FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\tilB
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General Information
Symbol
Dmel\tilB
Species
D. melanogaster
Name
touch insensitive larva B
Annotation Symbol
CG14620
Feature Type
protein_coding_gene
FlyBase ID
FBgn0014395
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Summary
touch insensitive larva B (tilB) encodes a protein required for the assembly and/or transport to the cilium of axonemal dynein arms. tilB depletion results in deafness and male sterility because it specifically affects chordotonal neurons and spermatids, the only fly motile cilia cells. It interacts with the product of Zmynd10, which has a similar distribution and mutant phenotype. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
20C1-20C1
Sequence location
Recombination map
1-66
RefSeq locus
NC_004354 REGION:22449737..22451463
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in axoneme assembly
inferred from mutant phenotype
(Kavlie et al., 2010)
involved_in cilium-dependent cell motility
inferred from mutant phenotype
(Kavlie et al., 2010)
involved_in male courtship behavior, veined wing generated song production
inferred from mutant phenotype
(Tauber and Eberl, 2001)
involved_in sensory perception of sound
inferred from mutant phenotype
(Kavlie et al., 2010, Gopfert and Robert, 2003, Eberl et al., 2000)
involved_in temperature compensation of the circadian clock
inferred from mutant phenotype
(Sehadova et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in outer dynein arm assembly
inferred from biological aspect of ancestor with PANTHER:PTN007663798
(GO Reference Genome Project, 2011-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Kavlie et al., 2010)
located_in dendrite
inferred from direct assay
(Kavlie et al., 2010)
located_in motile cilium
inferred from direct assay
(Kavlie et al., 2010)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN007663797
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the tilB family. (Q9VR52)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
touch insensitive larva B (tilB) encodes a protein required for the assembly and/or transport to the cilium of axonemal dynein arms. tilB depletion results in deafness and male sterility because it specifically affects chordotonal neurons and spermatids, the only fly motile cilia cells. It interacts with the product of Zmynd10, which has a similar distribution and mutant phenotype. [Date last reviewed: 2019-03-14]
Protein Function (UniProtKB)
Cilium-specific protein required for cilia structures in Johnston's sensory organ. Plays a role in motility of cilia and flagella.
(UniProt, Q9VR52)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\tilB for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VR52)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.49

Supported by strand-specific RNA-Seq data.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
tilB-RA
FBtr0077345
NM_134616
1358
395
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
tilB-PA
FBpp0077037
45.6
395
6.33
Q9VR52
NP_608460
AAF50954
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tilB using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.32

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 15
chordotonal organ precursor cell
(Newton et al., 2012)
mutational analysis
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
chordotonal neuron
(Zur Lage et al., 2019)
adult stage | male
spermatogonium

Comment: data from FlyAtlas

(Zur Lage et al., 2019)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Kavlie et al., 2010)
adult stage | male
testis
(Kavlie et al., 2010)
Additional Descriptive Data

As part of a survey of ciliary motility gene homologs in Drosophila, expression of tilB was assayed in motile ciliated cell types. Expression was observed in both chordotonal neurons and testis (sperm).

(Zur Lage et al., 2019)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Kavlie et al., 2010)
located_in dendrite
inferred from direct assay
(Kavlie et al., 2010)
located_in motile cilium
inferred from direct assay
(Kavlie et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\tilB in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of tilB
Transgenic constructs containing regulatory region of tilB
Aberrations (Deficiencies and Duplications) ( 21 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (34)
Hsap\DNAAF11
14 of 14
Yes
Yes
Hsap\LRRC23
3 of 14
No
Yes
Hsap\PPP1R7
3 of 14
No
No
Hsap\CEP97
2 of 14
No
No
Hsap\CNTRL
2 of 14
No
Yes
Hsap\DNAAF1
2 of 14
No
No
Hsap\DNAL1
2 of 14
No
No
1  
Hsap\DRC3
2 of 14
No
No
Hsap\LRGUK
2 of 14
No
No
Hsap\LRRC9
2 of 14
No
No
Hsap\LRRC46
2 of 14
No
No
Hsap\LRRC49
2 of 14
No
No
Hsap\LRRC56
2 of 14
No
No
Hsap\LRRC61
2 of 14
No
Yes
Hsap\LRRCC1
2 of 14
No
No
Hsap\LRRIQ3
2 of 14
No
Yes
Hsap\ANP32A
1 of 14
No
No
Hsap\ANP32B
1 of 14
No
No
Hsap\ANP32C
1 of 14
No
No
Hsap\ANP32D
1 of 14
No
No
Hsap\ANP32E
1 of 14
No
No
Hsap\CEP72
1 of 14
No
Yes
Hsap\CFAP410
1 of 14
No
No
Hsap\LGR6
1 of 14
No
No
1  
Hsap\LRMDA
1 of 14
No
No
Hsap\LRRC36
1 of 14
No
Yes
Hsap\LRRC43
1 of 14
No
No
Hsap\LRRC72
1 of 14
No
No
Hsap\LRRIQ1
1 of 14
No
Yes
Hsap\LUM
1 of 14
No
No
Hsap\NISCH
1 of 14
No
No
Hsap\SNRPA1
1 of 14
No
No
2  
Hsap\TBCEL
1 of 14
No
No
Hsap\TLR3
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (31)
Rnor\Dnaaf11
12 of 14
Yes
Yes
Rnor\Lrrc23
3 of 14
No
Yes
Rnor\Cep97
2 of 14
No
No
Rnor\Cntrl
2 of 14
No
Yes
Rnor\Dnal1
2 of 14
No
No
Rnor\Drc3
2 of 14
No
No
Rnor\Lrguk
2 of 14
No
No
Rnor\Lrrc46
2 of 14
No
No
Rnor\Lrrc49
2 of 14
No
No
Rnor\Lrrc56
2 of 14
No
No
Rnor\Lrrc61
2 of 14
No
No
Rnor\Lrrcc1
2 of 14
No
No
Rnor\Lrriq3
2 of 14
No
Yes
Rnor\Ppp1r7
2 of 14
No
No
Rnor\Anp32a
1 of 14
No
No
Rnor\Anp32b
1 of 14
No
No
Rnor\Anp32e
1 of 14
No
No
Rnor\Cep72
1 of 14
No
Yes
Rnor\Cfap410
1 of 14
No
No
Rnor\Dnaaf1
1 of 14
No
No
Rnor\Lgr6
1 of 14
No
No
Rnor\Lrrc9
1 of 14
No
No
Rnor\Lrrc43
1 of 14
No
No
Rnor\Lrrc51
1 of 14
No
No
Rnor\Lum
1 of 14
No
Yes
Rnor\Nisch
1 of 14
No
No
Rnor\Slitrk5
1 of 14
No
Yes
Rnor\Snrpa1
1 of 14
No
No
Rnor\Tbcel
1 of 14
No
No
Rnor\Tlr8
1 of 14
No
No
Rnor\Tlr13
1 of 14
No
No
Mus musculus (laboratory mouse) (33)
Mmus\Lrrc6
13 of 14
Yes
Yes
Mmus\Lrrc23
3 of 14
No
Yes
Mmus\Ppp1r7
3 of 14
No
No
Mmus\Cep97
2 of 14
No
No
Mmus\Cntrl
2 of 14
No
Yes
Mmus\Dnal1
2 of 14
No
No
Mmus\Drc3
2 of 14
No
No
Mmus\Lrguk
2 of 14
No
No
Mmus\Lrrc9
2 of 14
No
No
Mmus\Lrrc46
2 of 14
No
No
Mmus\Lrrc49
2 of 14
No
No
Mmus\Lrrc56
2 of 14
No
No
Mmus\Lrrc61
2 of 14
No
No
Mmus\Lrrcc1
2 of 14
No
Yes
Mmus\Lrriq1
2 of 14
No
No
Mmus\Lrriq3
2 of 14
No
Yes
Mmus\Anp32a
1 of 14
No
No
Mmus\Anp32b
1 of 14
No
No
Mmus\Anp32e
1 of 14
No
No
Mmus\Anp32-ps
1 of 14
No
No
Mmus\Cep72
1 of 14
No
Yes
Mmus\Cfap410
1 of 14
No
No
Mmus\Dnaaf1
1 of 14
No
No
Mmus\Lgr6
1 of 14
No
No
Mmus\Lrmda
1 of 14
No
No
Mmus\Lrrc36
1 of 14
No
Yes
Mmus\Lrrc43
1 of 14
No
No
Mmus\Lrrc51
1 of 14
No
No
Mmus\Lrrc72
1 of 14
No
No
Mmus\Lum
1 of 14
No
No
Mmus\Nisch
1 of 14
No
No
Mmus\Slitrk5
1 of 14
No
Yes
Mmus\Snrpa1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (26)
Xtro\dnaaf11
11 of 13
Yes
Yes
Xtro\lrrc23
2 of 13
No
Yes
Xtro\mnat1
2 of 13
No
No
Xtro\ppp1r7
2 of 13
No
No
Xtro\anp32a
1 of 13
No
No
Xtro\anp32b
1 of 13
No
No
Xtro\atp9a
1 of 13
No
No
Xtro\cep97
1 of 13
No
No
Xtro\cfap410
1 of 13
No
No
Xtro\cntrl
1 of 13
No
No
Xtro\cyb561d1
1 of 13
No
No
Xtro\dnaaf1
1 of 13
No
No
Xtro\dnal1
1 of 13
No
No
Xtro\drc3
1 of 13
No
No
Xtro\fam124b
1 of 13
No
No
Xtro\lamb2
1 of 13
No
No
Xtro\lgr5
1 of 13
No
No
Xtro\lrrc9
1 of 13
No
Yes
Xtro\lrrc56
1 of 13
No
No
Xtro\lrriq1
1 of 13
No
Yes
Xtro\lrriq3
1 of 13
No
Yes
Xtro\lrtomt
1 of 13
No
No
Xtro\snrpa1
1 of 13
No
No
Xtro\stk11ip
1 of 13
No
No
Xtro\sycp2l
1 of 13
No
No
Xtro\tbcel
1 of 13
No
No
Danio rerio (Zebrafish) (23)
Drer\dnaaf11
14 of 14
Yes
Yes
Drer\lrrc23
3 of 14
No
Yes
Drer\ppp1r7
3 of 14
No
No
Drer\dnal1
2 of 14
No
No
Drer\drc3
2 of 14
No
No
Drer\lrguk
2 of 14
No
No
Drer\lrrc61
2 of 14
No
No
Drer\lrrcc1
2 of 14
No
Yes
Drer\lrriq1
2 of 14
No
Yes
Drer\anp32a
1 of 14
No
No
Drer\anp32b
1 of 14
No
No
Drer\anp32e
1 of 14
No
No
Drer\cep72
1 of 14
No
Yes
Drer\cep97
1 of 14
No
No
Drer\cfap410
1 of 14
No
No
Drer\dnaaf1
1 of 14
No
No
Drer\LOC100331330
1 of 14
No
No
Drer\lrmda
1 of 14
No
No
Drer\lrrc51
1 of 14
No
No
Drer\lrrc56
1 of 14
No
No
Drer\si:ch211-237i5.4
1 of 14
No
No
Drer\si:dkey-267j14.7
1 of 14
No
Yes
Drer\snrpa1
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\C06A8.6
3 of 14
Yes
No
Cele\K10D2.8
3 of 14
Yes
No
Cele\sds-22
3 of 14
Yes
No
Cele\T05H4.3
2 of 14
No
No
Cele\F09G8.5
1 of 14
No
No
Cele\F33H2.3
1 of 14
No
No
Cele\mog-2
1 of 14
No
No
Cele\R02F11.4
1 of 14
No
No
Cele\T19H12.2
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (21)
Agam\AgaP_AGAP008927
12 of 12
Yes
Yes
Agam\AgaP_AGAP009839
3 of 12
No
No
Agam\AgaP_AGAP002013
2 of 12
No
No
Agam\AgaP_AGAP004416
2 of 12
No
No
Agam\AgaP_AGAP008526
2 of 12
No
No
Agam\AgaP_AGAP010129
2 of 12
No
No
Agam\AgaP_AGAP010180
2 of 12
No
No
Agam\AgaP_AGAP011969
2 of 12
No
No
Agam\AgaP_AGAP001422
1 of 12
No
No
Agam\AgaP_AGAP002792
1 of 12
No
No
Agam\AgaP_AGAP004832
1 of 12
No
No
Agam\AgaP_AGAP005075
1 of 12
No
No
Agam\AgaP_AGAP005693
1 of 12
No
No
Agam\AgaP_AGAP005870
1 of 12
No
No
Agam\AgaP_AGAP007457
1 of 12
No
Yes
Agam\AgaP_AGAP007552
1 of 12
No
No
Agam\AgaP_AGAP007670
1 of 12
No
No
Agam\AgaP_AGAP008815
1 of 12
No
No
Agam\AgaP_AGAP011394
1 of 12
No
No
Agam\AgaP_AGAP011947
1 of 12
No
No
Agam\LRC50_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (12)
Atha\AT5G19680
3 of 13
Yes
No
Atha\AT5G22320
3 of 13
Yes
No
Atha\AIR9
2 of 13
No
Yes
Atha\AT1G78230
2 of 13
No
No
Atha\AT4G03260
2 of 13
No
No
Atha\AT1G48540
1 of 13
No
No
Atha\AT2G27060
1 of 13
No
Yes
Atha\AT3G17920
1 of 13
No
No
Atha\AT3G50690
1 of 13
No
No
Atha\AT4G34280
1 of 13
No
Yes
Atha\RLP1
1 of 13
No
No
Atha\U2A'
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\SDS22
2 of 13
Yes
No
Scer\LEA1
1 of 13
No
No
Scer\NUD1
1 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\sds22
3 of 12
Yes
No
Spom\cdc11
1 of 12
No
No
Spom\lea1
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:tilB. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (21)
CG13708
3 of 13
sds22
3 of 13
TbCMF46
3 of 13
Cep97
2 of 13
CG10839
2 of 13
CG14185
2 of 13
dtr
2 of 13
ODA-Dnal1
2 of 13
Ppr-Y
2 of 13
CG9044
1 of 13
CG14995
1 of 13
CG15208
1 of 13
CG31076
1 of 13
CG31274
1 of 13
dom
1 of 13
f-cup
1 of 13
Mapmodulin
1 of 13
MESK4
1 of 13
rk
1 of 13
sbr
1 of 13
U2A
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    DNAAF11; dynein axonemal assembly factor 11
    14 of 14
    614930
    LRRC23; leucine rich repeat containing 23
    3 of 14
    620708
    PPP1R7; protein phosphatase 1 regulatory subunit 7
    3 of 14
    602877
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        Summary of Genetic Interactions
        Interaction Browsers
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        X
        Recombination map
        1-66
        Cytogenetic map
        20C1-20C1
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        20C1-20C1
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        1-66

        (FlyBase, 2016)

        1-66.3

        (Comeron et al., 2012)

        1-

        (Kernan et al., 1995)
        Left of (cM)
        Right of (cM)
        Notes

        Maps between flam and wap.

        (Kavlie et al., 2003)
        Stocks and Reagents
        Stocks (4)
        Genomic Clones (14)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (3)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              Isolated in a screen for seminal fluid proteins.

              (Mueller et al., 2004)

              Sperm from tilB mutants are non-motile and arrested at the last stage of maturation. The nine-fold radial symmetry of the sperm flagella is disrupted.

              (Kernan et al., 1995)
              Relationship to Other Genes
              Source for database merge of

              Source for merge of: tilB CG14620

              (Kavlie et al., 2005)
              Additional comments
              Nomenclature History
              Source for database identify of
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (6)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 31 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              References (60)