FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term beta-catenin destruction complex ID (Ontology) GO:0030877 (Gene Ontology)
Definition A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.[ PubMed:14600025 ]
Also Known As"APC-Axin-1-beta-catenin complex" ; "Axin-APC-beta-catenin-GSK3B complex" ; "BDC" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_CELLULAR_COMPONENT
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 beta-catenin destruction complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | beta-catenin destruction complex       --
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protein-containing complex
 |__intracellular protein-containing complex__
 |__catalytic complex_________________________|
                                              beta-catenin destruction complex  8 rec.
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Is a intracellular protein-containing complex
catalytic complex
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Synonyms
  • "23S APC complex" NARROW
    "APC-Axin-1-beta-catenin complex" EXACT
    "Axin-APC-beta-catenin-GSK3B complex" EXACT
    "BDC" EXACT[ PubMed:22899650 ]
    "beta-catenin degradation complex" EXACT
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