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General Information
Symbol
Dmel\Rab8UASp.YFP
Species
D. melanogaster
Name
FlyBase ID
FBal0215401
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UASp-YFP-Rab8
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASp regulatory sequences drive expression of wild-type Rab8 that is tagged at the N-terminal end with YFP.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Suppressor of
Statement
Reference
NOT Suppressor of
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The co-expression of Rab8Scer\UAS.P\T.T:Avic\GFP-YFP does not suppress the basement membrane deposition defects observed in follicle cells expressing stratGD10605 under the control of Scer\GAL4tj.PU.

Xenogenetic Interactions
Statement
Reference

The locomotion defects characteristic for third instar larvae expressing Hsap\SNCAScer\UAS.cUa under the control of either Scer\GAL4C164 or Scer\GAL4ple.PF can be suppressed by co-expression of Rab8Scer\UAS.P\T.T:Avic\GFP-YFP : the decrease in the distance crawled by third instar larvae per unit of time is significantly ameliorated.

The locomotion defects characteristic for third instar larvae expressing Hsap\SNCATP.Scer\UAS.cKa under the control of either Scer\GAL4C164 or Scer\GAL4ple.PF can be suppressed by co-expression of Rab8Scer\UAS.P\T.T:Avic\GFP-YFP : the decrease in the distance crawled by third instar larvae per unit of time is significantly ameliorated.

The locomotion defects characteristic for third instar larvae expressing Hsap\SNCAScer\UAS.cKa under the control of either Scer\GAL4C164 or Scer\GAL4ple.PF can be suppressed by co-expression of Rab8Scer\UAS.P\T.T:Avic\GFP-YFP : the decrease in the distance crawled by third instar larvae per unit of time is significantly ameliorated.

The negative geotaxis defects characteristic for flies expressing Hsap\SNCAScer\UAS.cUa under the control of either Scer\GAL4elav.PU can be suppressed by co-expression of Rab8Scer\UAS.P\T.T:Avic\GFP-YFP : the reduction in climbing activity of adult flies is significantly ameliorated.

The reduction in the number of dopaminergic neurons from the PPL1 clusters characteristic for adult flies expressing Hsap\SNCAScer\UAS.cKa under the control of either Scer\GAL4elav.PU or Scer\GAL4ple.PF can be fully rescued by co-expression with Rab8Scer\UAS.P\T.T:Avic\GFP-YFP. The loss of dopaminergic neurons from the PPM3 cluster seen in adult flies expressing Hsap\SNCAScer\UAS.cKa under the control of Scer\GAL4elav.PU is partially restored by co-expression with Rab8Scer\UAS.P\T.T:Avic\GFP-YFP.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Rab8Scer\UAS.P\T.T:Avic\GFP-YFP
Rab8UASp.YFP
Name Synonyms
Secondary FlyBase IDs
    References (13)