FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Rab5SN.FRT.UAS
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General Information
Symbol
Dmel\Rab5SN.FRT.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0190353
Feature type
allele
Associated gene
Dmel\Rab5
Associated Insertion(s)
Carried in Construct
P{UAS(FRT.HcRed1)Rab5.SN}
Key Links
Transgenic product class
dominant_negative_variant
(Marois et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Marois et al., 2006)
Mutagen
in vitro construct
(Marois et al., 2006)
Progenitor genotype
Carried in construct
P{UAS(FRT.HcRed1)Rab5.SN}
Cytology
Description

A disruptive FRT>HcRed1>FRT cassette separates UASt regulatory sequences from sequence encoding a dominant negative form of Rab5.

(Marois et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Rab5
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adulthood-only expression of Rab5SN.FRT.UAS under the control of Scer\GAL4esg.PU leads to a significant increase in the number of mitotic cells (phospho-H3 staining) in the adult midgut, as compared to controls. (The temporal regulation of expression is dependent on Gal80[ts] and induced by temperature shift to 29[o]C for 5-6 days during adulthood).

      (Zhang et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rab5SN.FRT.UAS
      Rab5SN.Scer\FRT.Scer\UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (5)