l(1)ts403, NXF1, NFX1, DmNXF1, nuclear export factor 1
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
Gene model reviewed during 6.19
The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus.
The C-terminal fragment, containing the TAP domain (also called UBA-like domain) and part of the NTF2-like domain, named the NPC-binding domain, mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for localization of NXF1 to the nuclear rim.
The RNA-binding domain is a non-canonical RNP-type domain.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sbr using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\sbr in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
Depletion of sbr in SL2 cells (using RNAi) inhibits cell growth and results in a rapid and robust accumulation of polyadenylated RNAs within the nucleus.
Neurons show pathfinding defects and body wall muscles have defective morphology in mutant embryos. Mutant adults have smaller and thinner bristles than normal with a reduced diameter.
Candidate gene for cyst length quantitative trait locus.
Most alleles homozygous and hemizygous lethal.