FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Toll-7P8
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General Information
Symbol
Dmel\Toll-7P8
Species
D. melanogaster
Name
FlyBase ID
FBal0295833
Feature type
allele
Associated gene
Dmel\Toll-7
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(McIlroy et al., 2013)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Toll-7P8, Toll-7P8, Toll-626, Toll-626 is an enhancer of neuron | embryonic stage phenotype of Myd88kra-56

      (Foldi et al., 2017)
      NOT Enhancer of
      Statement
      Reference

      Toll-7P8/Toll-7P8 is a non-enhancer of larval central nervous system | embryonic stage phenotype of Myd88kra-56

      (Foldi et al., 2017)

      Toll-7P8/Toll-7P8 is a non-enhancer of neuron | embryonic stage phenotype of Myd88kra-56

      (Foldi et al., 2017)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Toll-7P8/Toll-7P114;Toll-626/Toll-631 double mutant third instar larvae have slightly fewer eve-positive neurons in the ventral nerve cord compared to wild-type controls, but the effect is not statistically significant.

      The moderate loss of eve-positive neurons (from the lateral, EL, and U/CQ eve[+] clusters) in the embryonic central nervous system characteristic for Myd88kra-56 mutants is not exacerbated by combination with two copies of either Toll-7P8 or Toll-626. However, in Myd88kra-56 Toll-7P8;Toll-626 triple mutant embryos the neuronal loss is enhanced further as in addition to loss of neurons from the EL+U/CQ clusters, the number of neurons in the aCC pCC and RP2 groups are also reduced compared to controls.

      (Foldi et al., 2017)

      Toll-7P8/Toll-7P114;Toll-626/Toll-631 double mutant larvae crawl more slowly than controls.

      Toll-631/Df(3L)XG4, Toll-7P8/Toll-7P114 and Toll-7P114/Df(2R)BSC22 single mutants and Toll-7P8/Toll-7P114;Toll-626/Toll-631 double mutants exhibit deficient targeting and axonal misrouting of Fas2[+] ISNb/d. These mutants also display an increase in neuronal apoptosis.

      (McIlroy et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Toll-7P8
      (Foldi et al., 2017, McIlroy et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)