FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ALiX3
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General Information
Symbol
Dmel\ALiX3
Species
D. melanogaster
Name
FlyBase ID
FBal0302615
Feature type
allele
Associated gene
Dmel\ALiX
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

amorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Eikenes et al., 2015)

    amorphic allele - molecular evidence

    (Eikenes et al., 2015)
    Mutagen
    Progenitor genotype
    P{EPgy2}ALiXEY10362
    (Eikenes et al., 2015)
    Cytology
    Description

    Imprecise excision of the P{EPgy2}ALiXEY10362 progenitor insertion, resulting in a deletion that removes the start codon, exons 1 and 2, and most of exon 3 of ALiX.

    (Eikenes et al., 2015)

    Deletion that removes nucleotides 3R:23524881..23525741 (release 5 genome coordinates). Revision of data reported in FBrf0227451.

    (Haglund, 2015.5.18)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    deletion
    3R:27,699,159..27,700,019 [-]
    Comment:

    An 860 bp deletion resulting from the imprecise excsion of the P{EPgy2}ALiXEY10362 progenitor insertion, which removes the 5' end of the ALiX gene. The deleted sequences map to 3R:23524881..23525741 (in release 5 coordinates).

    (Eikenes et al., 2015, Haglund, 2015.5.18)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Approximately 60% of mutant egg chambers contain 32 germ cells. These egg chambers contain an oocyte with 5 ring canals.

        The fraction of mutant female germline stem cells (GSCs) which contain a spectrosome is smaller than wild type. The fraction of mutant GSC-cystoblast (CB) pairs with a midbody ring is reduced and mutant GSC-CB pairs with a midbody are not seen. More than half of the mutant female GSCs show abscission defects: linear or branched chains of GSCs are seen in approximately 20% and 40% of cases and approximately 2% of the cells are polyploid.

        Approximately 40% of mutant male germline stem cells are found interconnected to chains of daughter cells.

        (Eikenes et al., 2015)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        ALiX3 is rescued by ALiXCH322-119C06

        (Eikenes et al., 2015)

        ALiX3 is rescued by ALiXCH321-50C24

        (Eikenes et al., 2015)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        ALiX3
        (Haglund, 2015.5.18)
        alix3
        (Hermant et al., 2024, Lie-Jensen et al., 2019, Eikenes et al., 2015)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)