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General Information
Symbol
Dmel\sbr12
Species
D. melanogaster
Name
FlyBase ID
FBal0015176
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

sbr12 homozygotes are largely lethal but heterozygotes display normal viability relative to wild-type controls.

Mutant embryos show pathfinding errors in the ISNb pathway. sbr12/sbrmgln embryos show defects in muscle morphology (for example in muscles 6 and 7) at stage 16.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Suppressor of
Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

sbr12 does not suppress the degeneration seen in leg motor neuron clones expressing Hsap\TARDBPQ331K.Scer\UAS.cSa under the control of Scer\GAL4VGlut-OK371.

sbr12 heterozygotes expressing Zzzz\CGG60.Scer\UAS.T:Avic\GFP-EGFP driven by Scer\GAL4elav-C155 display reduced viability compared to controls. Neither of these manipulations alone causes any viability deficits.

Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

Eeken.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
References (12)