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Citation
Khezri, R., Rusten, T.E. (2019). Autophagy and Tumorigenesis in Drosophila.  Adv. Exp. Med. Biol. 1167(): 113--127.
FlyBase ID
FBrf0243418
Publication Type
Review
Abstract

The resurgence of Drosophila as a recognized model for carcinogenesis has contributed greatly to our conceptual advance and mechanistic understanding of tumor growth in vivo. With its powerful genetics, Drosophila has emerged as a prime model organism to study cell biology and physiological functions of autophagy. This has enabled exploration of the contributions of autophagy in several tumor models. Here we review the literature of autophagy related to tumorigenesis in Drosophila. Functional analysis of core autophagy components does not provide proof for a classical tumor suppression role for autophagy alone. Autophagy both serve to suppress or support tumor growth. These effects are context-specific, depending on cell type and oncogenic or tumor suppressive lesion. Future delineation of how autophagy impinges on tumorigenesis will demand to untangle in detail, the regulation and flux of autophagy in the respective tumor models. The downstream tumor-regulative roles of autophagy through organelle homeostasis, metabolism, selective autophagy or alternative mechanisms remain largely unexplored.

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Erratum

Correction to: Autophagy and Tumorigenesis in Drosophila.
Khezri and Rusten, 2019, Adv. Exp. Med. Biol. 1167: C1 [FBrf0249774]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Adv. Exp. Med. Biol.
    Title
    Advances in Experimental Medicine and Biology
    Publication Year
    1976-
    ISBN/ISSN
    0065-2598
    Data From Reference