FlyBase Gene Report: Dmel\fliI

General Information

Symbol

Dmel\fliI

Species

D. melanogaster

Name

flightless I

Annotation Symbol

CG1484

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000709

Gene Model Status

Current

Stock Availability

15 publicly available

Gene Summary

May play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. Alternatively, it may play a structural role in indirect flight muscle. Vital for embryonic development. (UniProt, Q24020)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
UniProtKB
Red Book
Interactive Fly

Also Known As

fli, flightless, W2, fltO, l(1)W-2

Key Links

Genomic Location

Cytogenetic map

19F5-19F5

Sequence location

X:21,339,741..21,345,088 [+]

Recombination map

1-65

RefSeq locus

NC_004354 REGION:21339741..21345088

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables actin binding

inferred from sequence or structural similarity with FLYBASE:Gel; FB:FBgn0010225

(Campbell et al., 1993)

inferred from sequence or structural similarity with UniProtKB:P09327

(Campbell et al., 1993)

enables actin filament binding

inferred from electronic annotation with InterPro:IPR007122

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN002633351

(GO Reference Genome Project, 2011-)

enables calcium ion binding

inferred from sequence or structural similarity with UniProtKB:P06396

(Campbell et al., 1993)

inferred from sequence or structural similarity with UniProtKB:P09327

(Campbell et al., 1993)

enables phosphatidylinositol-4,5-bisphosphate binding

inferred from biological aspect of ancestor with PANTHER:PTN000240164

(GO Reference Genome Project, 2011-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in adult somatic muscle development

inferred from mutant phenotype

(Schnorrer et al., 2010)

involved_in gastrulation involving germ band extension

inferred from mutant phenotype

(Perrimon et al., 1989)

involved_in myofibril assembly

inferred from mutant phenotype

(Gajewski et al., 2006)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in actin filament severing

inferred from biological aspect of ancestor with PANTHER:PTN000240164

(GO Reference Genome Project, 2011-)

involved_in actin polymerization or depolymerization

inferred from biological aspect of ancestor with PANTHER:PTN008531885

(GO Reference Genome Project, 2011-)

involved_in barbed-end actin filament capping

inferred from biological aspect of ancestor with PANTHER:PTN000240164

(GO Reference Genome Project, 2011-)

involved_in myofibril assembly

inferred from biological aspect of ancestor with PANTHER:PTN000944520

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

is_active_in Z disc

inferred from direct assay

(Deng et al., 2021)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in actin cytoskeleton

inferred from biological aspect of ancestor with PANTHER:PTN002633351

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000944520

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the villin/gelsolin family. (Q24020)

Protein Signatures (InterPro)

Summaries

Protein Function (UniProtKB)

(UniProt, Q24020)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

fliI

Both viable and lethal alleles isolated. Viable alleles are recessive and flightless; wing position normal; jumping abilities variously impaired depending on allele. Temperature-sensitive alleles show temperature-sensitive period to be during first half of pupal stage. Rearing fliI1 and fliI2 at 17 leads to weak flight and at 22 to flightlessness. Indirect-flight-muscle fibers wavy with amorphous internal structures; myofilaments disorganized; z bands and myofibrils abnormal; thin filaments often aggregated into bundles with striations (not seen in wild type). Mosaic analysis with fliI5 suggests primary defect in thoracic muscles (Koana and Hotta, 1978, J. Embryol. Exp. Morphol. 45: 123-43). Trans heterozygotes with sdby are flightless. Lethal alleles die in larval or pupal stages. Maternal effect lethal; progeny produced from homozygous female germline clones of severe alleles (e.g., fliI14) are not rescuable by normal allele of paternal origin; abnormal folding during gastrulation; mesoderm invagination abnormal; only patches of epidermis present at later stages; embryos from clones homozygous for weaker alleles (e.g. fliI22) were more nearly normal in appearance.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\fliI for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q24020)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

fliI-RA

FBtr0077192

NM_080358

4827

1256

Additional Transcript Data and Comments

Reported size (kB)

5.1 (northern blot)

(de Couet et al., 1995)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

fliI-PA

FBpp0076893

143.7

1256

5.56

Q24020

NP_525097

AAF50830

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

1256 (aa)

(Maleszka et al., 1998, de Couet et al., 1995)

1256 (aa); 144 (kD predicted)

(Campbell et al., 1993)

Comments

External Data

Domain

Consists of a leucine-rich N-terminal half, which is likely to be involved in protein-protein interaction, and a C-terminal half which has high sequence similarity to gelsolin and is therefore likely to be involved in actin-binding.

(UniProt, Q24020)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q24020

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fliI using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

fliI_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.77

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Maleszka et al., 1998, de Couet et al., 1995)

Additional Descriptive Data

fliI transcripts are detected in embryos, larvae, pupae, and adults on northern blots.

(Maleszka et al., 1998)

fliI transcripts are present at all developmental stages with the highest abundance in adults.

(de Couet et al., 1995)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 5

furrow canal

(Davy et al., 2000)

day 1 of adulthood

indirect flight muscle cell

• Z disc

(Deng et al., 2021)

day 3 of adulthood

indirect flight muscle cell

• Z disc

(Deng et al., 2021)

day 5 of adulthood

indirect flight muscle cell

• Z disc

(Deng et al., 2021)

day 7 of adulthood

indirect flight muscle cell

• Z disc

(Deng et al., 2021)

Additional Descriptive Data

fliI protein localizes to indirect flight muscle sarcomere Z discs at day 1, day 3, day 5, and day 7 after eclosion.

(Deng et al., 2021)

fliI protein localizes to cellularization structures in cellularizing blastoderms.

(Davy et al., 2000)

Marker for

Subcellular Localization

CV Term

Evidence

References

is_active_in Z disc

inferred from direct assay

(Deng et al., 2021)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\fliI in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\fliI

View exonic expression by tissue for Dmel\fliI

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000709

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33110/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000709

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000709

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000709

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1484

Flygut - An atlas of the Drosophila adult midgut

FBgn0000709

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 30 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of fliI

Transgenic constructs containing regulatory region of fliI

Aberrations (Deficiencies and Duplications) ( 163 )

Inferred from experimentation ( 163 )

Gene disrupted in

Df(1)2/19B

(Miklos and de Couet, 1990, Perrimon et al., 1989)

Df(1)14-11

(Munoz, 2003.12.10)

Df(1)16-1-88

(Munoz, 2004.1.5)

Df(1)16-3-22

(Miklos et al., 1987)

(Munoz, 2004.1.5)

(Munoz, 2004.1.5)

(Munoz, 2004.1.5)

(Munoz, 2004.1.5)

(Maleszka et al., 1996, de Couet et al., 1995, Campbell et al., 1993, Hayward et al., 1993, Russell et al., 1992, Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987, Eeken et al., 1985, Schalet and Lefevre, 1973)

Df(1)17-241

(Munoz, 2003.12.10)

Df(1)17-244

(Munoz, 2004.1.5)

Df(1)17-257

(Maleszka et al., 1996, de Couet et al., 1995, Campbell et al., 1993, Russell et al., 1992, Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987, Schalet and Lefevre, 1973)

Df(1)17-322

(Munoz, 2004.1.5)

Df(1)17-351

(Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987)

Df(1)17-489

(Perrimon et al., 1989, Miklos et al., 1987)

Df(1)18-36

(Munoz, 2004.1.5)

Df(1)18-80

(Munoz, 2004.1.5, Miklos and de Couet, 1990, Schalet and Lefevre, 1973)

Df(1)19-2

(Munoz, 2004.1.5)

Df(1)19-18

(Munoz, 2004.1.5, Munoz, 2003.12.10)

Df(1)26B

(Perrimon et al., 1989)

Df(1)54

(Schalet and Lefevre, 1973)

Df(1)156

(Paradi et al., 1983)

Df(1)217

(Paradi et al., 1983)

Df(1)218

(Paradi et al., 1983)

Df(1)A53

(Perrimon et al., 1989)

Df(1)B12

(Lifschytz and Yakobovitz, 1978, Lifschytz and Falk, 1969)

Df(1)B82

(Lifschytz and Falk, 1969)

Df(1)BSC588

(Cook et al., 2008.9.3)

Df(1)BSC708

(Christensen et al., 2008.12.28)

Df(1)C74

(Miklos and de Couet, 1990, Perrimon et al., 1989)

Df(1)D5

(Eeken et al., 1985)

Df(1)D43L1

(Kramers et al., 1991, Perrimon et al., 1989, Eeken et al., 1985, Kramers et al., 1983, Paradi et al., 1983, Schalet and Finnerty, 1968)

Df(1)DCB1-35b

(Perrimon et al., 1989, Deak et al., 1982)

Df(1)DCB1-35c

(Schalet and Finnerty, 1968)

Df(1)GA33

(Perrimon et al., 1989)

Df(1)GA37

(Perrimon et al., 1989)

Df(1)GA40

(Perrimon et al., 1989)

Df(1)GA104

(Maleszka et al., 1996, de Couet et al., 1995, Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987)

Df(1)GE263

(de Couet et al., 1995, Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987)

Df(1)HM44

(Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987, Miklos et al., 1986, Kramers et al., 1983)

Df(1)HM45

(Kramers et al., 1983)

Df(1)HM49

(Kramers et al., 1983)

Df(1)HM50

(Kramers et al., 1983)

Df(1)LB6

(Perrimon et al., 1989)

Df(1)LB7

(Perrimon et al., 1989)

Df(1)LB23

(Perrimon et al., 1989)

Df(1)mal3

(Kramers et al., 1991, Kramers et al., 1983, Chovnick et al., 1969)

Df(1)mal4

(Chovnick et al., 1969)

Df(1)mal6

(Kramers et al., 1991, Kramers et al., 1983, Paradi et al., 1983, Chovnick et al., 1969, Schalet and Finnerty, 1968)

Df(1)mal7

(Chovnick et al., 1969, Schalet and Finnerty, 1968)

Df(1)mal9

(Chovnick et al., 1969)

Df(1)mal12

(Paradi et al., 1983, Chovnick et al., 1969)

Df(1)mal13

(Chovnick et al., 1969, Schalet and Finnerty, 1968)

Df(1)n17-8

(Munoz, 2004.1.5)

Df(1)N77

(Perrimon et al., 1989)

Df(1)Q38

(Lifschytz and Falk, 1969)

Df(1)Q219

(Lifschytz and Falk, 1969)

Df(1)Q408

(Lifschytz and Falk, 1969)

Df(1)Q539

(Kramers et al., 1991, Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987, Kramers et al., 1983, Paradi et al., 1983, Lifschytz and Falk, 1969)

Df(1)R-9-1

(Lifschytz and Falk, 1969)

Df(1)R-10-5

(Lifschytz and Falk, 1969)

Df(1)S54

(de Couet et al., 1995, Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987)

Df(1)su(f)7085

(Lifschytz and Yakobovitz, 1978)

Df(1)su(f)9122

(Lifschytz and Yakobovitz, 1978)

Df(1)T100

(Paradi et al., 1983)

Df(1)T101

(Paradi et al., 1983)

Df(1)T103

(Paradi et al., 1983)

Df(1)T106

(Paradi et al., 1983)

Df(1)T107

(Paradi et al., 1983)

Df(1)T113

(Paradi et al., 1983)

Df(1)T114

(Paradi et al., 1983)

Df(1)T122

(Paradi et al., 1983)

Df(1)T123

(Paradi et al., 1983)

Df(1)T124

(Paradi et al., 1983)

Df(1)T130

(Paradi et al., 1983)

Df(1)T138

(Paradi et al., 1983)

Df(1)wl-2

(Lifschytz and Falk, 1969)

Df(1)yl-1

(Lifschytz and Falk, 1969)

Dp(1;Y)y⁺mal¹⁰⁷

(Chovnick et al., 1969)

Dp(1;Y)y⁺mal¹¹⁸

(Chovnick et al., 1969)

Dp(1;Y)y⁺mal¹²⁶

(Chovnick et al., 1969)

Gene not disrupted in

Df(1)2/19B

(Maleszka et al., 1996, de Couet et al., 1995, Hayward et al., 1993)

Df(1)16-2-13

(Miklos et al., 1987)

Df(1)16-3-35

(Kramers et al., 1991, Perrimon et al., 1989, Miklos et al., 1987, Eeken et al., 1985, Kramers et al., 1983, Paradi et al., 1983)

Df(1)16-3-53

(Munoz, 2004.1.5)

Df(1)17-137

(Kramers et al., 1991)

(Munoz, 2004.1.5)

(Munoz, 2004.1.5)

(Munoz, 2004.1.5)

(Munoz, 2004.1.5)

(Paradi et al., 1983)

Df(1)127

(Paradi et al., 1983)

Df(1)136

(Paradi et al., 1983)

Df(1)167

(Paradi et al., 1983)

Df(1)208

(Paradi et al., 1983)

Df(1)216

(Paradi et al., 1983)

Df(1)228

(Paradi et al., 1983)

Df(1)A19

(Lifschytz and Falk, 1969)

Df(1)A33

(Lifschytz and Falk, 1969)

Df(1)A58

(Lifschytz and Falk, 1969)

Df(1)A118

(Kramers et al., 1991, Perrimon et al., 1989, Miklos et al., 1987, Eeken et al., 1985, Kramers et al., 1983, Paradi et al., 1983, Lifschytz and Yakobovitz, 1978, Lifschytz and Falk, 1969)

Df(1)A122

(Lifschytz and Falk, 1969)

Df(1)A209

(Lifschytz and Falk, 1969)

Df(1)B56

(Lifschytz and Falk, 1969)

Df(1)B57

(de Couet et al., 1995, Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987, Lifschytz and Yakobovitz, 1978, Lifschytz and Falk, 1969)

Df(1)B111

(Lifschytz and Falk, 1969)

Df(1)B155

(Lifschytz and Falk, 1969)

Df(1)B214

(Lifschytz and Falk, 1969)

Df(1)B264

(Lifschytz and Falk, 1969)

Df(1)DCB1-35c

(Miklos et al., 1987)

Df(1)EA113

(Miklos et al., 1987)

Df(1)GA22

(Miklos et al., 1987)

Df(1)GA131

(Miklos et al., 1987)

Df(1)HC279

(Perrimon et al., 1989)

Df(1)HF359

(Miklos et al., 1987)

Df(1)HM5

(Kramers et al., 1983)

Df(1)HM8

(Kramers et al., 1983)

Df(1)HM47

(Kramers et al., 1983)

Df(1)HM418

(Kramers et al., 1983)

Df(1)HM422

(Kramers et al., 1983)

Df(1)HM444

(Kramers et al., 1983)

Df(1)HM455

(Kramers et al., 1983)

Df(1)JA21

(Miklos et al., 1987)

Df(1)JA117

(Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987)

Df(1)JC4

(de Couet et al., 1995, Miklos and de Couet, 1990, Miklos et al., 1987)

Df(1)JC77

(Hayward et al., 1993, Miklos and de Couet, 1990, Perrimon et al., 1989, Miklos et al., 1987)

Df(1)M31

(Lifschytz and Yakobovitz, 1978)

Df(1)M158

(Lifschytz and Yakobovitz, 1978)

Df(1)M171

(Lifschytz and Yakobovitz, 1978)

Df(1)M176

(Lifschytz and Yakobovitz, 1978)

Df(1)mal5

(Chovnick et al., 1969)

Df(1)mal8

(Kramers et al., 1991, Paradi et al., 1983, Chovnick et al., 1969, Schalet and Finnerty, 1968)

Df(1)mal10

(Perrimon et al., 1989, Paradi et al., 1983, Chovnick et al., 1969, Schalet and Finnerty, 1968)

Df(1)mal11

(Chovnick et al., 1969)

Df(1)mal17

(Perrimon et al., 1989, Chovnick et al., 1969)

Df(1)run1112

(Perrimon et al., 1989)

Df(1)Sp20A-F

(Schalet, 1986)

Df(1)su(f)4B

(Kramers et al., 1991, Kramers et al., 1983)

Df(1)su(f)724

(Lifschytz and Yakobovitz, 1978)

Df(1)su(f)733

(Lifschytz and Yakobovitz, 1978)

Df(1)su(f)754

(Lifschytz and Yakobovitz, 1978)

Df(1)su(f)795

(Lifschytz and Yakobovitz, 1978)

Df(1)su(f)7009

(Lifschytz and Yakobovitz, 1978)

Df(1)T2-14A

(Perrimon et al., 1989, Miklos et al., 1987)

Df(1)T105

(Paradi et al., 1983)

Df(1)T110

(Paradi et al., 1983)

Df(1)T136

(Paradi et al., 1983)

Df(1)T137

(Paradi et al., 1983)

Df(1)X-1

(Lifschytz and Falk, 1969)

Df(1)y-X15

(Kramers et al., 1991)

Dp(1;Y)y⁺mal¹⁰⁸

(Chovnick et al., 1969)

Dp(1;Y)y⁺mal¹¹³

(Chovnick et al., 1969)

Dp(1;Y)y⁺mal¹²⁶

(Lifschytz and Yakobovitz, 1978)

Gene not duplicated in

Dp(1;Y)Bar^S

(Kramers et al., 1991)

Dp(1;Y)y²67g19.1

(Eeken et al., 1985)

Dp(1;Y)y⁺mal¹²⁶

(Kramers et al., 1991, Miklos and de Couet, 1990, Kramers et al., 1983)

Inferred from location ( 22 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | adult stage

fliI²¹

lethal | germline clone | maternal effect

lethal | germline clone | maternal effect | recessive

lethal | larval stage

fliI¹⁴

lethal | larval stage | recessive

fliI¹⁰

lethal | maternal effect

fliI²²

lethal | non-rescuable maternal effect

fliI¹⁴

lethal | pupal stage

lethal | pupal stage | recessive

fliI¹⁸

lethal | recessive

lethal - all die before end of pupal stage | recessive

fliI²²

lethal - all die during embryonic stage | rescuable maternal effect

fliI¹⁴

partially lethal - majority die, with Scer\GAL4^Mef2.PR

fliI^GD1446

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

fliI^GD1446

viable, with Scer\GAL4^pnr-MD237

fliI^GD1446

viable, with Scer\GAL4^tin.CΔ4

fliI^GD1446

Other Phenotypes

Allele

abnormal flight

abnormal flight, with Scer\GAL4^Mef2.PR

fliI^GD1446

flightless

flightless, with Scer\GAL4^Mef2.PR

fliI^GD1446

flightless (with fliI⁵)

fliI^sdby

flightless (with fliI¹⁰)

fliI^sdby

flightless (with fliI^sdby)

flightless | recessive

flightless | recessive | heat sensitive

some die during embryonic stage | rescuable maternal effect

fliI¹⁴

some die during pupal stage | recessive

fliI²²

Phenotype manifest in

Allele

embryo | blastoderm stage

fliI¹⁴

embryo | gastrula stage | germline clone | maternal effect

fliI²²

embryo | germline clone

fliI¹⁴

embryo | maternal effect

fliI¹⁴

embryonic abdominal segment & epidermis | germ-line clone

fliI²¹

embryonic epidermis | germline clone | non-rescuable maternal effect

fliI¹⁴

embryonic epidermis | maternal effect

fliI¹⁴

indirect flight muscle cell

indirect flight muscle cell, with Scer\GAL4^Mef2.PR

fliI^GD1446

indirect flight muscle cell (with fliI³)

fliI⁴

indirect flight muscle cell (with fliI⁴)

fliI³

mesoderm | germline clone | non-rescuable maternal effect

fliI¹⁴

mesoderm | maternal effect

fliI¹⁴

muscle cell

fliI³

myofibril

myofibril, with Scer\GAL4^Mef2.PR

fliI^GD1446

myofibril (with fliI³)

fliI⁴

myofibril (with fliI⁴)

fliI³

presumptive embryonic/larval central nervous system

presumptive embryonic/larval peripheral nervous system

sarcomere

fliI^sdby

sarcomere, with Scer\GAL4^Mef2.PR

fliI^GD1446

striated muscle myosin thick filament

fliI³

striated muscle thin filament

Z disc

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (59)

Hsap\FLII

14 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\LRRC8B

1 of 14

Yes

Hsap\LRRC8D

1 of 14

Yes

Hsap\LRRC8E

1 of 14

Yes

Hsap\LRRC15

1 of 14

Hsap\LRRC30

1 of 14

Yes

Hsap\LRRC39

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (49)

Rnor\Flii

14 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Lrrc8e

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Lrrc69

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Phlpp1

1 of 14

Rnor\Phlpp2

1 of 14

Rnor\Podnl1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (49)

Mmus\Flii

14 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Lrrc10

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Lrrc69

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (46)

Xtro\flii

11 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ppp1r7

1 of 13

Xtro\rundc3a

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (49)

Drer\flii

13 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\scrib

1 of 14

Drer\shoc2

1 of 14

Drer\si:ch211-106h11.1

1 of 14

Yes

Drer\si:dkey-182i3.11

1 of 14

Drer\si:zfos-323e3.4

1 of 14

Yes

Drer\stk11ip

1 of 14

Drer\svilb

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (23)

Cele\fli-1

14 of 14

Yes

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (81)

Agam\AgaP_AGAP011292

12 of 12

Yes

3 of 12

3 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP005667

1 of 12

Yes

Agam\AgaP_AGAP005668

1 of 12

Yes

Agam\AgaP_AGAP005962

1 of 12

Agam\AgaP_AGAP006993

1 of 12

Agam\AgaP_AGAP007030

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP007443

1 of 12

Yes

Agam\AgaP_AGAP007445

1 of 12

Agam\AgaP_AGAP007446

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP007463

1 of 12

Agam\AgaP_AGAP007464

1 of 12

Yes

Agam\AgaP_AGAP007465

1 of 12

Agam\AgaP_AGAP007466

1 of 12

Agam\AgaP_AGAP007467

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP008172

1 of 12

Yes

Agam\AgaP_AGAP008173

1 of 12

Yes

Agam\AgaP_AGAP008593

1 of 12

Agam\AgaP_AGAP009087

1 of 12

Agam\AgaP_AGAP009228

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP013027

1 of 12

Agam\AgaP_AGAP013278

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (69)

Atha\VLN1

5 of 13

Yes

Atha\VLN4

5 of 13

Yes

Atha\VLN5

5 of 13

Yes

Atha\VLN2

4 of 13

Atha\VLN3

4 of 13

Atha\AT1G08590

1 of 13

Yes

Atha\AT1G17230

1 of 13

Yes

Atha\AT1G48540

1 of 13

Atha\AT1G63430

1 of 13

Yes

Atha\AT1G72180

1 of 13

Atha\AT1G74360

1 of 13

Yes

Atha\AT1G78230

1 of 13

Atha\AT2G15300

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT3G47090

1 of 13

Yes

Atha\AT3G47110

1 of 13

Yes

Atha\AT3G47570

1 of 13

Yes

Atha\AT3G47580

1 of 13

Yes

Atha\AT3G51560

1 of 13

Yes

Atha\AT3G56370

1 of 13

Atha\AT4G03010

1 of 13

Yes

Atha\AT4G03260

1 of 13

Atha\AT4G18670

1 of 13

Yes

Atha\AT4G26540

1 of 13

Yes

Atha\AT4G28650

1 of 13

Yes

Atha\AT4G33970

1 of 13

Yes

Atha\AT4G37250

1 of 13

Yes

Atha\AT5G07910

1 of 13

Atha\AT5G18350

1 of 13

Yes

Atha\AT5G37450

1 of 13

Atha\BAM3

1 of 13

Yes

Atha\BRL1

1 of 13

Atha\BRL2

1 of 13

Atha\CLV1

1 of 13

Yes

Atha\CLV2

1 of 13

Yes

Atha\ER

1 of 13

Atha\GHR1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\RLP1

1 of 13

Atha\RLP9

1 of 13

Yes

Atha\RLP11

1 of 13

Atha\RLP12

1 of 13

Atha\RLP13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\RLP56

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\CYR1

2 of 13

Yes

Scer\PAC2

1 of 13

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\cyr1

2 of 12

Yes

Spom\alp21

1 of 12

Spom\ssm4

1 of 12

Escherichia coli (enterobacterium) (1)

Ecol\yddK

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:fliI. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (34)

Gel

5 of 13

qua

4 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

18w

1 of 13

atk

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

chp

1 of 13

conv

1 of 13

hfw

1 of 13

lbk

1 of 13

Lrch

1 of 13

Lrr47

1 of 13

ltl

1 of 13

mlt

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

obesity, susceptibility to (postulated), FLII-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

fliI¹⁴

model of obesity

CEA with fliI³

(Park et al., 2018)

fliI³

model of obesity

CEA with fliI¹⁴

(Park et al., 2018)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

FLII; FLII actin remodeling protein

14 of 14

600362

CARDIOMYOPATHY, DILATED, 2J; CMD2J

AVIL; advillin

3 of 14

613397

NEPHROTIC SYNDROME, TYPE 21; NPHS21

nephrotic syndrome type 21

CAPG; capping actin protein, gelsolin like

3 of 14

153615

GSN; gelsolin

3 of 14

137350

AMYLOIDOSIS, FINNISH TYPE

Finnish type amyloidosis

3 of 14

3 of 14

3 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

fliI - CG8578

experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting

(Rhee et al., 2014, Guruharsha et al., 2011)

fliI - Myc

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

fliI - Rab7

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

fliI - sima

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

CanB2

suppressible

fliI

(Gajewski et al., 2006)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0000709

MIST (protein-protein) - An integrated Molecular Interaction Database

33110

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-65

Cytogenetic map

19F5-19F5

Sequence location

X:21,339,741..21,345,088 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

19F5-19F5

Limits computationally determined from genome sequence between P{EP}CG1702^EP1525 and P{EP}EP1465&P{EP}CG1486^EP1192

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

19F3-19F3

(de Couet et al., 1987)

Placed in 19F3 by deficiency mapping.

(de Couet et al., 1987)

Experimentally Determined Recombination Data

Location

1-65

(FlyBase, 2016)

1-66.0

(Comeron et al., 2012)

1-65.8

(Miklos and de Couet, 1990)

Left of (cM)

(Schalet, 1972)

Right of (cM)

(Miklos and de Couet, 1990)

(Schalet, 1972)

Notes

Stocks and Reagents

Stocks (15)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

4730

fliI³

7481

fliI¹⁴/FM6

27566

y¹ v¹; P{TRiP.JF02720}attP2

79264

y¹ w^* TI{CRIMIC.TG4.0}fliI^{CR00462-TG4.0}/FM7h

67119

y¹ w^* fliI^A P{neoFRT}19A/FM7c, P{GAL4-Kr.C}DC1, P{UAS-GFP.S65T}DC5, sn⁺

Kyoto

101092

fliI⁵

107849

fliI³

101241

y¹ fliI⁸

NIG-Fly

HMJ21764

y¹ v¹; P{TRiP.HMJ21764}attP40

VDRC

v330297

P{VSH330297}attP40

v39528

w¹¹¹⁸; P{GD1446}v39528

v318112

PBac{fTRG00467.sfGFP-TVPTBF}VK00033

More stocks available...

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (21)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD21753

Other clones

DPiM_LD21753

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000709

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000709

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Davy et al., 2000)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Maternally synthesized fliI is required for the proper distribution of actin along the membrane network and for cellularisation to proceed properly.

(Straub et al., 1996)

Molecular analysis of fliI indicates that a region of the S1-like domain of the molecule implicated in the binding of a calcium ion in gelsolin may be responsible for the observed flightless phenotype of the mutant.

(de Couet et al., 1995)

fliI gene locus has been molecularly cloned and the gene product characterised.

(Campbell et al., 1993)

fliI was involved in a study of the base of the X chromosome: genetic and germline clone analysis.

(Perrimon et al., 1989)

Mosaic analysis suggests primary defect in thoracic muscles.

(Koana and Hotta, 1978)

Viable and lethal alleles have been isolated. Viable alleles are recessive and flightless; wing position normal; jumping abilities variously impaired depending on allele. Temperature-sensitive alleles show temperature-sensitive period to be during first half of pupal stage. Indirect-flight-muscle fibers are wavy with amorphous internal structures; myofilaments disorganized; Z bands and myofibrils abnormal; thin filaments often aggregated into bundles with striations (not seen in wild type). Lethal alleles die in larval or pupal stages. Maternal effect lethal; progeny produced from homozygous female germ-line clones of severe alleles (e.g., fliI¹⁴) are not rescuable by normal allele of paternal origin; abnormal folding during gastrulation; mesoderm invagination abnormal; only patches of epidermis present at later stages; embryos from clones homozygous for weaker alleles (e.g. fliI²²) were more nearly normal in appearance.

Relationship to Other Genes

Source for database merge of

Source for merge of: fliI BcDNA:LD21753

(FlyBase, 1996-)

Additional comments

Source for merge of fliI BcDNA:LD21753 was sequence comparison ( date:990717 ).

(FlyBase, 1996-)

Allelism tests with flt mutants not carried out.

Nomenclature History

Source for database identify of

Source for identity of: fliI CG1484

(Li, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (30)

Reported As

Symbol Synonym

(Lifschytz and Falk, 1969)

BcDNA:LD21753

CG1484

(National Institute of Genetics Fly Stocks, 2023-, Kolkhof et al., 2017, Meadows, 2017.1.11, Hosono et al., 2015, Haelterman et al., 2014, Perkins et al., 2009, Mount, 2001.8.14, Goldstein and Gunawardena, 2000, Whitfield, 2000.5.3)

CT3691

(Hynes and Zhao, 2000)

DCA3-19

(Schalet and Finnerty, 1968)

EN3

(Kramers et al., 1991)

FLI-I

(Goldstein and Gunawardena, 2000)

Fli-I

(Lee and Stallcup, 2006)

(Lefevre and Watkins, 1986, Schalet, 1986, Lefevre, 1981, Lifschytz, 1978)

fli

(Chougule et al., 2020, Miklos, 1997.8.4, Maleszka et al., 1996, Russell et al., 1992, Miklos and Cotsell, 1990, Perrimon et al., 1989, Perrimon et al., 1989)

fli I

(Gajewski et al., 2006)

fli-I

(Hsu et al., 2001)

fliI

(Mukherjee et al., 2025, Deng et al., 2021, Gene Disruption Project members, 2018-, Park et al., 2018, Sarov et al., 2016, Haelterman et al., 2014, Kwon et al., 2013, Yamamoto et al., 2013-, Friedman et al., 2011, Schnorrer et al., 2010, Christensen et al., 2008.12.28, Cook et al., 2008.9.3, Dietzl et al., 2007, Cardoso et al., 2006, Davy et al., 2000)

fltI

(de Couet et al., 1987)

fltO

(Miklos et al., 1987, Deak et al., 1982)

l(1)18-80

l(1)19Fd

l(1)ESHS53

l(1)W-2

(Miklos et al., 1987, Paradi et al., 1983, Schalet, 1972)

lDCB2-19

(Schalet and Singer, 1971)

sdby

(Deak et al., 1982)

w-2

(Kramers et al., 1991, Kramers et al., 1983)

Name Synonyms

Flightless-I

(Lee and Stallcup, 2006)

flightless

(Ip and Gridley, 2002, Judd, 1998, Maleszka et al., 1998, de Couet et al., 1991, Miklos et al., 1991)

flightless I

(Schnorrer et al., 2010, Davy et al., 2000)

flightless-1

(Park et al., 2018)

gluful-2

(Schalet and Finnerty, 1968)

lgluful-2

(Schalet and Singer, 1971)

section 15

(Lifschytz and Falk, 1969)

standby

Secondary FlyBase IDs

FBgn0001732

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33110

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q24020

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q24020

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q24020

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000709

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33110/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000709

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000709

FlyMine - An integrated database for Drosophila genomics

FBgn0000709

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1484

MARRVEL_MODEL - MARRVEL (model organism gene)

33110

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000709

DroID - A comprehensive database of gene and protein interactions.

FBgn0000709

DRSC - Results frm RNAi screens

FBgn0000709

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

fliI_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000709

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000709

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1484

Flygut - An atlas of the Drosophila adult midgut

FBgn0000709

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012416

MIST (protein-protein) - An integrated Molecular Interaction Database

33110

References (116)

The following external sites may use different assemblies or annotations than FlyBase.

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