FlyBase Allele Report: Dmel\Toll-7[HM05230]

General Information

Symbol

Dmel\Toll-7^HM05230

Species

D. melanogaster

Name

FlyBase ID

FBal0241721

Feature type

allele

Associated gene

Dmel\Toll-7

Associated Insertion(s)

Carried in Construct

P{TRiP.HM05230}

Also Known As

UAS-Toll-7-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HM05230}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HM05230

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurodegenerative disease

modeled by Zzzz\CTG^{rCUG.99.UAS.Tag:MYC,Tag:FLAG}, Zzzz\CAG^{99.UAS.Tag:MYC,Tag:FLAG}

(Samaraweera et al., 2013)

ameliorates carcinoma

modeled by Ras85D^V12.UAS, l(2)gl⁴

(Ding et al., 2022)

modeled by scrib^GD11666

(Ding et al., 2022)

modeled by egr^{UAS.Tag:HA,Tag:MYC}

(Ding et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^elav.PLu

(Zhang et al., 2024)

abnormal neuroanatomy | adult stage, with Scer\GAL4^elav-C155

(Ward et al., 2015)

Phenotype Manifest In

adult antennal lobe projection neuron VA1d adPN, with Scer\GAL4^elav-C155

(Ward et al., 2015)

adult brain, with Scer\GAL4^elav.PLu

(Zhang et al., 2024)

adult dopaminergic neuron | decreased number, with Scer\GAL4^elav.PLu

(Zhang et al., 2024)

adult olfactory receptor neuron Or88a, with Scer\GAL4^elav-C155

(Ward et al., 2015)

Detailed Description

Statement

Reference

Expression of Toll-7^HM05230 under the control of Scer\GAL4^elav-C155 results in VA1d olfactory receptor neuron axons and projection neuron dendrites to mistarget to a medial position.

(Ward et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Toll-7^HM05230/Scer\GAL4^bab1-Gal4 is a non-enhancer of abnormal cell number | oogenesis phenotype of Scer\GAL4^bab1-Gal4, piwi^KK105350

(Lin et al., 2020)

Suppressor of

Statement

Reference

Toll-7^HM05230, Scer\GAL4^Act5C.PI is a suppressor of neoplasia | larval stage | somatic clone - tissue specific phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴

(Ding et al., 2022)

Scer\GAL4^ptc-559.1/Toll-7^HM05230 is a suppressor | partially of abnormal cell migration | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, egr^GS9830

(Ding et al., 2022)

Scer\GAL4^ptc-559.1/Toll-7^HM05230 is a suppressor | partially of abnormal cell migration | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, scrib^GD11666

(Ding et al., 2022)

Toll-7^HM05230/Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^{99.UAS.Tag:MYC,Tag:FLAG}, Zzzz\CTG^{rCUG.99.UAS.Tag:MYC,Tag:FLAG}

(Samaraweera et al., 2013)

NOT Suppressor of

Statement

Reference

Toll-7^HM05230/Scer\GAL4^bab1-Gal4 is a non-suppressor of abnormal cell number | oogenesis phenotype of Scer\GAL4^bab1-Gal4, piwi^KK105350

(Lin et al., 2020)

Scer\GAL4^da.PU/Toll-7^HM05230 is a non-suppressor of lethal phenotype of Scer\GAL4^da.PU, mad2^GD16427

(Liu et al., 2015)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Toll-7^HM05230/Scer\GAL4^bab1-Gal4 is a non-enhancer of female germline stem cell phenotype of Scer\GAL4^bab1-Gal4, piwi^KK105350

(Lin et al., 2020)

Toll-7^HM05230/Scer\GAL4^bab1-Gal4 is a non-enhancer of germarium phenotype of Scer\GAL4^bab1-Gal4, piwi^KK105350

(Lin et al., 2020)

Suppressor of

Statement

Reference

Scer\GAL4^ptc-559.1/Toll-7^HM05230 is a suppressor | partially of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, egr^GS9830

(Ding et al., 2022)

Scer\GAL4^ptc-559.1/Toll-7^HM05230 is a suppressor | partially of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, scrib^GD11666

(Ding et al., 2022)

Toll-7^HM05230, Scer\GAL4^Act5C.PI is a suppressor of eye-antennal disc | somatic clone - tissue specific phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴

(Ding et al., 2022)

Toll-7^HM05230, Scer\GAL4^Act5C.PI is a suppressor of larval ventral nerve cord | somatic clone - tissue specific phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴

(Ding et al., 2022)

Toll-7^HM05230/Scer\GAL4^GMR.PF is a suppressor of ommatidium phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^{99.UAS.Tag:MYC,Tag:FLAG}, Zzzz\CTG^{rCUG.99.UAS.Tag:MYC,Tag:FLAG}

(Samaraweera et al., 2013)

NOT Suppressor of

Statement

Reference

Toll-7^HM05230/Scer\GAL4^bab1-Gal4 is a non-suppressor of female germline stem cell phenotype of Scer\GAL4^bab1-Gal4, piwi^KK105350

(Lin et al., 2020)

Toll-7^HM05230/Scer\GAL4^bab1-Gal4 is a non-suppressor of germarium phenotype of Scer\GAL4^bab1-Gal4, piwi^KK105350

(Lin et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Under 30[o]C temperature conditions, the expression of mad2^GD16427 under the control of Scer\GAL4^da.PU induces lethality before adulthood, which is not suppressed by the co-expression of Toll-7^HM05230.

(Liu et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

30488

y¹ sc^* v¹ sev²¹; P{TRiP.HM05230}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Toll-7^HM05230

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections