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Michelet, X., Djeddi, A., Legouis, R. (2010). Developmental and cellular functions of the ESCRT machinery in pluricellular organisms.  Biol. Cell 102(3): 191--202.
FlyBase ID
FBrf0209668
Publication Type
Review
Abstract

ESCRTs (endosomal sorting complexes required for transport) were first discovered in yeast and are known to be required in the biogenesis of the MVB (multivesicular body). Most ESCRT research has been carried out in vitro using models such as yeast and mammalian cells in culture. The role of the ESCRTs genes in endosome maturation is conserved from yeast to mammals, but little is known about their function during development in multicellular organisms. Since ESCRTs play a leading role in regulating some cell signalling pathways by addressing receptors to the lysosome, it appears important to monitor ESCRT functions in multicellular models. The present review summarizes recent research on the developmental and cellular functions of the ESCRT in Caenorhabditis elegans, Drosophila melanogaster, Mus musculus or Arabidopsis thaliana.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Biol. Cell
    Title
    Biology of the Cell
    Publication Year
    1981-
    ISBN/ISSN
    0248-4900
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