FlyBase Allele Report: Dmel\sbr[HM05135]

General Information

Symbol

Dmel\sbr^HM05135

Species

D. melanogaster

Name

FlyBase ID

FBal0240264

Feature type

allele

Associated gene

Dmel\sbr

Associated Insertion(s)

Carried in Construct

P{TRiP.HM05135}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HM05135}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HM05135

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^58.UAS.EGFP

(Freibaum et al., 2015)

exacerbates frontotemporal dementia

modeled by Zzzz\GGGGCC^58.UAS.EGFP

(Freibaum et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

short lived, with Scer\GAL4^Ugt36A1.PK

(Fu et al., 2017)

Phenotype Manifest In

adult pericardial cell, with Scer\GAL4^Ugt36A1.PK

(Fu et al., 2017)

Detailed Description

Statement

Reference

Adult flies expressing sbr^HM05135 under the control of Scer\GAL4^Dot.PK display nephrocyte functional defects (measured by uptake assays) and reduced adult lifespan relative to controls.

(Fu et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

sbr^HM05135/Scer\GAL4^GMR.PU is an enhancer of visible phenotype of Scer\GAL4^GMR.PU, Zzzz\GGGGCC^58.UAS.EGFP

(Freibaum et al., 2015)

Suppressor of

Statement

Reference

sbr^HM05135/Scer\GAL4^da.G32 is a suppressor of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^da.G32, Zzzz\GGGGCC^36.UAS

(Hautbergue et al., 2017)

sbr^HM05135/Scer\GAL4^nSyb.PS is a suppressor of abnormal locomotor behavior | third instar larval stage phenotype of Scer\GAL4^nSyb.PS, Zzzz\GGGGCC^36.UAS

(Hautbergue et al., 2017)

Phenotype Manifest In

Enhancer of

Statement

Reference

sbr^HM05135/Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\GGGGCC^58.UAS.EGFP

(Freibaum et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of sbr^HM05135 enhances the rough eye phenotype seen in flies expressing Zzzz\GGGGCC^{58.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.PU.

(Freibaum et al., 2015)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

28924

y¹ v¹; P{TRiP.HM05135}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sbr^HM05135

sbr^RNAi

(Kacsoh et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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