FlyBase Allele Report: Dmel\arm[UAS.Exel]

General Information

Symbol

Dmel\arm^UAS.Exel

Species

D. melanogaster

Name

FlyBase ID

FBal0155641

Feature type

allele

Associated gene

Dmel\arm

Associated Insertion(s)

Carried in Construct

P{UAS-arm.Exel}

Also Known As

UAS-Arm

Key Links

Transgenic product class

wild_type

(Parks, 2004.5.12)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Parks, 2004.5.12)

Mutagen

in vitro construct

(Parks, 2004.5.12)

Progenitor genotype

Carried in construct

P{UAS-arm.Exel}

Cytology

Description

Wild type arm was cloned into P{Express-UAS}. Expression is governed by UAS regulatory sequences.

(Parks, 2004.5.12)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

arm

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of carcinoma

CEA

(Zhang et al., 2019)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of carcinoma

is exacerbated by Ras85D^V12.UAS

(Zhang et al., 2019)

exacerbates Huntington's disease

modeled by Hsap\HTT^Q200.FL.UAS

(Greco et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell migration | third instar larval stage, with Scer\GAL4^ptc-559.1

(Zhang et al., 2019)

decreased occurrence of cell division | third instar larval stage, with Scer\GAL4^ptc-559.1

(Zhang et al., 2019)

Phenotype Manifest In

anterior-posterior compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4^ptc-559.1

(Zhang et al., 2019)

eye photoreceptor cell, with Scer\GAL4^elav-C155

(Takacs et al., 2008)

wing disc | third instar larval stage, with Scer\GAL4^ptc-559.1

(Zhang et al., 2019)

Detailed Description

Statement

Reference

Expressing arm^UAS.Exel at the anterior/posterior boundary of the third instar larval wing disc (under the control of Scer\GAL4^ptc-559.1) leads to severe cell migration away from the ptc-positive domain, as well as to a significant decrease in cell division (phospho-H3) throughout the disc.

Whole eye-antennal disc clones that express arm^UAS.Exel under the control of Scer\GAL4^Act.PU do not form tumors.

(Zhang et al., 2019)

Expression of arm^{Scer\UAS.Exel} under the control of Scer\GAL4^elav-C155 results in photoreceptor cell apoptosis, although there rarely some ommatidia retain some photoreceptors.

(Takacs et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^ptc-559.1, arm^UAS.Exel has abnormal cell migration | third instar larval stage phenotype, suppressible | partially by bsk^DN.UAS/Scer\GAL4^ptc-559.1

(Zhang et al., 2019)

NOT Suppressor of

Statement

Reference

arm^UAS.Exel, Scer\GAL4^bbg-C96 is a non-suppressor of visible phenotype of Klp64D^NIG.10642R, Scer\GAL4^bbg-C96

(Vuong et al., 2014)

Other

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Act.PU, arm^UAS.Exel has neoplasia | somatic clone | larval stage phenotype

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, arm^UAS.Exel has abnormal cell migration | somatic clone | larval stage phenotype

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, arm^UAS.Exel has lethal - all die during larval stage | somatic clone phenotype

(Zhang et al., 2019)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^ptc-559.1, arm^UAS.Exel has anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype, suppressible | partially by bsk^DN.UAS/Scer\GAL4^ptc-559.1

(Zhang et al., 2019)

Scer\GAL4^elav-C155, arm^UAS.Exel has eye photoreceptor cell phenotype, suppressible by Apc2³³/Apc2³³

(Takacs et al., 2008)

NOT Suppressor of

Statement

Reference

arm^UAS.Exel, Scer\GAL4^bbg-C96 is a non-suppressor of wing margin phenotype of Klp64D^NIG.10642R, Scer\GAL4^bbg-C96

(Vuong et al., 2014)

Other

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Act.PU, arm^UAS.Exel has eye-antennal disc | somatic clone | third instar larval stage phenotype

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, arm^UAS.Exel has larval ventral nerve cord | somatic clone | larval stage phenotype

(Zhang et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Whole eye-antennal disc clones that co-express Ras85D^V12.UAS and arm^UAS.Exel under the control of Scer\GAL4^Act.PU form tumors that invade the adjacent ventral nerve cord by day 7 after egg laying.

(Zhang et al., 2019)

Expression of arm^{Scer\UAS.Exel} strongly suppresses the wing notching seen when Klp64D^NIG.10642R is expressed under the control of Scer\GAL4^bbg-C96. The wing margin bristles are partially restored.

(Vuong et al., 2014)

The photoreceptor apoptosis phenotype seen in flies expressing arm^{Scer\UAS.Exel} under the control of Scer\GAL4^elav-C155 is partially suppressed by Apc2³³/Apc2³³.

(Takacs et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

8369

y¹ w¹¹¹⁸; P{UAS-arm.Exel}2

8370

y¹ w¹¹¹⁸; P{UAS-arm.Exel}3/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

arm^{Scer\UAS.Exel}

arm^UAS.Exel

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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