FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Toll-7
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General Information
Symbol
Dmel\Toll-7
Species
D. melanogaster
Name
Toll-7
Annotation Symbol
CG8595
Feature Type
protein_coding_gene
FlyBase ID
FBgn0034476
Gene Model Status
Current
Stock Availability
19 publicly available
Gene Summary
Toll-7 (Toll-7) encodes a plasma membrane Toll receptor that binds to viral glycoproteins, leading to the activation of antiviral defenses including autophagy. [Date last reviewed: 2018-10-18] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Tl-7

Key Links
Genomic Location
Cytogenetic map
56E4-56E4
Sequence location
Recombination map
2-90
RefSeq locus
NT_033778 REGION:19826578..19832973
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (17 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables neurotrophin receptor activity
inferred from mutant phenotype
(McIlroy et al., 2013)
enables transmembrane signaling receptor activity
inferred from direct assay
(Chowdhury et al., 2019)
enables virion binding
inferred from direct assay
(Chowdhury et al., 2019, Nakamoto et al., 2012)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables pattern recognition receptor activity
inferred by curator from GO:0009897,GO:0010508,GO:0046790
(Nakamoto et al., 2012)
enables signaling receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN002809265
(GO Reference Genome Project, 2011-)
Biological Process (10 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from mutant phenotype
(Ward et al., 2015)
involved_in defense response to virus
inferred from mutant phenotype
(Nakamoto et al., 2012)
involved_in detection of virus
inferred from direct assay
(Chowdhury et al., 2019)
involved_in innate immune response
inferred from mutant phenotype
(Chowdhury et al., 2019)
involved_in positive regulation of antimicrobial peptide production
inferred from mutant phenotype
(Chowdhury et al., 2019)
involved_in positive regulation of autophagy
inferred from mutant phenotype
(Nakamoto et al., 2012)
involved_in regulation of defense response to virus
inferred from mutant phenotype
(Moy et al., 2014)
involved_in Toll signaling pathway
inferred from mutant phenotype
(Chowdhury et al., 2019)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in cell surface pattern recognition receptor signaling pathway
inferred by curator from GO:0009897,GO:0010508,GO:0046790
(Nakamoto et al., 2012)
involved_in signal transduction
inferred from electronic annotation with InterPro:IPR000157
(InterPro Project Members, 2004-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in external side of plasma membrane
inferred from direct assay
(Nakamoto et al., 2012)
located_in plasma membrane
inferred from direct assay
(Chowdhury et al., 2019)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN001224703
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the Toll-like receptor family. (Q7KIN0)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Toll-7 (Toll-7) encodes a plasma membrane Toll receptor that binds to viral glycoproteins, leading to the activation of antiviral defenses including autophagy. [Date last reviewed: 2018-10-18]
Gene Group (FlyBase)
TOLL RECEPTORS -
The Toll/Toll-like receptor (TLR) family members are type-I single-pass transmembrane receptors with an intracellular Toll IL-1R homology (TIR) domain and extracellular Leucine-rich repeats. The archetypal family member, Tl, was first characterized for its role in embryonic dorsal/ventral patterning. In larval and adult stages, Tl is involved with innate immune response. Tl is activated by binding an endogenous spatzle ligand and activation of NF-κB is the target of canonical Toll/Toll-like receptor signaling. Non-canonical signaling pathways are less well characterized. (Adapted from FBrf0130108, FBrf0212564 and FBrf0239503).
Pathway (FlyBase)
TOLL-NF-kappaB SIGNALING PATHWAY CORE COMPONENTS -
In Drosophila, the canonical Toll signaling pathway is initiated by the binding of a spatzle ligand to Toll (Tl) or a Toll-like receptor leading to the nuclear localization of the NF-κB (dl or Dif) transcription factor. (Adapted from FBrf0091014 and FBrf0223077).
Protein Function (UniProtKB)
Toll-related receptor which binds to the neurotrophins NT1 and spz5 (PubMed:10973475, PubMed:23892553). Essential for antiviral autophagy, it detects and binds to the vesicular stomatitis virus (vsv) following infection (PubMed:22464169). This role is likely to be independent of the canonical Toll, immune deficiency, and JAK-STAT signaling pathways (PubMed:22464169). Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe (PubMed:25741726). Function in the Va1d ORNs is necessary and sufficient for correct targeting to their partner PN dendrites (PubMed:25741726). Also involved in the targeting of other classes of ORN axons (PubMed:25741726). Functions with Toll-6 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:23892553). May be an upstream component of the NF-kappa-B (rel) regulatory cascade (PubMed:23892553).
(UniProt, Q7KIN0)
Summary (Interactive Fly)

Toll-like receptors - Neurotrophin receptors - regulation of locomotion, motor axon targeting and neuronal survival - innate immunity

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Toll-7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q7KIN0)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.51

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Toll-7-RA
FBtr0086336
NM_079073
6396
1446
Additional Transcript Data and Comments
Reported size (kB)

6.4, 5.2 (northern blot)

(Tauszig et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Toll-7-PA
FBpp0085638
160.9
1446
6.59
Q7KIN0
NP_523797
AAF57514
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

1446 (aa)

(Tauszig et al., 2000)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Toll-7 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.22

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 5
organism | restricted
(Kambris et al., 2002)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11
organism | segment polarity expression pattern
(Kambris et al., 2002)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior spiracle primordium

Comment: reported as posterior spiracle specific anlage

(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
embryonic/larval posterior spiracle
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
embryonic stage 14
larval neuron | subset
(Kambris et al., 2002)
ventral thoracic disc primordium
(Kambris et al., 2002)
embryonic large intestine
(Kambris et al., 2002)
embryonic/larval anterior spiracle
(Kambris et al., 2002)
embryonic/larval posterior spiracle
(Kambris et al., 2002)
embryonic stage 16
larval central nervous system
(Kambris et al., 2002)
wandering third instar larval stage
wing hinge primordium
(Yagi et al., 2010)
mesothoracic tergum primordium
(Yagi et al., 2010)
presumptive tarsal segment 2 -- presumptive tarsal segment 5
(Yagi et al., 2010)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Tauszig et al., 2000)
adult stage | male
(Tauszig et al., 2000)
Additional Descriptive Data

Tollo transcript is expressed in the proximal region of the wing disc, and distal segments of the leg discs; expression is absent from the wing pouch.

(Yagi et al., 2010)

Toll-7 is expressed dynamically throughout embryogenesis. At the beginning of germ band extension, a strong spot is seen in the head region and diffuse staining in the trunk. At full germ band extension, a pattern of 14 strips is seen and they are positioned posterior to the wg stripes. At germ band retraction, Toll-7 is expressed in some neurons of the CNS, in the precursors to the leg imaginal discs, in the ventral epithelium of the large intestine, and in the anterior and posterior spiracles. At stage 16 Toll-7 is reduced and is mostly restricted to the CNS.

(Kambris et al., 2002)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
pharate adult stage P8 -- adult stage
antennal lobe glomerulus DA1
(Ward et al., 2015)
antennal lobe glomerulus VA1d
(Ward et al., 2015)
antennal lobe glomerulus VA1v
(Ward et al., 2015)
adult antennal lobe commissure | restricted
(Ward et al., 2015)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

Toll-7-protein is enriched in a cluster of glomeruli in the anterior and lateral regions of the antennal lobe, which include the DA1, VA1d and VA1v glomeruli.

(Ward et al., 2015)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in external side of plasma membrane
inferred from direct assay
(Nakamoto et al., 2012)
located_in plasma membrane
inferred from direct assay
(Chowdhury et al., 2019)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Toll-7 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Toll-7
Transgenic constructs containing regulatory region of Toll-7
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2R)Toll-7AW1
(Ward et al., 2015)
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4e22c
lethal, with Scer\GAL4ptc-559.1
partially lethal - majority die (with Df(2R)BSC22)
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal cell migration | third instar larval stage, with Scer\GAL4ptc-559.1
abnormal immune response, with Scer\GAL4Act.PU
abnormal immune response (with Df(2R)BSC22)
abnormal neuroanatomy, with Scer\GAL4elav-C155
abnormal neuroanatomy | adult stage, with Scer\GAL4AM29
abnormal neuroanatomy | adult stage, with Scer\GAL4elav.PLu
abnormal neuroanatomy | adult stage, with Scer\GAL4elav-C155
abnormal neuroanatomy | adult stage (with Df(2R)BSC22)
decreased cell death, with Scer\GAL4elav-C155
decreased rate of adult locomotory behavior (with Df(2R)BSC22)
increased cell death | adult stage (with Df(2R)BSC22)
increased cell number | third instar larval stage, with Scer\GAL4elav.PU
increased occurrence of cell division | third instar larval stage, with Scer\GAL4ptc-559.1
increased size | third instar larval stage, with Scer\GAL4ptc-559.1
Phenotype manifest in
Allele
adult abdomen, with Scer\GAL432B
adult abdomen, with Scer\GAL4da.G32
adult antennal lobe projection neuron VA1d adPN, with Scer\GAL4elav-C155
adult brain, with Scer\GAL4elav.PLu
adult brain (with Df(2R)BSC22)
adult dopaminergic neuron | decreased number, with Scer\GAL4elav.PLu
adult dopaminergic neuron | decreased number (with Df(2R)BSC22)
adult olfactory receptor neuron Or67a, with Scer\GAL4AM29
adult olfactory receptor neuron Or88a, with Scer\GAL4elav-C155
anterior-posterior compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4ptc-559.1
eye, with Scer\GAL4da.G32
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4lz-gal4
larval central nervous system, with Scer\GAL4elav-C155
larval ventral nerve cord | third instar larval stage, with Scer\GAL4elav.PU
leg, with Scer\GAL4dpp.PS
leg disc, with Scer\GAL4dpp.PS
macrochaeta | ectopic, with Scer\GAL471B
macrochaeta | ectopic, with Scer\GAL4da.G32
neuron | increased number | third instar larval stage, with Scer\GAL4elav.PU
wing, with Scer\GAL4dpp.PS
wing disc, with Scer\GAL4dpp.PS
wing vein, with Scer\GAL4da.G32
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (131)
Hsap\TLR1
4 of 14
Yes
No
1  
Hsap\TLR2
4 of 14
Yes
No
1  
Hsap\TLR3
4 of 14
Yes
Yes
1  
Hsap\TLR6
4 of 14
Yes
No
1  
Hsap\TLR10
4 of 14
Yes
No
Hsap\CD180
3 of 14
No
Yes
Hsap\CHADL
3 of 14
No
Yes
Hsap\CPN2
3 of 14
No
No
Hsap\LRRC15
3 of 14
No
No
1  
Hsap\TLR4
3 of 14
No
No
Hsap\TLR7
3 of 14
No
Yes
Hsap\TLR8
3 of 14
No
Yes
1  
Hsap\TLR9
3 of 14
No
Yes
Hsap\CHAD
2 of 14
No
Yes
Hsap\GP1BA
2 of 14
No
Yes
Hsap\GP5
2 of 14
No
No
Hsap\IGFALS
2 of 14
No
No
Hsap\LINGO1
2 of 14
No
No
Hsap\LINGO2
2 of 14
No
No
Hsap\LINGO3
2 of 14
No
No
Hsap\LRRC3B
2 of 14
No
Yes
Hsap\LRRC17
2 of 14
No
Yes
Hsap\LRRC24
2 of 14
No
Yes
Hsap\LRRN1
2 of 14
No
No
1  
Hsap\LRRN2
2 of 14
No
No
Hsap\LRRN3
2 of 14
No
No
Hsap\LRRTM3
2 of 14
No
Yes
Hsap\LRRTM4
2 of 14
No
Yes
Hsap\NYX
2 of 14
No
Yes
Hsap\TLR5
2 of 14
No
No
Hsap\TRIL
2 of 14
No
Yes
Hsap\VASN
2 of 14
No
Yes
Hsap\AMIGO1
1 of 14
No
No
Hsap\ANP32A
1 of 14
No
No
Hsap\ANP32B
1 of 14
No
No
Hsap\ANP32C
1 of 14
No
No
Hsap\ANP32D
1 of 14
No
No
Hsap\ANP32E
1 of 14
No
No
Hsap\CEP97
1 of 14
No
No
Hsap\CRB1
1 of 14
No
No
1  
Hsap\DCN
1 of 14
No
No
Hsap\DRC3
1 of 14
No
No
Hsap\ELFN1
1 of 14
No
No
Hsap\ELFN2
1 of 14
No
No
Hsap\ERBIN
1 of 14
No
No
Hsap\FLII
1 of 14
No
No
1  
Hsap\FLRT1
1 of 14
No
Yes
Hsap\FLRT2
1 of 14
No
Yes
Hsap\FLRT3
1 of 14
No
No
Hsap\FSHR
1 of 14
No
No
Hsap\HMCN2
1 of 14
No
No
Hsap\IL1R1
1 of 14
No
No
Hsap\IL1RAP
1 of 14
No
No
Hsap\IL1RAPL1
1 of 14
No
No
Hsap\IL1RAPL2
1 of 14
No
No
1  
Hsap\IL1RL1
1 of 14
No
No
Hsap\IL1RL2
1 of 14
No
No
Hsap\IL18R1
1 of 14
No
No
Hsap\IL18RAP
1 of 14
No
No
1  
Hsap\ISLR2
1 of 14
No
No
Hsap\ISLR
1 of 14
No
No
Hsap\JAG1
1 of 14
No
No
0  
Hsap\KERA
1 of 14
No
Yes
Hsap\LGR4
1 of 14
No
No
1  
Hsap\LGR5
1 of 14
No
No
1  
Hsap\LGR6
1 of 14
No
No
1  
Hsap\LHCGR
1 of 14
No
No
2  
Hsap\LINGO4
1 of 14
No
No
Hsap\LRFN1
1 of 14
No
No
Hsap\LRFN2
1 of 14
No
No
Hsap\LRFN3
1 of 14
No
No
Hsap\LRFN4
1 of 14
No
No
Hsap\LRFN5
1 of 14
No
No
Hsap\LRG1
1 of 14
No
No
Hsap\LRGUK
1 of 14
No
No
Hsap\LRIG1
1 of 14
No
No
Hsap\LRIG2
1 of 14
No
No
Hsap\LRIG3
1 of 14
No
No
Hsap\LRIT1
1 of 14
No
No
Hsap\LRIT2
1 of 14
No
No
Hsap\LRIT3
1 of 14
No
No
Hsap\LRRC1
1 of 14
No
No
Hsap\LRRC3C
1 of 14
No
No
Hsap\LRRC4B
1 of 14
No
No
Hsap\LRRC4C
1 of 14
No
No
Hsap\LRRC4
1 of 14
No
No
1  
Hsap\LRRC7
1 of 14
No
No
Hsap\LRRC9
1 of 14
No
No
Hsap\LRRC32
1 of 14
No
No
Hsap\LRRC39
1 of 14
No
Yes
Hsap\LRRC47
1 of 14
No
No
Hsap\LRRC49
1 of 14
No
No
Hsap\LRRC56
1 of 14
No
No
Hsap\LRRC66
1 of 14
No
No
Hsap\LRRC70
1 of 14
No
No
Hsap\LRRD1
1 of 14
No
No
Hsap\LRRIQ1
1 of 14
No
Yes
Hsap\LRRK1
1 of 14
No
No
Hsap\LRRN4
1 of 14
No
Yes
Hsap\LRRTM1
1 of 14
No
No
Hsap\LRRTM2
1 of 14
No
No
Hsap\MFHAS1
1 of 14
No
No
Hsap\MXRA5
1 of 14
No
No
Hsap\MYD88
1 of 14
No
No
Hsap\NOTCH1
1 of 14
No
No
Hsap\NOTCH2
1 of 14
No
No
Hsap\NOTCH3
1 of 14
No
No
Hsap\NOTCH4
1 of 14
No
No
Hsap\NRROS
1 of 14
No
No
Hsap\PHLPP1
1 of 14
No
No
Hsap\PHLPP2
1 of 14
No
No
Hsap\PODNL1
1 of 14
No
No
Hsap\PPP1R7
1 of 14
No
No
Hsap\PXDN
1 of 14
No
No
3  
Hsap\RTN4R
1 of 14
No
Yes
Hsap\RTN4RL1
1 of 14
No
No
Hsap\RTN4RL2
1 of 14
No
No
Hsap\RXFP1
1 of 14
No
No
1  
Hsap\RXFP2
1 of 14
No
No
Hsap\SCRIB
1 of 14
No
No
1  
Hsap\SHOC2
1 of 14
No
No
Hsap\SIGIRR
1 of 14
No
Yes
Hsap\SLIT1
1 of 14
No
No
Hsap\SLIT2
1 of 14
No
No
Hsap\SLIT3
1 of 14
No
No
Hsap\SLITRK5
1 of 14
No
No
Hsap\SNED1
1 of 14
No
No
Hsap\SNRPA1
1 of 14
No
No
2  
Hsap\TIRAP
1 of 14
No
Yes
Hsap\TPBG
1 of 14
No
No
Hsap\TSHR
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (92)
Rnor\Tlr2
4 of 14
Yes
No
Rnor\Tlr6
4 of 14
Yes
No
Rnor\Cd180
3 of 14
No
Yes
Rnor\Cpn2
3 of 14
No
No
Rnor\Tlr1
3 of 14
No
No
Rnor\Tlr4
3 of 14
No
No
Rnor\Tlr5
3 of 14
No
No
Rnor\Tlr7
3 of 14
No
Yes
Rnor\Tlr9
3 of 14
No
Yes
Rnor\Tlr13
3 of 14
No
No
Rnor\Chadl
2 of 14
No
Yes
Rnor\Igfals
2 of 14
No
No
Rnor\Lingo4
2 of 14
No
No
Rnor\Lrrc3b
2 of 14
No
Yes
Rnor\Lrrc17
2 of 14
No
Yes
Rnor\Lrrn1
2 of 14
No
No
Rnor\Lrrn2
2 of 14
No
No
Rnor\Lrrn3
2 of 14
No
No
Rnor\Lrrtm3
2 of 14
No
Yes
Rnor\Nyx
2 of 14
No
Yes
Rnor\Tlr3
2 of 14
No
No
Rnor\Tlr8
2 of 14
No
No
Rnor\Tlr11
2 of 14
No
No
Rnor\Vasn
2 of 14
No
Yes
Rnor\Chad
1 of 14
No
No
Rnor\Crb1
1 of 14
No
No
Rnor\Elfn1
1 of 14
No
No
Rnor\Elfn2
1 of 14
No
No
Rnor\Flii
1 of 14
No
No
Rnor\Flrt1
1 of 14
No
Yes
Rnor\Gp1ba
1 of 14
No
No
Rnor\Gp5
1 of 14
No
No
Rnor\Il1r1
1 of 14
No
Yes
Rnor\Il1rapl1
1 of 14
No
Yes
Rnor\Il1rapl2
1 of 14
No
Yes
Rnor\Il1rap
1 of 14
No
Yes
Rnor\Il1rl1
1 of 14
No
Yes
Rnor\Il1rl2
1 of 14
No
Yes
Rnor\Il18r1
1 of 14
No
Yes
Rnor\Il18rap
1 of 14
No
Yes
Rnor\Jag1
1 of 14
No
No
Rnor\Jag2
1 of 14
No
No
Rnor\Lgr4
1 of 14
No
No
Rnor\Lgr5
1 of 14
No
No
Rnor\Lgr6
1 of 14
No
No
Rnor\Lingo1
1 of 14
No
No
Rnor\Lingo3
1 of 14
No
No
Rnor\Lrguk
1 of 14
No
No
Rnor\Lrig2
1 of 14
No
No
Rnor\Lrig3
1 of 14
No
No
Rnor\Lrrc1
1 of 14
No
No
Rnor\Lrrc3c
1 of 14
No
Yes
Rnor\Lrrc4b
1 of 14
No
No
Rnor\Lrrc4c
1 of 14
No
No
Rnor\Lrrc4
1 of 14
No
No
Rnor\Lrrc7
1 of 14
No
No
Rnor\Lrrc9
1 of 14
No
No
Rnor\Lrrc15
1 of 14
No
No
Rnor\Lrrc32
1 of 14
No
No
Rnor\Lrrc39
1 of 14
No
No
Rnor\Lrrc49
1 of 14
No
No
Rnor\Lrrc66
1 of 14
No
Yes
Rnor\Lrrd1
1 of 14
No
No
Rnor\Lrriq4
1 of 14
No
No
Rnor\Lrrn4
1 of 14
No
Yes
Rnor\LRRTM1
1 of 14
No
Yes
Rnor\Lrrtm2
1 of 14
No
No
Rnor\Lrrtm4
1 of 14
No
No
Rnor\Myd88
1 of 14
No
No
Rnor\Notch1
1 of 14
No
No
Rnor\Notch2
1 of 14
No
No
Rnor\Nrros
1 of 14
No
No
Rnor\Phlpp1
1 of 14
No
No
Rnor\Phlpp2
1 of 14
No
No
Rnor\Podnl1
1 of 14
No
Yes
Rnor\Ppp1r7
1 of 14
No
No
Rnor\Rtn4rl2
1 of 14
No
No
Rnor\Sigirr
1 of 14
No
Yes
Rnor\Slit1
1 of 14
No
No
Rnor\Slit2
1 of 14
No
No
Rnor\Slit3
1 of 14
No
No
Rnor\Slitrk1
1 of 14
No
Yes
Rnor\Slitrk2
1 of 14
No
Yes
Rnor\Slitrk3
1 of 14
No
Yes
Rnor\Slitrk5
1 of 14
No
Yes
Rnor\Slitrk6
1 of 14
No
Yes
Rnor\Ticam2
1 of 14
No
No
Rnor\Tirap
1 of 14
No
Yes
Rnor\Tlr10
1 of 14
No
Yes
Rnor\Tlr12
1 of 14
No
No
Rnor\Tril
1 of 14
No
No
Rnor\Tsku
1 of 14
No
No
Mus musculus (laboratory mouse) (89)
Mmus\Tlr1
4 of 14
Yes
No
Mmus\Tlr2
4 of 14
Yes
No
Mmus\Tlr13
4 of 14
Yes
No
Mmus\Cd180
3 of 14
No
Yes
Mmus\Cpn2
3 of 14
No
No
Mmus\Tlr4
3 of 14
No
No
Mmus\Tlr6
3 of 14
No
No
Mmus\Tlr7
3 of 14
No
Yes
Mmus\Tlr8
3 of 14
No
Yes
Mmus\Chadl
2 of 14
No
Yes
Mmus\Lgr6
2 of 14
No
No
Mmus\Lingo4
2 of 14
No
No
Mmus\Lrrc3b
2 of 14
No
Yes
Mmus\Lrrc3c
2 of 14
No
Yes
Mmus\Lrrc15
2 of 14
No
No
Mmus\Lrrn1
2 of 14
No
No
Mmus\Lrrn2
2 of 14
No
No
Mmus\Lrrn3
2 of 14
No
No
Mmus\Tlr3
2 of 14
No
No
Mmus\Tlr9
2 of 14
No
No
Mmus\Tlr12
2 of 14
No
No
Mmus\Vasn
2 of 14
No
Yes
Mmus\Chad
1 of 14
No
No
Mmus\Crb1
1 of 14
No
No
Mmus\Dnaaf1
1 of 14
No
No
Mmus\Elfn1
1 of 14
No
No
Mmus\Elfn2
1 of 14
No
No
Mmus\Flii
1 of 14
No
No
Mmus\Flrt1
1 of 14
No
Yes
Mmus\Gp1ba
1 of 14
No
No
Mmus\Gp5
1 of 14
No
No
Mmus\Hmcn2
1 of 14
No
No
Mmus\Igfals
1 of 14
No
No
Mmus\Il1r1
1 of 14
No
Yes
Mmus\Il1rapl1
1 of 14
No
Yes
Mmus\Il1rapl2
1 of 14
No
Yes
Mmus\Il1rap
1 of 14
No
Yes
Mmus\Il1rl1
1 of 14
No
Yes
Mmus\Il1rl2
1 of 14
No
Yes
Mmus\Il18r1
1 of 14
No
Yes
Mmus\Il18rap
1 of 14
No
Yes
Mmus\Jag1
1 of 14
No
No
Mmus\Jag2
1 of 14
No
No
Mmus\Lgr4
1 of 14
No
No
Mmus\Lgr5
1 of 14
No
No
Mmus\Lingo1
1 of 14
No
No
Mmus\Lingo2
1 of 14
No
No
Mmus\Lingo3
1 of 14
No
No
Mmus\Lrguk
1 of 14
No
No
Mmus\Lrig2
1 of 14
No
No
Mmus\Lrig3
1 of 14
No
No
Mmus\Lrrc4b
1 of 14
No
No
Mmus\Lrrc4c
1 of 14
No
No
Mmus\Lrrc4
1 of 14
No
No
Mmus\Lrrc7
1 of 14
No
No
Mmus\Lrrc9
1 of 14
No
No
Mmus\Lrrc17
1 of 14
No
Yes
Mmus\Lrrc24
1 of 14
No
No
Mmus\Lrrc32
1 of 14
No
No
Mmus\Lrrc39
1 of 14
No
No
Mmus\Lrrc49
1 of 14
No
No
Mmus\Lrrd1
1 of 14
No
No
Mmus\Lrrn4
1 of 14
No
No
Mmus\Lrrtm1
1 of 14
No
No
Mmus\Lrrtm2
1 of 14
No
No
Mmus\Lrrtm3
1 of 14
No
No
Mmus\Lrrtm4
1 of 14
No
No
Mmus\Myd88
1 of 14
No
No
Mmus\Nepn
1 of 14
No
No
Mmus\Notch1
1 of 14
No
No
0  
Mmus\Notch2
1 of 14
No
No
Mmus\Nrros
1 of 14
No
No
Mmus\Nyx
1 of 14
No
No
Mmus\Phlpp1
1 of 14
No
No
Mmus\Phlpp2
1 of 14
No
No
Mmus\Podnl1
1 of 14
No
Yes
Mmus\Ppp1r7
1 of 14
No
No
Mmus\Rtn4rl2
1 of 14
No
No
Mmus\Shoc2
1 of 14
No
No
Mmus\Sigirr
1 of 14
No
Yes
Mmus\Slit1
1 of 14
No
No
Mmus\Slit2
1 of 14
No
No
Mmus\Slit3
1 of 14
No
No
Mmus\Ticam2
1 of 14
No
No
Mmus\Tirap
1 of 14
No
Yes
Mmus\Tlr5
1 of 14
No
No
Mmus\Tlr11
1 of 14
No
No
Mmus\Tril
1 of 14
No
No
Mmus\Tsku
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (109)
Xtro\tlr2
4 of 13
Yes
No
Xtro\tlr3
4 of 13
Yes
Yes
Xtro\tlr13
4 of 13
Yes
Yes
Xtro\ube2k
4 of 13
Yes
No
Xtro\LOC100498493
3 of 13
No
No
Xtro\MGC147172
3 of 13
No
Yes
Xtro\tlr1
3 of 13
No
No
Xtro\tlr6
3 of 13
No
No
Xtro\tlr8
3 of 13
No
Yes
Xtro\tlr21
3 of 13
No
Yes
Xtro\tlr22
3 of 13
No
No
Xtro\tlrs5
3 of 13
No
Yes
Xtro\XB5889249
3 of 13
No
No
Xtro\chadl
2 of 13
No
No
Xtro\igfals
2 of 13
No
No
Xtro\lingo1
2 of 13
No
No
Xtro\LOC100495962
2 of 13
No
No
Xtro\lrrc3b
2 of 13
No
Yes
Xtro\lrrn3
2 of 13
No
No
Xtro\lrrtm1
2 of 13
No
Yes
Xtro\lrrtm4
2 of 13
No
Yes
Xtro\nyx
2 of 13
No
Yes
Xtro\tlr7
2 of 13
No
Yes
Xtro\tlr9
2 of 13
No
No
Xtro\tlr14.3
2 of 13
No
No
Xtro\tril
2 of 13
No
Yes
Xtro\vasn
2 of 13
No
No
Xtro\acly
1 of 13
No
No
Xtro\amigo1
1 of 13
No
Yes
Xtro\anp32a
1 of 13
No
No
Xtro\anp32b
1 of 13
No
No
Xtro\cd180
1 of 13
No
Yes
Xtro\chad
1 of 13
No
No
Xtro\ciapin1
1 of 13
No
No
Xtro\crb2
1 of 13
No
No
Xtro\dnaaf11
1 of 13
No
No
Xtro\ei24
1 of 13
No
No
Xtro\elfn1
1 of 13
No
Yes
Xtro\elfn2
1 of 13
No
No
Xtro\flii
1 of 13
No
No
Xtro\flrt1
1 of 13
No
Yes
Xtro\flrt2
1 of 13
No
No
Xtro\flrt3
1 of 13
No
Yes
Xtro\fmod
1 of 13
No
No
Xtro\gp5
1 of 13
No
No
Xtro\il1r1
1 of 13
No
Yes
Xtro\il1rapl2
1 of 13
No
Yes
Xtro\il1rap
1 of 13
No
Yes
Xtro\il18rap
1 of 13
No
Yes
Xtro\jag1
1 of 13
No
No
Xtro\lgr5
1 of 13
No
No
Xtro\lingo2
1 of 13
No
No
Xtro\lingo3
1 of 13
No
No
Xtro\LOC100485358
1 of 13
No
No
Xtro\LOC100485927
1 of 13
No
Yes
Xtro\LOC100490929
1 of 13
No
No
Xtro\LOC100496647
1 of 13
No
Yes
Xtro\LOC116409470
1 of 13
No
No
Xtro\LOC116409761
1 of 13
No
No
Xtro\LOC116410887
1 of 13
No
Yes
Xtro\lrfn1.1
1 of 13
No
No
Xtro\lrfn2
1 of 13
No
No
Xtro\lrfn3
1 of 13
No
No
Xtro\lrfn4
1 of 13
No
No
Xtro\lrfn5
1 of 13
No
No
Xtro\lrg1
1 of 13
No
No
Xtro\lrig1
1 of 13
No
No
Xtro\lrig2
1 of 13
No
No
Xtro\lrig3
1 of 13
No
No
Xtro\lrrc4b
1 of 13
No
No
Xtro\lrrc4c
1 of 13
No
No
Xtro\lrrc4
1 of 13
No
No
Xtro\lrrc8e
1 of 13
No
Yes
Xtro\lrrc9
1 of 13
No
Yes
Xtro\lrrc15
1 of 13
No
No
Xtro\lrrc32.1
1 of 13
No
No
Xtro\lrrc39
1 of 13
No
No
Xtro\lrrc40
1 of 13
No
No
Xtro\lrrc56
1 of 13
No
No
Xtro\lrrd1
1 of 13
No
No
Xtro\lrriq1
1 of 13
No
Yes
Xtro\lrriq4
1 of 13
No
No
Xtro\lrrn1-like
1 of 13
No
No
Xtro\lrrn1
1 of 13
No
No
Xtro\lrrn4
1 of 13
No
Yes
Xtro\mfhas1
1 of 13
No
Yes
Xtro\mxra5
1 of 13
No
No
Xtro\myd88
1 of 13
No
No
Xtro\notch2
1 of 13
No
No
Xtro\nrros
1 of 13
No
No
Xtro\pafah1b1
1 of 13
No
No
Xtro\pde6g
1 of 13
No
No
Xtro\phlpp1
1 of 13
No
No
Xtro\phlpp2
1 of 13
No
No
Xtro\pxdn
1 of 13
No
No
Xtro\rad50
1 of 13
No
No
Xtro\rmi1
1 of 13
No
Yes
Xtro\rtn4rl2
1 of 13
No
No
Xtro\rxfp1
1 of 13
No
No
Xtro\shoc2
1 of 13
No
No
Xtro\sigirr
1 of 13
No
Yes
Xtro\slc35g1
1 of 13
No
No
Xtro\slit1
1 of 13
No
No
Xtro\slit3
1 of 13
No
No
Xtro\slitrk3
1 of 13
No
Yes
Xtro\tlr14.2
1 of 13
No
No
Xtro\XB5829846
1 of 13
No
No
Xtro\XB5838993
1 of 13
No
No
Xtro\znf534
1 of 13
No
No
Danio rerio (Zebrafish) (106)
Drer\tlr21
6 of 14
Yes
No
Drer\tlr20.2
5 of 14
No
No
Drer\tlr22
5 of 14
No
No
Drer\tlr2
4 of 14
No
No
Drer\tlr4al
4 of 14
No
No
Drer\tlr4bb
4 of 14
No
No
Drer\tlr5b
4 of 14
No
No
Drer\cd180
3 of 14
No
No
Drer\LOC100332583
3 of 14
No
Yes
Drer\LOC103911657
3 of 14
No
No
Drer\tlr1
3 of 14
No
No
Drer\tlr4ba
3 of 14
No
No
Drer\tlr5a
3 of 14
No
No
Drer\tlr8a
3 of 14
No
Yes
Drer\tlr8b
3 of 14
No
Yes
Drer\tlr18
3 of 14
No
No
Drer\chadlb
2 of 14
No
Yes
Drer\igfals
2 of 14
No
Yes
Drer\lgr4
2 of 14
No
No
Drer\lingo4b
2 of 14
No
No
Drer\LOC572462
2 of 14
No
No
Drer\LOC100535105
2 of 14
No
No
Drer\lrrn1
2 of 14
No
No
Drer\nrros
2 of 14
No
Yes
Drer\si:ch211-180f4.1
2 of 14
No
No
Drer\tlr3
2 of 14
No
No
Drer\tlr9
2 of 14
No
No
Drer\tlr19.1
2 of 14
No
No
Drer\tlr20.4
2 of 14
No
No
Drer\chadla
1 of 14
No
No
Drer\elfn1b
1 of 14
No
No
Drer\elfn2a
1 of 14
No
Yes
Drer\eys
1 of 14
No
No
Drer\flii
1 of 14
No
No
Drer\flrt1b
1 of 14
No
Yes
Drer\il1rapl1a
1 of 14
No
Yes
Drer\il1rapl1b
1 of 14
No
Yes
Drer\il1rapl2
1 of 14
No
Yes
Drer\il1rl1
1 of 14
No
Yes
Drer\lgr6
1 of 14
No
No
Drer\lingo1a
1 of 14
No
No
Drer\lingo1b
1 of 14
No
No
Drer\lingo2b
1 of 14
No
No
Drer\lingo3a
1 of 14
No
No
Drer\lingo4a
1 of 14
No
No
Drer\LOC563710
1 of 14
No
No
Drer\LOC799279
1 of 14
No
Yes
Drer\LOC100004523
1 of 14
No
No
Drer\LOC100151059
1 of 14
No
No
Drer\LOC101882841
1 of 14
No
Yes
Drer\LOC101884430
1 of 14
No
No
Drer\lrguk
1 of 14
No
No
Drer\lrig1
1 of 14
No
No
Drer\lrrc3b
1 of 14
No
No
Drer\lrrc3ca
1 of 14
No
No
Drer\lrrc3
1 of 14
No
No
Drer\lrrc4.1
1 of 14
No
No
Drer\lrrc4.2
1 of 14
No
No
Drer\lrrc4ba
1 of 14
No
No
Drer\lrrc4bb
1 of 14
No
No
Drer\lrrc4ca
1 of 14
No
No
Drer\lrrc4cb
1 of 14
No
No
Drer\lrrc9
1 of 14
No
Yes
Drer\lrrc15
1 of 14
No
No
Drer\lrrc32
1 of 14
No
No
Drer\lrrc40
1 of 14
No
No
Drer\lrriq1
1 of 14
No
No
Drer\lrrn3a
1 of 14
No
No
Drer\lrrtm1
1 of 14
No
No
Drer\lrrtm4l1
1 of 14
No
No
Drer\lrrtm4l2
1 of 14
No
Yes
Drer\myd88
1 of 14
No
No
Drer\notch1a
1 of 14
No
No
Drer\notch1b
1 of 14
No
No
Drer\notch3
1 of 14
No
No
Drer\nyx
1 of 14
No
No
Drer\phlpp1
1 of 14
No
No
Drer\rtn4rl2a
1 of 14
No
No
Drer\rtn4rl2b
1 of 14
No
No
Drer\scrib
1 of 14
No
No
Drer\shoc2
1 of 14
No
No
Drer\si:ch211-170a17.1
1 of 14
No
No
Drer\si:ch211-237i5.4
1 of 14
No
No
Drer\si:dkey-1j5.4
1 of 14
No
No
Drer\si:dkey-90m5.4
1 of 14
No
No
Drer\si:dkey-182i3.11
1 of 14
No
No
Drer\sigirr
1 of 14
No
Yes
Drer\slit1a
1 of 14
No
No
Drer\slit1b
1 of 14
No
No
Drer\slit2
1 of 14
No
No
Drer\slit3
1 of 14
No
No
Drer\slitrk2
1 of 14
No
Yes
Drer\slitrk3a
1 of 14
No
Yes
Drer\slitrk3b
1 of 14
No
Yes
Drer\slitrk4
1 of 14
No
Yes
Drer\slitrk5b
1 of 14
No
Yes
Drer\slitrk6
1 of 14
No
Yes
Drer\tirap
1 of 14
No
Yes
Drer\tlr7
1 of 14
No
No
Drer\tlr20f
1 of 14
No
Yes
Drer\tril
1 of 14
No
No
Drer\tsku
1 of 14
No
No
Drer\vasna
1 of 14
No
No
Drer\vasnb
1 of 14
No
No
Drer\zgc:153913
1 of 14
No
No
Drer\zmp:0000000936
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (25)
Cele\tol-1
13 of 14
Yes
Yes
Cele\lron-8
2 of 14
No
Yes
Cele\dma-1
1 of 14
No
No
Cele\egg-6
1 of 14
No
No
Cele\F33H2.3
1 of 14
No
No
Cele\fli-1
1 of 14
No
No
Cele\fshr-1
1 of 14
No
No
Cele\iglr-1
1 of 14
No
No
Cele\let-4
1 of 14
No
No
Cele\let-413
1 of 14
No
No
Cele\lron-1
1 of 14
No
No
Cele\lron-2
1 of 14
No
No
Cele\lron-3
1 of 14
No
No
Cele\lron-7
1 of 14
No
No
Cele\lron-9
1 of 14
No
No
Cele\lron-11
1 of 14
No
No
Cele\lron-14
1 of 14
No
No
Cele\lron-15
1 of 14
No
No
Cele\phlp-2
1 of 14
No
No
Cele\slt-1
1 of 14
No
No
Cele\sma-10
1 of 14
No
No
Cele\soc-2
1 of 14
No
No
Cele\sym-1
1 of 14
No
No
Cele\T19H12.2
1 of 14
No
No
Cele\Y54E10A.6
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (124)
Agam\TOLL7
11 of 12
Yes
Yes
Agam\AgaP_AGAP012385
6 of 12
No
No
Agam\TOLL6
5 of 12
No
No
Agam\TOLL10
5 of 12
No
Yes
Agam\TOLL11
5 of 12
No
No
Agam\AgaP_AGAP010634
3 of 12
No
No
Agam\AgaP_AGAP013027
3 of 12
No
No
Agam\TOLL1A
3 of 12
No
No
Agam\TOLL5A
3 of 12
No
No
Agam\TOLL5B
3 of 12
No
No
Agam\TOLL9
3 of 12
No
No
Agam\AgaP_AGAP007466
2 of 12
No
Yes
Agam\AgaP_AGAP010637
2 of 12
No
No
Agam\AgaP_AGAP011117
2 of 12
No
Yes
Agam\TOLL1B
2 of 12
No
No
Agam\AgaP_AGAP000019
1 of 12
No
No
Agam\AgaP_AGAP000054
1 of 12
No
No
Agam\AgaP_AGAP000360
1 of 12
No
No
Agam\AgaP_AGAP000446
1 of 12
No
No
Agam\AgaP_AGAP000601
1 of 12
No
No
Agam\AgaP_AGAP001002
1 of 12
No
No
Agam\AgaP_AGAP001015
1 of 12
No
No
Agam\AgaP_AGAP001127
1 of 12
No
No
Agam\AgaP_AGAP001706
1 of 12
No
No
Agam\AgaP_AGAP002006
1 of 12
No
No
Agam\AgaP_AGAP002007
1 of 12
No
No
Agam\AgaP_AGAP002013
1 of 12
No
No
Agam\AgaP_AGAP002336
1 of 12
No
No
Agam\AgaP_AGAP002792
1 of 12
No
No
Agam\AgaP_AGAP002793
1 of 12
No
No
Agam\AgaP_AGAP003267
1 of 12
No
No
Agam\AgaP_AGAP003873
1 of 12
No
No
Agam\AgaP_AGAP003878
1 of 12
No
No
Agam\AgaP_AGAP003994
1 of 12
No
Yes
Agam\AgaP_AGAP004485
1 of 12
No
No
Agam\AgaP_AGAP004832
1 of 12
No
No
Agam\AgaP_AGAP004913
1 of 12
No
Yes
Agam\AgaP_AGAP004941
1 of 12
No
No
Agam\AgaP_AGAP005075
1 of 12
No
No
Agam\AgaP_AGAP005273
1 of 12
No
No
Agam\AgaP_AGAP005417
1 of 12
No
No
Agam\AgaP_AGAP005496
1 of 12
No
Yes
Agam\AgaP_AGAP005666
1 of 12
No
Yes
Agam\AgaP_AGAP005667
1 of 12
No
Yes
Agam\AgaP_AGAP005668
1 of 12
No
Yes
Agam\AgaP_AGAP005693
1 of 12
No
No
Agam\AgaP_AGAP005962
1 of 12
No
No
Agam\AgaP_AGAP006183
1 of 12
No
No
Agam\AgaP_AGAP006348
1 of 12
No
Yes
Agam\AgaP_AGAP006643
1 of 12
No
No
Agam\AgaP_AGAP006645
1 of 12
No
No
Agam\AgaP_AGAP006993
1 of 12
No
No
Agam\AgaP_AGAP007030
1 of 12
No
Yes
Agam\AgaP_AGAP007037
1 of 12
No
No
Agam\AgaP_AGAP007039
1 of 12
No
Yes
Agam\AgaP_AGAP007045
1 of 12
No
No
Agam\AgaP_AGAP007048
1 of 12
No
No
Agam\AgaP_AGAP007059
1 of 12
No
No
Agam\AgaP_AGAP007060
1 of 12
No
No
Agam\AgaP_AGAP007061
1 of 12
No
No
Agam\AgaP_AGAP007090
1 of 12
No
No
Agam\AgaP_AGAP007384
1 of 12
No
No
Agam\AgaP_AGAP007442
1 of 12
No
Yes
Agam\AgaP_AGAP007443
1 of 12
No
Yes
Agam\AgaP_AGAP007445
1 of 12
No
No
Agam\AgaP_AGAP007446
1 of 12
No
Yes
Agam\AgaP_AGAP007451
1 of 12
No
No
Agam\AgaP_AGAP007453
1 of 12
No
No
Agam\AgaP_AGAP007454
1 of 12
No
No
Agam\AgaP_AGAP007455
1 of 12
No
Yes
Agam\AgaP_AGAP007456
1 of 12
No
No
Agam\AgaP_AGAP007457
1 of 12
No
Yes
Agam\AgaP_AGAP007461
1 of 12
No
No
Agam\AgaP_AGAP007462
1 of 12
No
Yes
Agam\AgaP_AGAP007463
1 of 12
No
No
Agam\AgaP_AGAP007464
1 of 12
No
Yes
Agam\AgaP_AGAP007465
1 of 12
No
No
Agam\AgaP_AGAP007467
1 of 12
No
Yes
Agam\AgaP_AGAP007468
1 of 12
No
No
Agam\AgaP_AGAP007469
1 of 12
No
No
Agam\AgaP_AGAP007470
1 of 12
No
No
Agam\AgaP_AGAP007471
1 of 12
No
No
Agam\AgaP_AGAP007829
1 of 12
No
No
Agam\AgaP_AGAP007846
1 of 12
No
No
Agam\AgaP_AGAP008152
1 of 12
No
No
Agam\AgaP_AGAP008170
1 of 12
No
No
Agam\AgaP_AGAP008171
1 of 12
No
Yes
Agam\AgaP_AGAP008172
1 of 12
No
Yes
Agam\AgaP_AGAP008173
1 of 12
No
Yes
Agam\AgaP_AGAP008593
1 of 12
No
No
Agam\AgaP_AGAP008611
1 of 12
No
No
Agam\AgaP_AGAP009087
1 of 12
No
No
Agam\AgaP_AGAP009136
1 of 12
No
No
Agam\AgaP_AGAP009138
1 of 12
No
No
Agam\AgaP_AGAP009228
1 of 12
No
Yes
Agam\AgaP_AGAP009688
1 of 12
No
No
Agam\AgaP_AGAP009775
1 of 12
No
No
Agam\AgaP_AGAP010129
1 of 12
No
No
Agam\AgaP_AGAP010804
1 of 12
No
No
Agam\AgaP_AGAP010809
1 of 12
No
Yes
Agam\AgaP_AGAP011227
1 of 12
No
No
Agam\AgaP_AGAP011229
1 of 12
No
No
Agam\AgaP_AGAP011292
1 of 12
No
No
Agam\AgaP_AGAP011371
1 of 12
No
No
Agam\AgaP_AGAP011378
1 of 12
No
No
Agam\AgaP_AGAP011649
1 of 12
No
No
Agam\AgaP_AGAP011947
1 of 12
No
No
Agam\AgaP_AGAP012317
1 of 12
No
No
Agam\AgaP_AGAP012384
1 of 12
No
Yes
Agam\AgaP_AGAP012442
1 of 12
No
No
Agam\AgaP_AGAP012495
1 of 12
No
No
Agam\AgaP_AGAP012584
1 of 12
No
Yes
Agam\AgaP_AGAP013186
1 of 12
No
No
Agam\AgaP_AGAP013278
1 of 12
No
Yes
Agam\APL1A
1 of 12
No
No
Agam\APL1B
1 of 12
No
No
Agam\APL1C
1 of 12
No
No
Agam\GPRFSH
1 of 12
No
No
Agam\GPRGPH
1 of 12
No
No
Agam\GPRNNB1
1 of 12
No
No
Agam\GPRRK
1 of 12
No
No
Agam\HPX4
1 of 12
No
No
Agam\LRC50_ANOGA
1 of 12
No
No
Agam\MYD
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (155)
Atha\AT1G54475
2 of 13
Yes
Yes
Atha\AT1G65850
2 of 13
Yes
Yes
Atha\AT4G08450
2 of 13
Yes
Yes
Atha\RLP45
2 of 13
Yes
Yes
Atha\RLP56
2 of 13
Yes
Yes
Atha\RPP27
2 of 13
Yes
Yes
Atha\SNC1
2 of 13
Yes
Yes
Atha\AT1G09665
1 of 13
No
No
Atha\AT1G17600
1 of 13
No
Yes
Atha\AT1G27170
1 of 13
No
Yes
Atha\AT1G27180
1 of 13
No
Yes
Atha\AT1G31540
1 of 13
No
Yes
Atha\AT1G47370
1 of 13
No
Yes
Atha\AT1G51270
1 of 13
No
No
Atha\AT1G52900
1 of 13
No
Yes
Atha\AT1G56520
1 of 13
No
Yes
Atha\AT1G56540
1 of 13
No
Yes
Atha\AT1G57630
1 of 13
No
Yes
Atha\AT1G57670
1 of 13
No
No
Atha\AT1G57830
1 of 13
No
No
Atha\AT1G57850
1 of 13
No
No
Atha\AT1G60320
1 of 13
No
No
Atha\AT1G61105
1 of 13
No
Yes
Atha\AT1G63730
1 of 13
No
Yes
Atha\AT1G63740
1 of 13
No
Yes
Atha\AT1G63750
1 of 13
No
Yes
Atha\AT1G63860
1 of 13
No
Yes
Atha\AT1G63870
1 of 13
No
Yes
Atha\AT1G63880
1 of 13
No
Yes
Atha\AT1G66090
1 of 13
No
Yes
Atha\AT1G69550
1 of 13
No
Yes
Atha\AT1G72840
1 of 13
No
Yes
Atha\AT1G72850
1 of 13
No
Yes
Atha\AT1G72860
1 of 13
No
Yes
Atha\AT1G72870
1 of 13
No
No
Atha\AT1G72890
1 of 13
No
Yes
Atha\AT1G72900
1 of 13
No
No
Atha\AT1G72910
1 of 13
No
No
Atha\AT1G72920
1 of 13
No
Yes
Atha\AT1G72940
1 of 13
No
Yes
Atha\AT1G72950
1 of 13
No
Yes
Atha\AT1G73066
1 of 13
No
Yes
Atha\AT2G03030
1 of 13
No
No
Atha\AT2G03300
1 of 13
No
No
Atha\AT2G16870
1 of 13
No
Yes
Atha\AT2G17050
1 of 13
No
Yes
Atha\AT2G17060
1 of 13
No
Yes
Atha\AT2G20142
1 of 13
No
No
Atha\AT2G32140
1 of 13
No
Yes
Atha\AT2G34930
1 of 13
No
Yes
Atha\AT3G04210
1 of 13
No
Yes
Atha\AT3G04220
1 of 13
No
No
Atha\AT3G15410
1 of 13
No
No
Atha\AT3G44400
1 of 13
No
Yes
Atha\AT3G44630
1 of 13
No
Yes
Atha\AT3G44670
1 of 13
No
Yes
Atha\AT3G50690
1 of 13
No
No
Atha\AT3G51560
1 of 13
No
Yes
Atha\AT3G51570
1 of 13
No
Yes
Atha\AT4G04110
1 of 13
No
Yes
Atha\AT4G09420
1 of 13
No
No
Atha\AT4G09430
1 of 13
No
No
Atha\AT4G11170
1 of 13
No
Yes
Atha\AT4G11340
1 of 13
No
No
Atha\AT4G12010
1 of 13
No
Yes
Atha\AT4G14370
1 of 13
No
Yes
Atha\AT4G16900
1 of 13
No
Yes
Atha\AT4G16920
1 of 13
No
Yes
Atha\AT4G16940
1 of 13
No
Yes
Atha\AT4G16960
1 of 13
No
Yes
Atha\AT4G19500
1 of 13
No
Yes
Atha\AT4G19510
1 of 13
No
Yes
Atha\AT4G19520
1 of 13
No
Yes
Atha\AT4G19530
1 of 13
No
Yes
Atha\AT4G19910
1 of 13
No
Yes
Atha\AT4G19920
1 of 13
No
No
Atha\AT4G19925
1 of 13
No
Yes
Atha\AT4G23510
1 of 13
No
No
Atha\AT4G23515
1 of 13
No
No
Atha\AT4G36140
1 of 13
No
No
Atha\AT4G36150
1 of 13
No
Yes
Atha\AT5G11250
1 of 13
No
Yes
Atha\AT5G12940
1 of 13
No
Yes
Atha\AT5G17680
1 of 13
No
No
Atha\AT5G17970
1 of 13
No
Yes
Atha\AT5G18350
1 of 13
No
Yes
Atha\AT5G18360
1 of 13
No
Yes
Atha\AT5G18370
1 of 13
No
Yes
Atha\AT5G22320
1 of 13
No
No
Atha\AT5G22690
1 of 13
No
Yes
Atha\AT5G36930
1 of 13
No
Yes
Atha\AT5G38340
1 of 13
No
Yes
Atha\AT5G38344
1 of 13
No
No
Atha\AT5G38850
1 of 13
No
Yes
Atha\AT5G40100
1 of 13
No
Yes
Atha\AT5G40910
1 of 13
No
Yes
Atha\AT5G41540
1 of 13
No
Yes
Atha\AT5G41550
1 of 13
No
Yes
Atha\AT5G41740
1 of 13
No
Yes
Atha\AT5G41750
1 of 13
No
Yes
Atha\AT5G44900
1 of 13
No
Yes
Atha\AT5G44910
1 of 13
No
Yes
Atha\AT5G44920
1 of 13
No
Yes
Atha\AT5G45000
1 of 13
No
Yes
Atha\AT5G45060
1 of 13
No
Yes
Atha\AT5G45200
1 of 13
No
Yes
Atha\AT5G45210
1 of 13
No
Yes
Atha\AT5G45220
1 of 13
No
No
Atha\AT5G45230
1 of 13
No
Yes
Atha\AT5G45240
1 of 13
No
Yes
Atha\AT5G46260
1 of 13
No
Yes
Atha\AT5G46270
1 of 13
No
Yes
Atha\AT5G46450
1 of 13
No
Yes
Atha\AT5G46490
1 of 13
No
Yes
Atha\AT5G46510
1 of 13
No
Yes
Atha\AT5G46520
1 of 13
No
Yes
Atha\AT5G48770
1 of 13
No
Yes
Atha\AT5G48780
1 of 13
No
Yes
Atha\AT5G49140
1 of 13
No
Yes
Atha\AT5G51630
1 of 13
No
Yes
Atha\AT5G58120
1 of 13
No
Yes
Atha\AT5G58150
1 of 13
No
Yes
Atha\BRL1
1 of 13
No
No
Atha\CSA1
1 of 13
No
Yes
Atha\ER
1 of 13
No
No
Atha\FLS2
1 of 13
No
No
Atha\GHR1
1 of 13
No
Yes
Atha\GSO1
1 of 13
No
No
Atha\GSO2
1 of 13
No
No
Atha\LAZ5
1 of 13
No
Yes
Atha\PEPR2
1 of 13
No
No
Atha\PIRL2
1 of 13
No
No
Atha\PP2-A5
1 of 13
No
Yes
Atha\PP2-A6
1 of 13
No
Yes
Atha\PP2-A8
1 of 13
No
Yes
Atha\RLM1
1 of 13
No
Yes
Atha\RLM3
1 of 13
No
No
Atha\RLP1
1 of 13
No
No
Atha\RLP9
1 of 13
No
Yes
Atha\RLP14
1 of 13
No
Yes
Atha\RLP19
1 of 13
No
Yes
Atha\RLP21
1 of 13
No
Yes
Atha\RLP22
1 of 13
No
No
Atha\RLP32
1 of 13
No
No
Atha\RLP46
1 of 13
No
Yes
Atha\RLP49
1 of 13
No
No
Atha\RPP1
1 of 13
No
Yes
Atha\RPP4
1 of 13
No
Yes
Atha\RPP5
1 of 13
No
Yes
Atha\RPS4
1 of 13
No
Yes
Atha\RPS6
1 of 13
No
Yes
Atha\TAO1
1 of 13
No
Yes
Atha\TIR
1 of 13
No
Yes
Atha\U2A'
1 of 13
No
No
Atha\WRR4
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\CYR1
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Toll-7. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (68)
Tollo
11 of 13
18w
10 of 13
Toll-6
10 of 13
Tl
7 of 13
Tehao
6 of 13
Toll-4
6 of 13
Toll-9
6 of 13
MstProx
4 of 13
CG7509
3 of 13
CG32055
3 of 13
ltl
3 of 13
rdo
3 of 13
trn
3 of 13
2mit
2 of 13
caps
2 of 13
cDIP
2 of 13
CG4168
2 of 13
CG4950
2 of 13
CG6749
2 of 13
CG7800
2 of 13
CG7896
2 of 13
CG16974
2 of 13
CG18249
2 of 13
CG18480
2 of 13
CG42346
2 of 13
chp
2 of 13
Fili
2 of 13
kek5
2 of 13
lbk
2 of 13
alrm
1 of 13
atk
1 of 13
Cep97
1 of 13
CG5810
1 of 13
CG5819
1 of 13
CG6959
1 of 13
CG7702
1 of 13
CG13708
1 of 13
CG14762
1 of 13
CG18095
1 of 13
CG42709
1 of 13
Con
1 of 13
conv
1 of 13
crb
1 of 13
dtr
1 of 13
fliI
1 of 13
Gp150
1 of 13
haf
1 of 13
hfw
1 of 13
kek1
1 of 13
kek2
1 of 13
kek3
1 of 13
kek6
1 of 13
Lap1
1 of 13
Lgr1
1 of 13
Lgr3
1 of 13
Lgr4
1 of 13
Lrt
1 of 13
Mapmodulin
1 of 13
Myd88
1 of 13
N
1 of 13
Phlpp
1 of 13
Pxn
1 of 13
rk
1 of 13
scrib
1 of 13
sli
1 of 13
Sur-8
1 of 13
swi2
1 of 13
U2A
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 3 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
TLR1; toll like receptor 1
4 of 14
601194
     
    TLR2; toll like receptor 2
    4 of 14
    603028
     
    TLR3; toll like receptor 3
    4 of 14
    603029
       
      TLR6; toll like receptor 6
      4 of 14
      605403
           
          TLR10; toll like receptor 10
          4 of 14
          606270
              CD180; CD180 molecule
              3 of 14
              602226
                  CHADL; chondroadherin like
                  3 of 14
                  616236
                      CPN2; carboxypeptidase N subunit 2
                      3 of 14
                      603104
                          LRRC15; leucine rich repeat containing 15
                          3 of 14
                          619327
                               
                              TLR4; toll like receptor 4
                              3 of 14
                              603030
                                  TLR7; toll like receptor 7
                                  3 of 14
                                  300365
                                  TLR8; toll like receptor 8
                                  3 of 14
                                  300366
                                   
                                  TLR9; toll like receptor 9
                                  3 of 14
                                  605474
                                      Functional Complementation Data
                                      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                      Interactions
                                      Summary of Physical Interactions
                                      Summary of Genetic Interactions
                                      Interaction Browsers
                                      View in FlyBase Interactions Browser   View in MIST tool (external link)
                                      Please look at the allele data for full details of the genetic interactions
                                      Starting gene(s)
                                      Interaction type
                                      Interacting gene(s)
                                      Reference
                                      Toll-7
                                      suppressible
                                      bsk
                                      (Ding et al., 2022)
                                      Toll-7
                                      suppressible
                                      Egfr
                                      (Ding et al., 2022)
                                      Toll-7
                                      suppressible
                                      egr
                                      (Ding et al., 2022)
                                      Toll-7
                                      enhanceable
                                      Toll-6
                                      (Yagi et al., 2010)
                                      Toll-7
                                      enhanceable
                                      Tollo
                                      (Yagi et al., 2010)
                                      Toll-7
                                      suppressible
                                      yki
                                      (Ding et al., 2022)
                                      Starting gene(s)
                                      Interaction type
                                      Interacting gene(s)
                                      Reference
                                      egr
                                      suppressible
                                      Toll-7
                                      (Ding et al., 2022)
                                      Myd88
                                      enhanceable
                                      Toll-6|Toll-7
                                      (Foldi et al., 2017)
                                      NT1
                                      suppressible
                                      Toll-7
                                      (McIlroy et al., 2013)
                                      NT1|Toll-6
                                      suppressible
                                      Toll-7
                                      (McIlroy et al., 2013)
                                      Ras85D|l(2)gl
                                      suppressible
                                      Toll-7
                                      (Ding et al., 2022)
                                      scrib
                                      suppressible
                                      Toll-7
                                      (Ding et al., 2022)
                                      spz5|NT1
                                      suppressible
                                      Toll-7
                                      (McIlroy et al., 2013)
                                      spz
                                      suppressible
                                      Toll-7
                                      (McIlroy et al., 2013)
                                      Toll-6
                                      suppressible
                                      Toll-7
                                      (Ward et al., 2015)
                                      External Data
                                      Linkouts
                                      BioGRID - A database of protein and genetic interactions.
                                      DroID - A comprehensive database of gene and protein interactions.
                                      MIST (genetic) - An integrated Molecular Interaction Database
                                      MIST (protein-protein) - An integrated Molecular Interaction Database
                                      Pathways
                                      Signaling Pathways (FlyBase)
                                      Metabolic Pathways
                                      FlyBase
                                      External Links
                                      External Data
                                      Linkouts
                                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                      Class of Gene
                                      Genomic Location and Detailed Mapping Data
                                      Chromosome (arm)
                                      2R
                                      Recombination map
                                      2-90
                                      Cytogenetic map
                                      56E4-56E4
                                      Sequence location
                                      FlyBase Computed Cytological Location
                                      Cytogenetic map
                                      Evidence for location
                                      56E4-56E4
                                      Limits computationally determined from genome sequence between P{PZ}sm05338&P{PZ}emm1 and P{lacW}l(2)k08002k08002
                                      Experimentally Determined Cytological Location
                                      Cytogenetic map
                                      Notes
                                      References
                                      56E3-56F9
                                      (Tauszig, 2000.3.23)
                                      Experimentally Determined Recombination Data
                                      Location

                                      2-90

                                      (FlyBase, 2016)

                                      2-95.2

                                      (Comeron et al., 2012)
                                      Left of (cM)
                                      Right of (cM)
                                      Notes
                                      Stocks and Reagents
                                      Stocks (19)
                                      Genomic Clones (25)
                                      cDNA Clones (29)
                                       

                                      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                      cDNA clones, fully sequenced
                                      BDGP DGC clones
                                        Other clones
                                        Drosophila Genomics Resource Center cDNA clones

                                        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                        cDNA Clones, End Sequenced (ESTs)
                                        BDGP DGC clones
                                        Other clones
                                        RNAi and Array Information
                                        Linkouts
                                        DRSC - Results frm RNAi screens
                                        Antibody Information
                                        Laboratory Generated Antibodies
                                         

                                        polyclonal

                                        (Ward A., 2015.10.7, Ward et al., 2015, McIlroy et al., 2013, Nakamoto et al., 2012)
                                        Commercially Available Antibodies
                                         
                                        Cell Line Information
                                        Publicly Available Cell Lines
                                         
                                          Other Stable Cell Lines
                                           

                                          • New stable cell line derived from S2-ATCC : S2 cell lines stably expressing TIR-1 and TIR-7 (the intracellular domains of Tl and Toll-7) were established. S2 cells stably expressing RFP-GFP tandem fluorescent-tagged LC3 protein (phosphatidylethanolamine) were created to facilitate detection of autophagy.

                                            (Zhang et al., 2024)
                                          Other Comments

                                          Toll-6 acts cell autonomously to instruct the targeting of specific classes of olfactory receptor neuron axons.

                                          (Ward et al., 2015)

                                          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                                          (Kiger et al., 2003)
                                          Relationship to Other Genes
                                          Source for database merge of
                                          Additional comments

                                          The Toll-7 gene may have been derived from the chp gene by retroposition.

                                          (Pan and Zhang, 2009)

                                          The 18w and Toll-7 genes share at least 50% identity.

                                          (Langille and Clark, 2007)

                                          Source for identity of Toll-7 CG8595 was sequence comparison ( date:000721 ).

                                          (FlyBase, 1996-)
                                          Nomenclature History
                                          Source for database identify of

                                          Source for identity of: Toll-7 CG8595

                                          (FlyBase, 1996-)
                                          Nomenclature comments
                                          Etymology
                                          Synonyms and Secondary IDs (14)
                                          Reported As
                                          Symbol Synonym
                                          CG8595
                                          (National Institute of Genetics Fly Stocks, 2022-, Liu et al., 2015, Pan and Zhang, 2009, Perkins et al., 2009, Wasserman, 2000)
                                          CT24947
                                          (Hynes and Zhao, 2000)
                                          TOLL 7
                                          (Christophides et al., 2002)
                                          Tl-7
                                          (Khush and Lemaitre, 2000, Lemaitre, 2000.12.20)
                                          Toll
                                          (Wei et al., 2018)
                                          Toll 7
                                          (Denton et al., 2020, Castillo et al., 2015)
                                          Toll-7
                                          (Lyu et al., 2025, Pignataro et al., 2024, Pollex et al., 2024, Aromolaran et al., 2023, Bossen et al., 2023, Khan et al., 2023, Benoit et al., 2022, Ding et al., 2022, Valanne et al., 2022, DeAngelis et al., 2021, Li and Hidalgo, 2021, Michki et al., 2021, Paraskevopoulos and McGuigan, 2021, Rosendo Machado et al., 2021, Zhou et al., 2021, Alvarado et al., 2020, Iijima et al., 2020, Li et al., 2020, Liu et al., 2020, Tafesh-Edwards and Eleftherianos, 2020, Younes et al., 2020, Bali et al., 2019, Belmonte et al., 2019, Bhattacharjee et al., 2019, Chowdhury et al., 2019, Germani et al., 2018, La Fortezza et al., 2018, Lopez et al., 2018, Foldi et al., 2017, Franz et al., 2017, Levin and Malik, 2017, Ulian-Benitez et al., 2017, Shen et al., 2016, Liu et al., 2015, Neyen and Lemaitre, 2015, Vlisidou and Wood, 2015, dos Santos, 2014, Moy et al., 2014, Mulakkal et al., 2014, Paré et al., 2014, Xu and Cherry, 2014, McIlroy et al., 2013, Merkling and van Rij, 2013, Ozkan et al., 2013, Samaraweera et al., 2013, Díaz-Castillo et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Nakamoto et al., 2012, Yagi et al., 2010, Roeder et al., 2009, Swanson et al., 2009, Sandoval and Eldon, 2008, Wagner et al., 2008, Langille and Clark, 2007, Bartolome and Charlesworth, 2006, Ooi et al., 2002, Tauszig-Delamasure et al., 2002)
                                          Toll7
                                          (Zang and Bashaw, 2023, Lima et al., 2021, Graham et al., 2019)
                                          dTLR7
                                          (Silverman and Maniatis, 2001)
                                          dToll7
                                          (Singh et al., 2003)
                                          toll
                                          (Janssens and Beyaert, 2002)
                                          toll-7
                                          (Fischer et al., 2024, Ward A., 2015.10.7, Ward et al., 2015)
                                          Name Synonyms
                                          Toll-7
                                          (Anthoney et al., 2018, Kuo et al., 2018, Nie et al., 2018, Swevers et al., 2018, Panayidou et al., 2014, Moy and Cherry, 2013, Tauszig, 2000.3.23)
                                          Toll-like
                                          (Hynes and Zhao, 2000)
                                          Toll7
                                          (Palmer et al., 2018)
                                          toll receptor
                                          (Haesemeyer M et al., 2007)
                                          Secondary FlyBase IDs
                                            Datasets (0)
                                            Study focus (0)
                                            Experimental Role
                                            Project
                                            Project Type
                                            Title
                                            Study result (0)
                                            Result
                                            Result Type
                                            Title
                                            External Crossreferences and Linkouts ( 42 )
                                            Sequence Crossreferences
                                            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                            Other crossreferences
                                            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                            FlyMine - An integrated database for Drosophila genomics
                                            InterPro - A database of protein families, domains and functional sites
                                            KEGG Genes - Molecular building blocks of life in the genomic space.
                                            MARRVEL_MODEL - MARRVEL (model organism gene)
                                            Linkouts
                                            BioGRID - A database of protein and genetic interactions.
                                            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                            DroID - A comprehensive database of gene and protein interactions.
                                            DRSC - Results frm RNAi screens
                                            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                            Flygut - An atlas of the Drosophila adult midgut
                                            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                            MIST (genetic) - An integrated Molecular Interaction Database
                                            MIST (protein-protein) - An integrated Molecular Interaction Database
                                            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                            References (130)