FlyBase Gene Report: Dmel\atk

General Information

Symbol

Dmel\atk

Species

D. melanogaster

Name

artichoke

Annotation Symbol

CG5195

Feature Type

protein_coding_gene

FlyBase ID

FBgn0036995

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

artichoke (atk) encodes a leucine-rich-repeat extracellular matrix protein secreted by accessory cells in ciliated sensory organs. It surrounds the tip of the cilium, and contributes to its assembly. Its roles include cilium integrity, chemosensation and proprioception. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

77C3-77C4

Sequence location

3L:20,454,690..20,464,862 [-]

Recombination map

3-47

RefSeq locus

NT_037436 REGION:20454690..20464862

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in cilium assembly

inferred from mutant phenotype

(Andrés et al., 2014)

involved_in locomotion

inferred from mutant phenotype

(Andrés et al., 2014)

involved_in sensory organ development

inferred from mutant phenotype

(Andrés et al., 2014)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Andrés et al., 2014)

located_in extracellular matrix

inferred from direct assay

(Andrés et al., 2014)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Protein Function (UniProtKB)

Required for normal morphology and function of ciliated sensory organs.

(UniProt, Q9VPF0)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\atk for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VPF0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

atk-RA

FBtr0078223

NM_140971

5071

1535

atk-RB

FBtr0331569

NM_001275184

4756

1535

atk-RC

FBtr0331570

NM_001275185

4873

1535

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

atk-PA

FBpp0077881

172.1

1535

6.62

FBpp0303959

172.1

1535

6.62

FBpp0303960

172.1

1535

6.62

Q9VPF0

NP_001262114

AGB94807

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1535 aa isoforms: atk-PA, atk-PB, atk-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

UniProt

Q9VPF0

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\atk using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

atk_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.08

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15 -- 17

larval peripheral nervous system

(Andrés et al., 2014)

mechanosensory sensory organ

(Andrés et al., 2014)

chemosensory sensory organ

(Andrés et al., 2014)

Additional Descriptive Data

atk expression is observed at embryonic stages 15–17 in type I embryonic sensory organs, including ch and es mechanosensory organs and chemosensory organs of the head and tail. Transcription commences at stage 15 in the head and the terminal sensilla. At early stage 16, transcription starts in mechanosensory organs along the body segments. The strongest expression is seen in stage 16 embryos. At stage 17, expression disappears from mechanosensory organs along the body segments and weakens in the head and terminal sensilla.

(Andrés et al., 2014)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15 -- 17

larval peripheral nervous system

(Andrés et al., 2014)

mechanosensory sensory organ

(Andrés et al., 2014)

chemosensory sensory organ

(Andrés et al., 2014)

external sensory organ

(Andrés et al., 2014)

scolopidial dendritic cap cell

(Andrés et al., 2014)

trichogen cell

(Andrés et al., 2014)

Additional Descriptive Data

atk is specifically expressed in certain accessory cells in type I sensory organs, i.e., the cap cells of chordotonal organs and the shaft cells of es organs.

(Andrés et al., 2014)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Andrés et al., 2014)

located_in extracellular matrix

inferred from direct assay

(Andrés et al., 2014)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\atk in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\atk

View exonic expression by tissue for Dmel\atk

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40266/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036995

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036995

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036995

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5195

Flygut - An atlas of the Drosophila adult midgut

FBgn0036995

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of atk

Transgenic constructs containing regulatory region of atk

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

Df(3L)atk³³

(Andrés et al., 2014)

Df(3L)Exel6136

(Ryder, 2004.4.26)

Gene partially disrupted in

Df(3L)atk⁸

(Andrés et al., 2014)

Df(3L)atk²³

(Andrés et al., 2014)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

atk^GD5536

viable, with Scer\GAL4^Mef2.PR

atk^GD5536

viable, with Scer\GAL4^pnr-MD237

atk^GD5536

viable, with Scer\GAL4^tin.CΔ4

atk^GD5536

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal locomotor behavior | larval stage

visible, with Scer\GAL4^pnr-MD237

atk^GD5536

Phenotype manifest in

Allele

abdominal lateral pentascolopidial chordotonal organ lch5 | embryonic stage

mesonotum, with Scer\GAL4^pnr-MD237

atk^GD5536

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (137)

Hsap\IGFALS

2 of 14

Yes

Hsap\LRRC32

2 of 14

Yes

Hsap\NRROS

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\FMOD

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\LRRC8B

1 of 14

Yes

Hsap\LRRC8C

1 of 14

Yes

Hsap\LRRC8D

1 of 14

Yes

Hsap\LRRC8E

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (96)

Rnor\Igfals

2 of 14

Yes

Rnor\Lrrc15

2 of 14

Yes

Rnor\Lrrc32

2 of 14

Yes

Rnor\Nrros

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Cd14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Lrrc8e

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\LRRTM1

1 of 14

Yes

Rnor\Lrrtm2

1 of 14

Rnor\Lrrtm3

1 of 14

Rnor\Nepn

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (95)

Mmus\Igfals

2 of 14

Yes

Mmus\Lrrc15

2 of 14

Yes

Mmus\Nrros

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Cd14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Lrrc66

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Phlpp1

1 of 14

Mmus\Phlpp2

1 of 14

Mmus\Podnl1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (108)

Xtro\chadl

2 of 13

Yes

Xtro\igfals

2 of 13

Yes

Xtro\lrrc32.1

2 of 13

Yes

Xtro\nrros

2 of 13

Yes

Xtro\tsku

2 of 13

Yes

Xtro\anp32a

1 of 13

Xtro\anp32b

1 of 13

Xtro\aspn

1 of 13

Yes

Xtro\cep97

1 of 13

Xtro\cetn3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\lrrc8c

1 of 13

Yes

Xtro\lrrc8e.2

1 of 13

Xtro\lrrc8e

1 of 13

Yes

Xtro\lrrc9

1 of 13

Yes

Xtro\lrrc17

1 of 13

Xtro\lrrc23

1 of 13

Xtro\lrrc32.2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\lrrtm1

1 of 13

Xtro\lrrtm4

1 of 13

Xtro\mfhas1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\slitrk2

1 of 13

Yes

Xtro\slitrk3

1 of 13

Yes

Xtro\slitrk4

1 of 13

Yes

Xtro\slitrk5

1 of 13

Xtro\slitrk6

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\XB5838993

1 of 13

Xtro\XB5889249

1 of 13

Xtro\znf534

1 of 13

Danio rerio (Zebrafish) (115)

Drer\si:dkey-182i3.11

3 of 14

Yes

Drer\lrrc32

2 of 14

Yes

Drer\nrros

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\cd180

1 of 14

Drer\cep72

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\lrrc10

1 of 14

Drer\lrrc15

1 of 14

Drer\lrrc18a

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\lrrtm4l1

1 of 14

Drer\lum

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch211-180f4.1

1 of 14

Drer\si:ch211-237i5.4

1 of 14

Drer\si:dkey-1j5.4

1 of 14

Drer\si:dkey-6n6.1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\zgc:153913

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (37)

Cele\let-4

2 of 14

Yes

Cele\lron-2

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (141)

Agam\AgaP_AGAP011947

11 of 12

Yes

Agam\AgaP_AGAP001002

2 of 12

Agam\AgaP_AGAP007829

2 of 12

Yes

Agam\APL1A

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP004016

1 of 12

Yes

Agam\AgaP_AGAP004017

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP005666

1 of 12

Yes

Agam\AgaP_AGAP005667

1 of 12

Yes

Agam\AgaP_AGAP005668

1 of 12

Yes

Agam\AgaP_AGAP005693

1 of 12

Agam\AgaP_AGAP005744

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP006348

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP007034

1 of 12

Yes

Agam\AgaP_AGAP007037

1 of 12

Agam\AgaP_AGAP007039

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP007443

1 of 12

Yes

Agam\AgaP_AGAP007445

1 of 12

Agam\AgaP_AGAP007446

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP007456

1 of 12

Agam\AgaP_AGAP007457

1 of 12

Yes

Agam\AgaP_AGAP007461

1 of 12

Agam\AgaP_AGAP007462

1 of 12

Yes

Agam\AgaP_AGAP007463

1 of 12

Agam\AgaP_AGAP007464

1 of 12

Yes

Agam\AgaP_AGAP007465

1 of 12

Agam\AgaP_AGAP007466

1 of 12

Agam\AgaP_AGAP007467

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP008172

1 of 12

Yes

Agam\AgaP_AGAP008173

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP010770

1 of 12

Agam\AgaP_AGAP010804

1 of 12

Agam\AgaP_AGAP010809

1 of 12

Yes

Agam\AgaP_AGAP010847

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP011649

1 of 12

Agam\AgaP_AGAP012317

1 of 12

Agam\AgaP_AGAP012384

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (48)

Atha\AIR9

1 of 13

Yes

Atha\AT1G06840

1 of 13

Yes

Atha\AT1G33590

1 of 13

Yes

Atha\AT1G48540

1 of 13

Yes

Atha\AT1G73066

1 of 13

Yes

Atha\AT2G24230

1 of 13

Yes

Atha\AT2G25790

1 of 13

Yes

Atha\AT2G33170

1 of 13

Yes

Atha\AT3G15410

1 of 13

Yes

Atha\AT3G17920

1 of 13

Yes

Atha\AT3G50690

1 of 13

Yes

Atha\AT4G08850

1 of 13

Yes

Atha\AT4G36180

1 of 13

Yes

Atha\AT5G10020

1 of 13

Yes

Atha\AT5G12940

1 of 13

Yes

Atha\AT5G19680

1 of 13

Yes

Atha\AT5G63930

1 of 13

Yes

Atha\BAM3

1 of 13

Yes

Atha\BRI1

1 of 13

Yes

Atha\BRL1

1 of 13

Yes

Atha\BRL2

1 of 13

Yes

Atha\BRL3

1 of 13

Yes

Atha\ER

1 of 13

Yes

Atha\ERL1

1 of 13

Yes

Atha\FLS2

1 of 13

Yes

Atha\GHR1

1 of 13

Yes

Atha\GSO1

1 of 13

Yes

Atha\GSO2

1 of 13

Yes

Atha\HSL1

1 of 13

Yes

Atha\HSL2

1 of 13

Yes

Atha\LRR XI-23

1 of 13

Yes

Atha\PEPR1

1 of 13

Yes

Atha\PFI

1 of 13

Yes

Atha\PIRL2

1 of 13

Yes

Atha\RLP1

1 of 13

Yes

Atha\RLP7

1 of 13

Yes

Atha\RLP12

1 of 13

Yes

Atha\RLP15

1 of 13

Yes

Atha\RLP19

1 of 13

Yes

Atha\RLP24

1 of 13

Yes

Atha\RLP26

1 of 13

Yes

Atha\RLP32

1 of 13

Yes

Atha\RLP34

1 of 13

Yes

Atha\RLP35

1 of 13

Yes

Atha\RLP45

1 of 13

Yes

Atha\RLP52

1 of 13

Yes

Atha\RLP54

1 of 13

Yes

Atha\RLP55

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\CYR1

1 of 13

Yes

Scer\MEX67

1 of 13

Yes

Scer\NUD1

1 of 13

Yes

Scer\PAC2

1 of 13

Yes

Scer\SDS22

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\alp21

1 of 12

Yes

Spom\cdc11

1 of 12

Yes

Spom\cyr1

1 of 12

Yes

Spom\mex67

1 of 12

Yes

Escherichia coli (enterobacterium) (1)

Ecol\yddK

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:atk. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (69)

CG42346

3 of 13

conv

3 of 13

2mit

2 of 13

18w

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

chp

2 of 13

Con

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

dtr

1 of 13

Fili

1 of 13

fliI

1 of 13

haf

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

lbk

1 of 13

Lgr1

1 of 13

Lgr3

1 of 13

Lgr4

1 of 13

Lrt

1 of 13

ltl

1 of 13

Mapmodulin

1 of 13

mlt

1 of 13

MstProx

1 of 13

Phlpp

1 of 13

Ppr-Y

1 of 13

Pxn

1 of 13

rdo

1 of 13

sbr

1 of 13

scrib

1 of 13

sli

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

trn

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0036995

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47

Cytogenetic map

77C3-77C4

Sequence location

3L:20,454,690..20,464,862 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

77C3-77C4

Limits computationally determined from genome sequence between P{EP}trbl^EP3519 and P{EP}fng^EP3082&P{lacW}skd^L7062

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-47

(FlyBase, 2016)

3-43.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

44959

y¹ w^*; Mi{MIC}atk^MI08402

53211

y¹ w^*; Mi{MIC}atk^MI10012

20078

y¹ w^67c23; P{EPgy2}Uhg8^EY07139

64917

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05790}attP2

VDRC

v100110

P{KK103682}VIE-260B

v31044

w¹¹¹⁸; P{GD5536}v31044

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (55)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE27764

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0036995

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0036995

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Andrés et al., 2014)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: atk CG5195

(Andrés et al., 2014)

Nomenclature comments

Etymology

Named 'artichoke' because of the morphology of the lch5 organ in mutants.

(Andrés et al., 2014)

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

CG5195

(Ruland et al., 2018, Andrés et al., 2014, Ozkan et al., 2013, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Perkins et al., 2009, Roeder et al., 2009, Swanson et al., 2009, Laurençon et al., 2007, Betz and Darnell, 2006, Dierick and Greenspan, 2006)

CT16609

(Hynes and Zhao, 2000)

atk

(Adashev et al., 2022, Wang et al., 2021, Andrés et al., 2014)

tartan/capricious-like

(Hynes and Zhao, 2000)

Name Synonyms

Artichoke

(Li Zheng et al., 2020, Castillo et al., 2015)

artichoke

(Alvarado et al., 2020, Andrés et al., 2014)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 36 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40266

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VPF0

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VPF0

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VPF0

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40266/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036995

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036995

FlyMine - An integrated database for Drosophila genomics

FBgn0036995

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG5195

MARRVEL_MODEL - MARRVEL (model organism gene)

40266

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0036995

DroID - A comprehensive database of gene and protein interactions.

FBgn0036995

DRSC - Results frm RNAi screens

FBgn0036995

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

atk_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036995

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0036995

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5195

Flygut - An atlas of the Drosophila adult midgut

FBgn0036995

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC033174

References (42)

The following external sites may use different assemblies or annotations than FlyBase.

1.08

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