FlyBase Allele Report: Dmel\bam[BG]

General Information

Symbol

Dmel\bam^BG

Species

D. melanogaster

Name

FlyBase ID

FBal0180868

Feature type

allele

Associated gene

Dmel\bam

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | germline clone | oogenesis

(Zhang et al., 2024)

male sterile (with bam^Δ86)

(Flores et al., 2015)

Phenotype Manifest In

female germline cell | germline clone | increased number

(Zhang et al., 2024)

Detailed Description

Statement

Reference

The completely sterility of bam^BG/bam^Δ86 males is not improved upon Wolbachia pipientis infection.

(Flores et al., 2015)

Mutant testes are filled with early stage germ cells.

(Zhao et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

bam^BG has increased cell number | oogenesis | germline clone phenotype, enhanceable by hpo^3D/hpo^3D

(Zhang et al., 2024)

Suppressed by

Statement

Reference

bam^BG has increased cell number | germline clone | oogenesis phenotype, suppressible by AGO1^k08121/AGO1^k08121

(Zhang et al., 2024)

bam^BG, hpo^3D has increased cell number | germline clone | oogenesis phenotype, suppressible by AGO1^k08121/AGO1^k08121

(Zhang et al., 2024)

bam^Δ86/bam^BG has male sterile phenotype, suppressible by Dsim\bam^bam.Venus

(Flores et al., 2015)

Other

Statement

Reference

bam^BG, yki^B5 has cell lethal | germline clone | oogenesis phenotype

(Zhang et al., 2024)

Dcr-1^HMS00141, Scer\GAL4^{VP16.nanos.UTR}, bam^Δ86/bam^BG has decreased cell number | oogenesis phenotype

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR}, bam^Δ86/bam^BG has increased occurrence of cell division | oogenesis phenotype

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR}, bam^Δ86/bam^BG has abnormal cell number | oogenesis phenotype

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR}, bam^Δ86/bam^BG has decreased cell size | oogenesis phenotype

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR}, bam^Δ86/bam^BG has increased size | oogenesis phenotype

(Zhang et al., 2024)

Phenotype Manifest In

Enhanced by

Statement

Reference

bam^BG has female germline cell | increased number | germline clone phenotype, enhanceable by hpo^3D/hpo^3D

(Zhang et al., 2024)

Suppressed by

Statement

Reference

bam^BG has female germline cell | increased number | germline clone phenotype, suppressible by AGO1^k08121/AGO1^k08121

(Zhang et al., 2024)

bam^BG, hpo^3D has female germline cell | increased number | germline clone phenotype, suppressible by AGO1^k08121/AGO1^k08121

(Zhang et al., 2024)

Suppressor of

Statement

Reference

bam[+]/bam^BG is a suppressor of ovary phenotype of nanos¹⁸/Df(3R)nanos

(Li et al., 2009)

bam[+]/bam^BG is a suppressor of germline stem cell phenotype of nanos¹⁸/Df(3R)nanos

(Li et al., 2009)

bam[+]/bam^BG is a suppressor of ovary phenotype of nanos⁵³/Df(3R)nanos

(Li et al., 2009)

bam[+]/bam^BG is a suppressor of germline stem cell phenotype of nanos⁵³/Df(3R)nanos

(Li et al., 2009)

Other

Statement

Reference

Dcr-1^HMS00141, Scer\GAL4^{VP16.nanos.UTR}, bam^Δ86/bam^BG has female germline cell | absent phenotype

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR}, bam^Δ86/bam^BG has ovary phenotype

(Zhang et al., 2024)

Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR}, bam^Δ86/bam^BG has female germline cell phenotype

(Zhang et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Ovaries of nos¹⁸/Df(3R)nos females that are also heterozygous for bam^BG produce many egg chambers. Removing one copy of bam increases egg chamber formation at least 10-fold in a nos¹⁸/Df(3R)nos background.

(Li et al., 2009)

Xenogenetic Interactions

Statement

Reference

Expression of Dsim\bam^{bam.T:Avic\GFP-YFP.Venus} restores fertility of the otherwise sterile bam^BG/bam^Δ86 males (even under sperm exhaustion conditions).

(Flores et al., 2015)

Complementation and Rescue Data

Partially rescued by

bam^Δ86/bam^BG is partially rescued by bam^4.1.Venus

(Flores et al., 2015)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

bam^BG

(Zhang et al., 2024, Zhang et al., 2024, Zhang et al., 2023, Zhao et al., 2018, Shan et al., 2017, Flores et al., 2015, Chen et al., 2014, Xin et al., 2013, Guo and Wang, 2009, Li et al., 2009, Yang et al., 2007)

bam^bg

(Zhao et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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