Open Close
Reference
Citation
Chen, C., Cummings, R., Mordovanakis, A., Hunt, A.J., Mayer, M., Sept, D., Yamashita, Y.M. (2018). Cytokine receptor-Eb1 interaction couples cell polarity and fate during asymmetric cell division.  eLife 7(): e33685.
FlyBase ID
FBrf0238664
Publication Type
Research paper
Abstract

Asymmetric stem cell division is a critical mechanism for balancing self-renewal and differentiation. Adult stem cells often orient their mitotic spindle to place one daughter inside the niche and the other outside of it to achieve asymmetric division. It remains unknown whether and how the niche may direct division orientation. Here we discover a novel and evolutionary conserved mechanism that couples cell polarity to cell fate. We show that the cytokine receptor homolog Dome, acting downstream of the niche-derived ligand Upd, directly binds to the microtubule-binding protein Eb1 to regulate spindle orientation in Drosophila male germline stem cells (GSCs). Dome's role in spindle orientation is entirely separable from its known function in self-renewal mediated by the JAK-STAT pathway. We propose that integration of two functions (cell polarity and fate) in a single receptor is a key mechanism to ensure an asymmetric outcome following cell division.

PubMed ID
PubMed Central ID
PMC5886756 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    eLife
    Title
    eLife
    ISBN/ISSN
    2050-084X
    Data From Reference
    Aberrations (1)
    Alleles (38)
    Genes (16)
    Physical Interactions (6)
    Natural transposons (2)
    Insertions (1)
    Experimental Tools (3)
    Transgenic Constructs (31)