FlyBase Allele Report: Dmel\Toll-9[KO]

General Information

Symbol

Dmel\Toll-9^KO

Species

D. melanogaster

Name

FlyBase ID

FBal0258379

Feature type

allele

Associated gene

Dmel\Toll-9

Associated Insertion(s)

TI{TI}Toll-9^KO

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

ends-out gene targeting

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Narbonne-Reveau et al., 2011)

Mutagen

ends-out gene targeting

(Narbonne-Reveau et al., 2011)

Progenitor genotype

Associated Insertion(s)

TI{TI}Toll-9^KO

Cytology

Description

The genomic region from 852bp upstream of the Toll-9 ATG to 41bp downstream of the Toll-9 stop codon has been replaced by a w^+mW.hs marker.

(Narbonne-Reveau et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

3L:20,361,999..20,366,770 [-]

Comment:

The region from 852 bp upstream of the Toll-9 ATG to 41 bp after the Toll-9 stop codon has been deleted and replaced with a w^+mW.hs marker by homologous recombination.

(Narbonne-Reveau et al., 2011)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cSa

(Sakakibara et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate

(Narbonne-Reveau et al., 2011)

abnormal oxidative stress response | adult stage

(Sakakibara et al., 2023)

partially lethal - majority die

(Narbonne-Reveau et al., 2011)

short lived

(Narbonne-Reveau et al., 2011)

short lived | chemical conditional

(Sakakibara et al., 2023)

some die during embryonic stage

(Narbonne-Reveau et al., 2011)

Phenotype Manifest In

embryonic/larval hemocyte

(Narbonne-Reveau et al., 2011)

Detailed Description

Statement

Reference

Toll-9^KO mutants exhibit partial embryonic lethality, a delay in emergence from eclosion, and reduced lifespan.

Embryonic hematopoiesis is not affected in Toll-9^KO mutants, indeed the number of larval hemocytes is slightly increased in Toll-9^KO mutants.

Toll-9^KO mutant flies resist clean injury and septic injuries performed with either Gram-positive or Gram-negative bacteria just as well as control flies. The numbers of intestinal stem cells and young enterocytes are similar in unaffected Toll-9^KO mutants and control guts. Upon infection, the epithelium renewal occurs normally in Toll-9^KO mutant midguts.

(Narbonne-Reveau et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Toll-9^KO is an enhancer of abnormal neuroanatomy | adult stage phenotype of Hsap\MAPT^UAS.cSa, Scer\GAL4^GMR.PF

(Sakakibara et al., 2023)

Phenotype Manifest In

Enhancer of

Statement

Reference

Toll-9^KO is an enhancer of lamina phenotype of Hsap\MAPT^UAS.cSa, Scer\GAL4^GMR.PF

(Sakakibara et al., 2023)

Toll-9^KO is an enhancer of axon phenotype of Hsap\MAPT^UAS.cSa, Scer\GAL4^GMR.PF

(Sakakibara et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Toll-9 KO

(Sakakibara et al., 2023)

Toll-9^KO

Name Synonyms

KO Toll-9

(Narbonne-Reveau et al., 2011)

Secondary FlyBase IDs

References (2)

Report Sections

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