FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Vps25
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General Information
Symbol
Dmel\Vps25
Species
D. melanogaster
Name
Vacuolar protein sorting 25
Annotation Symbol
CG14750
Feature Type
protein_coding_gene
FlyBase ID
FBgn0022027
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Summary
Vacuolar protein sorting 25 (Vps25) encodes a member of the ESCRT-II complex, which sorts certain endocytosed receptors for degradation via the multivesicular body. As part of this complex, the product of Vps25 also has a role in bcd RNA localization. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(2)44Db, ESCRT-II, l(2)k08904

Key Links
Genomic Location
Cytogenetic map
44D5-44D5
Sequence location
Recombination map
2-59
RefSeq locus
NT_033778 REGION:8625451..8626180
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (17 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables protein homodimerization activity
inferred from biological aspect of ancestor with PANTHER:PTN000322234
(GO Reference Genome Project, 2011-)
enables structural molecule activity
inferred from biological aspect of ancestor with PANTHER:PTN000322234
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with SGD:S000003863
(Gene Ontology Curators, 2002-)
Biological Process (14 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
involved_in autophagosome maturation
inferred from mutant phenotype
(Juhász et al., 2008, Rusten et al., 2007)
involved_in bicoid mRNA localization
inferred from mutant phenotype
(Irion and St Johnston, 2007)
involved_in endosomal transport
inferred from mutant phenotype
(Vaccari and Bilder, 2005)
involved_in endosome transport via multivesicular body sorting pathway
inferred from mutant phenotype
(Thompson et al., 2005)
involved_in epithelial structure maintenance
inferred from mutant phenotype
(Thompson et al., 2005, Vaccari and Bilder, 2005)
involved_in imaginal disc-derived male genitalia morphogenesis
inferred from mutant phenotype
(Lee et al., 2011)
involved_in intracellular protein localization
inferred from mutant phenotype
(Irion and St Johnston, 2007)
involved_in maintenance of epithelial cell apical/basal polarity
inferred from mutant phenotype
(Thompson et al., 2005, Vaccari and Bilder, 2005)
involved_in negative regulation of epithelial cell proliferation
inferred from mutant phenotype
(Thompson et al., 2005, Vaccari and Bilder, 2005)
involved_in regulation of apoptotic process
inferred from mutant phenotype
(Herz et al., 2009, Herz et al., 2006)
involved_in ubiquitin-dependent endocytosis
inferred from mutant phenotype
(Juhász et al., 2008)
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
inferred from mutant phenotype
(Herz et al., 2009, Vaccari et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in multivesicular body sorting pathway
inferred from electronic annotation with InterPro:IPR008570
(InterPro Project Members, 2004-)
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
inferred from biological aspect of ancestor with PANTHER:PTN000322234
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of ESCRT II complex
inferred from sequence or structural similarity with SGD:S000003863
(Vaccari et al., 2009)
inferred from biological aspect of ancestor with PANTHER:PTN000322234
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR008570
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the VPS25 family. (Q7JXV9)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Vacuolar protein sorting 25 (Vps25) encodes a member of the ESCRT-II complex, which sorts certain endocytosed receptors for degradation via the multivesicular body. As part of this complex, the product of Vps25 also has a role in bcd RNA localization. [Date last reviewed: 2019-03-21]
Gene Group (FlyBase)
ESCRT-II COMPLEX -
The ESCRT (Endosomal Sorting Complexes Required for Transport) machinery is made up of five complexes, ESCRT-0 to -III and the Vps4-Vta1 ATPase complex, which are sequentially recruited to the cytosolic face of the membrane, and mediate cargo recognition, membrane budding and fission. ESCRT-II is a constitutive heterotetramer. It interacts with 3-phosphoinositides, ubiquitin and ESCRT-I, with which it mediates the formation of the membrane bud and stabilizes the neck region. It recruits ESCRT-III. (Adapted from PMID:22361144 and FBrf0209668).
Protein Function (UniProtKB)
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). Seems to function as a tumor suppressor by regulating Notch trafficking, hence preventing non-autonomous overproliferation. May be involved in the regulation of autophagy. ESCRT-II interacts with bicoid mRNA, which is required for the anterior localization of bicoid mRNA in the developing egg.
(UniProt, Q7JXV9)
Summary (Interactive Fly)

a member of the ESCRT-II complex, which sorts certain endocytosed receptors for degradation via the multivesicular body - as part of this complex, Vps25 also has a role in bicoid RNA localization

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Vps25 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q7JXV9)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.49

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Vps25-RA
FBtr0088694
NM_136554
678
174
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Vps25-PA
FBpp0087774
20.6
174
4.79
Q7JXV9
NP_610398
AAF59066
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Component of the endosomal sorting complex required for transport II (ESCRT-II) (By similarity). Interacts with Lsn/Snf8/Vps22 (Probable).

(UniProt, Q7JXV9)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Vps25 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

3.83

Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Vps25 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Vps25
Transgenic constructs containing regulatory region of Vps25
Aberrations (Deficiencies and Duplications) ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4insc-Mz1407
lethal (with Vps25K2)
lethal (with Vps25N55)
lethal | recessive
lethal | somatic clone
lethal - all die before end of larval stage (with Df(2R)Exel8047)
lethal - all die before end of larval stage (with Vps25A3)
lethal - all die before end of larval stage (with Vps25k08904)
lethal - all die before end of larval stage | recessive
lethal - all die before end of prepupal stage | somatic clone
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during embryonic stage
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
partially lethal, with Scer\GAL4dome-PG14
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile | germline clone | recessive
Other Phenotypes
Allele
abnormal cell growth | cell non-autonomous | somatic clone
abnormal cell number | larval stage, with Scer\GAL4dome-PG14
abnormal cell polarity | larval stage | somatic clone
abnormal cell shape | larval stage | somatic clone
abnormal cell shape | oogenesis | somatic clone
abnormal developmental rate | larval stage | somatic clone
abnormal immune response | larval stage, with Scer\GAL4dome-PG14
abnormal pain response | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
abnormal size | adult stage (with Vps25K2)
abnormal size | adult stage (with Vps25N55)
decreased cell number | pupal stage | somatic clone
decreased occurrence of cell division | larval stage, with Scer\GAL4dome-PG14
hyperplasia | adult stage | cell non-autonomous | somatic clone
hyperplasia | cell non-autonomous | somatic clone
hyperplasia | cell non-autonomous | somatic clone | wandering third instar larval stage
hyperplasia | somatic clone
increased body size | larval stage | somatic clone
increased cell death | cell autonomous | somatic clone
increased cell death | cell autonomous | somatic clone | wandering third instar larval stage
increased cell death | larval stage | somatic clone
increased cell death | somatic clone
increased cell death | somatic clone | third instar larval stage
increased cell number, with Scer\GAL4NP1624
increased occurrence of cell division | cell non-autonomous | larval stage
increased occurrence of cell division | cell non-autonomous | larval stage | somatic clone
increased occurrence of cell division | cell non-autonomous | third instar larval stage
increased size | larval stage, with Scer\GAL4dome-PG14
increased size | larval stage | somatic clone - tissue specific
neoplasia | third instar larval stage (with Vps25K2)
neoplasia | third instar larval stage (with Vps25N55)
short lived, with Scer\GAL4dome-PG14
short lived, with Scer\GAL4MESO.dome, Scer\GAL80elav.PU
some die during embryonic stage
some die during larval stage (with Df(2R)Exel8047)
some die during larval stage (with Vps25A3)
some die during larval stage (with Vps25k08904)
some die during larval stage | recessive
some die during prepupal stage | somatic clone
some die during pupal stage, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
adult head | cell non-autonomous | somatic clone
adult midgut | somatic clone, with Scer\GAL4Act.PU
early endosome | somatic clone
egg | germline clone
egg chamber, with Scer\GAL4GR1
egg chamber | somatic clone
endoplasmic reticulum | adult stage | somatic clone, with Scer\GAL4Act.PU
endosome & imaginal disc epithelial cell | somatic clone | cell autonomous | third instar larval stage
endosome | somatic clone
epithelium, with Scer\GAL4NP1624
epithelium | somatic clone
eye | cell non-autonomous | somatic clone
eye | somatic clone
eye | somatic clone (with Vps25K2)
eye | somatic clone (with Vps25N55)
eye-antennal disc | cell autonomous | somatic clone | third instar larval stage
eye-antennal disc | cell non-autonomous | somatic clone | third instar larval stage
eye-antennal disc | third instar larval stage
eye disc | cell non-autonomous | somatic clone
eye disc | somatic clone
female germline cyst, with Scer\GAL4NP1624
female germline cyst | somatic clone
follicle cell | somatic clone
lamellocyte | increased number | larval stage | conditional, with Scer\GAL4dome-PG14
larval brain | larval stage, with Scer\GAL4insc-Mz1407
larval digestive system
larval dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4ppk.1.9
leg | somatic clone
male genitalia, with Scer\GAL4Abd-B-LDN
nucleus | increased number | larval stage, with Scer\GAL4dome-PG14
nurse cell, with Scer\GAL4GR1
ommatidial precursor cluster | cell autonomous | somatic clone | wandering third instar larval stage
plasma membrane | somatic clone
primary lobe of embryonic/larval lymph gland | larval stage, with Scer\GAL4dome-PG14
primary lobe of embryonic/larval lymph gland | larval stage | somatic clone - tissue specific
secondary lobe of embryonic/larval lymph gland | larval stage, with Scer\GAL4dome-PG14
stalk follicle cell, with Scer\GAL4NP1624
stalk follicle cell | somatic clone
tertiary lobe of embryonic/larval lymph gland | larval stage, with Scer\GAL4dome-PG14
wing | somatic clone
wing disc | cell autonomous | somatic clone
wing disc | cell non-autonomous | somatic clone
wing disc | somatic clone
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\VPS25
14 of 14
Yes
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Vps25
14 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Vps25
13 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\vps25
11 of 13
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\vps25
14 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\vps-25
14 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP011497
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\VPS25
13 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\VPS25
12 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\vps25
11 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Vps25. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 5 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 3 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
VPS25; vacuolar protein sorting 25 homolog
14 of 14
610907
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Vps25 - Gsc
      two hybrid
      (Hu et al., 2017.6.13)
      Vps25 - lsn
      two hybrid
      (Hu et al., 2017.6.13)
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Vps25
      suppressible
      Atg6
      (Shravage et al., 2013)
      Vps25
      suppressible
      Diap1
      (Herz et al., 2006)
      Vps25
      suppressible
      hpo
      (Herz et al., 2006)
      Vps25
      suppressible
      N
      (Herz et al., 2009, Herz et al., 2006)
      Vps25
      suppressible
      Stat92E
      (Vaccari and Bilder, 2005)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      hid
      suppressible
      Vps25
      (Herz et al., 2009, Herz et al., 2006)
      rho
      suppressible
      Vps25
      (Tjota et al., 2011)
      sky
      suppressible
      Vps25
      (Uytterhoeven et al., 2011)
      External Data
      Subunit Structure (UniProtKB)
      Component of the endosomal sorting complex required for transport II (ESCRT-II) (By similarity). Interacts with Lsn/Snf8/Vps22 (Probable).
      (UniProt, Q7JXV9 )
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2R
      Recombination map
      2-59
      Cytogenetic map
      44D5-44D5
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      44D5-44D5
      Limits computationally determined from genome sequence between P{lacW}Rs1k09514&P{lacW}l(2)k03110k03110 and P{lacW}Vps25k08904&P{lacW}ptck02507
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      44D4-44D5
      (determined by in situ hybridisation)
      (Spradling et al., 1999)
      44D4-44D5
      (BDGP Project Members, 1994-1999)
      Experimentally Determined Recombination Data
      Location

      2-59

      (FlyBase, 2016)

      2-57.8

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (11)
      Genomic Clones (14)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (17)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          Vps25 mosaics disply non-autonomous cell survival and overgrowth, and autonomous apoptosis.

          (Herz et al., 2006)

          Identification: in a screen for suppressors of W.

          (Herz, 2006)

          In Vps25 mutant cells, sorting defects prevent degradation of the signaling receptor N, enhancing signaling output that alter the proliferative behavior of neighboring wild-type cells.

          (Vaccari and Bilder, 2006)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: l(2)44Db CG14750

          (Levis, 2002.11.27)
          Additional comments
          Nomenclature History
          Source for database identify of

          Source for identity of: Vps25 CG14750

          (Vaccari, 2006.3.1)
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (12)
          Reported As
          Symbol Synonym
          CG14750
          (Hosono et al., 2015, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009.3.31, Vaccari et al., 2009, Herz et al., 2006, Thompson et al., 2005, Giot et al., 2003)
          ESCRT-I
          (Juhász et al., 2008)
          ESCRT-II
          (Tognon et al., 2014, Vaccari et al., 2008, Rusten et al., 2007)
          VPS25
          (Haberman et al., 2008)
          Vps25
          (Bandyadka et al., 2025, Muita and Baxter, 2023, Zhuang et al., 2023, Gong et al., 2021, Mesquita et al., 2021, Baker, 2020, Hall et al., 2019, Khezri and Rusten, 2019, Meltzer et al., 2019, Snigdha et al., 2019, Cho et al., 2018, Salazar and Yamamoto, 2018, Baker, 2017, Hu et al., 2017.6.13, Tang et al., 2017, Li and Blissard, 2015, Loncle et al., 2015, Portela et al., 2015, Amoyel and Bach, 2014, Berns et al., 2014, Morelli et al., 2014, Zhang et al., 2014, Shravage et al., 2013, Vaccari, 2013.11.5, Yang et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Friedman et al., 2011, Grusche et al., 2011, Halbsgut et al., 2011, Yuva-Aydemir et al., 2011, Michelet et al., 2010, Windler and Bilder, 2010, Coumailleau et al., 2009, Juhász et al., 2008, Philips et al., 2008, Childress et al., 2007, Rusten and Stenmark, 2007, Childress et al., 2006, Vaccari and Bilder, 2005)
          dVps25
          (Akbar et al., 2007)
          l(2)44Db
          (Yamamoto et al., 2017, Foley and O'Farrell, 2004, Levis, 2002.11.27, Dockendorff et al., 2000)
          l(2)k08904
          (Spradling et al., 1999)
          vps25
          (Saez-Carrion et al., 2024, Enomoto and Igaki, 2022, Wu et al., 2021, Morata and Calleja, 2020, Cong et al., 2018, Mukherjee et al., 2016, Neyen et al., 2016, Enomoto et al., 2015, Tognon et al., 2014, Woodfield et al., 2013, Zoranovic et al., 2013, Graves et al., 2012, Lee et al., 2011, Ohsawa et al., 2011, Tjota et al., 2011, Uytterhoeven et al., 2011, Gilbert et al., 2009, Herz et al., 2009, Lee et al., 2009, Vaccari et al., 2009, Vaccari et al., 2008, Irion and St Johnston, 2007, Irion and St Johnston, 2007, Menut et al., 2007, Rusten et al., 2007, Tountas and Fortini, 2007, Childress et al., 2006, Giebel and Wodarz, 2006, Herz, 2006, Herz et al., 2006, Vaccari, 2006.3.1, Thompson et al., 2005, Vaccari and Bilder, 2005)
          Name Synonyms
          Vacuolar protein sorting 25
          (Amoyel and Bach, 2014, Herz, 2006.2.28)
          lethal (2) 44Db
          vesicle protein sorting 25
          (Tountas and Fortini, 2007)
          Secondary FlyBase IDs
          • FBgn0033314
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 38 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          References (123)