FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ewgP1
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General Information
Symbol
Dmel\ewgP1
Species
D. melanogaster
Name
FlyBase ID
FBal0270108
Feature type
allele
Associated gene
Dmel\ewg
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: R171C.

    (Xin et al., 2011)

    Nucleotide substitution: C?T.

    (Xin et al., 2011)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    X:273,907..273,907 [-]
    Nucleotide change:

    C273907T

    Reported nucleotide change:

    C?T

    Amino acid change:

    R171C | ewg-PA; R171C | ewg-PB; R171C | ewg-PC; R171C | ewg-PD; R171C | ewg-PE; R171C | ewg-PF; R171C | ewg-PG; R171C | ewg-PH; R171C | ewg-PJ; R171C | ewg-PK; R171C | ewg-PL; R171C | ewg-PM; R171C | ewg-PN

    Reported amino acid change:

    R171C

    (Xin et al., 2011)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        ameliorates  colorectal cancer
        modeled by ApcQ8
        (Tian et al., 2017)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        ewgP1 mutant adults do not show any significant increase in the number of progenitor cells (intestinal stem cells and enteroblasts) in the midgut and neither do they display any aberrations in the overall architecture of the midgut epithelium, as compared to controls.

        (Tian et al., 2017)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        ewgP1 is a suppressor of increased cell number | adult stage phenotype of ApcQ8

        (Tian et al., 2017)

        ewgP1 is a suppressor of abnormal cell polarity | adult stage phenotype of ApcQ8

        (Tian et al., 2017)

        ewgP1 is a suppressor of abnormal cell adhesion | adult stage phenotype of ApcQ8

        (Tian et al., 2017)

        ewgP1 is a suppressor of cell lethal | adult stage phenotype of ApcQ8

        (Xin et al., 2011)

        ewgP1/ewg2 is a suppressor of cell lethal | adult stage phenotype of ApcQ8

        (Xin et al., 2011)

        ewgP1/ewg2 is a suppressor of abnormal size | adult stage phenotype of ApcQ8

        (Xin et al., 2011)
        Other
        Statement
        Reference

        ApcQ8, ewgP1, ewgSC3ORF.elav has cell lethal | adult stage phenotype

        (Xin et al., 2011)
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        ewgP1 is a suppressor of intestinal stem cell | increased number | adult stage phenotype of ApcQ8

        (Tian et al., 2017)

        ewgP1 is a suppressor of enteroblast | increased number | adult stage phenotype of ApcQ8

        (Tian et al., 2017)

        ewgP1 is a suppressor of adult midgut epithelium phenotype of ApcQ8

        (Tian et al., 2017)

        ewgP1 is a suppressor of photoreceptor | adult stage phenotype of ApcQ8

        (Xin et al., 2011)

        ewgP1/ewg2 is a suppressor of photoreceptor | adult stage phenotype of ApcQ8

        (Xin et al., 2011)

        ewgP1/ewg2 is a suppressor of rhabdomere | adult stage phenotype of ApcQ8

        (Xin et al., 2011)
        Other
        Statement
        Reference

        ApcQ8, ewgP1, ewgSC3ORF.elav has photoreceptor | adult stage phenotype

        (Xin et al., 2011)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The adult midgut epithelium defects (increased number of progenitor cells, cell polarity and adhesion defects along with epithelium multi-layering) can be rescued by combination with ewgP1 mutant alleles.

        (Tian et al., 2017)

        Hemizygous ewgP1 suppresses the apoptosis seen in ApcQ8 mutant photoreceptors. This apoptosis can be restored by expressing ewgelav.NS.

        Hemizygous ewgP1/ewg2 suppresses the apoptosis seen in ApcQ8 mutant photoreceptors. The shortening of photoreceptor length seen prior to apoptosis is also suppressed, and the rhabdomere enlargement seen as a result of misspecification of all of the photoreceptors in the dorsal half of the retina to a dorsal rim area fate is also partially suppressed. This is most evident near the dorsal-ventral equator.

        (Xin et al., 2011)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        ewgP1
        (Tian et al., 2017, Xin et al., 2011)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)