FlyBase Gene Report: Dmel\Svil

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Svil using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.23

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

organism | pair rule expression pattern

(Fisher et al., 2012)

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

central brain anlage in statu nascendi

(Fisher et al., 2012)

anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

ventral ectoderm

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

organism | pair rule expression pattern

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | pair rule expression pattern

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic ventral epidermis

(Fisher et al., 2012)

embryonic hypopharynx

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{GT1}Svil^BG02427

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male & spermatogenesis

cyst cell of testis

(Bunt et al., 2012)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Svil in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Svil

View exonic expression by tissue for Dmel\Svil

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0266696

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38306/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0266696

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0266696

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 42 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 17 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Svil

Transgenic constructs containing regulatory region of Svil

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene partially disrupted in

Df(3L)Spn-Δ3.1

(Muhammad et al., 2015)

Gene disrupted in

Df(3L)Exel6090

(Ryder, 2004.4.26)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Svil^GD8120

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

Svil^GD13356

lethal - all die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Svil^GD8120

viable

Svil^EY06775

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Svil^GD7292

Sterility

Allele

fertile

Svil^EY06775

Other Phenotypes

Allele

flightless, with Scer\GAL4^Mef2.PR

short lived, with Scer\GAL4^Mef2.PR

Svil^GD13356

some die during pupal stage, with Scer\GAL4^pnr-MD237

Svil^GD13356

Phenotype manifest in

Allele

myofibril, with Scer\GAL4^Mef2.PR

Svil^GD10849

sarcomere, with Scer\GAL4^Mef2.PR

Svil^GD10849

Z disc, with Scer\GAL4^Mef2.PR

Svil^GD10849

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (14)

Hsap\SVIL

8 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (12)

Rnor\Svil

8 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (14)

Mmus\Svil

8 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (14)

Xtro\svil

5 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\phlpp1

1 of 13

Xtro\podn

1 of 13

Yes

Xtro\scin

1 of 13

Danio rerio (Zebrafish) (21)

Drer\svila

7 of 14

Yes

Drer\svilc

7 of 14

Yes

Drer\svild

7 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\tlr21

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (7)

Cele\viln-1

7 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (8)

Agam\AgaP_AGAP007181

6 of 12

Yes

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Yes

Agam\TOLL5B

1 of 12

Agam\TOLL11

1 of 12

Arabidopsis thaliana (thale-cress) (37)

Atha\VLN1

3 of 13

Yes

Atha\VLN2

3 of 13

Yes

Atha\VLN3

3 of 13

Yes

Atha\VLN4

3 of 13

Yes

Atha\VLN5

3 of 13

Yes

Atha\AT1G08590

1 of 13

Yes

Atha\AT1G72180

1 of 13

Atha\AT3G47090

1 of 13

Yes

Atha\AT3G47110

1 of 13

Yes

Atha\AT3G47570

1 of 13

Yes

Atha\AT3G47580

1 of 13

Yes

Atha\AT3G51560

1 of 13

Yes

Atha\AT4G26540

1 of 13

Yes

Atha\AT4G28650

1 of 13

Yes

Atha\AT5G18350

1 of 13

Yes

Atha\AT5G37450

1 of 13

Atha\BRL1

1 of 13

Atha\CLV1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\RLP1

1 of 13

Atha\RLP9

1 of 13

Yes

Atha\RLP11

1 of 13

Atha\RLP12

1 of 13

Atha\RLP13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\RLP56

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Svil. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (6)

fliI

3 of 13

Gel

3 of 13

qua

3 of 13

chp

1 of 13

conv

1 of 13

Unc-115a

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

SVIL; supervillin

model of myofibrillar myopathy 10

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SVIL; supervillin

8 of 14

604126

MYOFIBRILLAR MYOPATHY 10; MFM10

myofibrillar myopathy 10

AVIL; advillin

3 of 14

613397

NEPHROTIC SYNDROME, TYPE 21; NPHS21

nephrotic syndrome type 21

VIL1; villin 1

3 of 14

193040

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Svil - Mef2

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Svil - p53

pull down, autoradiography

(Lunardi et al., 2010)

Svil - rl

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0266696

MIST (protein-protein) - An integrated Molecular Interaction Database

38306

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-3

Cytogenetic map

62D7-62E4

Sequence location

3L:2,377,655..2,499,226 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

62D7-62E4

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-3

(FlyBase, 2016)

3-4.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (35)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

66165

w^*; P{UASp-GFP.Svil}attP2

77111

w^*; P{CEP01124-GAL4}attP2

24741

w¹¹¹⁸; Mi{ET1}Svil^MB05048

25368

w¹¹¹⁸; Mi{ET1}Svil^MB08137

29110

w¹¹¹⁸; Mi{ET1}Svil^MB10299

10953

11705

11759

1141R-2

12790R-1

v108962

v43583

w¹¹¹⁸; P{GD8120}v43583

More stocks available...

Genomic Clones (56)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (157)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0266696

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA has been made from templates generated with primers directed against this gene.

(Pilot et al., 2006)

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

New annotation (CG33231) in release 3.2 of the genome annotation.

(FlyBase Genome Annotators, 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

(Rogers et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG12790 CG13797 CG16763

(Misra, 2001.8.10)

Source for merge of: CG32306 CG33231

(FlyBase Genome Annotators, 2010)

Source for merge of: CG12790 CG13798 CG13799

(FlyBase Genome Annotators, 2002-2003)

Source for merge of: CG42669 CG33232 CG13800

(FlyBase Genome Annotators, 2014)

Additional comments

Annotations CG42669, CG33232 and CG13800 merged as CG45186 in release 5.55 of the genome annotation.

(FlyBase Genome Annotators, 2014)

Annotations CG32306 and CG33231 merged as CG42669 in release 5.25 of the genome annotation.

(FlyBase Genome Annotators, 2010)

Annotations CG1141 and CG16764 merged as CG33232 in release 3.2 of the genome annotation.

(FlyBase Genome Annotators, 2004)

Annotations CG12790, CG13797, CG13798, CG13799 and CG16763 merged as CG32306 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: Svil CG45186

(Ogneva et al., 2016)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (19)

Reported As

Symbol Synonym

CG1141

(Pilot et al., 2006, Rogers et al., 2003, Goldstein and Gunawardena, 2000)

CG12790

CG13797

(Stathopoulos et al., 2002, Misra, 2001.8.10)

CG13798

(Boutros et al., 2004)

CG13799

CG13800

(Ashwal-Fluss et al., 2014, Wasbrough et al., 2010, Perkins et al., 2009, Biemar et al., 2006, Manak et al., 2006)

CG16763

(Misra, 2001.8.10)

CG16764

CG32306

(Ashwal-Fluss et al., 2014, Malmendal et al., 2013, Schertel et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Lunardi et al., 2010, Makunin and Yurlova, 2010, Makunin and Yurlova, 2010, Keleman et al., 2009.8.5, Southall and Brand, 2009, Lipatov et al., 2005)

CG33231

(Perkins et al., 2009)

CG33232

(Hosono et al., 2015, Ashwal-Fluss et al., 2014, Chen et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2010.12.1, Li et al., 2009, Ni et al., 2008, Bakal et al., 2007, Buszczak et al., 2007, Pilot et al., 2006)

CG42669

(Kwon et al., 2013, Rodriguez et al., 2012, Tunstall et al., 2012, Friedman et al., 2011, FlyBase Genome Annotators, 2010, Ni et al., 2010.12.1, Wasbrough et al., 2010)

CG45186

(Delamotte et al., 2025, Deng et al., 2021, Arbel et al., 2019, Hall et al., 2019, Meltzer et al., 2019, Fochler et al., 2017, Solis et al., 2017, Dominguez et al., 2016, Harris, 2016.8.24, FlyBase Genome Annotators, 2014)

Svil

(Lee et al., 2024, Yamamoto et al., 2024, Saha et al., 2022, Chougule et al., 2020, Geigges et al., 2020, Stegeman et al., 2018, Kupriyanova et al., 2016, Ogneva et al., 2016)

c62E-11

(Keegan et al., 2001)

Name Synonyms

Supervillin

(Trivedi et al., 2022, Jiang et al., 2019)

Villin-like

(Serio et al., 2010, Rogers et al., 2003)

supervillin

(Ogneva et al., 2016)

villin-like

(Rogers et al., 2003)

Secondary FlyBase IDs

FBgn0261551
FBgn0052306
FBgn0035339
FBgn0035340
FBgn0035341
FBgn0035342
FBgn0040693
FBgn0053231
FBgn0035347
FBgn0035345
FBgn0053232
FBgn0035338

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 190 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38306

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

X2JAM4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

X2JAM4

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0266696

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38306/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0266696

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0266696

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG45186

MARRVEL_MODEL - MARRVEL (model organism gene)

38306

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0266696

DroID - A comprehensive database of gene and protein interactions.

FBgn0266696

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0266696

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

MIST (protein-protein) - An integrated Molecular Interaction Database

38306

References (121)

The following external sites may use different assemblies or annotations than FlyBase.

2.23

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