FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ApcS76
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General Information
Symbol
Dmel\ApcS76
Species
D. melanogaster
Name
FlyBase ID
FBal0091897
Feature type
allele
Associated gene
Dmel\Apc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: W488term.

    (Ahmed et al., 1998)

    Nucleotide substitution: G1671A.

    (Ahmed et al., 1998)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:28,839,298..28,839,298 [-]
    Nucleotide change:

    G28839298A

    Amino acid change:

    W488term | Apc-PA; W488term | Apc-PB

    (Ahmed et al., 1998)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Ectopic photoreceptor apoptosis is seen in the developing eyes of ApcS76/ApcQ8 pupae, beginning at around 35 hours after puparium formation (APF) and peaking at 42 hours APF. This timing is identical to that of photoreceptor apoptosis occurring at the periphery of the developing eye in wild-type pupae.

        (Lin et al., 2004)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Statement
        Reference

        ApcQ8/ApcS76 has increased cell death | pupal stage phenotype, suppressible | partially by Df(3L)H99/+

        (Lin et al., 2004)
        Phenotype Manifest In
        Suppressed by
        Statement
        Reference

        ApcQ8/ApcS76 has eye photoreceptor cell | P-stage phenotype, suppressible | partially by Df(3L)H99/+

        (Lin et al., 2004)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Ectopic photoreceptor apoptosis in the developing eyes of ApcS76/ApcQ8 pupae is greatly reduced by Df(3L)H99/+.

        (Lin et al., 2004)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        ApcS76
        D-APCS76
        (Ahmed et al., 1998)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)