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General Information
Symbol
Dmel\Apc233
Species
D. melanogaster
Name
FlyBase ID
FBal0213105
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
complex substitution
Comment:

1738 bp deletion resulting from the imprecise excision of the P{EPgy2}EY09246. 720bp of the insertion remain at this deletion site. There is also a 4 bp deletion of bases 1313-1316 relative to the Apc2 transcription start site (R5.1).

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the P{EPgy2}EY09246 insertion, resulting in a deletion of nucleotides -431 to +1307 relative to the Apc2 transcription start site. 720bp of the insertion remain at this deletion site. There is a second deletion of 4bp at positions +1313 to +1316.

Insertion components
P{?EPgy2}Apc233
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Embryos maternally and zygotically mutant for Apc233 have an average cuticle score of 3.2 (based on the numerical scale described in McCartney et al., 1994, where 0 is a wild type embryo and 6 indicates the most severe defects).

Severe hypomorph.

Homozygous embryos derived from homozygous females show an expansion of naked cuticle at the expense of denticles.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

No apical constriction is seen in the cells surrounding the wing pouch in ApcQ8 Apc233 double mutant third instar larval clones.

Apc219-3 ApcQ8 double mutant clone cells generated in the medullar region of third instar larval brains sometimes segregate from their neighbours to form cysts. When clones are induced in the medullar neurons the axons extend correctly to the medullar neuropil.

Apc233 ApcQ8 double mutant intestinal stem cell clones in the adult midgut show hyperplasia.

The hyperplasia seen in Apc233 ApcQ8 double mutant intestinal stem cell clones in the adult midgut is completely suppressed if they are also expressing panΔN.Scer\UAS under the control of Scer\GAL4tub.

The photoreceptor apoptosis phenotype seen in flies expressing armScer\UAS.Exel under the control of Scer\GAL4elav-C155 is partially suppressed by Apc233/Apc233.

ApcQ8 Apc25-3/ApcQ8 Apc233 double mutants show expansion of sternal territory in the abdomen and ectopic sternal bristles, at the expense of the pleura.

ApcQ8 Apc2G5028/ApcQ8 Apc233 double mutants show expansion of sternal territory in the abdomen and ectopic sternal bristles, at the expense of the pleura.

The photoreceptor cell apoptosis phenotype seen in ApcQ8 homozygotes is suppressed by Apc233/+.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)