FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\ALiX
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General Information
Symbol
Dmel\ALiX
Species
D. melanogaster
Name
ALG-2 interacting protein X
Annotation Symbol
CG12876
Feature Type
protein_coding_gene
FlyBase ID
FBgn0086346
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Summary
ALG-2 interacting protein X (ALiX) encodes an adaptor protein implicated in multiple cellular processes, including positive regulation of mitotic cytokinesis, exosomal secretion and apoptosis. [Date last reviewed: 2019-02-28] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
98B1-98B1
Sequence location
Recombination map
3-94
RefSeq locus
NT_033777 REGION:27696466..27700110
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (7 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
involved_in actin filament polymerization
inferred from mutant phenotype
(Rogers et al., 2003)
involved_in exosomal secretion
inferred from mutant phenotype
(Corrigan et al., 2014)
involved_in female germ-line stem cell asymmetric division
inferred from mutant phenotype
(Eikenes et al., 2015)
involved_in male germ-line stem cell asymmetric division
inferred from mutant phenotype
(Eikenes et al., 2015)
involved_in mitotic cytokinesis
inferred from mutant phenotype
(Eikenes et al., 2015)
involved_in positive regulation of JNK cascade
inferred from direct assay
(Tsuda et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in mitotic cytokinesis
inferred from biological aspect of ancestor with PANTHER:PTN001126206
(GO Reference Genome Project, 2011-)
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
inferred from sequence or structural similarity with SGD:S000006005
(Gene Ontology Curators, 2002-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in centrosome
inferred from direct assay
(Eikenes et al., 2015)
located_in contractile ring
inferred from direct assay
(Eikenes et al., 2015)
located_in intercellular bridge
inferred from direct assay
(Eikenes et al., 2015)
located_in midbody
inferred from direct assay
(Eikenes et al., 2015)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in endosome
inferred from biological aspect of ancestor with PANTHER:PTN000547070
(GO Reference Genome Project, 2011-)
located_in endosome
inferred from sequence or structural similarity with SGD:S000006005
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
ALG-2 interacting protein X (ALiX) encodes an adaptor protein implicated in multiple cellular processes, including positive regulation of mitotic cytokinesis, exosomal secretion and apoptosis. [Date last reviewed: 2019-02-28]
Summary (Interactive Fly)

adaptor protein - intracellular protein trafficking - regulates mitotic spindle orientation - forms a complex with Shrub - required for completion of cytokinetic abscission during asymmetric germline stem cell division - associates with the ESCRT machinery assisting with cargo recruitment and intraluminal vesicle formation in multivesicular bodies

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\ALiX for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VB05)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
ALiX-RA
FBtr0085241
NM_143325
2892
836
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
ALiX-PA
FBpp0084610
92.5
836
5.10
Q9VB05
NP_651582
AAF56740
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ALiX using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.01

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female & oogenesis
female germline stem cell
(Eikenes et al., 2015)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in centrosome
inferred from direct assay
(Eikenes et al., 2015)
located_in contractile ring
inferred from direct assay
(Eikenes et al., 2015)
located_in intercellular bridge
inferred from direct assay
(Eikenes et al., 2015)
located_in midbody
inferred from direct assay
(Eikenes et al., 2015)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\ALiX in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 19 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ALiX
Transgenic constructs containing regulatory region of ALiX
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-sterile
fertile
Other Phenotypes
Allele
abnormal cytokinesis
abnormal cytokinesis, with Scer\GAL4nanos.PG
abnormal cytokinesis | oogenesis
abnormal eye color, with Scer\GAL4GMR.PF
majority die during embryonic stage | maternal effect
melanotic necrosis, with Scer\GAL4GMR.PF
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4ptc-559.1
Phenotype manifest in
Allele
egg chamber
egg chamber, with Scer\GAL4nanos.PG
egg chamber, with Scer\GAL4VP16.bam
egg chamber, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
epithelium | oogenesis
extracellular exosome, with Scer\GAL4dsx.KI
eye, with Scer\GAL4GMR.PF
female germline cell
female germline cell, with Scer\GAL4nanos.PG
female germline cell, with Scer\GAL4VP16.bam
female germline cell, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
female germline stem cell
female germline stem cell, with Scer\GAL4nanos.PG
Flemming body
germarium
male accessory gland secondary cell, with Scer\GAL4dsx.KI
male accessory gland secondary cell, with Scer\GAL4NP0261
male accessory gland secondary cell, with Scer\GAL4NP7397
male germline stem cell
midbody
multivesicular body, internal vesicle, with Scer\GAL4NP0261
multivesicular body, with Scer\GAL4NP0261
nucleus, with Scer\GAL4NP7397
spectrosome
wing hair, with Scer\GAL4ptc-559.1
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (14)
Hsap\PDCD6IP
13 of 14
Yes
Yes
Hsap\PTPN23
3 of 14
No
No
Hsap\RHPN1
2 of 14
No
No
Hsap\RHPN2
2 of 14
No
No
Hsap\BROX
1 of 14
No
Yes
Hsap\CDIP1
1 of 14
No
No
Hsap\CYSTM1
1 of 14
No
Yes
Hsap\DNM3
1 of 14
No
No
Hsap\LITAFD
1 of 14
No
No
Hsap\NOTCH2
1 of 14
No
No
Hsap\RHPN2P1
1 of 14
No
No
Hsap\RRBP1
1 of 14
No
No
Hsap\SHISA2
1 of 14
No
Yes
Hsap\SUPT5H
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (11)
Rnor\Pdcd6ip
13 of 14
Yes
Yes
Rnor\Ptpn23
3 of 14
No
No
Rnor\Rhpn1
2 of 14
No
No
Rnor\Rhpn2
2 of 14
No
No
Rnor\Brox
1 of 14
No
Yes
Rnor\Cdip1
1 of 14
No
No
Rnor\Cpne1
1 of 14
No
No
Rnor\Litafd
1 of 14
No
No
Rnor\Ms4a14
1 of 14
No
No
Rnor\Rbm12
1 of 14
No
No
Rnor\Supt5h
1 of 14
No
No
Mus musculus (laboratory mouse) (16)
Mmus\Pdcd6ip
13 of 14
Yes
Yes
Mmus\Ptpn23
2 of 14
No
No
Mmus\Rhpn1
2 of 14
No
No
Mmus\Rhpn2
2 of 14
No
No
Mmus\Anxa11
1 of 14
No
No
Mmus\Brox
1 of 14
No
Yes
Mmus\Catsper2
1 of 14
No
No
Mmus\Cdip1
1 of 14
No
No
Mmus\Cntrl
1 of 14
No
No
Mmus\Cystm1
1 of 14
No
Yes
Mmus\Gm5767
1 of 14
No
No
Mmus\Ms4a14
1 of 14
No
No
Mmus\Myo9b
1 of 14
No
No
Mmus\Shisa5
1 of 14
No
Yes
1  
Mmus\Smg6
1 of 14
No
No
Mmus\Supt5
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (8)
Xtro\pdcd6ip
11 of 13
Yes
Yes
Xtro\ptpn23
2 of 13
No
No
Xtro\brox
1 of 13
No
Yes
Xtro\cln8
1 of 13
No
No
Xtro\cystm1
1 of 13
No
No
Xtro\LOC100498592
1 of 13
No
No
Xtro\LOC101730868
1 of 13
No
No
Xtro\slc34a3
1 of 13
No
Yes
Danio rerio (Zebrafish) (21)
Drer\pdcd6ip
13 of 14
Yes
Yes
Drer\ptpn23a
3 of 14
No
No
Drer\ptpn23b
3 of 14
No
No
Drer\rhpn1
2 of 14
No
No
Drer\rhpn2
2 of 14
No
No
Drer\brox
1 of 14
No
Yes
Drer\cdip1
1 of 14
No
No
Drer\LOC103911283
1 of 14
No
No
Drer\mia3
1 of 14
No
No
Drer\prr13
1 of 14
No
Yes
Drer\shisa10.1
1 of 14
No
Yes
Drer\shisa10.2
1 of 14
No
Yes
Drer\si:ch211-157c3.4
1 of 14
No
No
Drer\si:ch211-160j14.2
1 of 14
No
Yes
Drer\si:ch211-202h22.7
1 of 14
No
No
Drer\si:ch211-202h22.8
1 of 14
No
No
Drer\si:ch211-202h22.9
1 of 14
No
No
Drer\si:dkeyp-75b4.8
1 of 14
No
No
Drer\supt5h
1 of 14
No
No
Drer\xrn1
1 of 14
No
No
Drer\zgc:165573
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\alx-1
13 of 14
Yes
Yes
Cele\B0507.2
2 of 14
No
Yes
Cele\ego-2
2 of 14
No
No
Cele\ama-1
1 of 14
No
No
Cele\F36G3.3
1 of 14
No
No
Cele\nmr-1
1 of 14
No
No
Cele\Y22D7AL.15
1 of 14
No
No
Cele\Y41C4A.11
1 of 14
No
No
Cele\Y87G2A.18
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (51)
Agam\AgaP_AGAP005531
12 of 12
Yes
Yes
Agam\AgaP_AGAP011586
3 of 12
No
No
Agam\AgaP_AGAP000243
1 of 12
No
No
Agam\AgaP_AGAP000745
1 of 12
No
No
Agam\AgaP_AGAP004928
1 of 12
No
No
Agam\AgaP_AGAP005471
1 of 12
No
No
Agam\AgaP_AGAP009051
1 of 12
No
No
Agam\AgaP_AGAP010109
1 of 12
No
No
Agam\AgaP_AGAP012866
1 of 12
No
No
Agam\CPR1
1 of 12
No
No
Agam\CPR2
1 of 12
No
No
Agam\CPR4
1 of 12
No
No
Agam\CPR5
1 of 12
No
No
Agam\CPR6
1 of 12
No
No
Agam\CPR10
1 of 12
No
No
Agam\CPR47
1 of 12
No
No
Agam\CPR49
1 of 12
No
No
Agam\CPR51
1 of 12
No
No
Agam\CPR53
1 of 12
No
No
Agam\CPR54
1 of 12
No
No
Agam\CPR58
1 of 12
No
No
Agam\CPR60
1 of 12
No
No
Agam\CPR64
1 of 12
No
No
Agam\CPR70
1 of 12
No
No
Agam\CPR71
1 of 12
No
No
Agam\CPR72
1 of 12
No
No
Agam\CPR82
1 of 12
No
No
Agam\CPR86
1 of 12
No
No
Agam\CPR94
1 of 12
No
No
Agam\CPR96
1 of 12
No
No
Agam\CPR98
1 of 12
No
No
Agam\CPR99
1 of 12
No
No
Agam\CPR101
1 of 12
No
No
Agam\CPR107
1 of 12
No
No
Agam\CPR109
1 of 12
No
No
Agam\CPR114
1 of 12
No
No
Agam\CPR115
1 of 12
No
No
Agam\CPR116
1 of 12
No
No
Agam\CPR117
1 of 12
No
No
Agam\CPR118
1 of 12
No
No
Agam\CPR119
1 of 12
No
No
Agam\CPR120
1 of 12
No
No
Agam\CPR121
1 of 12
No
No
Agam\CPR122
1 of 12
No
No
Agam\CPR123
1 of 12
No
No
Agam\CPR131
1 of 12
No
No
Agam\CPR135
1 of 12
No
No
Agam\CPR136
1 of 12
No
No
Agam\CPR139
1 of 12
No
No
Agam\CPR142
1 of 12
No
No
Agam\CU01_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (7)
Atha\AT1G15130
12 of 13
Yes
Yes
Atha\AT1G13310
1 of 13
No
Yes
Atha\AT1G73390
1 of 13
No
Yes
Atha\AT2G32210
1 of 13
No
Yes
Atha\AT2G45620
1 of 13
No
No
Atha\AT3G50570
1 of 13
No
Yes
Atha\AT3G63460
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (25)
Scer\RIM20
13 of 13
Yes
Yes
Scer\BRO1
6 of 13
No
No
Scer\YBR012W-B
1 of 13
No
Yes
Scer\YDR098C-B
1 of 13
No
Yes
Scer\YDR210C-D
1 of 13
No
Yes
Scer\YDR261C-D
1 of 13
No
Yes
Scer\YDR316W-B
1 of 13
No
Yes
Scer\YDR365W-B
1 of 13
No
Yes
Scer\YER138C
1 of 13
No
Yes
Scer\YER160C
1 of 13
No
Yes
Scer\YGR038C-B
1 of 13
No
Yes
Scer\YGR161C-D
1 of 13
No
Yes
Scer\YHR214C-B
1 of 13
No
Yes
Scer\YJR027W
1 of 13
No
Yes
Scer\YLR035C-A
1 of 13
No
Yes
Scer\YLR157C-B
1 of 13
No
Yes
Scer\YLR227W-B
1 of 13
No
Yes
Scer\YML039W
1 of 13
No
Yes
Scer\YML045W
1 of 13
No
Yes
Scer\YMR050C
1 of 13
No
Yes
Scer\YOL103W-B
1 of 13
No
Yes
Scer\YOR142W-B
1 of 13
No
Yes
Scer\YPL257W-B
1 of 13
No
Yes
Scer\YPR158C-D
1 of 13
No
Yes
Scer\YPR158W-B
1 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\SPAC17G6.05c
7 of 12
Yes
Yes
Spom\SPAC2G11.05c
5 of 12
No
Yes
Spom\pabp
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:ALiX. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (23)
mop
5 of 13
Rhp
2 of 13
ana1
1 of 13
Ccp84Ac
1 of 13
Ccp84Ae
1 of 13
Ccp84Ag
1 of 13
CG7924
1 of 13
CG13559
1 of 13
CG13670
1 of 13
CG34461
1 of 13
CG34462
1 of 13
Cpr5C
1 of 13
Cpr23B
1 of 13
Cpr47Ee
1 of 13
Cpr62Bb
1 of 13
Cpr64Aa
1 of 13
Cpr64Ab
1 of 13
Cpr64Ac
1 of 13
Cpr66Cb
1 of 13
Cpr92A
1 of 13
Crys
1 of 13
drosha
1 of 13
Edg84A
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PDCD6IP; programmed cell death 6 interacting protein
    13 of 14
    608074
    PTPN23; protein tyrosine phosphatase non-receptor type 23
    3 of 14
    606584
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      ALiX
      enhanceable
      POSH
      (Tsuda et al., 2006)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map
      3-94
      Cytogenetic map
      98B1-98B1
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      98B1-98B1
      Limits computationally determined from genome sequence between P{PZ}sda03884 and P{PZ}btzrL203
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      3-94

      (FlyBase, 2016)

      3-91.5

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (12)
      Genomic Clones (19)
      cDNA Clones (142)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Salvia et al., 2017, Eikenes et al., 2015)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

          (Rogers et al., 2003)

          Overexpression of Aip1 is sufficient to induce cell death in the developing eye imaginal discs.

          (Tsuda et al., 2003)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: Aip1 CG12876

          (Tsuda et al., 2006)
          Additional comments
          Nomenclature History
          Source for database identify of

          Source for identity of: ALiX Aip1 CG12876

          (Tsuda et al., 2006)
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (13)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 40 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          References (80)