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General Information
Symbol
Dmel\fliI14
Species
D. melanogaster
Name
FlyBase ID
FBal0004048
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
W-2, l(1)W-2
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

No lesions were detected by Southern blotting within the boundaries of the fliI locus.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Embryos produced from germline clones exhibit only small patches that show the contour of the cleavage furrow when cellularisation begins. The layer of nuclei begins to look disorganised, on the surface the cell pattern is irregular but cell size is normal. Cell membranes reach into the embryos and grow perpendicular to the surface, the membranes reach varying depths. The actin cytoskeleton reaches to various depths in the peripheral cytoplasm and is unevenly distributed along the membranes as it accumulates in grains instead of in straight filaments. As gastrulation begins the epithelia begins to disintegrate. The nuclei move out of the incompletely cellularised peripheral layer of cytoplasm into the inside of the egg. Embryos succeed to varying degrees to make a ventral furrow. Phenotype can be mildly rescued by paternal contribution of fliI.

Blastoderm embryos are not properly cellularised.

Homozygous germline clones display maternal effect lethality. Embryos derived from heterozygous mothers are poorly differentiated. Defects are detectable soon after blastoderm formation: abnormal folds and mesoderm formation, and only patches of epidermis are present.

Progeny produced from homozygous female germ-line clones are not rescuable by normal allele of paternal origin. They show abnormal folding during gastrulation, abnormal mesoderm invagination and only patches of epidermis are present at later stages. Stronger allele than fliI22.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

Lifschytz.

Comments
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (10)
References (17)