FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\hpo3D
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General Information
Symbol
Dmel\hpo3D
Species
D. melanogaster
Name
FlyBase ID
FBal0194625
Feature type
allele
Associated gene
Dmel\hpo
Associated Insertion(s)
Carried in Construct
Also Known As
hippo3D
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: ?185term.

    (Herz et al., 2006)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2R:19,496,196..19,496,196 [-]
    Nucleotide change:

    C19496196T

    Amino acid change:

    Q185term | hpo-PA; Q185term | hpo-PB

    Reported amino acid change:

    Q185term

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Herz et al., 2006)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  carcinoma
        CEA
        (Pérez et al., 2015)
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        model of  carcinoma
        is exacerbated by ykiUAS.cHa
        (Pérez et al., 2015)
        is ameliorated by Atg1UAS.cSa
        (Pérez et al., 2015)
        exacerbates  carcinoma
        modeled by Vps25N55
        (Herz et al., 2006)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Enhancer of
        Statement
        Reference

        hpo3D/hpo3D is an enhancer of increased cell number | oogenesis | germline clone phenotype of bamBG

        (Zhang et al., 2024)
        NOT Enhancer of
        Statement
        Reference

        hpo3D/hpo3D is a non-enhancer of increased cell number | oogenesis | germline clone phenotype of bgcn1

        (Zhang et al., 2024)
        Suppressor of
        Statement
        Reference

        hpo3D is a suppressor of increased cell death | somatic clone phenotype of Vps25N55

        (Herz et al., 2006)

        hpo3D is a suppressor of increased cell death | somatic clone | larval stage phenotype of Vps25N55

        (Herz et al., 2006)
        NOT Suppressor of
        Statement
        Reference

        hpo3D/hpo3D is a non-suppressor of increased cell number | germline clone | oogenesis phenotype of bgcn1

        (Zhang et al., 2024)
        Phenotype Manifest In
        Suppressed by
        Enhancer of
        Statement
        Reference

        hpo3D/hpo3D is an enhancer of female germline cell | increased number | germline clone phenotype of bamBG

        (Zhang et al., 2024)
        NOT Enhancer of
        Statement
        Reference

        hpo3D/hpo3D is a non-enhancer of female germline cell | increased number | germline clone phenotype of bgcn1

        (Zhang et al., 2024)
        NOT Suppressor of
        Statement
        Reference

        hpo3D/hpo3D is a non-suppressor of female germline cell | increased number | germline clone phenotype of bgcn1

        (Zhang et al., 2024)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Vps25N55 hpo3D mutant clones do not undergo apoptosis.

        (Herz et al., 2006)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        hippo3D
        (Pérez et al., 2015)
        hpo3D
        (Zhang et al., 2024, Zhang et al., 2023)
        Name Synonyms
        hippo3D
        (Herz et al., 2006)
        Secondary FlyBase IDs
          References (4)