FlyBase Allele Report: Dmel\Toll-6[26]

General Information

Symbol

Dmel\Toll-6²⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0295829

Feature type

allele

Associated gene

Dmel\Toll-6

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(McIlroy et al., 2013)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(McIlroy et al., 2013)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Toll-6²⁶, Toll-7^P8 has some die during embryonic stage | heat sensitive phenotype, suppressible by Toll-7^{ΔLRR.UAS.Tag:HA}/Scer\GAL4^ChAT.7.4

(McIlroy et al., 2013)

Toll-6²⁶, Toll-7^P8 has some die during embryonic stage | heat sensitive phenotype, suppressible by Toll-7^{C993Y.UAS.Tag:FLAG}/Scer\GAL4^ChAT.7.4

(McIlroy et al., 2013)

NT1⁴¹, Toll-6²⁶ has some die during embryonic stage | heat sensitive phenotype, suppressible by Toll-7^{C993Y.UAS.Tag:FLAG}/Scer\GAL4^Toll-7

(McIlroy et al., 2013)

Toll-6²⁶, Toll-7^P8 has some die during embryonic stage | heat sensitive phenotype, suppressible by Toll-6^{ΔLRR.UAS.Tag:HA}/Scer\GAL4^ChAT.7.4

(McIlroy et al., 2013)

NT1⁴¹, Toll-6²⁶ has some die during embryonic stage | heat sensitive phenotype, suppressible by Scer\GAL4^Toll-7/Toll-6^{C1020Y.UAS.Tag:FLAG}

(McIlroy et al., 2013)

Other

Statement

Reference

Toll-6²⁶, Toll-7^P8 has some die during embryonic stage | heat sensitive phenotype

(McIlroy et al., 2013)

NT1⁴¹, Toll-6²⁶ has some die during embryonic stage | heat sensitive phenotype

(McIlroy et al., 2013)

Toll-6²⁶, spz5^e03444 has viable phenotype

(McIlroy et al., 2013)

Toll-6³¹/Toll-6²⁶, Toll-7^P8/Toll-7^P114 has some die during embryonic stage | heat sensitive phenotype

(McIlroy et al., 2013)

Phenotype Manifest In

Enhancer of

Statement

Reference

Toll-6²⁶/Toll-6²⁶ is an enhancer of larval central nervous system | embryonic stage phenotype of Myd88^kra-56

(Foldi et al., 2017)

Toll-7^P8, Toll-7^P8, Toll-6²⁶, Toll-6²⁶ is an enhancer of neuron | embryonic stage phenotype of Myd88^kra-56

(Foldi et al., 2017)

NOT Enhancer of

Statement

Reference

Toll-6²⁶/Toll-6²⁶ is a non-enhancer of larval central nervous system | embryonic stage phenotype of Myd88^kra-56

(Foldi et al., 2017)

Toll-6²⁶/Toll-6²⁶ is a non-enhancer of neuron | embryonic stage phenotype of Myd88^kra-56

(Foldi et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Toll-7^P8/Toll-7^P114;Toll-6²⁶/Toll-6³¹ double mutant third instar larvae have slightly fewer eve-positive neurons in the ventral nerve cord compared to wild-type controls, but the effect is not statistically significant.

The moderate loss of eve-positive neurons (from the lateral, EL, and U/CQ eve[+] clusters) in the embryonic central nervous system characteristic for Myd88^kra-56 mutants is not exacerbated by combination with two copies of either Toll-7^P8 or Toll-6²⁶. However, in Myd88^kra-56 Toll-7^P8;Toll-6²⁶ triple mutant embryos the neuronal loss is enhanced further as in addition to loss of neurons from the EL+U/CQ clusters, the number of neurons in the aCC pCC and RP2 groups are also reduced compared to controls.

(Foldi et al., 2017)

Toll-7^P8/Toll-7^P114;Toll-6²⁶/Toll-6³¹ double mutant larvae crawl more slowly than controls.

(McIlroy et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Toll-6²⁶

(Foldi et al., 2017, Ulian-Benitez et al., 2017, McIlroy et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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