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FB2026_01
,
released March 12, 2026
APC1, D-APC, dAPC, adenomatous polyposis coli, dAPC1
adenomatous polyposis coli homolog involved in the wingless pathway - functions in neural development
Please see the JBrowse view of Dmel\Apc for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.48
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Translational frameshifting postulated (FBrf0216436).
Gene model reviewed during 6.07
8 (northern blot)
2416 (aa); 260 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Apc using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Apc transcripts are observed in very early embyros and are not seen again until after germ band retraction. At that time they are concentrated in the CNS where they are restricted to postmitotic cells. Transcripts are also found in the epidermis.
Embryonic expression of Apc protein is ubiquitous, but more pronounced in the CNS.
Apc protein is detected in the nervous system of embryos from germ-band retraction on. It localizes to axon fiber tracts and motor neurons. Initially, similar levels are found in longitudinal and commissural tracts. Later, staining is more intense in the longitudinal tracts and is distributed in patches or streaks within specific fibers in the longitudinal tracts.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Apc in JBrowse
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Identification: cDNA expression library with an antibody against Hsap\APC.
Source for merge of: Apc CG1451
"S(CycEJP)1S3" is unlikely to correspond to "Apc"; mutations in the two loci complement each other.
