ept, erupted, vps23, ESCRT-I, dTsg101
an ESCRT-I complex component that acts as an adapter for membrane rearrangements operated by ESCRT-III - binds monoubiquitinated substrates predicted to be ubiquitinated cytoplasmic tails of membrane bound proteins; this interaction delivers cargos to the lysosome via multivesicular bodies.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\TSG101 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\TSG101 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
TSG101 mutant cells in the eye-antennal disc survive poorly. The eyes and heads of flies that contain TSG101 mutant cells are dramatically overgrown, yet are composed of mostly wild type cells. TSG101 mutant cells hyperactivate N signaling and overproduce the secreted growth factor os. TSG101 mutant cells provoke local tissue hyperplasia and ectopic S phase entry in surrounding wild type cells; the resulting overgrowth is dependent upon signaling through the os-responsive JAK/STAT pathway.
Named 'Tumor susceptibility gene 101' after the symbol of the human ortholog.