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Citation
Artiushin, G., Zhang, S.L., Tricoire, H., Sehgal, A. (2018). Endocytosis at the Drosophila blood-brain barrier as a function for sleep.  eLife 7(): e43326.
FlyBase ID
FBrf0240827
Publication Type
Research paper
Abstract

Glia are important modulators of neural activity, yet few studies link glia to sleep regulation. We find that blocking activity of the endocytosis protein, dynamin, in adult Drosophila glia increases sleep and enhances sleep need, manifest as resistance to sleep deprivation. Surface glia comprising the fly equivalent of the blood-brain barrier (BBB) mediate the effect of dynamin on sleep. Blocking dynamin in the surface glia causes ultrastructural changes, albeit without compromising the integrity of the barrier. Supporting a role for endocytic trafficking in sleep, a screen of Rab GTPases identifies sleep-modulating effects of the recycling endosome Rab11 in surface glia. We also find that endocytosis is increased in BBB glia during sleep and reflects sleep need. We propose that endocytic trafficking through the BBB represents a function of sleep.

PubMed ID
PubMed Central ID
PMC6255390 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    eLife
    Title
    eLife
    ISBN/ISSN
    2050-084X
    Data From Reference
    Alleles (30)
    Genes (11)
    Natural transposons (1)
    Insertions (7)
    Experimental Tools (1)
    Transgenic Constructs (25)