FlyBase Allele Report: Dmel\sbr[5]

General Information

Symbol

Dmel\sbr⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0015169

Feature type

allele

Associated gene

Dmel\sbr

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Zhimulev, 1982)

Progenitor genotype

Cytology

Description

Deletion of 492 nucleotides, resulting in removal of a portion of the NTF2-like domain.

(Golubkova et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:10,833,742..10,834,233 [-]

Comment:

A deletion which includes 5 bases of exon 8, 430 bases of exon 9 and all of the intervening intron.

(Golubkova et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Zhimulev et al., 1987)

lethal | heat sensitive (with sbr^ts148)

(Wilkie et al., 2001)

visible (with sbr¹)

(Korey et al., 2001)

Phenotype Manifest In

embryonic somatic muscle cell (with sbr^mgln)

(Korey et al., 2001)

larval intersegmental nerve

(Korey et al., 2001)

larval intersegmental nerve (with sbr^mgln)

(Korey et al., 2001)

macrochaeta (with sbr¹)

(Korey et al., 2001)

muscle cell of A1-7 ventral longitudinal muscle 3 (with sbr^mgln)

(Korey et al., 2001)

muscle cell of A1-7 ventral longitudinal muscle 4 (with sbr^mgln)

(Korey et al., 2001)

Detailed Description

Statement

Reference

sbr⁵/Y and sbr⁵/sbr^mgln embryos show pathfinding errors in the ISNb pathway. sbr⁵/sbr^mgln embryos show defects in muscle morphology (for example in muscles 6 and 7) at stage 16. sbr¹/sbr⁵ flies have smaller than normal and missing macrochaetae on the notum.

(Korey et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

sbr^ts148

(Wilkie et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Kotchneva.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

l(1)K4

(Pougatchova et al., 2002, Tretyakova et al., 2002, Golubkova et al., 2001, Mamon et al., 1999, Tretyakova and Mamon, 1998, Zhimulev, 1982)

sbr5

(Golubkova et al., 2005, Pougatchova et al., 2002)

sbr⁵

(Golubkova et al., 2009, Wilkie et al., 2001)

sbr^K4

(Zhimulev et al., 1987)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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