FB2026_02 , released June 18, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Rab5, Lrrk
FlyBase ID
FBig0000103574
Interaction Network
Interactions Browser links
Rab5 network
Lrrk network
Reported Interactions
FBrf0217544-1.coIP.WB
Reference
Dodson et al., 2012
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
Rab5 

Rab5

bait

GFP tag

Lrrk 

Lrrk

prey

Myc tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Dodson et al., 2012)

The G1914S mutation of Lrrk does not reduce binding to Rab5 (as it does for binding to Rab7).

(Dodson et al., 2012)

Positive control.

(Dodson et al., 2012)
FBrf0226910-1.coIP.WB
Reference
Dodson et al., 2014
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
Rab5 

Rab5

bait

YFP tag

Lrrk 

Lrrk

prey

Myc tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Dodson et al., 2014)

Lrrk coimmunoprecipitates with Rab5 and more strongly with Rab9, but not with Rab11.

(Dodson et al., 2014)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)