

Toll-9^HM05227

ameliorates neurodegenerative disease

modeled by Zzzz\CTG^{rCUG.99.UAS.Tag:MYC,Tag:FLAG}, Zzzz\CAG^{99.UAS.Tag:MYC,Tag:FLAG}

(Samaraweera et al., 2013)

Toll-9^KO

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cSa

(Sakakibara et al., 2023)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

TLR1; toll like receptor 1

8 of 14

601194

LEPROSY, SUSCEPTIBILITY TO, 5; LPRS5

TLR2; toll like receptor 2

8 of 14

603028

colorectal cancer

TLR6; toll like receptor 6

8 of 14

605403

TLR10; toll like receptor 10

8 of 14

606270

TLR4; toll like receptor 4

3 of 14

603030

TLR5; toll like receptor 5

3 of 14

603031

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Toll-9 - wek

anti tag coimmunoprecipitation, anti tag western blot

(Chen et al., 2006)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0036978

MIST (protein-protein) - An integrated Molecular Interaction Database

40245

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47

Cytogenetic map

77B6-77B6

Sequence location

3L:20,361,843..20,366,724 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

77B6-77B6

Limits computationally determined from genome sequence between P{PZ}eRF1⁰⁰¹⁰³ and P{EP}trbl^EP3519

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-47

(FlyBase, 2016)

3-43.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

29264

w¹¹¹⁸; Mi{ET1}Toll-9^MB11953

62581

w¹¹¹⁸; PBac{IT.GAL4}Toll-9^0024-G4

20928

y¹ w^67c23; P{EPgy2}Toll-9^EY14405

30535

y¹ sc^* v¹ sev²¹; P{TRiP.HM05227}attP2

34853

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00171}attP2

NIG-Fly

5528R-2

P{NIG.5528R}2

5528R-3

P{NIG.5528R}3

HMS00171

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00171}attP2

VDRC

v109635

P{KK101880}VIE-260B

v36308

w¹¹¹⁸; P{GD14431}v36308

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (3)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0036978

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0036978

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Toll-9 is not required to maintain a basal anti-microbial response nor to mount an efficient immune response to bacterial infection.

(Narbonne-Reveau et al., 2011)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Toll-9 CG5528

(Imler, 2000.10.17)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

CG5528

(Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009, Ooi et al., 2002, Imler, 2000.10.17)

CT17508

(Hynes and Zhao, 2000)

Dm Toll-9

(Waterhouse et al., 2007)

TOLL 9

(Christophides et al., 2002)

Tak/Toll-like

(Hynes and Zhao, 2000)

Tl-5

(Lemaitre, 2000.12.20)

Tl-9

(Khush and Lemaitre, 2000, Lemaitre, 2000.12.20)

Toll

(Wei et al., 2018)

Toll 9

(Leclerc and Reichhart, 2004)

Toll-6

(Levin and Malik, 2017)

Toll9

(Lima et al., 2021, Alpar et al., 2018)

dTLR9

(Silverman and Maniatis, 2001)

dToll9

(Brennan and Anderson, 2004, Singh et al., 2003)

toll

(Janssens and Beyaert, 2002)

toll-9

(Fischer et al., 2024)

Name Synonyms

Toll-9

(Anthoney et al., 2018, Nie et al., 2018)

toll receptor

(Haesemeyer M et al., 2007)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 39 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40245

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VPH1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VPH1

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40245/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036978

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036978

FlyMine - An integrated database for Drosophila genomics

FBgn0036978

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG5528

MARRVEL_MODEL - MARRVEL (model organism gene)

40245

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0036978

DroID - A comprehensive database of gene and protein interactions.

FBgn0036978

DRSC - Results frm RNAi screens

FBgn0036978

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036978

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0036978

Flygut - An atlas of the Drosophila adult midgut

FBgn0036978

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0036978

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC033974

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

40245

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (91)

The following external sites may use different assemblies or annotations than FlyBase.

-0.42

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