FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sbr10
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General Information
Symbol
Dmel\sbr10
Species
D. melanogaster
Name
FlyBase ID
FBal0015174
Feature type
allele
Associated gene
Dmel\sbr
Associated Insertion(s)
Carried in Construct
Also Known As
l(1)ts403
Key Links
Genomic Maps

Allele class

heat sensitive gain of function allele

Mutagen
    Nature of the Allele
    Allele class

    heat sensitive gain of function allele

    (Nikitina et al., 2003)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide substitution: C416T. Nucleotide substitution: A1477T. Nucleotide substitution: G1497T. Amino acid replacement: P139L. Amino acid replacement: T493S. Amino acid replacement: M499I.

    (Korey et al., 2001)

    Amino acid replacement: P139L.

    (Wilkie et al., 2001)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    X:10,837,150..10,837,150 [-]
    Nucleotide change:

    C10837150T

    Reported nucleotide change:

    C416T

    Amino acid change:

    P139L | sbr-PA; P3L | sbr-PB; P3L | sbr-PC

    Reported amino acid change:

    P139L

    Comment:

    In addition to the Pro to Leu change at residue 139, two conservative amino acid changes are observed in the sbr10 mutant.

    (Korey et al., 2001)
    point_mutation
    X:10,834,117..10,834,117 [-]
    Nucleotide change:

    A10834117T

    Reported nucleotide change:

    A1477T

    Amino acid change:

    T493S | sbr-PA; T357S | sbr-PB; T357S | sbr-PC

    Reported amino acid change:

    T493S

    Comment:

    One of two conservative amino acid changes observed in the sbr10 mutant in addition to the Pro to Leu change at residue 139.

    (Korey et al., 2001)
    point_mutation
    X:10,834,097..10,834,097 [-]
    Nucleotide change:

    G10834097T

    Reported nucleotide change:

    G1497T

    Amino acid change:

    M499I | sbr-PA; M363I | sbr-PB; M363I | sbr-PC

    Reported amino acid change:

    M499I

    Comment:

    One of two conservative amino acid changes observed in the sbr10 mutant in addition to the Pro to Leu change at residue 139.

    (Korey et al., 2001)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In

        meiosis & nuclear chromosome

        (Tret'iakova et al., 2001)
        Detailed Description
        Statement
        Reference

        Flies subjected to heat shocks have high learning indices immediately and 30 minutes after training, indicating normal learning and memory acquisition in the mutant flies. Memory retention 3 hours after training is impaired.

        (Nikitina et al., 2003)

        Mutant females exposed to 37oC for 1 hour show a high frequency of nondisjunction and loss of sex chromosomes in meiosis. This phenotype shows incomplete dominance. Homozygous females exposed to 37oC for 1 hour show reduced viability and low fertility.

        (Nikitina et al., 2003)

        Heat treated females show a high frequency of meiotic sex-chromosome nondisjunction.

        (Tret'iakova et al., 2001)

        Under normal conditions, juvenile hormone (JH)-hydrolysing activity in 1 or 6 day old mutant females does not differ from wild type. Mutant and wild-type females exposed to 38oC show a significant decrease in JH-hydrolysing activity compared to control females at 25oC. 1 day old mutant females have lower levels of stress reactivity (calculated as the percent decrease in JH-hydrolysing activity at 38oC relative to normal conditions) than control females. 6 day old mutant females have significantly higher levels of stress reactivity than control females.

        (Gruntenko et al., 2000)

        Mutation shows no maternal effect. Mutation affects early embryonic thermosensitivity.

        (Mamon et al., 1999)

        Heat shock of 37oC for 1 hour during oogenesis stages 6-14 causes a high frequency of chromosome loss and non-disjunction. Successive action of anoxia and heat shock decreased the frequency of chromosome loss and non-disjunction.

        (Mamon et al., 1992)

        Lethal at 29oC, semi-lethal at 25oC, escapers have a small body.

        (Zhimulev, 1982)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to complement

        sbrts148

        (Wilkie et al., 2001)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        After heat shock, mutant cells lack Hsp83 and Hsp35 expression, and also lack expression of some of the Hsp70 genes. A 72kD heat shock cognate protein which is not usually induced by high temperatures is intensively synthesised in mutant cells after heat shock.

        (Evgen'ev and Denisenko, 1990)

        The dynamics of heat-shock puff activity and cell nuclei electrophoretic mobility in sbr10 larval salivary glands after heat shock have been studied.

        (Strashnyuk et al., 1990)

        There is a delay in reaching the maximum level of heat shock protein synthesis and a more prolonged synthesis of these proteins after heat shock compared to wild-type.

        (Mamon and Kutskova, 1993)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        References (30)