FB2026_02 , released June 18, 2026
Allele: Dmel\atk23
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General Information
Symbol
Dmel\atk23
Species
D. melanogaster
Name
FlyBase ID
FBal0295813
Feature type
allele
Associated gene
Dmel\atk
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Andrés et al., 2014)
Mutagen
P-element activity
(Andrés et al., 2014)
Progenitor genotype
P{EPgy2}Uhg8EY07139
(Andrés et al., 2014)
Caused by aberration
Df(3L)atk23
Cytology
Description

Imprecise excision of P{EPgy2}Uhg8EY07139, resulting in deletion of 436bp from the 3' end of atk, including 122 C-terminal amino acids.

(Andrés et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:20,454,706..20,455,141 [-]
Comment:

Inferred boundaries of 436 bp deletion resulting from the imprecise excision of P{EPgy2}Uhg8EY07139. Deleted bases include those encoding the 122 C-terminal amino acids of atk.

(Andrés et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      atk23 mutants show defective morphology of embryonic lch5 organs: cilia are not parallel to each other but point out in different directions (though they still contact the cap cell); neuronal cell bodies appear frequently disorganized.

      Mutant larvae exhibit severe defects in locomotion: the number of direction changes is significantly increased, and the total path length is significantly reduced.

      Mutant larvae do not show an altered response to sucrose in a chemotaxis assay.

      (Andrés et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      atk23
      (Andrés et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)