FB2025_05 , released December 11, 2025
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Apc, dia
FlyBase ID
FBig0000098460
Interaction Network
Interactions Browser links
Apc network
dia network
Reported Interactions
FBrf0207596-4.PD.WB
Reference
Webb et al., 2009
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Apc 

APC1

bait

GST tag

Apc 
dia 

Dia

prey

His tag

dia 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
dia 
C-terminal domain
sufficient binding region
aa 519-1091

coordinates relative to dia-PA

Apc 
basic region
sufficient binding region
aa 2135-2412

coordinates relative to Apc-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in bacterial system; prey produced as a recombinant fusion protein in bacterial system.

(Webb et al., 2009)
FBrf0221540-1.PD.WB
Reference
Jaiswal et al., 2013
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Apc 

APC1

bait

GST tag

Apc 
dia 

Dia

prey

His tag

dia 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Apc 
basic domain
sufficient binding region
aa 2136-2417
dia 
DAD domain
sufficient binding region
aa 1003-1091
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in bacterial system; prey produced as a recombinant fusion protein in bacterial system.

(Jaiswal et al., 2013)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)