FlyBase Allele Report: Dmel\Vps25[k08904]

General Information

Symbol

Dmel\Vps25^k08904

Species

D. melanogaster

Name

FlyBase ID

FBal0064311

Feature type

allele

Associated gene

Dmel\Vps25

Associated Insertion(s)

P{lacW}Vps25^k08904

Carried in Construct

Also Known As

l(2)k08904, l(2)44Db^k08904

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}Vps25^k08904

Cytology

Description

P{lacW}Vps25^k08904 is inserted into the wing helix domain A of Vps25 and is predicted to cause termination at residue 32.

(Vaccari and Bilder, 2005)

P{lacW} is inserted into the protein coding region of Vps25.

(Levis, 2002.11.27)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:8,625,676..8,625,676 [+]

(Yang et al., 2013, Herz et al., 2006, Vaccari and Bilder, 2005, Levis, 2002.11.27, Dockendorff et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA

(Yamamoto et al., 2017)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

lethal - all die before end of larval stage (with Df(2R)Exel8047)

(Vaccari and Bilder, 2005)

lethal - all die before end of larval stage (with Vps25^A3)

(Vaccari and Bilder, 2005)

some die during larval stage (with Df(2R)Exel8047)

(Vaccari and Bilder, 2005)

some die during larval stage (with Vps25^A3)

(Vaccari and Bilder, 2005)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Vps25^Pb2931

(Thompson et al., 2005)

Vps25^A3

(Vaccari and Bilder, 2005)

Rescued by

Vps25^k08904 is rescued by Vps25^UAS.cHa

(Herz et al., 2006)

Vps25^k08904 is rescued by Vps25^hs.PH

(Herz et al., 2006)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

10839

y¹ w^67c23; P{lacW}Vps25^k08904/CyO

Kyoto

102675

y¹ w^67c23 ; P{lacW}Vps25^k08904 / CyO

Notes on Origin

Discoverer

I. Kiss.

(BDGP Project Members, 1994-1999)

Comments

Complements: Rho1^k02107b. Complements: ptc^k02507. Complements: l(2)44DEa^k16116. Complements: ptc^rH075. Complements: ptc^rH081. Complements: l(2)s1878^s1878.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Vps25^k08904

l(2)44Db^k08904

(Yamamoto et al., 2017, Levis, 2002.11.27)

l(2)k08904

(Dockendorff et al., 2000, Spradling et al., 1999)

l(2)k08904^k08904

vps25^P<up>k08901</up>

(Thompson et al., 2005)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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